David Kashatus
@dkashatus.bsky.social
Associate Professor and Assistant Dean for Research at the University of Virginia School of Medicine studying mitochondria, metabolism and cancer.
Reposted by David Kashatus
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
December 16, 2025 at 12:11 PM
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
Reposted by David Kashatus
Feeling mitochondrially challenged lately?
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
The Origin and Diversification of Mitochondria
Moving beyond the simplistic view of mitochondria as the power house of the cell,
Roger et al. present the immense diversity of mitochondria and mitochondrial functions
across eukaryotes, and bring th...
www.cell.com
August 28, 2025 at 10:28 PM
Feeling mitochondrially challenged lately?
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by David Kashatus
Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!
July 29, 2025 at 11:33 PM
Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!
Reposted by David Kashatus
do you ever stare at the ceiling and think about how the worldwide scientific establishment did the impossible and created a COVID vaccine in under a year and the response of the general public has been to go on an unstoppable rampage to destroy science and scientists
July 20, 2025 at 6:46 PM
do you ever stare at the ceiling and think about how the worldwide scientific establishment did the impossible and created a COVID vaccine in under a year and the response of the general public has been to go on an unstoppable rampage to destroy science and scientists
Reposted by David Kashatus
A must-read for anyone in mitochondria research!
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Special Issue: Cell Biology of Mitochondria - MitoWorld
The special issue of Journal of Cell Science (JCS) on the “Cell Biology of Mitochondria” looks to be one of the most comprehensive open series of papers, opinions, perspectives, interviews, reviews an...
mitoworld.org
May 26, 2025 at 11:31 AM
A must-read for anyone in mitochondria research!
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!
View our summary mitoworld.org/special-issu...
Banner day for our grad students at the always amazing Dept. of Microbiology, Immunology & Cancer Biology Retreat. Congrats to Daniel and Salma for “lightning talk” and “poster” awards! Great science all around!!
May 17, 2025 at 12:59 AM
Banner day for our grad students at the always amazing Dept. of Microbiology, Immunology & Cancer Biology Retreat. Congrats to Daniel and Salma for “lightning talk” and “poster” awards! Great science all around!!
Reposted by David Kashatus
🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!
April 24, 2025 at 8:20 PM
🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Reposted by David Kashatus
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:56 PM
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Reposted by David Kashatus
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
April 10, 2025 at 1:38 PM
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
This one hurts a lot. Richard is a great scientist. His elegant work inspired me to get into mitochondrial biology and he went out of his way to help me establish myself in the field. So sad for our whole community.
Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
April 2, 2025 at 1:51 AM
This one hurts a lot. Richard is a great scientist. His elegant work inspired me to get into mitochondrial biology and he went out of his way to help me establish myself in the field. So sad for our whole community.
Reposted by David Kashatus
Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration's latest firing blitz.
www.wired.com
April 2, 2025 at 12:28 AM
Dr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
Reposted by David Kashatus
🧪 Scientists have created the first map of mitochondria throughout the entire brain
https://go.nature.com/42j9YCV
https://go.nature.com/42j9YCV
First map of human brain mitochondria is ‘groundbreaking’ achievement
Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
go.nature.com
March 29, 2025 at 4:37 PM
🧪 Scientists have created the first map of mitochondria throughout the entire brain
https://go.nature.com/42j9YCV
https://go.nature.com/42j9YCV
Reposted by David Kashatus
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 6:05 PM
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
Reposted by David Kashatus
Abstracts are due TOMORROW! Please share!
📢🚨Deadline to submit an abstract for the 2025 Showcase is this Friday, March 21st!📢🚨
Registration free!
Speakers chosen from abstracts and non-faculty only!
Amazing poster session and workshops!
Sign up today at: www.cancermetabolismshowcase.org
Registration free!
Speakers chosen from abstracts and non-faculty only!
Amazing poster session and workshops!
Sign up today at: www.cancermetabolismshowcase.org
9:30 AM - 3 PM EST, May 5th and 6th, 2025
www.cancermetabolismshowcase.org
March 20, 2025 at 8:31 PM
Abstracts are due TOMORROW! Please share!
Reposted by David Kashatus
mtDNA goes places, and sometimes nucleoids end up in stressful situations. Our next speaker @lauraenewmanphd.bsky.social
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
March 3, 2025 at 4:45 PM
mtDNA goes places, and sometimes nucleoids end up in stressful situations. Our next speaker @lauraenewmanphd.bsky.social
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
is keeping an eye (or two) on this, and will tell us all about it.
This week, usual time and place.
Reposted by David Kashatus
1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
February 17, 2025 at 7:23 PM
1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
Reposted by David Kashatus
My editorial on the indirect cuts. This is an opportunity for campuses to come together to make the case for higher education. Leaders need to step up and ask for support and lead. www.science.org/doi/10.1126/...
A direct hit
Late last week, the Trump administration set off a frenzy in the US scientific community when the National Institutes of Health (NIH) announced that indirect cost reimbursement for federally funded re...
www.science.org
February 11, 2025 at 3:03 PM
My editorial on the indirect cuts. This is an opportunity for campuses to come together to make the case for higher education. Leaders need to step up and ask for support and lead. www.science.org/doi/10.1126/...
Reposted by David Kashatus
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
rdcu.be/d8xLv (1/6)
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.
rdcu.be
February 4, 2025 at 1:54 PM
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
rdcu.be/d8xLv (1/6)
Reposted by David Kashatus
Proud to see this #relentlessdiscovery, by @rjdlab.bsky.social & colleages, visualized about how mitochondrial ETC is much more active in tumors that have metastasized than in tumors still growing in the kidney. Watch ⬇️ www.youtube.com/watch?v=-pmz... or read more ➡️ cri.utsw.edu/kidney-cance... 🧪
Science in 60+: Renal Revelations
YouTube video by UT Southwestern Medical Center
www.youtube.com
January 29, 2025 at 11:27 PM
Proud to see this #relentlessdiscovery, by @rjdlab.bsky.social & colleages, visualized about how mitochondrial ETC is much more active in tumors that have metastasized than in tumors still growing in the kidney. Watch ⬇️ www.youtube.com/watch?v=-pmz... or read more ➡️ cri.utsw.edu/kidney-cance... 🧪
Reposted by David Kashatus
ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al.
Read it for free until March 19th at:
authors.elsevier.com/a/1kWLq3jDgW...
Read it for free until March 19th at:
authors.elsevier.com/a/1kWLq3jDgW...
January 29, 2025 at 2:46 PM
ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al.
Read it for free until March 19th at:
authors.elsevier.com/a/1kWLq3jDgW...
Read it for free until March 19th at:
authors.elsevier.com/a/1kWLq3jDgW...