ConcepcIonLab@UChicago
@concepcionlab.bsky.social
We study Ion Channels in Immunity
Reposted by ConcepcIonLab@UChicago
The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”
October 8, 2025 at 9:55 AM
The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”
Reposted by ConcepcIonLab@UChicago
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/3VNrH1s
go.nature.com/3VNrH1s
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 10:52 AM
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/3VNrH1s
go.nature.com/3VNrH1s
Thank you to @jphysiol.bsky.social for highlighting our review on volume-regulated anion channels #VRACs in #Immunity and featuring it in the August 2025 Editor’s Choice issue. 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 27, 2025 at 2:28 PM
Thank you to @jphysiol.bsky.social for highlighting our review on volume-regulated anion channels #VRACs in #Immunity and featuring it in the August 2025 Editor’s Choice issue. 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by ConcepcIonLab@UChicago
📣 Online now - the Feature Review "LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation" from Thomas Jentsch et al.
#VolumeRegulatedAnionChannel #VRAC #SWELL1 #Transporter #CellSignaling
Read it here: authors.elsevier.com/sd/article/S...
#VolumeRegulatedAnionChannel #VRAC #SWELL1 #Transporter #CellSignaling
Read it here: authors.elsevier.com/sd/article/S...
August 6, 2025 at 3:32 PM
📣 Online now - the Feature Review "LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation" from Thomas Jentsch et al.
#VolumeRegulatedAnionChannel #VRAC #SWELL1 #Transporter #CellSignaling
Read it here: authors.elsevier.com/sd/article/S...
#VolumeRegulatedAnionChannel #VRAC #SWELL1 #Transporter #CellSignaling
Read it here: authors.elsevier.com/sd/article/S...
Reposted by ConcepcIonLab@UChicago
🎉 NEW ISSUE LIVE🎉
This special issue, guest-edited by Jorge E. Contreras of ucd-physiology.bsky.social, explores 'Current advances in Large‐pore channels: from structure‐function to physiology and disease' 🔍
📖 Access it here: physoc.onlinelibrary.wiley.com/toc/14697793...
This special issue, guest-edited by Jorge E. Contreras of ucd-physiology.bsky.social, explores 'Current advances in Large‐pore channels: from structure‐function to physiology and disease' 🔍
📖 Access it here: physoc.onlinelibrary.wiley.com/toc/14697793...
August 13, 2025 at 10:00 AM
🎉 NEW ISSUE LIVE🎉
This special issue, guest-edited by Jorge E. Contreras of ucd-physiology.bsky.social, explores 'Current advances in Large‐pore channels: from structure‐function to physiology and disease' 🔍
📖 Access it here: physoc.onlinelibrary.wiley.com/toc/14697793...
This special issue, guest-edited by Jorge E. Contreras of ucd-physiology.bsky.social, explores 'Current advances in Large‐pore channels: from structure‐function to physiology and disease' 🔍
📖 Access it here: physoc.onlinelibrary.wiley.com/toc/14697793...
Reposted by ConcepcIonLab@UChicago
Research by Yulia Kostritskaia et al. observes that Sphingosine-1-phosphate activates LRRC8 volume-regulated #anion channels through Gβγ signalling 🔬 📶
Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 15, 2025 at 11:01 AM
Research by Yulia Kostritskaia et al. observes that Sphingosine-1-phosphate activates LRRC8 volume-regulated #anion channels through Gβγ signalling 🔬 📶
Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by ConcepcIonLab@UChicago
Jorge E. Contreras of ucd-physiology.bsky.social introduces the special issue 'Current advances in large-pore channels: From structure–function to physiology and disease' in this #Editorial ✍️
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 19, 2025 at 12:00 PM
Jorge E. Contreras of ucd-physiology.bsky.social introduces the special issue 'Current advances in large-pore channels: From structure–function to physiology and disease' in this #Editorial ✍️
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by ConcepcIonLab@UChicago
Friday, 15 August, is the last day to submit your abstract to be considering for a short talk and/or travel award for SGP 2025!http://sgp2025.com Join us to hear talks by Henry Colecraft, Sheel Dodani, Rod MacKinnon, and many other great speakers!
August 15, 2025 at 1:46 AM
Friday, 15 August, is the last day to submit your abstract to be considering for a short talk and/or travel award for SGP 2025!http://sgp2025.com Join us to hear talks by Henry Colecraft, Sheel Dodani, Rod MacKinnon, and many other great speakers!
Reposted by ConcepcIonLab@UChicago
#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...
August 7, 2025 at 8:45 PM
#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...
Reposted by ConcepcIonLab@UChicago
Large-pore channels: the Transformers of membrane proteins, versatile, dramatic, and never just selective or passive conduits.
Not just simple (typical) ion channels, they’re molecular multitaskers we’re beginning to comprehend.
Don’t miss the first-ever special issue dedicated to this!
Not just simple (typical) ion channels, they’re molecular multitaskers we’re beginning to comprehend.
Don’t miss the first-ever special issue dedicated to this!
Current advances in large‐pore channels: From structure–function to physiology and disease
Click on the article title to read more.
physoc.onlinelibrary.wiley.com
July 29, 2025 at 6:45 PM
Large-pore channels: the Transformers of membrane proteins, versatile, dramatic, and never just selective or passive conduits.
Not just simple (typical) ion channels, they’re molecular multitaskers we’re beginning to comprehend.
Don’t miss the first-ever special issue dedicated to this!
Not just simple (typical) ion channels, they’re molecular multitaskers we’re beginning to comprehend.
Don’t miss the first-ever special issue dedicated to this!
Reposted by ConcepcIonLab@UChicago
📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
July 22, 2025 at 2:41 PM
📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
Reposted by ConcepcIonLab@UChicago
Exciting news! The EPIC/SGP Symposium at UC Davis will be accompanied by a special issue in the Journal of General Physiology. Stay tuned for more details about this incredible event celebrating cutting-edge research on ion channels!
📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
July 23, 2025 at 2:05 AM
Exciting news! The EPIC/SGP Symposium at UC Davis will be accompanied by a special issue in the Journal of General Physiology. Stay tuned for more details about this incredible event celebrating cutting-edge research on ion channels!
Reposted by ConcepcIonLab@UChicago
Many warned me about the risks of speaking up publicly for science. I’m here to say I’ve faced no retaliation. On the contrary, I’ve received support, appreciation, and even some positive outcomes. Do what you can to save 🧪
July 17, 2025 at 4:04 AM
Many warned me about the risks of speaking up publicly for science. I’m here to say I’ve faced no retaliation. On the contrary, I’ve received support, appreciation, and even some positive outcomes. Do what you can to save 🧪
Reposted by ConcepcIonLab@UChicago
Join us for the 11th Intnl #GDTcells conf in Toronto (May 20-23) as we celebrate emerging research and inspire future directions. I will be wearing two hats: conf organizer and repping #GDTcellclub w/ @eberlmat.bsky.social. Pls come say hi! @forum-gd.bsky.social
na.eventscloud.com/website/7048...
na.eventscloud.com/website/7048...
May 14, 2025 at 9:56 PM
Join us for the 11th Intnl #GDTcells conf in Toronto (May 20-23) as we celebrate emerging research and inspire future directions. I will be wearing two hats: conf organizer and repping #GDTcellclub w/ @eberlmat.bsky.social. Pls come say hi! @forum-gd.bsky.social
na.eventscloud.com/website/7048...
na.eventscloud.com/website/7048...
Reposted by ConcepcIonLab@UChicago
Now online! The structure of human sweetness
The structure of human sweetness
A single taste receptor initiates our reactions to both sugars and artificial sweeteners, triggering a signaling process that drives our intense attraction to sweet foods. Single-particle cryo-EM reveals the structure of the human sweet taste receptor, a heteromer composed of TAS1R2 + TAS1R3 GPCRs.
dlvr.it
May 7, 2025 at 6:51 PM
Now online! The structure of human sweetness
Reposted by ConcepcIonLab@UChicago
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
youtu.be
May 3, 2025 at 7:20 PM
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Reposted by ConcepcIonLab@UChicago
#CallForPapers 📣 We invite submissions on the topic of @sgpweb’s 2025 Meeting “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Guest Editors are Anne Carlson & Zhaozhu Qiu 👉 rupress.org/JGP/pages/ca...
April 16, 2025 at 2:19 PM
#CallForPapers 📣 We invite submissions on the topic of @sgpweb’s 2025 Meeting “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Guest Editors are Anne Carlson & Zhaozhu Qiu 👉 rupress.org/JGP/pages/ca...
Reposted by ConcepcIonLab@UChicago
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.
chemsymposia.com
chemsymposia.com
Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026
Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...
chemsymposia.com
April 11, 2025 at 4:35 PM
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.
chemsymposia.com
chemsymposia.com
Reposted by ConcepcIonLab@UChicago
#CallForPapers! Topics of interest include, but are not limited to, chloride channel and transporter structures and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
April 3, 2025 at 7:15 PM
#CallForPapers! Topics of interest include, but are not limited to, chloride channel and transporter structures and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
Reposted by ConcepcIonLab@UChicago
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
March 26, 2025 at 4:29 PM
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
Reposted by ConcepcIonLab@UChicago
Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/...
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Rewilding catalyzes maturation of the humoral immune system
Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.
www.science.org
March 8, 2025 at 2:40 PM
Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/...
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Reposted by ConcepcIonLab@UChicago
Now in #Science #Immunology: @ejohnwherry.bsky.social & al use Tox-inducible KO mice to show that continuous #TOX expression in established exhausted #CD8 #Tcells (Tex cells) acts as enduring epigenetic control to reinforce Tex cell fate. Findings suggest TOX might be useful therapeutic target!
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.
www.science.org
March 7, 2025 at 8:20 PM
Now in #Science #Immunology: @ejohnwherry.bsky.social & al use Tox-inducible KO mice to show that continuous #TOX expression in established exhausted #CD8 #Tcells (Tex cells) acts as enduring epigenetic control to reinforce Tex cell fate. Findings suggest TOX might be useful therapeutic target!
Reposted by ConcepcIonLab@UChicago
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 12, 2025 at 5:04 PM
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Reposted by ConcepcIonLab@UChicago
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted by ConcepcIonLab@UChicago
It’s wild that US NIH study sections—literally the backbone of biomedical research funding and future medicines—didn’t miss a single session during the pandemic. Not one. And yet, here we are…
February 4, 2025 at 5:18 PM
It’s wild that US NIH study sections—literally the backbone of biomedical research funding and future medicines—didn’t miss a single session during the pandemic. Not one. And yet, here we are…