David Konrad
@dbkonrad.bsky.social
Tenure-Track Professor @univie.ac.at & Research Group Leader @lmumuenchen.bsky.social. Cancer Chemical Biology, (Chemo)Proteomics, Medicinal Chemistry and Chemical Methology Development. #newPI | #FirstGen
Homepage: https://konrad.cup.uni-muenchen.de
Homepage: https://konrad.cup.uni-muenchen.de
Reposted by David Konrad
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 10:27 AM
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Reposted by David Konrad
Join us as the first PhD student in my group! Based in the beautiful city of Münster, Germany, you will develop the chemo-enzymatic synthesis of modified nucleotides, which are used as building blocks of mRNA.
Here is the link:
stellen.uni-muenster.de/jobposting/6...
#chemsky #chembio
Here is the link:
stellen.uni-muenster.de/jobposting/6...
#chemsky #chembio
October 17, 2025 at 12:20 PM
Join us as the first PhD student in my group! Based in the beautiful city of Münster, Germany, you will develop the chemo-enzymatic synthesis of modified nucleotides, which are used as building blocks of mRNA.
Here is the link:
stellen.uni-muenster.de/jobposting/6...
#chemsky #chembio
Here is the link:
stellen.uni-muenster.de/jobposting/6...
#chemsky #chembio
Reposted by David Konrad
Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...
Early Career Research (ECR) Group Leader position (m/f/d) with the thematic focus on “Catalysis” within the Cluster of Excellence RESOLV
jobs.ruhr-uni-bochum.de
October 2, 2025 at 1:54 PM
Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...
Reposted by David Konrad
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
August 19, 2025 at 8:57 AM
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
It is a great pleasure to share that our extensive review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie....
June 18, 2025 at 9:14 AM
It is a great pleasure to share that our extensive review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie....
I am incredibly excited that our manuscript: "A Platform for the Development of Highly Red-Shifted Azobenzene-based Optical Tools" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie... 🤩
June 4, 2025 at 10:52 AM
I am incredibly excited that our manuscript: "A Platform for the Development of Highly Red-Shifted Azobenzene-based Optical Tools" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie... 🤩
We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!
May 14, 2025 at 5:01 PM
We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!
Reposted by David Konrad
We are very excited that we will be hosting the 15th International Activity Based Protein Profiling (ABPP) Meeting in Leiden in 2027. If you do not want to miss anything, make sure to follow this page to see all the information in the future.
April 23, 2025 at 8:00 AM
We are very excited that we will be hosting the 15th International Activity Based Protein Profiling (ABPP) Meeting in Leiden in 2027. If you do not want to miss anything, make sure to follow this page to see all the information in the future.
📢 Only one more week to apply!
We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!
April 7, 2025 at 10:26 AM
📢 Only one more week to apply!
We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!
March 21, 2025 at 2:51 PM
We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!
Reposted by David Konrad
We have a new homepage @tum.de including The Hall of Fame of Graduates - check it out!
👇
www.mls.ls.tum.de/tnm
👇
www.mls.ls.tum.de/tnm
Startseite
Wir verwenden Google für unsere Suche. Mit Klick auf „Suche aktivieren“ aktivieren Sie das Suchfeld und akzeptieren die Nutzungsbedingungen.
www.mls.ls.tum.de
March 14, 2025 at 7:34 PM
We have a new homepage @tum.de including The Hall of Fame of Graduates - check it out!
👇
www.mls.ls.tum.de/tnm
👇
www.mls.ls.tum.de/tnm
So cool! 🤩
The combined power of halogen bonding and asymmetric counteranion-directed catalysis = XB-ACDC: pubs.acs.org/doi/10.1021/.... Thanks to @mertenlab.bsky.social for structure elucidation and to the List group for this beautiful cooperation! A perfect #RESOLV project! @solvationsci.bsky.social
Asymmetric Counteranion-Directed Halogen Bonding Catalysis
Halogen bonding has been established as a promising tool in organocatalysis. Asymmetric processes are nevertheless scarce, and their applications are limited to a few studies applying chiral halogen b...
pubs.acs.org
March 3, 2025 at 8:19 PM
So cool! 🤩
Reposted by David Konrad
Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
DNA Mimic Foldamer Recognition of a Chromosomal Protein
Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...
onlinelibrary.wiley.com
February 27, 2025 at 10:31 AM
Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by David Konrad
February 21, 2025 at 2:00 AM
Reposted by David Konrad
A surprise finding with interesting chemistry: protein bound zinc ions can activate Proton Pump Inhibitors (PPIs)
Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues!
www.nature.com/articles/s41...
Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues!
www.nature.com/articles/s41...
February 20, 2025 at 11:20 AM
A surprise finding with interesting chemistry: protein bound zinc ions can activate Proton Pump Inhibitors (PPIs)
Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues!
www.nature.com/articles/s41...
Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues!
www.nature.com/articles/s41...
Managing to score a professorship without a Cell, Science or Nature paper.
February 18, 2025 at 3:10 PM
Managing to score a professorship without a Cell, Science or Nature paper.
PI had an important conference to attend...
Gandalf was delayed...😂
YouTube video by Memex
youtu.be
February 18, 2025 at 3:02 PM
PI had an important conference to attend...
Voting for our new government in 🇩🇪✔️
February 16, 2025 at 1:04 PM
Voting for our new government in 🇩🇪✔️
Reposted by David Konrad
Reposting this #molswitch #molmachine starter pack. If you want to be included in it, please let me know
go.bsky.app/EwimNbK
go.bsky.app/EwimNbK
January 16, 2025 at 3:10 PM
Reposting this #molswitch #molmachine starter pack. If you want to be included in it, please let me know
go.bsky.app/EwimNbK
go.bsky.app/EwimNbK
Reposted by David Konrad
The "Fluorescent Probes, Sensors and Fluorophores" starter pack got substantial additions worth a new look.
Please raise you hand 👋 in the replies if you want to be added too.
go.bsky.app/MtgJE4w
Please raise you hand 👋 in the replies if you want to be added too.
go.bsky.app/MtgJE4w
November 15, 2024 at 9:39 AM
The "Fluorescent Probes, Sensors and Fluorophores" starter pack got substantial additions worth a new look.
Please raise you hand 👋 in the replies if you want to be added too.
go.bsky.app/MtgJE4w
Please raise you hand 👋 in the replies if you want to be added too.
go.bsky.app/MtgJE4w
Reposted by David Konrad
We had the pleasure to host @dbkonrad.bsky.social today for a @unisyscat.bsky.social Colloquium!
Thanks for the great scientific discussion, David!
🤩
Thanks for the great scientific discussion, David!
🤩
February 12, 2025 at 7:32 PM
We had the pleasure to host @dbkonrad.bsky.social today for a @unisyscat.bsky.social Colloquium!
Thanks for the great scientific discussion, David!
🤩
Thanks for the great scientific discussion, David!
🤩
What do you think about matching tattoos @dirktrauner.bsky.social?
Dear #ChemSky, I have an important question: Do I need to tattoo a permanent version of my PhD thesis onto my back?
February 11, 2025 at 2:59 PM
What do you think about matching tattoos @dirktrauner.bsky.social?
Very excited to share our review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family", where we discuss their potential for the development of analgesics, structure-activity relationships on NaV channels, biosynthetic hypotheses and chemical syntheses: tinyurl.com/ye6nwnwu.
January 30, 2025 at 8:22 AM
Very excited to share our review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family", where we discuss their potential for the development of analgesics, structure-activity relationships on NaV channels, biosynthetic hypotheses and chemical syntheses: tinyurl.com/ye6nwnwu.