Organic & Biomolecular Chemistry
@orgbiomolchem.rsc.org
Rapid publication of organic synthesis, physical organic, chemical biology and supramolecular chemistry research.
Published by @rsc.org 🌐 Website: rsc.li/orgbiomolchem
Published by @rsc.org 🌐 Website: rsc.li/orgbiomolchem
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📢Our latest issue is now online!
This is a special themed issue celebrating our New Talent collection highlighting the excellent work being carried out by the next generation of leaders in the #organicchemistry community!
Find all the articles in the collection here🔽
pubs.rsc.org/en/journals/...
This is a special themed issue celebrating our New Talent collection highlighting the excellent work being carried out by the next generation of leaders in the #organicchemistry community!
Find all the articles in the collection here🔽
pubs.rsc.org/en/journals/...
Take a look in our latest issue at this paper from Wei-Min Liu & co. demonstrating an unconventional synthetic pathway for the reaction of alkynyl sulfonium ylides with aromatic acid anhydrides #orgchem
📍Fu Jen Catholic University
📍Fu Jen Catholic University
An unconventional synthetic pathway for the reaction of alkynyl sulfonium ylides with aromatic acid anhydrides leading to the formation of sulfonium diacylmethylide frameworks
Here, we demonstrate an unconventional synthetic pathway for the reaction of alkynyl sulfonium ylides with aromatic acid anhydrides, leading to the remarkable generation of sulfonium diacylmethylide…
pubs.rsc.org
December 21, 2025 at 9:48 AM
Take a look in our latest issue at this paper from Wei-Min Liu & co. demonstrating an unconventional synthetic pathway for the reaction of alkynyl sulfonium ylides with aromatic acid anhydrides #orgchem
📍Fu Jen Catholic University
📍Fu Jen Catholic University
Be sure to read research from Chada Raji Reddy et al. at CSIR-IICT in our latest issue presenting the hydrogen atom transfer-assisted dearomative ipso-annulation of N-benzylacrylamides to azaspirocycles #orgchem
Find it in full below👇
Find it in full below👇
Hydrogen atom transfer-assisted dearomative ipso-annulation of N-benzylacrylamides to azaspirocycles
Herein, we present a dearomative ipso-annulation of N-benzylacrylamides promoted by iron-catalyzed hydrogen atom transfer (HAT), enabling the assembly of azaspirocyclic structural frameworks. This…
pubs.rsc.org
December 20, 2025 at 10:15 AM
Be sure to read research from Chada Raji Reddy et al. at CSIR-IICT in our latest issue presenting the hydrogen atom transfer-assisted dearomative ipso-annulation of N-benzylacrylamides to azaspirocycles #orgchem
Find it in full below👇
Find it in full below👇
Don't miss in our latest issue this paper from Yangen Huang & co. at Donghua University on the photoredox catalyzed synthesis of β-trifluoromethyl β-aminoketones #orgchem
Check it out in full on our website🔽
Check it out in full on our website🔽
Photoredox catalyzed synthesis of β-trifluoromethyl β-aminoketones from N-trifluoroethyl hydroxylamine reagent and silyl enol ethers
This study presents a photoredox-catalyzed two-component alkylative coupling between silyl enol ethers and an N-trifluoroethyl hydroxylamine reagent via a radical 1,2-H shift, establishing a novel…
pubs.rsc.org
December 19, 2025 at 9:48 AM
Don't miss in our latest issue this paper from Yangen Huang & co. at Donghua University on the photoredox catalyzed synthesis of β-trifluoromethyl β-aminoketones #orgchem
Check it out in full on our website🔽
Check it out in full on our website🔽
Check out research exploring DMSO as a versatile radical reagent for organic transformations by Saravanan Preethika & Rajagopal Nagarajan at the University of Hyderabad in our latest issue #orgchem
Read their full report here👇
Read their full report here👇
Beyond the solvent role: discovery of DMSO as a versatile radical reagent for organic transformations
DMSO is well-known as a solvent but here we have explored DMSO as a sole reagent for dehydrogenation of tetrahydrocarbazoles, oxidation of alcohols to carbonyl compounds, decarboxylation of…
pubs.rsc.org
December 18, 2025 at 10:30 AM
Check out research exploring DMSO as a versatile radical reagent for organic transformations by Saravanan Preethika & Rajagopal Nagarajan at the University of Hyderabad in our latest issue #orgchem
Read their full report here👇
Read their full report here👇
Take a look in our latest issue at a paper by Salvador Blasco, M. Teresa Albelda, Enrique García-España et al. reporting the self-assembly of azamacrocyclic ligands into vesicular structures #orgchem #supramolecular
📍 @uv.es
📍 @uv.es
Self-assembly of azamacrocyclic ligands into vesicular structures: from design to functional properties and applications
We report on the design and synthesis of novel scorpiand-like macrocyclic ligands that self-assemble into vesicular structures. These ligands, derived from a…
pubs.rsc.org
December 17, 2025 at 1:30 PM
Take a look in our latest issue at a paper by Salvador Blasco, M. Teresa Albelda, Enrique García-España et al. reporting the self-assembly of azamacrocyclic ligands into vesicular structures #orgchem #supramolecular
📍 @uv.es
📍 @uv.es
Read research by Bor-Cherng Hong et al. from the National Chung Cheng University in our latest issue describing one-pot cyclobutane synthesis via sequential [2+2] photocycloaddition and photo-Nef reaction of nitroalkenes and 2-vinylpyridines #orgchem
Find in full below🔽
Find in full below🔽
A one-pot visible-light strategy for cyclobutanone synthesis via sequential [2 + 2] cycloaddition and Nef reaction of nitroalkenes and 2-vinylpyridines
A visible-light-driven one-pot strategy for pyridinyl–cyclobutanone synthesis has been developed, involving sequential [2 + 2] photocycloaddition and photo-Nef reactions of nitroalkenes and…
pubs.rsc.org
December 16, 2025 at 10:01 AM
Read research by Bor-Cherng Hong et al. from the National Chung Cheng University in our latest issue describing one-pot cyclobutane synthesis via sequential [2+2] photocycloaddition and photo-Nef reaction of nitroalkenes and 2-vinylpyridines #orgchem
Find in full below🔽
Find in full below🔽
🔓Don't miss this #OpenAccess paper from Charlotte Hind, @jennifer-hiscock.bsky.social & co. @kent.ac.uk, @ukhsa.bsky.social & @crhorizons.bsky.social investigating supramolecular self-associating amphiphiles as antimicrobials against ESKAPE pathogens
Check it out below👇
Check it out below👇
Dicarboxylate and dicarboxylic acid appended supramolecular self-associating amphiphiles as antimicrobial agents against high priority bacterial pathogens
Antimicrobial resistance remains a significant global health challenge. Supramolecular self-associating amphiphiles (SSAs) represent a promising class of compounds for development as antimicrobial…
pubs.rsc.org
December 15, 2025 at 12:15 PM
🔓Don't miss this #OpenAccess paper from Charlotte Hind, @jennifer-hiscock.bsky.social & co. @kent.ac.uk, @ukhsa.bsky.social & @crhorizons.bsky.social investigating supramolecular self-associating amphiphiles as antimicrobials against ESKAPE pathogens
Check it out below👇
Check it out below👇
Check out this review in our latest issue by Rambabu Dandela et al. from ICT Bhubaneswar examining the recent advances in the catalytic chemoselective C–N and C–O cross-coupling of amino alcohols #orgchem
Read the full article here🔽
Read the full article here🔽
Catalytic chemoselective C–N and C–O cross-coupling of amino alcohols: mechanistic perspectives and synthetic advancements
The development of sustainable and selective cross-coupling strategies for arylation of bifunctional substrates containing both amine and alcohol groups remains a central challenge in modern…
pubs.rsc.org
December 14, 2025 at 10:00 AM
Check out this review in our latest issue by Rambabu Dandela et al. from ICT Bhubaneswar examining the recent advances in the catalytic chemoselective C–N and C–O cross-coupling of amino alcohols #orgchem
Read the full article here🔽
Read the full article here🔽
Take a look at a paper by Xiaoyu Liu, Xiaozhen Jiao, Ping Xie & co. in our latest issue describing the synthesis of isoxazoline analogs of stellettins #orgchem #naturalproducts
📍Peking Union Medical College
📍Peking Union Medical College
Synthesis of isoxazoline analogs of stellettins
We designed and synthesized (±)-stellettin analogs featuring an isoxazoline ring. The key synthetic steps included the Meyer–Schuster rearrangement, an intramolecular nitrile oxide cycloaddition to…
pubs.rsc.org
December 13, 2025 at 9:48 AM
Take a look at a paper by Xiaoyu Liu, Xiaozhen Jiao, Ping Xie & co. in our latest issue describing the synthesis of isoxazoline analogs of stellettins #orgchem #naturalproducts
📍Peking Union Medical College
📍Peking Union Medical College
Be sure to read research from Sungduk Gwak, Hyeok-Jun Kwon, Hogyu Han et al. at Korea University reporting a new diazo-transfer reagent for the metal-free conversion of amines to azides in our latest issue #orgchem
Find their full report on our website👇
Find their full report on our website👇
Phenoxysulfonyl azide: a new diazo-transfer reagent for the metal-free conversion of amines to azides
Phenoxysulfonyl azide (PSA, 1) was synthesized from 1,1′-sulfonylbis(2-methyl-1H-imidazole) (2) and studied for its diazo-transfer reactivity. The reaction with 1 was found to convert primary amines…
pubs.rsc.org
December 12, 2025 at 9:48 AM
Be sure to read research from Sungduk Gwak, Hyeok-Jun Kwon, Hogyu Han et al. at Korea University reporting a new diazo-transfer reagent for the metal-free conversion of amines to azides in our latest issue #orgchem
Find their full report on our website👇
Find their full report on our website👇
Don't miss this paper in our latest issue by Patrick Toullec, Aitor Maestro & co. @ehu.eus & @univbordeaux.bsky.social on the development and application of heterogeneous chiral bifunctional alkaloid-thioureas as recyclable organocatalysts #orgchem
Check it out here🔽
pubs.rsc.org/en/content/a...
Check it out here🔽
pubs.rsc.org/en/content/a...
Development and applications of heterogeneous chiral bifunctional alkaloid-thioureas as recyclable organocatalysts
The development of heterogeneous chiral catalysts is a growing research field, offering recyclable alternatives to their homogeneous counterparts. With the aim of identifying a general and reliable…
pubs.rsc.org
December 11, 2025 at 2:04 PM
Don't miss this paper in our latest issue by Patrick Toullec, Aitor Maestro & co. @ehu.eus & @univbordeaux.bsky.social on the development and application of heterogeneous chiral bifunctional alkaloid-thioureas as recyclable organocatalysts #orgchem
Check it out here🔽
pubs.rsc.org/en/content/a...
Check it out here🔽
pubs.rsc.org/en/content/a...
📢Our final issue of 2025 is online!
🔓Check out the #OpenAccess paper behind the cover by Vandana Srivastava, Sundaram Singh & co. at IIT Varanasi reporting the photocatalytic synthesis of imidazo[1,2-a]pyridines via C(sp)3–H functionalization using ethylarene #orgchem
pubs.rsc.org/en/content/a...
🔓Check out the #OpenAccess paper behind the cover by Vandana Srivastava, Sundaram Singh & co. at IIT Varanasi reporting the photocatalytic synthesis of imidazo[1,2-a]pyridines via C(sp)3–H functionalization using ethylarene #orgchem
pubs.rsc.org/en/content/a...
December 10, 2025 at 11:30 AM
📢Our final issue of 2025 is online!
🔓Check out the #OpenAccess paper behind the cover by Vandana Srivastava, Sundaram Singh & co. at IIT Varanasi reporting the photocatalytic synthesis of imidazo[1,2-a]pyridines via C(sp)3–H functionalization using ethylarene #orgchem
pubs.rsc.org/en/content/a...
🔓Check out the #OpenAccess paper behind the cover by Vandana Srivastava, Sundaram Singh & co. at IIT Varanasi reporting the photocatalytic synthesis of imidazo[1,2-a]pyridines via C(sp)3–H functionalization using ethylarene #orgchem
pubs.rsc.org/en/content/a...
Reposted by Organic & Biomolecular Chemistry
🎉 Registration for #RSCPoster 2026 is now OPEN!
Register now to secure your place and join us on 4 March 2026 at 12:00 GMT for a day of collaboration, discovery, and community.
We can’t wait to see your posters and your science ➡️ https://rsc.li/3XGGvzS
Register now to secure your place and join us on 4 March 2026 at 12:00 GMT for a day of collaboration, discovery, and community.
We can’t wait to see your posters and your science ➡️ https://rsc.li/3XGGvzS
December 8, 2025 at 6:09 PM
🎉 Registration for #RSCPoster 2026 is now OPEN!
Register now to secure your place and join us on 4 March 2026 at 12:00 GMT for a day of collaboration, discovery, and community.
We can’t wait to see your posters and your science ➡️ https://rsc.li/3XGGvzS
Register now to secure your place and join us on 4 March 2026 at 12:00 GMT for a day of collaboration, discovery, and community.
We can’t wait to see your posters and your science ➡️ https://rsc.li/3XGGvzS
🔓Read in our latest issue a #OpenAccess paper by Jonathan H. George & co. at the University of Adelaide & @unisouthampton.bsky.social on the biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol #natprod
Find in full below👇
Find in full below👇
Biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol
Motivated by a biosynthetic proposal which suggests a chemical relationship between capilloquinol and capillobenzopyranol, our studies report the first synthesis of their probable biogenetic…
pubs.rsc.org
December 9, 2025 at 1:15 PM
🔓Read in our latest issue a #OpenAccess paper by Jonathan H. George & co. at the University of Adelaide & @unisouthampton.bsky.social on the biomimetic synthesis of Sinularia meroterpenoids and photochemical reactivity of capillobenzopyranol #natprod
Find in full below👇
Find in full below👇
🔓Don't miss this #OpenAccess paper by Arun K. Ghosh & Denver Hopkins @purduechemistry.bsky.social on the synthesis of 8-oxabicyclo-[3.2.1]-octenone heterocycles by diastereoselective intramolecular oxidopyrylium–alkene [5+2]-cycloaddition #orgchem
Check it out here🔽
Check it out here🔽
Diastereoselective intramolecular oxidopyrylium–alkene [5 + 2]-cycloaddition of substrates with a β-chiral center on alkene tethers: synthesis of 8-oxabicyclo-[3.2.1]-octenone heterocycles
We investigated the asymmetric intramolecular oxidopyrylium–alkene [5 + 2]-cycloaddition reaction of substrates bearing tethered alkenes containing β-chiral centers. The effect on the cycloadduct…
pubs.rsc.org
December 8, 2025 at 3:02 PM
🔓Don't miss this #OpenAccess paper by Arun K. Ghosh & Denver Hopkins @purduechemistry.bsky.social on the synthesis of 8-oxabicyclo-[3.2.1]-octenone heterocycles by diastereoselective intramolecular oxidopyrylium–alkene [5+2]-cycloaddition #orgchem
Check it out here🔽
Check it out here🔽
Check out research from Wu Zhang & co. at Anhui Normal University in our latest issue reporting the electrochemical synthesis of hydroxyalkylated quinoxalines via C–H functionalization #orgchem
Read their full report below👇
Read their full report below👇
Electrochemical synthesis of hydroxyalkylated quinoxalines via C–H functionalization
An efficient electrochemical C–H hydroxyalkylation of quinoxalines with aldehydes and ketones has been developed in an undivided cell. A variety of aliphatic and aromatic aldehydes as well as ketones…
pubs.rsc.org
December 7, 2025 at 9:48 AM
Check out research from Wu Zhang & co. at Anhui Normal University in our latest issue reporting the electrochemical synthesis of hydroxyalkylated quinoxalines via C–H functionalization #orgchem
Read their full report below👇
Read their full report below👇
Take a look in our latest issue at a paper from Brajendra K. Singh et al. describing the Ru(ii)-catalyzed site-selective N-directed C(sp2)–H alkylation of quinoxalinones with maleimide #orgchem
📍University of Delhi
📍University of Delhi
Ru(II)-catalyzed site-selective N-directed C(sp2)–H alkylation of quinoxalinones with maleimide
An efficient and highly regioselective ruthenium(ii)-catalyzed ortho-C–H alkylation of N-alkyl-3-phenylquinoxalin-2(1H)-ones with a broad array of N-alkyl maleimides is described. Systematic…
pubs.rsc.org
December 6, 2025 at 10:00 AM
Take a look in our latest issue at a paper from Brajendra K. Singh et al. describing the Ru(ii)-catalyzed site-selective N-directed C(sp2)–H alkylation of quinoxalinones with maleimide #orgchem
📍University of Delhi
📍University of Delhi
Be sure to read this review by Shinichiro Fuse from @en.nagoya-u.ac.jp in our latest issue discussing the recent developments in the continuous-flow synthesis of peptides #orgchem
Find the full article on our website👇
Find the full article on our website👇
Accelerating innovation in peptide synthesis through continuous-flow
Peptide-based pharmaceuticals, a representative class of medium-sized molecule drugs, have now surpassed 110 approved compounds. Their significance is also increasing in fields such as agrochemicals…
pubs.rsc.org
December 5, 2025 at 9:45 AM
Be sure to read this review by Shinichiro Fuse from @en.nagoya-u.ac.jp in our latest issue discussing the recent developments in the continuous-flow synthesis of peptides #orgchem
Find the full article on our website👇
Find the full article on our website👇
Don't miss research in our latest issue from Constantinos G. Neochoritis & co. at the University of Crete reporting a scalable Passerini-based method for synthesizing α-ketoamides #medchem #orgchem
Check it out in full here🔽
Check it out in full here🔽
Privileged scaffolds on demand: a Passerini-based strategy toward α-ketoamides
We report a scalable Passerini-based method for synthesizing α-ketoamides, key medicinal motifs. Using p-hydroxybenzoic acid and ethanol, Mumm rearrangement was interrupted to yield α-hydroxyamides…
pubs.rsc.org
December 4, 2025 at 1:04 PM
📢Our latest issue is now online!
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...
December 3, 2025 at 2:30 PM
📢Our latest issue is now online!
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...
Reposted by Organic & Biomolecular Chemistry
📢 Save the Date! We’re delighted to announce that #RSCPoster 2026 will take place on 3 March 2026 at 12:00 GMT.
Join researchers from around the world for a day of sharing, connecting, and celebrating scientific creativity across disciplines.
Mark your calendars — more details coming soon!
Join researchers from around the world for a day of sharing, connecting, and celebrating scientific creativity across disciplines.
Mark your calendars — more details coming soon!
December 2, 2025 at 5:40 PM
📢 Save the Date! We’re delighted to announce that #RSCPoster 2026 will take place on 3 March 2026 at 12:00 GMT.
Join researchers from around the world for a day of sharing, connecting, and celebrating scientific creativity across disciplines.
Mark your calendars — more details coming soon!
Join researchers from around the world for a day of sharing, connecting, and celebrating scientific creativity across disciplines.
Mark your calendars — more details coming soon!
🔓Don't miss in our latest issue #OpenAccess research by @breugstlab.bsky.social & co. from TU Chemnitz, part of our New Talent collection, undertaking a computational analysis of substituent effects in pnictogen-, chalcogen-, and halogen-bond donors #orgchem #compchem
A computational analysis of substituent effects in pnictogen-, chalcogen-, and halogen-bond donors
The interaction enthalpies of differently substituted cationic pnictogen-, chalcogen-, and halogen-bond donors with the fluoride anion have been analyzed computationally. In general,…
pubs.rsc.org
December 2, 2025 at 1:02 PM
🔓Don't miss in our latest issue #OpenAccess research by @breugstlab.bsky.social & co. from TU Chemnitz, part of our New Talent collection, undertaking a computational analysis of substituent effects in pnictogen-, chalcogen-, and halogen-bond donors #orgchem #compchem
🔓Check out this #OpenAccess paper by Eoghan M. McGarrigle et al. from @ucddublin.bsky.social showing how H-bonding, not remote participation, explains the influence of remote substituents on stereoselectivity in α-galactosylations #orgchem
Read in full below🔽
Read in full below🔽
H-bonding, not remote participation, explains the influence of remote substituents on stereoselectivity in α-galactosylations
The underlying roles of remote substituents in the stereochemical control of the formation of acetals and related reactions have been heavily debated. The competing prevailing theories were…
pubs.rsc.org
December 1, 2025 at 12:30 PM
🔓Check out this #OpenAccess paper by Eoghan M. McGarrigle et al. from @ucddublin.bsky.social showing how H-bonding, not remote participation, explains the influence of remote substituents on stereoselectivity in α-galactosylations #orgchem
Read in full below🔽
Read in full below🔽
Take a look at this review from M. Rajeswara Rao, Ritambhara Sharma & co. in our latest issue summarising the construction of polycyclic heteroaromatics via metal-catalysed intramolecular X–CH activation #organicchemistry
📍IIT Dharwad
📍IIT Dharwad
Construction of polycyclic heteroaromatics via metal-catalysed intramolecular X–CH activation
π-Conjugated heteroaromatic systems are known for their unique optical and electronic properties and are important for a wide range of semiconducting applications. Metal-catalysed C–H activation has…
pubs.rsc.org
November 30, 2025 at 10:30 AM
Take a look at this review from M. Rajeswara Rao, Ritambhara Sharma & co. in our latest issue summarising the construction of polycyclic heteroaromatics via metal-catalysed intramolecular X–CH activation #organicchemistry
📍IIT Dharwad
📍IIT Dharwad
Read research, part of our New Talent collection, by Shipeng Luo, Chenguang Liu et al. from Fuzhou University on a photocatalytic hydro/deutero-alkylation of propellane for the synthesis of α-silylated bicyclo[1.1.1]pentanes in our latest issue #orgchem
Find in full👇
Find in full👇
Visible light photocatalytic reductive hydroalkylation and deuterium alkylation to access α-silylated bicyclo[1.1.1]pentanes
As pharmacophoric elements, both bicyclo[1.1.1]pentanes (BCPs) and silyl substituents have found widespread applications in drug discovery. However, systematic synthetic methods for α-silylated BCPs…
pubs.rsc.org
November 29, 2025 at 9:45 AM
Read research, part of our New Talent collection, by Shipeng Luo, Chenguang Liu et al. from Fuzhou University on a photocatalytic hydro/deutero-alkylation of propellane for the synthesis of α-silylated bicyclo[1.1.1]pentanes in our latest issue #orgchem
Find in full👇
Find in full👇