Claudio Cortes
@clcortex.bsky.social
Scientist #devbio in congenital heart disease @Oxford #microscopy🇨🇱🇦🇺🇫🇷🇬🇧 #SciComm/#SciArt🔬♥🧬// He/Him // Climbing - drumming - scuba
Reposted by Claudio Cortes
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
A toolkit for testing membrane-localising tags across species
Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...
www.biorxiv.org
October 23, 2025 at 8:16 AM
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
Reposted by Claudio Cortes
Happy to share our paper now out in @cp-cellreports.bsky.social - and check out our thread about the findings at bsky.app/profile/vale...
In vivo differentiation of embryonic cells devoid of key reprogramming factors
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Youlten, Miao et al. use zebrafish transplantation to understand the fate of cells lacking pluripotency factors Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and cell identity establishment. They found that NPS are required for proper cell identity for most, but not all, lineages, likely through nuclear and cytoplasmic reprogramming.
dlvr.it
November 13, 2025 at 12:34 AM
Happy to share our paper now out in @cp-cellreports.bsky.social - and check out our thread about the findings at bsky.app/profile/vale...
Reposted by Claudio Cortes
Felix Zhou's u-Segment3D is out:
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
November 12, 2025 at 2:41 AM
Felix Zhou's u-Segment3D is out:
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
Reposted by Claudio Cortes
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
November 12, 2025 at 10:16 AM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
Reposted by Claudio Cortes
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
www.mskcc.org/research/ski...
Faculty Positions
The Sloan Kettering Institute is seeking innovative scientists to join our faculty.
www.mskcc.org
October 27, 2025 at 2:45 PM
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
www.mskcc.org/research/ski...
Reposted by Claudio Cortes
🚨 TLM Online Seminar Series - 05.11.25 | 16:00 UK
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
October 28, 2025 at 8:19 AM
🚨 TLM Online Seminar Series - 05.11.25 | 16:00 UK
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
Reposted by Claudio Cortes
Our Microscopy Training Grants with @jcellsci.bsky.social could be used to support your attendance at this course. Check out the details to see if you are eligible: www.biologists.com/grants/jcs-f...
Or reach out if you have any questions about the grants.
Or reach out if you have any questions about the grants.
October 28, 2025 at 9:56 AM
Our Microscopy Training Grants with @jcellsci.bsky.social could be used to support your attendance at this course. Check out the details to see if you are eligible: www.biologists.com/grants/jcs-f...
Or reach out if you have any questions about the grants.
Or reach out if you have any questions about the grants.
Reposted by Claudio Cortes
#EPFL has an open faculty position - tenure track or tenured!! - in AI driven biophysics. Deadline is Nov 15th. Please spread the word!
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Assistant/associate Professor of AI-assisted Biophysics at the Ecole polytechnique fédérale de Lausanne (EPFL) and Group Leader at the Paul Scherrer Institute (PSI)
The School of Basic Sciences (Physics, Chemistry and Mathematics) at EPFL and the Paul Scherrer Institute (PSI) jointly seek to appoint a Tenure Track Assistant or tenured Associate Professor in AI-As...
www.epfl.ch
October 28, 2025 at 2:56 AM
#EPFL has an open faculty position - tenure track or tenured!! - in AI driven biophysics. Deadline is Nov 15th. Please spread the word!
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Reposted by Claudio Cortes
During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4
October 7, 2025 at 10:26 AM
Such a treasure trove!
Thank you for continuing work on such a useful community tool 🐟🧬🤍
Thank you for continuing work on such a useful community tool 🐟🧬🤍
📢 The #Danioheart atlas webpage has been updated.
In addition to the whole dataset (>34,000 zebrafish heart cells across 10 developmental stages) we now provide subclusters of each major cardiac cell population. #zebrafish #heart #scRNAseq
@stainierlab.bsky.social
www.mpi-hlr.de/danioheartat...
In addition to the whole dataset (>34,000 zebrafish heart cells across 10 developmental stages) we now provide subclusters of each major cardiac cell population. #zebrafish #heart #scRNAseq
@stainierlab.bsky.social
www.mpi-hlr.de/danioheartat...
danioheartatlas
www.mpi-hlr.de
October 7, 2025 at 8:34 AM
Such a treasure trove!
Thank you for continuing work on such a useful community tool 🐟🧬🤍
Thank you for continuing work on such a useful community tool 🐟🧬🤍
Reposted by Claudio Cortes
Looking forward to working with new colleagues on a collaborative project in lung disease modelling and transcriptomics - please share! And email Jenny @jennydickens41.bsky.social, or me, with any questions. 😀
www.jobs.cam.ac.uk/job/52936/
www.jobs.cam.ac.uk/job/52936/
Research Associate: Human Lung Disease Mechanisms (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate: Human Lung Disease Mechanisms (Fixed Term) in the Gurdon Institute at the University of Cambridge.
www.jobs.cam.ac.uk
October 2, 2025 at 3:14 PM
Looking forward to working with new colleagues on a collaborative project in lung disease modelling and transcriptomics - please share! And email Jenny @jennydickens41.bsky.social, or me, with any questions. 😀
www.jobs.cam.ac.uk/job/52936/
www.jobs.cam.ac.uk/job/52936/
Reposted by Claudio Cortes
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
October 5, 2025 at 10:35 AM
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
So many possibilities! Exciting development
Finally .. incredible much awaited wok on deriving avian naive ESCs
“Derivation of embryonic stem cells across avian species”
www.nature.com/articles/s41...
“Derivation of embryonic stem cells across avian species”
www.nature.com/articles/s41...
Derivation of embryonic stem cells across avian species - Nature Biotechnology
Embryonic stem cells for chicken and seven other avian species are derived.
www.nature.com
October 3, 2025 at 11:58 AM
So many possibilities! Exciting development
A riveting read and VERY cool timelapses!
Very interested in the vector space of contractility/compaction and the link with implantation, not to mention the differences in aged embryos. Read and enjoy!
Very interested in the vector space of contractility/compaction and the link with implantation, not to mention the differences in aged embryos. Read and enjoy!
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 9:14 PM
A riveting read and VERY cool timelapses!
Very interested in the vector space of contractility/compaction and the link with implantation, not to mention the differences in aged embryos. Read and enjoy!
Very interested in the vector space of contractility/compaction and the link with implantation, not to mention the differences in aged embryos. Read and enjoy!
Reposted by Claudio Cortes
This comic is becoming increasingly realistic.
m.xkcd.com/3056/
m.xkcd.com/3056/
September 29, 2025 at 10:50 AM
This comic is becoming increasingly realistic.
m.xkcd.com/3056/
m.xkcd.com/3056/
Reposted by Claudio Cortes
Absolutely delighted to host Dr Jenna Cash from @edinburgh-uni.bsky.social for our next @kiroxford.bsky.social External Seminar on Monday 29 September at 12 pm !
Please join us if you want to learn more about how the most recent spatial omics technologies can be used to understand skin biology!
Please join us if you want to learn more about how the most recent spatial omics technologies can be used to understand skin biology!
On Monday 29 September, Dr Jenna Cash from the University of Edinburgh will visit us to talk about "Derailed Cellular Choreography in the Skin Ulcer Niche: Roadblocks to Repair". Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/743...
September 26, 2025 at 12:21 PM
Absolutely delighted to host Dr Jenna Cash from @edinburgh-uni.bsky.social for our next @kiroxford.bsky.social External Seminar on Monday 29 September at 12 pm !
Please join us if you want to learn more about how the most recent spatial omics technologies can be used to understand skin biology!
Please join us if you want to learn more about how the most recent spatial omics technologies can be used to understand skin biology!
Reposted by Claudio Cortes
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
Cornell University, Molecular Biology & Genetics
Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US
academicjobsonline.org
September 24, 2025 at 4:16 AM
Reposted by Claudio Cortes
New perspective in @jcb.org by @maikbischoff.bsky.social & @mayorlab.bsky.social about how mesenchymal cells use contact-dependent rules to generate swarm-like behaviors, patterns & organ forms. rupress.org/jcb/article/...
#CellBio #CellMigration #Morphogenesis #Development #Science
#CellBio #CellMigration #Morphogenesis #Development #Science
September 23, 2025 at 6:52 PM
New perspective in @jcb.org by @maikbischoff.bsky.social & @mayorlab.bsky.social about how mesenchymal cells use contact-dependent rules to generate swarm-like behaviors, patterns & organ forms. rupress.org/jcb/article/...
#CellBio #CellMigration #Morphogenesis #Development #Science
#CellBio #CellMigration #Morphogenesis #Development #Science
Just gorgeous!
Conservation (impact), third place is particularly jarring. We need to do better to our planet and all who we share it with!
Conservation (impact), third place is particularly jarring. We need to do better to our planet and all who we share it with!
Ocean Photographer of the Year 2025 – in pictures
The competition showcases breath-taking images that celebrate the ocean’s beauty & highlight the urgent need to protect it.
🧪🐟🐬🦀
www.theguardian.com/artanddesign...
The competition showcases breath-taking images that celebrate the ocean’s beauty & highlight the urgent need to protect it.
🧪🐟🐬🦀
www.theguardian.com/artanddesign...
Ocean Photographer of the Year 2025 – in pictures
The winner of the Ocean Photographer of the Year 2025 has been revealed. The competition, presented by Oceanographic and Blancpain, showcases breathtaking images that celebrate the ocean’s beauty and ...
www.theguardian.com
September 23, 2025 at 9:54 AM
Just gorgeous!
Conservation (impact), third place is particularly jarring. We need to do better to our planet and all who we share it with!
Conservation (impact), third place is particularly jarring. We need to do better to our planet and all who we share it with!
Great place to postdoc! State of the art microscopy, supportive environment and cool topic?
Yes !
Yes !
✨ Post-doc opportunity in axon biology, funded by #ATIP-Avenir!
👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches.
Apply at: emploi.cnrs.fr/Offres/CDD/U...
Thank you for sharing! 👋 🙏
👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches.
Apply at: emploi.cnrs.fr/Offres/CDD/U...
Thank you for sharing! 👋 🙏
Portail Emploi CNRS - Offre d'emploi - Post-doctoral researcher in axon biology (M/F)
emploi.cnrs.fr
September 15, 2025 at 7:55 AM
Great place to postdoc! State of the art microscopy, supportive environment and cool topic?
Yes !
Yes !
Reposted by Claudio Cortes
Oh look at this!! Beautiful, and it will be out just in time for your Xmas shopping. Great gift idea for kids, a coloring book about vision!!! 🤩
We are currently working on the last edits of our third volume - all about the visual system!
English and French editions coming soon! 👀🧠☀️
English and French editions coming soon! 👀🧠☀️
September 14, 2025 at 11:42 PM
Oh look at this!! Beautiful, and it will be out just in time for your Xmas shopping. Great gift idea for kids, a coloring book about vision!!! 🤩
Reposted by Claudio Cortes
🦐 High-res microCT of #Parhyale hawaiensis for #3DThursday! A powerful crustacean model for studying limb development, regeneration, and evo-devo.
🥼: Nipam Patel & Andrew Gillis, 2017
🏛️: University of Cambridge @cam.ac.uk
🎬: syGlass.io
#Parhyale #MicroCT #DevBio #EvoDevo #ModelOrganisms #syGlass
🥼: Nipam Patel & Andrew Gillis, 2017
🏛️: University of Cambridge @cam.ac.uk
🎬: syGlass.io
#Parhyale #MicroCT #DevBio #EvoDevo #ModelOrganisms #syGlass
September 11, 2025 at 2:29 PM
🦐 High-res microCT of #Parhyale hawaiensis for #3DThursday! A powerful crustacean model for studying limb development, regeneration, and evo-devo.
🥼: Nipam Patel & Andrew Gillis, 2017
🏛️: University of Cambridge @cam.ac.uk
🎬: syGlass.io
#Parhyale #MicroCT #DevBio #EvoDevo #ModelOrganisms #syGlass
🥼: Nipam Patel & Andrew Gillis, 2017
🏛️: University of Cambridge @cam.ac.uk
🎬: syGlass.io
#Parhyale #MicroCT #DevBio #EvoDevo #ModelOrganisms #syGlass
Reposted by Claudio Cortes
🚨 Don’t miss it! Abstract submission closes Monday, Sept 15. frenchzebrafishmeeting.fr
Fantastic keynote speaker @KarinaYaniv and a great opportunity to connect with the @FrenchZebrafish Community. All talks will be in English. Join us! #FZM #zebrafish
Fantastic keynote speaker @KarinaYaniv and a great opportunity to connect with the @FrenchZebrafish Community. All talks will be in English. Join us! #FZM #zebrafish
2nd French Zebrafish Meeting : Abstract's submission deadline extended to September 15th 2025.
Spread the word ... Registration deadline : October 10th.
More info on www.frenchzebrafishmeeting.fr
#zebrafish #FZM2025 #scientificcommunity #biology #behavior #diseasemodels #regeneration #evolution
Spread the word ... Registration deadline : October 10th.
More info on www.frenchzebrafishmeeting.fr
#zebrafish #FZM2025 #scientificcommunity #biology #behavior #diseasemodels #regeneration #evolution
September 13, 2025 at 4:05 AM
🚨 Don’t miss it! Abstract submission closes Monday, Sept 15. frenchzebrafishmeeting.fr
Fantastic keynote speaker @KarinaYaniv and a great opportunity to connect with the @FrenchZebrafish Community. All talks will be in English. Join us! #FZM #zebrafish
Fantastic keynote speaker @KarinaYaniv and a great opportunity to connect with the @FrenchZebrafish Community. All talks will be in English. Join us! #FZM #zebrafish
Reposted by Claudio Cortes
This is why we are all in this field…to see, and one day to be able to produce work like this.
Patho-DBiT-seq
www.cell.com/cell/fulltex...
Patho-DBiT-seq
www.cell.com/cell/fulltex...
Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues
Patho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA, microRNA,
tRNA, splicing isoform, etc.) all at once in clinical formalin-fixed paraffin-embedded
tissue with high sensitivit...
www.cell.com
November 29, 2024 at 11:35 PM
This is why we are all in this field…to see, and one day to be able to produce work like this.
Patho-DBiT-seq
www.cell.com/cell/fulltex...
Patho-DBiT-seq
www.cell.com/cell/fulltex...
Reposted by Claudio Cortes
STAMP brings us non-destructive single-cell profiling without the sequencing
www.omic.ly/stamp-brings...
www.omic.ly/stamp-brings...
STAMP brings us non-destructive single-cell profiling without the sequencing
No sequencer needed: Imaging based single-cell multiomics
www.omic.ly
July 3, 2025 at 7:26 AM
STAMP brings us non-destructive single-cell profiling without the sequencing
www.omic.ly/stamp-brings...
www.omic.ly/stamp-brings...