Eachan Johnson
@eachanjohnson.bsky.social
Group leader at The Francis Crick Institute in London. Opinions are my own. he/him
🦠 M. tuberculosis, K. pneumoniae, other pathogenic bacteria
🧫 antimicrobial resistance
🧬 molecular genetics
⚗️ chemical biology
🦠 M. tuberculosis, K. pneumoniae, other pathogenic bacteria
🧫 antimicrobial resistance
🧬 molecular genetics
⚗️ chemical biology
Pinned
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
📢 PhD Opportunity @crick.ac.uk
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Reposted by Eachan Johnson
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
🚨Deadline for our Senior Scientist applications is next week.
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
The Francis Crick Institute hiring Senior Laboratory Research Scientist in London Area, United Kingdom | LinkedIn
Posted 2:43:22 PM. Senior Laboratory Research Scientist - Johnson LabDetails of the role:Reports to: Eachan Johnson…See this and similar jobs on LinkedIn.
www.linkedin.com
November 1, 2025 at 12:49 PM
🚨Deadline for our Senior Scientist applications is next week.
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
Reposted by Eachan Johnson
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
October 27, 2025 at 2:07 PM
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Reposted by Eachan Johnson
Just a few weeks left to apply for our clinical PhD programme.
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
Doctoral clinical fellows
The Crick's clinical PhD programme.
www.crick.ac.uk
October 30, 2025 at 9:41 AM
Just a few weeks left to apply for our clinical PhD programme.
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
The Francis Crick Institute hiring Senior Laboratory Research Scientist in London Area, United Kingdom | LinkedIn
Posted 2:43:22 PM. Senior Laboratory Research Scientist - Johnson LabDetails of the role:Reports to: Eachan Johnson…See this and similar jobs on LinkedIn.
www.linkedin.com
October 24, 2025 at 3:25 PM
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 9:47 PM
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
Reposted by Eachan Johnson
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:
idm.uct.ac.za/media/739223
idm.uct.ac.za/media/739223
October 9, 2025 at 11:28 AM
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:
idm.uct.ac.za/media/739223
idm.uct.ac.za/media/739223
Reposted by Eachan Johnson
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
October 5, 2025 at 4:10 PM
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
Reposted by Eachan Johnson
Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com
The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all
Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.
www.statnews.com
October 6, 2025 at 12:15 PM
Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com
Reposted by Eachan Johnson
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery
Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...
chemrxiv.org
September 23, 2025 at 12:10 PM
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
📢 PhD Opportunity @crick.ac.uk
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 6, 2025 at 9:40 AM
📢 PhD Opportunity @crick.ac.uk
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Reposted by Eachan Johnson
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
www.nature.com
September 19, 2025 at 1:52 PM
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Eachan Johnson
Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social
More info below ⬇️
More info below ⬇️
📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
📅 Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
#DevBio
Guest Editors: Alex Hughes and Rashmi Priya
📅 Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
#DevBio
September 19, 2025 at 9:48 AM
Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social
More info below ⬇️
More info below ⬇️
Reposted by Eachan Johnson
Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Systematic antigen selection is an enduring challenge in tuberculosis (TB) vaccine development. An antigen screen ranks protective CD4 T cell antigens and yields a novel trivalent mRNA vaccine that protects against TB challenges in mice.
dlvr.it
September 15, 2025 at 6:52 PM
Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Reposted by Eachan Johnson
Be my colleague! Cal Poly San Luis Obispo is hiring two tenure-track positions for Fall 2026, chemical education and coatings technology.
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Cal Poly - Details - Tenure Track Position - Chemistry
jobs.calpoly.edu
September 17, 2025 at 6:05 PM
Be my colleague! Cal Poly San Luis Obispo is hiring two tenure-track positions for Fall 2026, chemical education and coatings technology.
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Reposted by Eachan Johnson
The EMBL PhD programme is open until 13th October (entry ~Sep 2026):
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
EMBL International PhD Programme – Unique in the world and waiting for you!
www.embl.org
September 17, 2025 at 3:49 PM
The EMBL PhD programme is open until 13th October (entry ~Sep 2026):
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
Reposted by Eachan Johnson
Please apply to our tenure-track faculty position at
@stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely!
chemh.stanford.edu/opportunitie...
@stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely!
chemh.stanford.edu/opportunitie...
Faculty Recruitment
chemh.stanford.edu
September 17, 2025 at 5:54 PM
Please apply to our tenure-track faculty position at
@stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely!
chemh.stanford.edu/opportunitie...
@stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely!
chemh.stanford.edu/opportunitie...
Reposted by Eachan Johnson
My institution is looking to hire a new microbiologist: apply.interfolio.com/173702. Please share, and let me know if you have any questions about the position or UTA.
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 16, 2025 at 6:51 PM
My institution is looking to hire a new microbiologist: apply.interfolio.com/173702. Please share, and let me know if you have any questions about the position or UTA.
Reposted by Eachan Johnson
So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)
Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study
Background Current efforts to reduce global tuberculosis incidence have proved insufficient, highlighting that urgent action is needed to address underlying modifiable risk factors such as undernutrit...
doi.org
September 10, 2025 at 4:11 AM
So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)
Reposted by Eachan Johnson
How to make training data from tacit knowledge in medicinal chemistry is one of the big challenges.
August 25, 2025 at 11:03 PM
How to make training data from tacit knowledge in medicinal chemistry is one of the big challenges.
Reposted by Eachan Johnson
A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Monitoring single cell bioenergetic status and cell lysis in dense and differentiating Bacillus subtilis cultures
Bacillus subtilis is a major model organism for studying population heterogeneity in clonal bacterial cultures due to its high genetic tractability and ability to differentiate into subpopulations wit...
www.biorxiv.org
August 22, 2025 at 7:24 AM
A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Eachan Johnson
Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable @lucy-watson.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine - Nature Communications
Cryptosporidium is an important threat to public health, yet it lacks a robust genetic toolkit. Here, Watson et al. introduce a targeted CRISPR-based screening method to identify parasite genes that a...
www.nature.com
August 20, 2025 at 5:58 PM
Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable @lucy-watson.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Eachan Johnson
My Friday night hot take is that replication studies are largely a waste of time & $
If a result is worth following up on, it's better to address from a different angle & see if it holds water. Strong ideas withstand this
Conversely, there R infinite ways a replication can fail that teach you zip
If a result is worth following up on, it's better to address from a different angle & see if it holds water. Strong ideas withstand this
Conversely, there R infinite ways a replication can fail that teach you zip
August 16, 2025 at 1:47 AM
My Friday night hot take is that replication studies are largely a waste of time & $
If a result is worth following up on, it's better to address from a different angle & see if it holds water. Strong ideas withstand this
Conversely, there R infinite ways a replication can fail that teach you zip
If a result is worth following up on, it's better to address from a different angle & see if it holds water. Strong ideas withstand this
Conversely, there R infinite ways a replication can fail that teach you zip
Reposted by Eachan Johnson
Are you excited about using cyclic #peptides in #DrugDiscovery?
Here is a great opportunity to perform a #postdoc with a great mentor in the group of @ljwalport.bsky.social at @imperialcollegeldn.bsky.social!
www.linkedin.com/posts/louise...
#ChemBio #Chemistry #ChemSky
Here is a great opportunity to perform a #postdoc with a great mentor in the group of @ljwalport.bsky.social at @imperialcollegeldn.bsky.social!
www.linkedin.com/posts/louise...
#ChemBio #Chemistry #ChemSky
🚨 Looking for a new research opportunity?🚨 | Louise Walport
🚨 Looking for a new research opportunity?🚨
We are looking to recruit two talented postdocs to join our group based at the Molecular Science Research Hub at Imperial College London:
- Both to join ou...
www.linkedin.com
August 10, 2025 at 7:59 AM
Are you excited about using cyclic #peptides in #DrugDiscovery?
Here is a great opportunity to perform a #postdoc with a great mentor in the group of @ljwalport.bsky.social at @imperialcollegeldn.bsky.social!
www.linkedin.com/posts/louise...
#ChemBio #Chemistry #ChemSky
Here is a great opportunity to perform a #postdoc with a great mentor in the group of @ljwalport.bsky.social at @imperialcollegeldn.bsky.social!
www.linkedin.com/posts/louise...
#ChemBio #Chemistry #ChemSky