Dan Liebler
@dliebler.bsky.social
Retired biomedical scientist, consulting in chemistry and toxicology. Guitar is my lifelong pastime. I love steel string flattops.
Reposted by Dan Liebler
An inspirational example of 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐜𝐫𝐞𝐚𝐭𝐢𝐯𝐢𝐭𝐲, 𝐨𝐫𝐢𝐠𝐢𝐧𝐚𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐢𝐠𝐨𝐫:
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
November 27, 2025 at 1:45 PM
An inspirational example of 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐜𝐫𝐞𝐚𝐭𝐢𝐯𝐢𝐭𝐲, 𝐨𝐫𝐢𝐠𝐢𝐧𝐚𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐢𝐠𝐨𝐫:
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter Mitchell proposed & rigorously articulated the radical ...
Reposted by Dan Liebler
I’ve been in Toronto at the #astmh meeting these past few days and last night some very good news was presented here: A new malaria drug has proven efficacious in a large trial and could soon be approved.🧪
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
‘A sigh of relief’: New malaria drug succeeds in large clinical trial
As existing drugs falter because of resistance, the world gets a backup—but hard choices loom on how to use it
www.science.org
November 13, 2025 at 1:27 PM
I’ve been in Toronto at the #astmh meeting these past few days and last night some very good news was presented here: A new malaria drug has proven efficacious in a large trial and could soon be approved.🧪
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
Reposted by Dan Liebler
Maine has voted in a landslide to reject a Republican-supported ballot initiative that would have restricted voting access heading into the critical 2026 midterms
Mainers defeat Republican effort to institute voter ID and limit absentee voting
The no side of Question 1 had 60.2% of votes to 39.8% for the yes side when the Bangor Daily News and its national partner, Decision Desk HQ, called the race at 9:26 p.m. Tuesday.
www.bangordailynews.com
November 5, 2025 at 2:40 AM
Maine has voted in a landslide to reject a Republican-supported ballot initiative that would have restricted voting access heading into the critical 2026 midterms
Turn the volume up!
November 5, 2025 at 4:37 AM
Turn the volume up!
Reposted by Dan Liebler
“Tell your children who the cowards were.”
October 27, 2025 at 10:19 PM
“Tell your children who the cowards were.”
Reposted by Dan Liebler
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com
October 26, 2025 at 5:02 PM
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com/articles/d41...
Reposted by Dan Liebler
Let's see how that government ban on White House demolition photos is going.
www.pbs.org/newshour/pol...
www.pbs.org/newshour/pol...
October 21, 2025 at 6:02 PM
Let's see how that government ban on White House demolition photos is going.
www.pbs.org/newshour/pol...
www.pbs.org/newshour/pol...
Vanderbilt response to the Trump ‘compact’ is too clever by half. Dodging the immoral dominance play and pretending it’s a reasoned conversation. Vandy wishes to play ball as an elite institution on a level with MIT, Penn and UVA. Struck out looking.
Vanderbilt has arrived, late to the chat, with this shambles of a response. While technically true, this is a clear abdication of any moral responsibility. They even work in a mention of their commitment to "institutional neutrality" later in the email.
October 20, 2025 at 10:09 PM
Vanderbilt response to the Trump ‘compact’ is too clever by half. Dodging the immoral dominance play and pretending it’s a reasoned conversation. Vandy wishes to play ball as an elite institution on a level with MIT, Penn and UVA. Struck out looking.
Reposted by Dan Liebler
I repeat myself: this is a town of 6000 people in Waldo County, Maine
October 18, 2025 at 8:09 PM
I repeat myself: this is a town of 6000 people in Waldo County, Maine
Reposted by Dan Liebler
1700 people out for No Kings in rural Rockland, Maine today… more than 4% of the population of Knox County.
#NoKings #Maine #MEPolitics
#NoKings #Maine #MEPolitics
October 18, 2025 at 5:44 PM
1700 people out for No Kings in rural Rockland, Maine today… more than 4% of the population of Knox County.
#NoKings #Maine #MEPolitics
#NoKings #Maine #MEPolitics
Reposted by Dan Liebler
Speculation: There has been a recency bias in citations for a long time, because the newer work should contain more up-to-date knowledge.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
October 17, 2025 at 12:35 PM
Speculation: There has been a recency bias in citations for a long time, because the newer work should contain more up-to-date knowledge.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
This could reverse. People might increasingly refer to work before the 2020s, because it wouldn't have been corrupted by gen AI.
Reposted by Dan Liebler
Turns out, boron-based heterocycles are anything but boring! In fact, some of them are pretty magical...1,2-oxaborines, for example, can be used as precursors to 11(!) other ring systems!
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
These shape-shifting rings create customizable cores
1,2-oxaborines can shift into 11 different ring shapes to make modifying molecular cores easy
cen.acs.org
October 13, 2025 at 2:59 PM
Turns out, boron-based heterocycles are anything but boring! In fact, some of them are pretty magical...1,2-oxaborines, for example, can be used as precursors to 11(!) other ring systems!
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
Read more in my latest for @cenmag.bsky.social
cen.acs.org/synthesis/sh...
Reposted by Dan Liebler
People need to start highlighting that Miller is actually the shadow President and the one calling the shots. When it was Musk who was doing it, it caused a rift between them so big that after he was out, Musk was bashing Trump claiming he is in the Epstein files.
October 12, 2025 at 5:26 PM
People need to start highlighting that Miller is actually the shadow President and the one calling the shots. When it was Musk who was doing it, it caused a rift between them so big that after he was out, Musk was bashing Trump claiming he is in the Epstein files.
Reposted by Dan Liebler
Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
September 17, 2025 at 10:24 PM
Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Dan Liebler
Elaine Buckberg: To address "range anxiety," states should enact laws that require fast chargers to report real-time status that any EV mapping app can access via @brookings.edu Hutchins Center. www.brookings.edu/articles/cha...
Charger data transparency: Curing range anxiety, powering EV adoption | Brookings
Proposal for states to require fast chargers to report real-time status accessible by any EV mapping app, so drivers can reliably navigate to chargers.
www.brookings.edu
September 9, 2025 at 1:10 PM
Elaine Buckberg: To address "range anxiety," states should enact laws that require fast chargers to report real-time status that any EV mapping app can access via @brookings.edu Hutchins Center. www.brookings.edu/articles/cha...
Reposted by Dan Liebler
70 years ago, on this date, Emmett Till was kidnapped and brutally murdered by white men.
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
August 28, 2025 at 1:14 PM
70 years ago, on this date, Emmett Till was kidnapped and brutally murdered by white men.
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
His family, including his cousin who was with him at the time, is repeating the train ride he took from Chicago to Mississippi in 1955 to mark the anniversary
Reposted by Dan Liebler
Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:
August 27, 2025 at 11:15 PM
Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:
Reposted by Dan Liebler
If you measure and interpret RNA levels in single cells, read this:
"𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙."
1/2
"𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙."
1/2
August 23, 2025 at 5:19 PM
If you measure and interpret RNA levels in single cells, read this:
"𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙."
1/2
"𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙."
1/2
Reposted by Dan Liebler
Protein degradation is often considered as a final step in regulating gene expression.
It also regulates the first step: Transcription
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
👇
It also regulates the first step: Transcription
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
👇
Protein synthesis is among the most energy demanding processes in a cell.
𝐖𝐡𝐲 𝐚𝐫𝐞 𝐭𝐡𝐞𝐧 𝐬𝐨𝐦𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧𝐬 𝐜𝐨𝐧𝐭𝐢𝐧𝐮𝐨𝐮𝐬𝐥𝐲 𝐬𝐲𝐧𝐭𝐡𝐞𝐬𝐢𝐳𝐞𝐝 𝐚𝐧𝐝 𝐢𝐦𝐦𝐞𝐝𝐢𝐚𝐭𝐞𝐥𝐲 𝐝𝐞𝐠𝐫𝐚𝐝𝐞𝐝 ?
blog.slavovlab.net/2025/08/16/p...
𝐖𝐡𝐲 𝐚𝐫𝐞 𝐭𝐡𝐞𝐧 𝐬𝐨𝐦𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧𝐬 𝐜𝐨𝐧𝐭𝐢𝐧𝐮𝐨𝐮𝐬𝐥𝐲 𝐬𝐲𝐧𝐭𝐡𝐞𝐬𝐢𝐳𝐞𝐝 𝐚𝐧𝐝 𝐢𝐦𝐦𝐞𝐝𝐢𝐚𝐭𝐞𝐥𝐲 𝐝𝐞𝐠𝐫𝐚𝐝𝐞𝐝 ?
blog.slavovlab.net/2025/08/16/p...
Proteins made to die
Protein synthesis is among the most energy-demanding processes in a cell. Yet, some proteins are synthesized and immediately degraded. This may seem like a futile cycle, but it’s a remarkable…
blog.slavovlab.net
August 22, 2025 at 10:22 AM
Protein degradation is often considered as a final step in regulating gene expression.
It also regulates the first step: Transcription
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
👇
It also regulates the first step: Transcription
Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
⬛️ It has a key advantage.
👇
Reposted by Dan Liebler
The homeless are painful to look at because they remind us of how unfair our world is, of how much suffering it contains, of how arbitrary and undeserved and precarious our own comforts and health are, of how we have failed to be sufficiently generous and merciful to others.
August 22, 2025 at 12:34 AM
The homeless are painful to look at because they remind us of how unfair our world is, of how much suffering it contains, of how arbitrary and undeserved and precarious our own comforts and health are, of how we have failed to be sufficiently generous and merciful to others.
Reposted by Dan Liebler
Widespread Post-transcriptional Attenuation of
Genomic Copy-Number Variation in Cancer
Genomic Copy-Number Variation in Cancer
August 8, 2025 at 11:07 AM
Widespread Post-transcriptional Attenuation of
Genomic Copy-Number Variation in Cancer
Genomic Copy-Number Variation in Cancer
Reposted by Dan Liebler
Holocaust and genocide scholar Omer Bartov makes it clear why “genocide” is the correct word to use to describe what Israel is doing in Gaza — with all the many legal, moral, ethical, and commemorative implications that flow from this necessary recognition. Gift link: www.nytimes.com/2025/07/15/o...
Opinion | I’m a Genocide Scholar. I Know It When I See It.
www.nytimes.com
July 15, 2025 at 3:19 PM
Holocaust and genocide scholar Omer Bartov makes it clear why “genocide” is the correct word to use to describe what Israel is doing in Gaza — with all the many legal, moral, ethical, and commemorative implications that flow from this necessary recognition. Gift link: www.nytimes.com/2025/07/15/o...
Reposted by Dan Liebler
If you asked me 5 years ago if it would be possible to use a de novo tool on DIA data, I would have thought it would only exist in science fiction. Love being proved wrong. Great work from Justin Sanders. #proteomics #massspectrometry
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data - Nature Methods
Cascadia is a mass spectrometry-based de novo sequencing model that uses a transformer architecture to handle data-independent acquisition data and achieves substantially improved performance across a...
www.nature.com
July 2, 2025 at 5:19 PM
If you asked me 5 years ago if it would be possible to use a de novo tool on DIA data, I would have thought it would only exist in science fiction. Love being proved wrong. Great work from Justin Sanders. #proteomics #massspectrometry
www.nature.com/articles/s41...
www.nature.com/articles/s41...