Dominique Guerrot
@dguerrot.bsky.social
Nephrology, Hypertension, ADPKD, Clinical investigation | Rouen University Hospital, France
Reposted by Dominique Guerrot
I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment
November 8, 2025 at 11:48 PM
I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment
Reposted by Dominique Guerrot
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 7, 2025 at 4:36 PM
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
Reposted by Dominique Guerrot
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Reposted by Dominique Guerrot
Machine perfusion is better than just cold storage for kidneys
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
November 5, 2025 at 10:37 PM
Machine perfusion is better than just cold storage for kidneys
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
Reposted by Dominique Guerrot
Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025
Abstract. ADPKD is the most common monogenic cause of kidney failure globally and a significant cause of morbidity and mortality. It is now recognized that
academic.oup.com
November 1, 2025 at 11:02 AM
Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Reposted by Dominique Guerrot
Among participants with advanced pheochromocytoma or paraganglioma, belzutifan showed durable antitumor activity and a reduced need for antihypertensives, although most participants had treatment-related adverse events. Full LITESPARK-015 phase 2 trial results: nej.md/475bfP9
#ESMO25
#ESMO25
October 18, 2025 at 8:20 AM
Among participants with advanced pheochromocytoma or paraganglioma, belzutifan showed durable antitumor activity and a reduced need for antihypertensives, although most participants had treatment-related adverse events. Full LITESPARK-015 phase 2 trial results: nej.md/475bfP9
#ESMO25
#ESMO25
Reposted by Dominique Guerrot
🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences.
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
August 6, 2025 at 10:05 AM
🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences.
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
Reposted by Dominique Guerrot
New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes: an individual participant-level meta-analysis
SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of
the size of the acute dip in eGFR. Kidney benefits are evident irrespective of diabetes
status, heart failure status,...
thelancet.com
October 10, 2025 at 10:38 PM
New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
Reposted by Dominique Guerrot
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
SGLT-2 I in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
YouTube video by MARKUS at HOMe
youtu.be
October 10, 2025 at 6:21 PM
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
Reposted by Dominique Guerrot
Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1)
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social
October 9, 2025 at 3:17 PM
Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1)
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social
Reposted by Dominique Guerrot
Childhood obesity has quadrupled since the 1960s. Now over 20% of kids meet the definition (>95th percentile of BMI).
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
September 16, 2025 at 5:36 PM
Childhood obesity has quadrupled since the 1960s. Now over 20% of kids meet the definition (>95th percentile of BMI).
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵
Reposted by Dominique Guerrot
In this video, Professor Dominique Guerrot presents the DAPA-PKD study, a collaborative research effort he co-leads with Professor Emilie Cornec-Le Gall (Brest). This important study will evaluate the potential of SGLT2 inhibitors, such as dapagliflozin, in the treatment of #ADPKD.
September 12, 2025 at 6:32 AM
In this video, Professor Dominique Guerrot presents the DAPA-PKD study, a collaborative research effort he co-leads with Professor Emilie Cornec-Le Gall (Brest). This important study will evaluate the potential of SGLT2 inhibitors, such as dapagliflozin, in the treatment of #ADPKD.
Reposted by Dominique Guerrot
Tonight it's all about ADPKD!
KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller
youtu.be/qjnYDsYbx0Q?...
@rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social
KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller
youtu.be/qjnYDsYbx0Q?...
@rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social
ADPKD: KDIGO GL / ERA Genes & Kidney WG - Prof. Roser Torra, Prof. Roman-Ulrich Müller
YouTube video by MARKUS at HOMe
youtu.be
September 12, 2025 at 5:54 PM
Tonight it's all about ADPKD!
KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller
youtu.be/qjnYDsYbx0Q?...
@rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social
KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller
youtu.be/qjnYDsYbx0Q?...
@rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social
Reposted by Dominique Guerrot
I have a feeling sales of home blood pressure cuffs are going to spike because people working in Primary Care like myself are going to be telling patients to confirm what the Apple watch is telling them with an actual blood pressure cuff.
September 12, 2025 at 10:32 AM
I have a feeling sales of home blood pressure cuffs are going to spike because people working in Primary Care like myself are going to be telling patients to confirm what the Apple watch is telling them with an actual blood pressure cuff.
Reposted by Dominique Guerrot
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
September 3, 2025 at 4:03 PM
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
Reposted by Dominique Guerrot
📚 The 2025 #KDIGO Guidelines recommend ambitious BP targets to manage hypertension in ADPKD:
🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2),
🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.
🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2),
🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.
August 6, 2025 at 10:05 AM
📚 The 2025 #KDIGO Guidelines recommend ambitious BP targets to manage hypertension in ADPKD:
🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2),
🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.
🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2),
🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.
#NephrOdio podcasts 🎧
🚀 Half a million downloads !
🚀 Half a million downloads !
August 24, 2025 at 4:27 PM
#NephrOdio podcasts 🎧
🚀 Half a million downloads !
🚀 Half a million downloads !
Reposted by Dominique Guerrot
New 2025 AHA/ACC Hypertension Guideline dropped!
www.jacc.org/doi/10.1016/...
#hypertension #medsky #nephsky
www.jacc.org/doi/10.1016/...
#hypertension #medsky #nephsky
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College o...
www.jacc.org
August 14, 2025 at 6:06 PM
New 2025 AHA/ACC Hypertension Guideline dropped!
www.jacc.org/doi/10.1016/...
#hypertension #medsky #nephsky
www.jacc.org/doi/10.1016/...
#hypertension #medsky #nephsky
Reposted by Dominique Guerrot
CONFIDENCE trial: For patients with both chronic kidney disease and type 2 diabetes, whether combination therapy with finerenone and empagliflozin would improve outcomes over single-drug therapy is unclear. Research findings are summarized in a new Quick Take video. nej.md/40Szhuy
August 13, 2025 at 7:09 PM
CONFIDENCE trial: For patients with both chronic kidney disease and type 2 diabetes, whether combination therapy with finerenone and empagliflozin would improve outcomes over single-drug therapy is unclear. Research findings are summarized in a new Quick Take video. nej.md/40Szhuy
Reposted by Dominique Guerrot
In the introduction, @johngreensbluesky.bsky.social drops some TB facts
Annually more than a million people die of TB
Overall, more than a *billion* people have died of TB in last 2 centuries
That’s also something like 1 in 7 people who have ever lived 🤯
#NephJCBookClub
Annually more than a million people die of TB
Overall, more than a *billion* people have died of TB in last 2 centuries
That’s also something like 1 in 7 people who have ever lived 🤯
#NephJCBookClub
June 29, 2025 at 7:50 PM
In the introduction, @johngreensbluesky.bsky.social drops some TB facts
Annually more than a million people die of TB
Overall, more than a *billion* people have died of TB in last 2 centuries
That’s also something like 1 in 7 people who have ever lived 🤯
#NephJCBookClub
Annually more than a million people die of TB
Overall, more than a *billion* people have died of TB in last 2 centuries
That’s also something like 1 in 7 people who have ever lived 🤯
#NephJCBookClub
🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences.
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
August 6, 2025 at 10:05 AM
🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences.
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
Reposted by Dominique Guerrot
should we screen for CKD in the general population?
Finally, flozins, finerenone and GLP1s allow a good cost-effectiveness case
www.nephjc.com/news/2025/7/... for #NephJC shorts
Time to stop just being dialysis-ologists and flozinate, glipinate!
#NephSky
Finally, flozins, finerenone and GLP1s allow a good cost-effectiveness case
www.nephjc.com/news/2025/7/... for #NephJC shorts
Time to stop just being dialysis-ologists and flozinate, glipinate!
#NephSky
NephJC Shorts: Should we Screen for Kidney Disease? — NephJC
Should we screen for CKD?
www.nephjc.com
July 31, 2025 at 5:45 PM
should we screen for CKD in the general population?
Finally, flozins, finerenone and GLP1s allow a good cost-effectiveness case
www.nephjc.com/news/2025/7/... for #NephJC shorts
Time to stop just being dialysis-ologists and flozinate, glipinate!
#NephSky
Finally, flozins, finerenone and GLP1s allow a good cost-effectiveness case
www.nephjc.com/news/2025/7/... for #NephJC shorts
Time to stop just being dialysis-ologists and flozinate, glipinate!
#NephSky
Reposted by Dominique Guerrot
Awesome infographic on genetic testing in ADPKD by Neera Dahl, @pranavgarimella.bsky.social and Fouad Chebib www.kidneynews.org/view/journal...
July 28, 2025 at 7:30 PM
Awesome infographic on genetic testing in ADPKD by Neera Dahl, @pranavgarimella.bsky.social and Fouad Chebib www.kidneynews.org/view/journal...
Reposted by Dominique Guerrot
July 20, 2025 at 5:18 PM