Feyza Engin
@enginlab.bsky.social
Associate Professor @University of Wisconsin-Madison. Previously Harvard University & Baylor College of Medicine.
www.enginlab.org
www.enginlab.org
Reposted by Feyza Engin
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
https://link.springer.com/article/10.100…
November 14, 2025 at 3:33 AM
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Reposted by Feyza Engin
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism
LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...
nature.com
July 21, 2025 at 10:48 AM
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
Reposted by Feyza Engin
Inflammation, unfolded protein response, and secretory hormone processing create #T1D epitopes in human cytokine-treated #islets www.cell.com/cell-reports...
The antigen presentation landscape of cytokine-stressed human pancreatic islets
Nanaware et al. characterize peptides presented by MHC proteins in inflamed human
pancreatic islets and test them for reactivity with CD4 and CD8 T cells from patients
with T1D. These results identify...
www.cell.com
July 19, 2025 at 9:41 PM
Inflammation, unfolded protein response, and secretory hormone processing create #T1D epitopes in human cytokine-treated #islets www.cell.com/cell-reports...
Really interesting www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
July 18, 2025 at 7:36 PM
Really interesting www.nature.com/articles/s41...
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication: Cell Metabolism www.cell.com/cell-metabol...
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Tong et al. utilize advanced imaging approaches to reveal that beta cells located
next to alpha cells are specially adapted as glucagon sensors by virtue of their high
expression levels of GLP1R. Thes...
www.cell.com
July 15, 2025 at 12:27 AM
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication: Cell Metabolism www.cell.com/cell-metabol...
Reposted by Feyza Engin
One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/...
For more trending articles, visit ow.ly/Me2U50SkLRZ.
For more trending articles, visit ow.ly/Me2U50SkLRZ.
July 14, 2025 at 4:45 PM
One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/...
For more trending articles, visit ow.ly/Me2U50SkLRZ.
For more trending articles, visit ow.ly/Me2U50SkLRZ.
Reposted by Feyza Engin
The combination of verapamil and low-dose mATG outperformed monotherapy in reversing recent-onset type 1 #diabetes in NOD mice #T1D @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Verapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset type 1 diabetes in NOD mice by acting on the beta cell and immune axes - Diabetologia
Aims/hypothesis Verapamil, a calcium channel blocker, and low doses of anti-thymocyte globulin (ATG) have individually shown efficacy in preserving beta cell function in people with recent-onset sympt...
link.springer.com
July 12, 2025 at 7:19 PM
The combination of verapamil and low-dose mATG outperformed monotherapy in reversing recent-onset type 1 #diabetes in NOD mice #T1D @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Reposted by Feyza Engin
About 1 in 3 young people who are 12 to 17 years old have prediabetes, new national data show, putting them at risk not just for type 2 diabetes but also for heart disease and stroke.
www.statnews.com/2025/07/09/p...
www.statnews.com/2025/07/09/p...
Nearly 1 in 3 teens have prediabetes, CDC finds, in ‘wake-up call’
Nearly 1 in 3 American adolescents have prediabetes, a CDC report finds. An official notes "it’s not too late to change course."
www.statnews.com
July 10, 2025 at 2:27 AM
About 1 in 3 young people who are 12 to 17 years old have prediabetes, new national data show, putting them at risk not just for type 2 diabetes but also for heart disease and stroke.
www.statnews.com/2025/07/09/p...
www.statnews.com/2025/07/09/p...
Reposted by Feyza Engin
Very excited to share new work on the origins of beta cell senescence in #T1D led by talented PhD student Jasmine Pipella! 🥂🎉 online today!
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes
Type 1 diabetes (T1D) results from a complex dialogue between the immune system and islets characterized by T cell–mediated autoimmune destruction of pancr
diabetesjournals.org
June 11, 2025 at 8:04 PM
Very excited to share new work on the origins of beta cell senescence in #T1D led by talented PhD student Jasmine Pipella! 🥂🎉 online today!
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
Reposted by Feyza Engin
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
June 27, 2025 at 11:21 AM
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Reposted by Feyza Engin
New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...
www.biorxiv.org
June 27, 2025 at 3:52 PM
New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Feyza Engin
Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?
Mice lacking this amino acid lost 30% of their body weight
But eliminating cysteine, which is found in high-protein foods, from human diets would be challenging.
www.nature.com
May 24, 2025 at 1:33 PM
Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?
Reposted by Feyza Engin
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage
Lysosomes are damaged in quiescent cells, and UPR regulators, IRE-1/XBP-1, promote
lysosome repair for cell-cycle re-entry. Lysosome damage in quiescent cells is caused
in part by macroautophagy and i...
www.cell.com
May 15, 2025 at 9:04 PM
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...
Reposted by Feyza Engin
Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis
Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…
www.sciencedirect.com
April 17, 2025 at 9:24 PM
Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
Reposted by Feyza Engin
Be on the lookout for a new paper from the lab:
"iCLAP: A high-plex immunostaining with high sensitivity for co-detection of low-abundance antigens".
In this paper, we introduce ICLAP to detect and spatially map low-abundance proteins, such as senescence markers, in FFPE tissue sections.
"iCLAP: A high-plex immunostaining with high sensitivity for co-detection of low-abundance antigens".
In this paper, we introduce ICLAP to detect and spatially map low-abundance proteins, such as senescence markers, in FFPE tissue sections.
April 5, 2025 at 3:20 PM
Be on the lookout for a new paper from the lab:
"iCLAP: A high-plex immunostaining with high sensitivity for co-detection of low-abundance antigens".
In this paper, we introduce ICLAP to detect and spatially map low-abundance proteins, such as senescence markers, in FFPE tissue sections.
"iCLAP: A high-plex immunostaining with high sensitivity for co-detection of low-abundance antigens".
In this paper, we introduce ICLAP to detect and spatially map low-abundance proteins, such as senescence markers, in FFPE tissue sections.
Reposted by Feyza Engin
Online Now: STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders Online now:
STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders
STING signaling in the innate immune system is well known for its role in the antiviral type I interferon response. Tang et al. find that STING acts as an immune sensor of lysosomal activity. When the lysosome becomes defective, STING is activated and exerts a dual function that induces both immune signaling and lysosomal biogenesis.
dlvr.it
April 3, 2025 at 7:14 PM
Online Now: STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders Online now:
Reposted by Feyza Engin
New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 28, 2025 at 10:41 AM
New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Feyza Engin
Huo, Wang et al. reveal that #adipocytes experiencing endoplasmic reticulum stress secrete #ceramide in lipoprotein form to #hepatocytes, activating the unfolded protein response by reducing membrane fluidity. rupress.org/jcb/article/...
#ER_literature
#ER_literature
March 26, 2025 at 4:17 PM
Huo, Wang et al. reveal that #adipocytes experiencing endoplasmic reticulum stress secrete #ceramide in lipoprotein form to #hepatocytes, activating the unfolded protein response by reducing membrane fluidity. rupress.org/jcb/article/...
#ER_literature
#ER_literature
Reposted by Feyza Engin
Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social
Excited to share that work from my PhD is now available in @natmetabolism.bsky.social! Here, we uncover a link between heme production, BCAA metabolism, and thermogenesis—implicating heme synthesis in #aging, #obesity, and #T2D.
Link to paper: urldefense.com/v3/__https:/...
A Thread (1/15)
Link to paper: urldefense.com/v3/__https:/...
A Thread (1/15)
Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
Nature Metabolism - Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs...
urldefense.com
March 25, 2025 at 2:41 PM
Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social
Reposted by Feyza Engin
Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
March 24, 2025 at 9:01 PM
Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Feyza Engin
www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
How Metabolism Can Shape Cells’ Destinies | Quanta Magazine
A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.
www.quantamagazine.org
March 21, 2025 at 4:57 PM
www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...