Fabrizio Chiodo
@fabriziochiodo.bsky.social
Glyco-Scientist,
Research Associate Prof. Italian National Research Council (CNR), Collaborator Finlay Vaccines Institute.
Research Associate Prof. Italian National Research Council (CNR), Collaborator Finlay Vaccines Institute.
Reposted by Fabrizio Chiodo
154 million lives and counting: 5 charts reveal the power of vaccines. Story by @heidiledford.bsky.social www.nature.com/articles/d41...
154 million lives and counting: 5 charts reveal the power of vaccines
But public-health specialists worry that misinformation and funding cuts could affect vaccination rates.
www.nature.com
April 11, 2025 at 7:47 PM
154 million lives and counting: 5 charts reveal the power of vaccines. Story by @heidiledford.bsky.social www.nature.com/articles/d41...
Safeguarding immunisation: a core function of WHO - The Lancet www.thelancet.com/journals/lan...
Safeguarding immunisation: a core function of WHO
Vaccination remains the most cost-effective public health intervention, preventing
millions of deaths and reducing disease burden worldwide.1 However, their impact is
rendered meaningless if vaccines ...
www.thelancet.com
March 30, 2025 at 10:40 AM
Safeguarding immunisation: a core function of WHO - The Lancet www.thelancet.com/journals/lan...
Reposted by Fabrizio Chiodo
Microplastics are facilitating antibiotic resistance
journals.asm.org/doi/epub/10.... open-access
journals.asm.org/doi/epub/10.... open-access
March 11, 2025 at 2:28 PM
Microplastics are facilitating antibiotic resistance
journals.asm.org/doi/epub/10.... open-access
journals.asm.org/doi/epub/10.... open-access
Reposted by Fabrizio Chiodo
Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise
https://go.nature.com/4hDtGhL
https://go.nature.com/4hDtGhL
Asteroid fragments upend theory of how life on Earth bloomed
Samples from Bennu contain the chemical building blocks of life - but with a twist.
go.nature.com
January 29, 2025 at 4:38 PM
Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise
https://go.nature.com/4hDtGhL
https://go.nature.com/4hDtGhL
Reposted by Fabrizio Chiodo
Our latest editorial is now online, in advance of our February issue that will be available next week.
Brain microbiome: is it all in our heads?
www.thelancet.com/journals/lan...
Brain microbiome: is it all in our heads?
www.thelancet.com/journals/lan...
Brain microbiome: is it all in our heads?
In their September 2018 Editorial, The Lancet Infectious Diseases discussed the over-reaching
inferences leading to suggestions of a placental microbiome, and touched on how the
same extrapolations we...
www.thelancet.com
January 30, 2025 at 12:32 PM
Our latest editorial is now online, in advance of our February issue that will be available next week.
Brain microbiome: is it all in our heads?
www.thelancet.com/journals/lan...
Brain microbiome: is it all in our heads?
www.thelancet.com/journals/lan...
Reposted by Fabrizio Chiodo
#CLRpower! Sensing of microbiota after gut barrier disruption reprograms the bone marrow & myeloid functions via the C-type lectin receptor Mincle!! @cp-immunitt.bsky.social from @sancholab.bsky.social &co! 👇👇👇
#immunosky #microbiomesky FREE LINK @cp-immunity.bsky.social!
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly
Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity
in myeloid bone marrow progenito...
www.cell.com
January 23, 2025 at 12:02 PM
#CLRpower! Sensing of microbiota after gut barrier disruption reprograms the bone marrow & myeloid functions via the C-type lectin receptor Mincle!! @cp-immunitt.bsky.social from @sancholab.bsky.social &co! 👇👇👇
Reposted by Fabrizio Chiodo
But, who is sensing E. faecalis? We found that Mincle is sensing E. faecalis and that Mincle mediates trained immunity in response to their many ligands. Staphylococcus aureus, another bacteria translocated to the BM, is also sensed and inducing trained immunity via Mincle.
January 23, 2025 at 11:04 AM
But, who is sensing E. faecalis? We found that Mincle is sensing E. faecalis and that Mincle mediates trained immunity in response to their many ligands. Staphylococcus aureus, another bacteria translocated to the BM, is also sensed and inducing trained immunity via Mincle.
Reposted by Fabrizio Chiodo
New paper alert 📢! (Cell) @cp-cell.bsky.social
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8
January 21, 2025 at 12:37 PM
New paper alert 📢! (Cell) @cp-cell.bsky.social
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8
Reposted by Fabrizio Chiodo
Polysialic acids are upregulated on activated T cells #glycotime
Polysialylation is a general feature of immune activation
Sialic acids are critical regulators of immune responses and the sialic acid-Siglec axis has receive much attention recently for it role as a new immune checkpoint. While α2,3- and α2,6-linked sialosi...
www.biorxiv.org
January 16, 2025 at 8:42 PM
Polysialic acids are upregulated on activated T cells #glycotime
Reposted by Fabrizio Chiodo
#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology
Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...
www.nature.com
January 8, 2025 at 3:48 PM
#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance
Reposted by Fabrizio Chiodo
Five years ago, on 31 December 2019, WHO’s Country Office in #China picked up a media statement by the Wuhan Municipal Health Commission from their website on cases of ‘viral pneumonia’ in Wuhan, China. 🧵
December 30, 2024 at 4:10 PM
Five years ago, on 31 December 2019, WHO’s Country Office in #China picked up a media statement by the Wuhan Municipal Health Commission from their website on cases of ‘viral pneumonia’ in Wuhan, China. 🧵
Reposted by Fabrizio Chiodo
Global immunization efforts have saved an estimated 154 million lives – that is 6 lives every minute – since the founding of the Expanded Programme on Immunization, 50 years ago.
bit.ly/4gpxQJK
bit.ly/4gpxQJK
December 27, 2024 at 7:35 AM
Global immunization efforts have saved an estimated 154 million lives – that is 6 lives every minute – since the founding of the Expanded Programme on Immunization, 50 years ago.
bit.ly/4gpxQJK
bit.ly/4gpxQJK
"Collectively, these results demonstrate the ability of the innate and adaptive immune systems to recognize chlorovirus glycoproteins, a process dependent on their specific N-glycan structures..."
Our #glycotime study just published @commsbio.bsky.social
www.nature.com/articles/s42...
Our #glycotime study just published @commsbio.bsky.social
www.nature.com/articles/s42...
Carbohydrate-mediated interactions between chloroviruses and the immune system - Communications Biology
This study explores how viral N-linked glycans play a role in the interaction between chloroviruses glycoproteins and key receptors of the innate immune system.
www.nature.com
December 19, 2024 at 1:43 PM
"Collectively, these results demonstrate the ability of the innate and adaptive immune systems to recognize chlorovirus glycoproteins, a process dependent on their specific N-glycan structures..."
Our #glycotime study just published @commsbio.bsky.social
www.nature.com/articles/s42...
Our #glycotime study just published @commsbio.bsky.social
www.nature.com/articles/s42...
Reposted by Fabrizio Chiodo
Valerie Lensch of @kiesslinglab.bsky.social and the Johnson group reviewed different glycan-based strategies for eliciting an immune response: academic.oup.com/glycob/artic... #glycotime
Glycoconjugate vaccines: platforms and adjuvants for directed immunity
Abstract. Central to immune recognition is the glycocalyx, a glycan-rich coat on all cells that plays a crucial role in interactions that enable pathogen d
academic.oup.com
December 9, 2024 at 12:27 PM
Valerie Lensch of @kiesslinglab.bsky.social and the Johnson group reviewed different glycan-based strategies for eliciting an immune response: academic.oup.com/glycob/artic... #glycotime
Reposted by Fabrizio Chiodo
New 🚨 #glycotime in @science.org H5N1 "a Gln226Leu substitution switched Texas HA binding specificity to human-type receptors, which was enhanced when combined with an Asn224Lys mutation"
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www.science.org/doi/10.1126/...
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www.science.org/doi/10.1126/...
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...
www.science.org
December 5, 2024 at 9:44 PM
New 🚨 #glycotime in @science.org H5N1 "a Gln226Leu substitution switched Texas HA binding specificity to human-type receptors, which was enhanced when combined with an Asn224Lys mutation"
⬇️⬇️
www.science.org/doi/10.1126/...
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www.science.org/doi/10.1126/...
Reposted by Fabrizio Chiodo
The danger theory of immunity strikes back... rdcu.be/d1uQN
November 26, 2024 at 6:13 PM
The danger theory of immunity strikes back... rdcu.be/d1uQN
Reposted by Fabrizio Chiodo
This month in #ScienceImmunology, @virusesimmunity.bsky.social & colleagues reported that #ERV -reactive #B1Cells secrete #antibodies that recognize GlcNAc moieties on both ERV #glycoproteins as well as glycoproteins of other enveloped #viruses!
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses
Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.
www.science.org
November 20, 2024 at 9:59 PM
This month in #ScienceImmunology, @virusesimmunity.bsky.social & colleagues reported that #ERV -reactive #B1Cells secrete #antibodies that recognize GlcNAc moieties on both ERV #glycoproteins as well as glycoproteins of other enveloped #viruses!
