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orgbiomolchem.rsc.org
Organic & Biomolecular Chemistry
@orgbiomolchem.rsc.org
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Rapid publication of organic synthesis, physical organic, chemical biology and supramolecular chemistry research.

Published by @rsc.org 🌐 Website: rsc.li/orgbiomolchem
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orgbiomolchem.rsc.org
Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · Nov 5
📢Our latest issue is now online!

This is a special themed issue celebrating our New Talent collection highlighting the excellent work being carried out by the next generation of leaders in the #organicchemistry community!

Find all the articles in the collection here🔽
pubs.rsc.org/en/journals/...
Reposted by Organic & Biomolecular Chemistry
natprodreports.rsc.org
Don't miss your chance to present your research at Directing Biosynthesis VIII!

⏳Time is running out until the oral abstract deadline on the 2nd of February▶️ rsc.li/dbviii

Be sure to join us and the rest of the #Biosynthesis community in Manchester this summer

#natprod #secmet #DBVIII
A picture of a plant with chemical molecules highlighting the oral abstract deadline for Directing Biosynthesis eight that closes on the 2nd of February 2026
January 16, 2026 at 9:24 AM
orgbiomolchem.rsc.org
Be sure to read this review looking at the recent advances in the photocatalytic synthesis of isoquinoline-1,3-dione derivatives by Jin-Wei Yuan & co. from Henan University of Technology in our latest issue #orgchem #photochem

Find it on our website👇
Recent advances in the photocatalytic synthesis of isoquinoline-1,3-dione derivatives
Isoquinoline-1,3(2H,4H)-diones constitute an important class of nitrogen-containing heterocycles that are broadly distributed in natural products and bioactive pharmaceutical compounds, exhibiting…
pubs.rsc.org
January 16, 2026 at 9:30 AM
orgbiomolchem.rsc.org
Don't miss this paper in our latest issue from José Kovensky, Vincent Chagnault et al. at @upjv-univ.bsky.social looking at sulfonated, sulfated thioglycosides and multivalence in heparanase inhibition #orgchem

Check it out in full here🔽
Sulfonated, sulfated thioglycosides and multivalence in heparanase inhibition
Heparan sulfate (HS) analogs are synthetic oligo- and polysaccharides designed to mimic or enhance several biological properties of native HS. Organic synthesized compounds are very useful tools for…
pubs.rsc.org
January 15, 2026 at 2:00 PM
orgbiomolchem.rsc.org
📢Our latest issue is now online!

🔓Check out the #OpenAccess research behind the cover by @michaelaeverly.bsky.social & Patrick J. Hrdlicka from @uidaho.bsky.social using single-stranded LNA/MOE mixmers and chimeric Invader:XenoRNA probes for DNA targeting #orgchem

pubs.rsc.org/en/content/a...
January 14, 2026 at 3:22 PM
orgbiomolchem.rsc.org
Don't miss this review in our latest issue by Rafał Loska et al. from the Institute of Organic Chemistry, PAS looking at how nitrones can be used as directing groups in transition metal-catalysed C–H activation #orgchem

Check it out in full on our website🔽
Nitrones as directing groups in transition metal-catalysed C–H activation
During about the last 15 years, nitrones have emerged as versatile directing groups for transition metal-catalysed C–H activation reactions. Apart from simple functionalization of the aryl ring…
pubs.rsc.org
January 13, 2026 at 1:01 PM
orgbiomolchem.rsc.org
Check out #OpenAccess research from Christopher Batchelor-McAuley, @joannamcgouran.bsky.social & co. @tcddublin.bsky.social showing how electrochemically-generated ferricyanide enables thiol–ene capture of protein–protein binding #orgchem

Read in full below👇
Electrochemically-generated ferricyanide enables thiol–ene capture of protein–protein binding
Due to its efficiency, selectivity and biocompatibility, the thiol–ene coupling has demonstrated its potential for protein labelling. Here, we report the electrochemical thiol–ene activation to…
pubs.rsc.org
January 12, 2026 at 2:03 PM
Reposted by Organic & Biomolecular Chemistry
delbiancom.bsky.social
Well done Dominik!
Leveraging Mirror-Image Glycans in #CarbohydrateMaterials out today in @orgbiomolchem.rsc.org !

@rsc.org, @mpici.bsky.social

pubs.rsc.org/en/content/a...
Leveraging Mirror-Image Glycans in Carbohydrate Materials
Chirality has become a fundamental design principle to craft peptide materials. In contrast, the systematic exploitation of chirality to build glycan materials remains largely unexplored, despite the ...
pubs.rsc.org
January 12, 2026 at 9:11 AM
orgbiomolchem.rsc.org
Take a look at a #OpenAccess paper in our latest issue from Ashwani Sharma & co. reporting a label-free fluorescence-assisted method for RNA engineering of three-way junctions #orgchem

📍IISER Tirupati
FLARE: a label-free fluorescence-assisted method for RNA engineering of three-way junctions
RNA three-way junction (3WJ) motifs are important structural elements found in the majority of RNAs, and the thermal stability of these structural motifs is crucial in determining RNA's biological…
pubs.rsc.org
January 11, 2026 at 10:15 AM
orgbiomolchem.rsc.org
Read this review focused on the recent advances in coupling reactions on heteroaromatic rings via C–H bond functionalization by Nai-Xing Wang, Dumitra Lucan, Yalan Xing et al. at the Chinese Academy of Sciences & @hofstrau.bsky.social #orgchem

Find it on our website👇
Direct C–H functionalization on heteroaromatic rings
Direct C–H functionalization on heteroaromatic rings has emerged as a prominent topic in the field of catalytic organic synthesis. Among these, oxidative coupling methodologies involving C–H bond...
pubs.rsc.org
January 10, 2026 at 12:00 PM
orgbiomolchem.rsc.org
Don't miss this paper by Junichiro Yamaguchi & co. from Waseda University describing a transition-metal-free deoxygenative functionalization of trifluoromethyl ketones offering a concise and efficient route to benzylic CF3 scaffolds #orgchem

Check it out in full here🔽
Deoxygenative functionalization of trifluoromethyl ketones
A transition-metal-free deoxygenative functionalization of trifluoromethyl ketones via a Pudovik addition/phospha-Brook rearrangement sequence followed by benzylic substitution has been developed.…
pubs.rsc.org
January 9, 2026 at 11:00 AM
orgbiomolchem.rsc.org
📢Our first issue of 2026 is now online!

🔓Check out the #OpenAccess paper behind the cover from @furthlab.bsky.social & co. at @uu.se using heterocyclic scaffold-fused dimethoxy-dibenzocyclooctynes for photoactivatable click chemistry to create this great image #orgchem

pubs.rsc.org/en/content/a...
January 8, 2026 at 3:22 PM
orgbiomolchem.rsc.org
Take a look in our latest issue at this paper from Wei-Min Liu & co. demonstrating an unconventional synthetic pathway for the reaction of alkynyl sulfonium ylides with aromatic acid anhydrides #orgchem

📍Fu Jen Catholic University
An unconventional synthetic pathway for the reaction of alkynyl sulfonium ylides with aromatic acid anhydrides leading to the formation of sulfonium diacylmethylide frameworks
Here, we demonstrate an unconventional synthetic pathway for the reaction of alkynyl sulfonium ylides with aromatic acid anhydrides, leading to the remarkable generation of sulfonium diacylmethylide…
pubs.rsc.org
December 21, 2025 at 9:48 AM
orgbiomolchem.rsc.org
Be sure to read research from Chada Raji Reddy et al. at CSIR-IICT in our latest issue presenting the hydrogen atom transfer-assisted dearomative ipso-annulation of N-benzylacrylamides to azaspirocycles #orgchem

Find it in full below👇
Hydrogen atom transfer-assisted dearomative ipso-annulation of N-benzylacrylamides to azaspirocycles
Herein, we present a dearomative ipso-annulation of N-benzylacrylamides promoted by iron-catalyzed hydrogen atom transfer (HAT), enabling the assembly of azaspirocyclic structural frameworks. This…
pubs.rsc.org
December 20, 2025 at 10:15 AM
orgbiomolchem.rsc.org
Don't miss in our latest issue this paper from Yangen Huang & co. at Donghua University on the photoredox catalyzed synthesis of β-trifluoromethyl β-aminoketones #orgchem

Check it out in full on our website🔽
Photoredox catalyzed synthesis of β-trifluoromethyl β-aminoketones from N-trifluoroethyl hydroxylamine reagent and silyl enol ethers
This study presents a photoredox-catalyzed two-component alkylative coupling between silyl enol ethers and an N-trifluoroethyl hydroxylamine reagent via a radical 1,2-H shift, establishing a novel…
pubs.rsc.org
December 19, 2025 at 9:48 AM
orgbiomolchem.rsc.org
Check out research exploring DMSO as a versatile radical reagent for organic transformations by Saravanan Preethika & Rajagopal Nagarajan at the University of Hyderabad in our latest issue #orgchem

Read their full report here👇
Beyond the solvent role: discovery of DMSO as a versatile radical reagent for organic transformations
DMSO is well-known as a solvent but here we have explored DMSO as a sole reagent for dehydrogenation of tetrahydrocarbazoles, oxidation of alcohols to carbonyl compounds, decarboxylation of…
pubs.rsc.org
December 18, 2025 at 10:30 AM
orgbiomolchem.rsc.org
Take a look in our latest issue at a paper by Salvador Blasco, M. Teresa Albelda, Enrique García-España et al. reporting the self-assembly of azamacrocyclic ligands into vesicular structures #orgchem #supramolecular

📍 @uv.es
Self-assembly of azamacrocyclic ligands into vesicular structures: from design to functional properties and applications
We report on the design and synthesis of novel scorpiand-like macrocyclic ligands that self-assemble into vesicular structures. These ligands, derived from a…
pubs.rsc.org
December 17, 2025 at 1:30 PM
orgbiomolchem.rsc.org
Read research by Bor-Cherng Hong et al. from the National Chung Cheng University in our latest issue describing one-pot cyclobutane synthesis via sequential [2+2] photocycloaddition and photo-Nef reaction of nitroalkenes and 2-vinylpyridines #orgchem

Find in full below🔽
A one-pot visible-light strategy for cyclobutanone synthesis via sequential [2 + 2] cycloaddition and Nef reaction of nitroalkenes and 2-vinylpyridines
A visible-light-driven one-pot strategy for pyridinyl–cyclobutanone synthesis has been developed, involving sequential [2 + 2] photocycloaddition and photo-Nef reactions of nitroalkenes and…
pubs.rsc.org
December 16, 2025 at 10:01 AM
orgbiomolchem.rsc.org
🔓Don't miss this #OpenAccess paper from Charlotte Hind, @jennifer-hiscock.bsky.social & co. @kent.ac.uk, @ukhsa.bsky.social & @crhorizons.bsky.social investigating supramolecular self-associating amphiphiles as antimicrobials against ESKAPE pathogens

Check it out below👇
Dicarboxylate and dicarboxylic acid appended supramolecular self-associating amphiphiles as antimicrobial agents against high priority bacterial pathogens
Antimicrobial resistance remains a significant global health challenge. Supramolecular self-associating amphiphiles (SSAs) represent a promising class of compounds for development as antimicrobial…
pubs.rsc.org
December 15, 2025 at 12:15 PM
orgbiomolchem.rsc.org
Check out this review in our latest issue by Rambabu Dandela et al. from ICT Bhubaneswar examining the recent advances in the catalytic chemoselective C–N and C–O cross-coupling of amino alcohols #orgchem

Read the full article here🔽
Catalytic chemoselective C–N and C–O cross-coupling of amino alcohols: mechanistic perspectives and synthetic advancements
The development of sustainable and selective cross-coupling strategies for arylation of bifunctional substrates containing both amine and alcohol groups remains a central challenge in modern…
pubs.rsc.org
December 14, 2025 at 10:00 AM
orgbiomolchem.rsc.org
Take a look at a paper by Xiaoyu Liu, Xiaozhen Jiao, Ping Xie & co. in our latest issue describing the synthesis of isoxazoline analogs of stellettins #orgchem #naturalproducts

📍Peking Union Medical College
Synthesis of isoxazoline analogs of stellettins
We designed and synthesized (±)-stellettin analogs featuring an isoxazoline ring. The key synthetic steps included the Meyer–Schuster rearrangement, an intramolecular nitrile oxide cycloaddition to…
pubs.rsc.org
December 13, 2025 at 9:48 AM
orgbiomolchem.rsc.org
Be sure to read research from Sungduk Gwak, Hyeok-Jun Kwon, Hogyu Han et al. at Korea University reporting a new diazo-transfer reagent for the metal-free conversion of amines to azides in our latest issue #orgchem

Find their full report on our website👇
Phenoxysulfonyl azide: a new diazo-transfer reagent for the metal-free conversion of amines to azides
Phenoxysulfonyl azide (PSA, 1) was synthesized from 1,1′-sulfonylbis(2-methyl-1H-imidazole) (2) and studied for its diazo-transfer reactivity. The reaction with 1 was found to convert primary amines…
pubs.rsc.org
December 12, 2025 at 9:48 AM
orgbiomolchem.rsc.org
Don't miss this paper in our latest issue by Patrick Toullec, Aitor Maestro & co. @ehu.eus & @univbordeaux.bsky.social on the development and application of heterogeneous chiral bifunctional alkaloid-thioureas as recyclable organocatalysts #orgchem

Check it out here🔽
pubs.rsc.org/en/content/a...
Development and applications of heterogeneous chiral bifunctional alkaloid-thioureas as recyclable organocatalysts
The development of heterogeneous chiral catalysts is a growing research field, offering recyclable alternatives to their homogeneous counterparts. With the aim of identifying a general and reliable…
pubs.rsc.org
December 11, 2025 at 2:04 PM
orgbiomolchem.rsc.org
📢Our final issue of 2025 is online!

🔓Check out the #OpenAccess paper behind the cover by Vandana Srivastava, Sundaram Singh & co. at IIT Varanasi reporting the photocatalytic synthesis of imidazo[1,2-a]pyridines via C(sp)3–H functionalization using ethylarene #orgchem

pubs.rsc.org/en/content/a...
December 10, 2025 at 11:30 AM
Reposted by Organic & Biomolecular Chemistry
rsc.org
🎉 Registration for #RSCPoster 2026 is now OPEN!

Register now to secure your place and join us on 4 March 2026 at 12:00 GMT for a day of collaboration, discovery, and community.

We can’t wait to see your posters and your science ➡️ https://rsc.li/3XGGvzS
Promotional image for a 24-hour online conference on LinkedIn hosted by American Elements and Royal Society of Chemistry, scheduled from March 3, 2026, at 12:00 GMT to March 4, 2026, at 12:00 GMT. Features an orange and black background with abstract geometric designs and the text 'Save the date.'
December 8, 2025 at 6:09 PM
orgbiomolchem.rsc.org
🔓Read in our latest issue a #OpenAccess paper by Jonathan H. George & co. at the University of Adelaide & @unisouthampton.bsky.social on the biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol #natprod

Find in full below👇
Biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol
Motivated by a biosynthetic proposal which suggests a chemical relationship between capilloquinol and capillobenzopyranol, our studies report the first synthesis of their probable biogenetic…
pubs.rsc.org
December 9, 2025 at 1:15 PM