Jeannine Hess
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jeanninehess.bsky.social
Jeannine Hess
@jeanninehess.bsky.social
Group Leader @the Crick
Lecturer @King's College London
Bioinorganic chemist lover addressing infectious disease 💚❤️💚
📣Fully-funded 4-Year PhD available in my lab! Join the team to shape the future of metal-based antibiotic drug discovery.

Application deadline 5th of November! Spread the word

www.crick.ac.uk/careers-stud...
Hess Lab | Metal-based Heterobifunctional Scaffolds to Capture Challenging Proteins
www.crick.ac.uk
October 13, 2025 at 7:26 AM
Come work with us! We have a PhD opportunity available with the Sedgwick and Giuliani groups. Please reach out if you are interested.

@CRUKCOLcentre
www.colcc.ac.uk/2026-phd-pro...
2026 PhD Project Sedgwick
Metal-based Photoimmunotherapy Agents for the Targeted Treatment of Neuroblastoma Primary supervisor: Adam Sedgwick, King's College London Secondary supervisor: Jeannine Hess, The Francis Crick Ins...
www.colcc.ac.uk
October 13, 2025 at 7:26 AM
Reposted by Jeannine Hess
2026 PhD recruitment is now open.

As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:

www.crick.ac.uk/careers-stud...
PhD student recruitment
PhD recruitment information.
www.crick.ac.uk
October 7, 2025 at 3:14 PM
Reposted by Jeannine Hess
📆 Deadline: 14 November.
🩺 Doctoral Clinical Fellows programme (3-year PhD)
🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social
Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
✍️ Apply here: www.crick.ac.uk/careers-stud...
Johnson lab and Hess lab | Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
www.crick.ac.uk
October 6, 2025 at 9:40 AM
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery
Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...
chemrxiv.org
September 23, 2025 at 12:10 PM
Reposted by Jeannine Hess
Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...
July 24, 2025 at 5:33 AM
📣Preprint 📣
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1
The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the cli...
doi.org
July 24, 2025 at 6:23 AM
🚨Less than a week left to apply (deadline 19/03/25) for this exciting fully funded 4 Year Phd position in my group.

Multidisciplinary project on the design of novel metallo-NBTIs including all the fun of chemistry and much more! Please RT!

Apply here: www.crick.ac.uk/careers-stud...
Hess Lab | Metal-based Heterobifunctional Scaffolds to Capture Challenging Proteins
www.crick.ac.uk
March 13, 2025 at 9:35 AM