Peng Wu
@pengwu.bsky.social
Professor at Scripps Research. Interested in glycosylation, cancer immunology, and autoimmunity.
This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime
Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune
responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null,
TCR-sufficient anti-CD19...
www.cell.com
August 31, 2025 at 8:41 PM
This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime
I inherited a huge bottle of GDP-fucose from the Paulson lab today, thanks Jim! # glycotime
June 23, 2025 at 8:15 PM
I inherited a huge bottle of GDP-fucose from the Paulson lab today, thanks Jim! # glycotime
In this incredible work, @srouhanifard.bsky.social developed a new catalyst, which makes CuAAC truly biocompatible
rdcu.be/enfHz
rdcu.be/enfHz
inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst
Nature Communications - Tracking biomolecules in living cells requires fast but gentle labeling. Here, authors introduce inCu-click, a DNA-conjugated ligand that localizes copper to enable...
rdcu.be
June 17, 2025 at 1:15 AM
In this incredible work, @srouhanifard.bsky.social developed a new catalyst, which makes CuAAC truly biocompatible
rdcu.be/enfHz
rdcu.be/enfHz
The Rabinovichlab discovered that MDSC-specific deletion of ST6Gal1 enhanced GAL1-driven suppressive signals and accelerated tumor growth, effects that can be ameliorated by GAL1-blocking antibodies www.cell.com/immunity/ful...
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells
Blidner et al. identify a glycosylation-dependent, galectin-driven circuit as a common
mechanism that simultaneously induces immunosuppressive and pro-angiogenic functions
in myeloid-derived suppresso...
www.cell.com
June 3, 2025 at 4:24 PM
The Rabinovichlab discovered that MDSC-specific deletion of ST6Gal1 enhanced GAL1-driven suppressive signals and accelerated tumor growth, effects that can be ameliorated by GAL1-blocking antibodies www.cell.com/immunity/ful...
Such an inspiring talk by Dr. Rabinovich #Glyco27 on the immuno-modulatory functions of galectins #immunotherapy
June 3, 2025 at 4:07 PM
Such an inspiring talk by Dr. Rabinovich #Glyco27 on the immuno-modulatory functions of galectins #immunotherapy
The 33rd commencement at Scripps starts now
May 16, 2025 at 5:08 PM
The 33rd commencement at Scripps starts now
Congratulations to Ellie for successfully defending her Ph.D. Her thesis work provided new insights into the inhibitory interactions between sialoglycans and SIglecs #glycotime We are so proud of you!
May 1, 2025 at 2:09 PM
Congratulations to Ellie for successfully defending her Ph.D. Her thesis work provided new insights into the inhibitory interactions between sialoglycans and SIglecs #glycotime We are so proud of you!
Reposted by Peng Wu
“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.”
www.nytimes.com/2025/04/28/o...
www.nytimes.com/2025/04/28/o...
Opinion | The White House Tech Bros Owe Their Fortunes to the Research They’re Killing
Underlying many investments are breakthroughs in medicine and technology from great universities.
www.nytimes.com
April 30, 2025 at 5:58 AM
“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.”
www.nytimes.com/2025/04/28/o...
www.nytimes.com/2025/04/28/o...
Reposted by Peng Wu
#glycotime "OGT protects the genome against TET-mediated DNA demethylation and loss of heterochromatin integrity, preventing the aberrant increase in transposable element expression noted in cancer, autoimmune-inflammatory diseases, cellular senescence and aging" www.nature.com/articles/s41...
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide - Nature Structural & Molecular Biology
Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos...
www.nature.com
April 3, 2025 at 6:26 AM
#glycotime "OGT protects the genome against TET-mediated DNA demethylation and loss of heterochromatin integrity, preventing the aberrant increase in transposable element expression noted in cancer, autoimmune-inflammatory diseases, cellular senescence and aging" www.nature.com/articles/s41...
It’s nice meet to meet with @roviralab.bsky.social to discuss our fucosylation enzymes. Thank you for your kind host!
Thank you so much @pengwu.bsky.social for taking time to visit us at @ub.edu! We appreciate your insight and discussions on protein glycosylation mechanisms.
@scripps.edu
@scripps.edu
April 1, 2025 at 8:48 PM
It’s nice meet to meet with @roviralab.bsky.social to discuss our fucosylation enzymes. Thank you for your kind host!
Reposted by Peng Wu
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
March 28, 2025 at 2:15 AM
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
@rpdevrieslab.bsky.social fantastic work on the involvement of the LacNAc chains in human influenza A virus hemaglutinin receptor interactions #glycotime rdcu.be/dD4Q0
Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling
Nature Communications - Binding modes of antigenically drifted hemagglutinins of human influenza A viruses have been determined by NMR using synthetic N-glycans having 13C-labeled monosaccharides...
rdcu.be
March 28, 2025 at 11:02 PM
@rpdevrieslab.bsky.social fantastic work on the involvement of the LacNAc chains in human influenza A virus hemaglutinin receptor interactions #glycotime rdcu.be/dD4Q0
Stromal cell sialylation suppresses NK cell function through Siglec-10 engagement #glycotime www.biorxiv.org/content/10.1...
Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...
www.biorxiv.org
March 27, 2025 at 4:59 PM
Stromal cell sialylation suppresses NK cell function through Siglec-10 engagement #glycotime www.biorxiv.org/content/10.1...
Reposted by Peng Wu
Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social
🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
February 19, 2025 at 9:43 PM
Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social
Reposted by Peng Wu
Reposted by Peng Wu
If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus?
www.nytimes.com/2025/02/14/o...
www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 15, 2025 at 1:59 AM
If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus?
www.nytimes.com/2025/02/14/o...
www.nytimes.com/2025/02/14/o...
Look forward to speak at the 2025 Carbohydrate GRC #glycotime
Registration is open for the 2025 Gordon Research Conference on Carbohydrates and the associated Gordon Research Seminar! 🧪 We have a exciting line-up of confirmed speakers and more to be added!
www.grc.org/carbohydrate...
The conference will be held June 15 - 20 in Holderness, NH.
www.grc.org/carbohydrate...
The conference will be held June 15 - 20 in Holderness, NH.
2025 Carbohydrates Conference GRC
The 2025 Gordon Research Conference on Carbohydrates will be held in Holderness, New Hampshire. Apply today to reserve your spot.
www.grc.org
February 14, 2025 at 10:39 PM
Look forward to speak at the 2025 Carbohydrate GRC #glycotime
Reposted by Peng Wu
Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.
www.washingtonpost.com/health/2025/...
www.washingtonpost.com/health/2025/...
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com
February 8, 2025 at 5:12 PM
Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.
www.washingtonpost.com/health/2025/...
www.washingtonpost.com/health/2025/...
Enhancing glycosylation levels is good for CAR-T, maintaining their anti-tumor efficacy without causing GvHD #glycotime
Changes in Glycosylation on the Cell Surface Result in Highly Potent and Long-Lasting Allogeneic CAR-T Therapy in Patients
Disclosures. No relevant conflicts of interest to declare.
ashpublications.org
February 3, 2025 at 6:10 PM
Enhancing glycosylation levels is good for CAR-T, maintaining their anti-tumor efficacy without causing GvHD #glycotime
Happy Chinese new year!
January 29, 2025 at 4:34 PM
Happy Chinese new year!
Siglec binding to sulfated glycan @siglecdude.bsky.social #glycotine. Thanks for including us in this fantastic work.
Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs
Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...
pubs.acs.org
January 22, 2025 at 8:58 PM
Siglec binding to sulfated glycan @siglecdude.bsky.social #glycotine. Thanks for including us in this fantastic work.
Reposted by Peng Wu
#WeekendRead! #EveryOrganIsAnImmuneOrgan 😉! The Balachandran lab &co show @ Nature that the alarmin domain of IL33 expands lymphoneogenic ILC2s which favor tertiary lymphoid organ formation in colitis & during tumor growth! Engineered IL33 can be an antitumoral! www.nature.com/articles/s41...
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer - Nature
IL-33 induces tertiary lymphoid structures.
www.nature.com
January 19, 2025 at 3:52 PM
#WeekendRead! #EveryOrganIsAnImmuneOrgan 😉! The Balachandran lab &co show @ Nature that the alarmin domain of IL33 expands lymphoneogenic ILC2s which favor tertiary lymphoid organ formation in colitis & during tumor growth! Engineered IL33 can be an antitumoral! www.nature.com/articles/s41...
Aging is accompanied by a down-regulation of the bisected glycan and an up-regulation of the digalactosylated glycan on IgG #glycotime
Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics
Immunoglobulin G (IgG) N-glycans have been identified as associated with aging; however, previous studies predominantly quantified changes based on the relative percentages of each glycan within the t...
www.biorxiv.org
January 19, 2025 at 6:32 AM
Aging is accompanied by a down-regulation of the bisected glycan and an up-regulation of the digalactosylated glycan on IgG #glycotime