Alexandre Hofer
@hofalex.bsky.social
R&D bioorganic chemist in biotech.
High affinity to nucleotides and nucleic acids.
All views my own.
High affinity to nucleotides and nucleic acids.
All views my own.
Pinned
Reposted by Alexandre Hofer
Even I’m not sure this will end well. Graphics courtesy of Dylan Patel of SemiAnalysis.
September 23, 2025 at 5:42 AM
Even I’m not sure this will end well. Graphics courtesy of Dylan Patel of SemiAnalysis.
Reposted by Alexandre Hofer
📆 Deadline: 14 November.
🩺 Doctoral Clinical Fellows programme (3-year PhD)
🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social
Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
✍️ Apply here: www.crick.ac.uk/careers-stud...
🩺 Doctoral Clinical Fellows programme (3-year PhD)
🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social
Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
✍️ Apply here: www.crick.ac.uk/careers-stud...
Johnson lab and Hess lab | Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
www.crick.ac.uk
October 6, 2025 at 9:40 AM
📆 Deadline: 14 November.
🩺 Doctoral Clinical Fellows programme (3-year PhD)
🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social
Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
✍️ Apply here: www.crick.ac.uk/careers-stud...
🩺 Doctoral Clinical Fellows programme (3-year PhD)
🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social
Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
✍️ Apply here: www.crick.ac.uk/careers-stud...
Reposted by Alexandre Hofer
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery
Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...
chemrxiv.org
September 23, 2025 at 12:10 PM
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
On the benefits of a 4-day work week: www.nature.com/articles/d41...
Biggest trial of four-day work week finds workers are happier and feel just as productive
Compressing five days of work into four can create stress, but the benefits outweigh the downsides, sprawling study shows.
www.nature.com
July 27, 2025 at 10:02 PM
On the benefits of a 4-day work week: www.nature.com/articles/d41...
Reposted by Alexandre Hofer
📣Preprint 📣
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1
The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the cli...
doi.org
July 24, 2025 at 6:23 AM
📣Preprint 📣
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...
July 24, 2025 at 5:33 AM
Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...
🚨Less than a week left to apply (deadline 19/03/25) for this exciting fully funded 4 Year Phd position in my group.
Multidisciplinary project on the design of novel metallo-NBTIs including all the fun of chemistry and much more! Please RT!
Apply here: www.crick.ac.uk/careers-stud...
Multidisciplinary project on the design of novel metallo-NBTIs including all the fun of chemistry and much more! Please RT!
Apply here: www.crick.ac.uk/careers-stud...
Hess Lab | Metal-based Heterobifunctional Scaffolds to Capture Challenging Proteins
www.crick.ac.uk
March 13, 2025 at 12:36 PM
If you're looking to do a PhD in bioinorganic and medicinal chemistry in a wonderful research group at a world-leading institute, here's a great opportunity:
www.crick.ac.uk/careers-stud...
@jeanninehess.bsky.social
www.crick.ac.uk/careers-stud...
@jeanninehess.bsky.social
Hess Lab | Metal-based Heterobifunctional Scaffolds to Capture Challenging Proteins
www.crick.ac.uk
February 27, 2025 at 4:20 PM
If you're looking to do a PhD in bioinorganic and medicinal chemistry in a wonderful research group at a world-leading institute, here's a great opportunity:
www.crick.ac.uk/careers-stud...
@jeanninehess.bsky.social
www.crick.ac.uk/careers-stud...
@jeanninehess.bsky.social
Great transition into the new year with a well-organised party...
January 1, 2025 at 3:53 PM
Great transition into the new year with a well-organised party...
A white Christmas for once...
December 26, 2024 at 10:54 PM
A white Christmas for once...
Little copycats in the house...
December 23, 2024 at 8:40 AM
Little copycats in the house...
Reposted by Alexandre Hofer
Reposted by Alexandre Hofer
Do not confuse...
chemsky
chemsky
November 17, 2024 at 9:46 AM
Do not confuse...
chemsky
chemsky
Reposted by Alexandre Hofer
Do not confuse...
November 16, 2024 at 10:28 PM
Do not confuse...
Do not confuse...
November 16, 2024 at 9:36 PM
Do not confuse...
Reposted by Alexandre Hofer
Thanks @cambridgeindy.bsky.social for publishing my view on closing the Mill Road Bridge for private vehicles.
October 3, 2024 at 10:51 AM
Thanks @cambridgeindy.bsky.social for publishing my view on closing the Mill Road Bridge for private vehicles.
"Prioritizing family life has earned me respect in my field — and my research has improved, too"
www.nature.com/articles/d41...
www.nature.com/articles/d41...
What it means to be a successful male academic
Prioritizing family life has earned me respect in my field — and my research has improved, too, says Dritjon Gruda. Prioritizing family life has earned me respect in my field — and my research has imp...
www.nature.com
June 28, 2024 at 5:45 AM
"Prioritizing family life has earned me respect in my field — and my research has improved, too"
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Quite faint in the middle of town, but one could clearly see the northern lights in Cambridge, UK.
May 11, 2024 at 8:58 AM
Quite faint in the middle of town, but one could clearly see the northern lights in Cambridge, UK.
Reposted by Alexandre Hofer
You wouldn’t think that formaldehyde is an actual cellular signaling molecule, would you? But here we are!
Formaldehyde, You Say?
www.science.org
March 14, 2024 at 3:04 PM
You wouldn’t think that formaldehyde is an actual cellular signaling molecule, would you? But here we are!
Reposted by Alexandre Hofer
This report on the CACHE competition is worth a read. It’s about as close as we’ve gotten to some open benchmarking of AI impact to the drug discovery process.
I’d suggest a title change to “When Can AI Deliver the Drugs?” though. A few more thoughts👇 1/
I’d suggest a title change to “When Can AI Deliver the Drugs?” though. A few more thoughts👇 1/
When can AI deliver the drug discovery hits?
The CACHE hit-finding competition highlights the potential of AI to identify small molecules that bind to hard-to-drug targets — and the long road ahead for these computational screening approaches. T...
www.nature.com
February 22, 2024 at 4:38 PM
This report on the CACHE competition is worth a read. It’s about as close as we’ve gotten to some open benchmarking of AI impact to the drug discovery process.
I’d suggest a title change to “When Can AI Deliver the Drugs?” though. A few more thoughts👇 1/
I’d suggest a title change to “When Can AI Deliver the Drugs?” though. A few more thoughts👇 1/
Reposted by Alexandre Hofer
Absolutely agree. And I only play the nice guy on here, but reality might be closer to this meme:
January 26, 2024 at 7:24 AM
Absolutely agree. And I only play the nice guy on here, but reality might be closer to this meme:
"Then they took the extra step, rarely realized in such papers [...], of actually synthesizing hundreds of the hit molecules and experimentally testing them against the real proteins. (Faint cheers can be heard echoing from the lab benches and fume hoods)." 😅
Using AlphaFold protein models to screen against has been looking like not-so-great idea. But it might work better than you'd have thought: 🧪 Chemsky
www.science.org/content/blog...
www.science.org/content/blog...
January 23, 2024 at 8:43 PM
"Then they took the extra step, rarely realized in such papers [...], of actually synthesizing hundreds of the hit molecules and experimentally testing them against the real proteins. (Faint cheers can be heard echoing from the lab benches and fume hoods)." 😅
Reposted by Alexandre Hofer
We should spend a massively less amount of time politically kneecapping our most globally competitive export industry that employs more than 2% of the entire US workforce
Shocked at how high this is: "About one in 40 U.S. workers draws a paycheck from a college or university" www.wsj.com/us-news/educ...
January 21, 2024 at 11:19 PM
We should spend a massively less amount of time politically kneecapping our most globally competitive export industry that employs more than 2% of the entire US workforce