Chymkowitch lab
@chymkowitchlab.bsky.social
Associate Professor at the university of Oslo
🌟 Congratulations to my PhD student Patrizia Nothnagel! 🌟
Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.
Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.
September 25, 2025 at 1:12 PM
🌟 Congratulations to my PhD student Patrizia Nothnagel! 🌟
Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.
Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.
I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾
👉 rdcu.be/ezA5o
👉 rdcu.be/ezA5o
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells
Nature Communications - Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte...
rdcu.be
August 6, 2025 at 5:49 PM
I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾
👉 rdcu.be/ezA5o
👉 rdcu.be/ezA5o
We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social
Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo
Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025
www.jobbnorge.no
May 12, 2025 at 4:49 PM
We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social
Totipotent-like cells in early mouse embryos reorganize their genome via Z-DNA and Zscan4-driven interactions to form a “Z compartment” first supporting ZGA and later compartmentalisation to safeguard the totipotent-like state. Chromatin plasticity at its finest!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization
A remarkable transition during murine development is the progression from the 1-cell embryo to the 2-cell stage, accompanied by the activation of a specific set of embryonic genes, epigenome reprogram...
www.biorxiv.org
April 25, 2025 at 11:19 AM
Totipotent-like cells in early mouse embryos reorganize their genome via Z-DNA and Zscan4-driven interactions to form a “Z compartment” first supporting ZGA and later compartmentalisation to safeguard the totipotent-like state. Chromatin plasticity at its finest!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
We’re Hiring!
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
April 23, 2025 at 1:00 PM
We’re Hiring!
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.
This study is a very elegant characterisation of the epigenetic and transcriptional divergence between white and beige adipocytes. Very useful to those studying the epigenetic mechanisms supporting cellular reprogramming.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes
Epigenetic regulation is a key determinant of adipocyte fate and function, conferring phenotypic plasticity to adipose tissue in response to metabolic and thermal challenges. To understand the spatiot...
www.biorxiv.org
April 14, 2025 at 7:12 AM
This study is a very elegant characterisation of the epigenetic and transcriptional divergence between white and beige adipocytes. Very useful to those studying the epigenetic mechanisms supporting cellular reprogramming.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Chymkowitch lab
Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW
plos.io/3DRtAEW
March 18, 2025 at 6:54 PM
Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW
plos.io/3DRtAEW
Our recent in vivo study reveals that inhibiting SUMOylation with TAK-981 disrupts fat accumulation, leading to impaired adipogenesis and increased immune cell infiltration in perigonadal white adipose tissue.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue
Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue...
www.tandfonline.com
March 6, 2025 at 12:46 PM
Our recent in vivo study reveals that inhibiting SUMOylation with TAK-981 disrupts fat accumulation, leading to impaired adipogenesis and increased immune cell infiltration in perigonadal white adipose tissue.
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
My group @biovitenskap.bsky.social is #hiring a Post-doc in bioinformatics and biostatistics to work on #epigenetic memory in stem cells and during cell reprogramming. The position is co-supervised by @amathelier.bsky.social from @nordicembl.bsky.social
January 22, 2025 at 4:56 AM
My group @biovitenskap.bsky.social is #hiring a Post-doc in bioinformatics and biostatistics to work on #epigenetic memory in stem cells and during cell reprogramming. The position is co-supervised by @amathelier.bsky.social from @nordicembl.bsky.social
Thanks for sharing the first of the two positions that we will propose in the next 6 months @biovitenskap.bsky.social
Stay tuned!
Stay tuned!
We are #hiring a postdoc to study the epigenetic imprinting of cell fate during adipogenesis.
Cool interdisciplinary project to analyze ChIP-seq, ATAC-seq, Hi-C, and CAGE. The postdoc will be co-supervised by @chymkowitchlab.bsky.social and me.
Spread the word!
www.jobbnorge.no/en/available...
Cool interdisciplinary project to analyze ChIP-seq, ATAC-seq, Hi-C, and CAGE. The postdoc will be co-supervised by @chymkowitchlab.bsky.social and me.
Spread the word!
www.jobbnorge.no/en/available...
Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869) | University of Oslo
Job title: Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869), Employer: University of Oslo, Deadline: Friday, February 28, 2025
www.jobbnorge.no
January 21, 2025 at 8:06 PM
Thanks for sharing the first of the two positions that we will propose in the next 6 months @biovitenskap.bsky.social
Stay tuned!
Stay tuned!
Reposted by Chymkowitch lab
As part of this initiative, two postdoctoral fellowships will soon be advertised. One focusing on Molecular and Cell Biology, and one focusing on bioinformatics and biostatistics.
Stay tuned for more updates and details about these positions!
@chymkowitchlab.bsky.social
www.mn.uio.no/ibv/english/...
Stay tuned for more updates and details about these positions!
@chymkowitchlab.bsky.social
www.mn.uio.no/ibv/english/...
Funding to Research on Epigenetic memory
- Department of Biosciences
Pierre Chymkowitch at the University of Oslo is awarded 12 million NOK by The Norwegian Research Council, to investigate how SUMOylation influences epigenetic stability and could prevent diseases like...
www.mn.uio.no
January 21, 2025 at 1:02 PM
As part of this initiative, two postdoctoral fellowships will soon be advertised. One focusing on Molecular and Cell Biology, and one focusing on bioinformatics and biostatistics.
Stay tuned for more updates and details about these positions!
@chymkowitchlab.bsky.social
www.mn.uio.no/ibv/english/...
Stay tuned for more updates and details about these positions!
@chymkowitchlab.bsky.social
www.mn.uio.no/ibv/english/...
Reposted by Chymkowitch lab
Oslo skeeps.
We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data."
You can also book a time to meet him.
More info at www.mn.uio.no/bils/english...
We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data."
You can also book a time to meet him.
More info at www.mn.uio.no/bils/english...
Dr. Michael Hoffman
- Bioinformatics in Life Science – BiLS
Dr. Michael Hoffman, Chair of the Computational Biology and Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, and Associate Professor at the Department of Medical ...
www.mn.uio.no
January 20, 2025 at 7:24 PM
Oslo skeeps.
We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data."
You can also book a time to meet him.
More info at www.mn.uio.no/bils/english...
We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data."
You can also book a time to meet him.
More info at www.mn.uio.no/bils/english...
Reposted by Chymkowitch lab
Three more days to register and submit your abstract for the upcoming TriRhena Gene Regulation Club. #epigenetics
The next TriRhena Gene Regulation Club takes place at
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.
📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.
www.ie-freiburg.mpg.de/gene-regulat...
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.
📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.
www.ie-freiburg.mpg.de/gene-regulat...
January 21, 2025 at 7:45 AM
Three more days to register and submit your abstract for the upcoming TriRhena Gene Regulation Club. #epigenetics
Reposted by Chymkowitch lab
Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!
📣 #EMBLSingleMolecule is open for registrations!
Our aim is to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 🧬🔍
👉🏼 s.embl.org/grg25-01-bl
📅 15 – 18 July 2025
📜 Submit your abstract by 8 April!
Our aim is to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 🧬🔍
👉🏼 s.embl.org/grg25-01-bl
📅 15 – 18 July 2025
📜 Submit your abstract by 8 April!
January 15, 2025 at 1:11 PM
Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!
Reposted by Chymkowitch lab
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
December 20, 2024 at 11:18 AM
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
Reposted by Chymkowitch lab
Many workplaces have parties or team meals to celebrate the end of the working year, but some show true appreciation by cultivating group traditions. Nature asked group leaders to explain these, and how they thank colleagues for their hard work. #AcademicSky
How to thank your lab mates: eight ways to show gratitude at the end of year
Alongside secret Santas and seasonal parties, many laboratories develop traditions to show appreciation to colleagues — from sweets and mulled wine to quizzes and ice-skating trips.
go.nature.com
December 22, 2024 at 9:23 PM
Many workplaces have parties or team meals to celebrate the end of the working year, but some show true appreciation by cultivating group traditions. Nature asked group leaders to explain these, and how they thank colleagues for their hard work. #AcademicSky
Reposted by Chymkowitch lab
6️⃣0️⃣ Marie Skłodowska-Curie (1867-1934) 🇵🇱🇫🇷 #womeninSTEM The most famous scientist in the world. 1st woman professor at Sorbonne, only woman to win the Nobel in 2 different fields. During WWI, she invented a mobile X-ray unit that could travel to the battlefront.
www.nobelprize.org/womenwhochan...
www.nobelprize.org/womenwhochan...
December 22, 2024 at 1:12 PM
6️⃣0️⃣ Marie Skłodowska-Curie (1867-1934) 🇵🇱🇫🇷 #womeninSTEM The most famous scientist in the world. 1st woman professor at Sorbonne, only woman to win the Nobel in 2 different fields. During WWI, she invented a mobile X-ray unit that could travel to the battlefront.
www.nobelprize.org/womenwhochan...
www.nobelprize.org/womenwhochan...
Reposted by Chymkowitch lab
Congratulations, Pierre @chymkowitchlab.bsky.social. It's a fantastic news indeed!
I look forward to continuing to collaborate with you on this great project.
Bioinformaticians/data scientists: stay tuned for an upcoming postdoc position to analyze cool multi-omics data supervised by Pierre and I!
I look forward to continuing to collaborate with you on this great project.
Bioinformaticians/data scientists: stay tuned for an upcoming postdoc position to analyze cool multi-omics data supervised by Pierre and I!
A sincere thank you to everyone who contributed to this achievement, including collaborators @uio.no — @amathelier.bsky.social, Jorrit Enserink, Philippe Collas, Nolwenn Briand, Kari Rygg and Magnar Bjørås — as well as Stéphanie Le Gras and Bernard Jost at IGBMC, BRIC and @univbordeaux.bsky.social
December 20, 2024 at 10:08 AM
Congratulations, Pierre @chymkowitchlab.bsky.social. It's a fantastic news indeed!
I look forward to continuing to collaborate with you on this great project.
Bioinformaticians/data scientists: stay tuned for an upcoming postdoc position to analyze cool multi-omics data supervised by Pierre and I!
I look forward to continuing to collaborate with you on this great project.
Bioinformaticians/data scientists: stay tuned for an upcoming postdoc position to analyze cool multi-omics data supervised by Pierre and I!
Reposted by Chymkowitch lab
Very exciting; I strongly recommend!
A PhD position in computational genomics is open in our group at Imperial/MRC LMS! 🌟
Join the DANIO-ReCODE Doctoral Network and work on gene regulation, evolution, development, and tissue regeneration. Open to all (except those residing in the UK in the past year). Deadline: 8 Jan 2025. t.ly/fDdDW
Join the DANIO-ReCODE Doctoral Network and work on gene regulation, evolution, development, and tissue regeneration. Open to all (except those residing in the UK in the past year). Deadline: 8 Jan 2025. t.ly/fDdDW
Research Assistant with funding to undertake PhD - London (Central), London (Greater) (GB) job with Imperial College London (ICL) | 12834104
About the role: We are seeking an applicant for a fully-funded HORIZON-MSCA-2023-DN Research Assistant position with funding to undertake PhD in th...
www.nature.com
December 20, 2024 at 10:10 AM
Very exciting; I strongly recommend!
🎄 What a fantastic Christmas gift! Our #FRIPRO application on the regulation of epigenetic fate by #SUMOylation has been awarded 12MNOK by the Research Council of Norway!
December 20, 2024 at 8:01 AM
🎄 What a fantastic Christmas gift! Our #FRIPRO application on the regulation of epigenetic fate by #SUMOylation has been awarded 12MNOK by the Research Council of Norway!
Thousands of people have donated to rebuild Notre-Dame de Paris, including me. But there are hundreds of heritage sites that deserve our attention. Why not make small donations to support projects like this surprising pagoda in the heart of France? www.fondation-patrimoine.org/les-projets/...
Pagode du Petit Jonas à Ambazac
Aujourd'hui très délabrée, la pagode du Petit Jonas va faire l'objet d'une campagne de restauration globale, dans le cadre de la redynamisation d'une base de loisirs entreprise par la commune d'Ambaza...
www.fondation-patrimoine.org
December 15, 2024 at 10:10 AM
Thousands of people have donated to rebuild Notre-Dame de Paris, including me. But there are hundreds of heritage sites that deserve our attention. Why not make small donations to support projects like this surprising pagoda in the heart of France? www.fondation-patrimoine.org/les-projets/...
Superb story studying obesity from an epigenetic memory angle rdcu.be/d2Jun
Adipose tissue retains an epigenetic memory of obesity after weight loss
Nature - Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially...
rdcu.be
December 7, 2024 at 7:39 AM
Superb story studying obesity from an epigenetic memory angle rdcu.be/d2Jun
Reposted by Chymkowitch lab
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
December 2, 2024 at 4:44 PM
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
A superbe afternoon sun over the Oslo fjord during the retreat of the BMB section. Thanks to all speakers and poster presenters for their contribution 👏👍
@biovitenskap.bsky.social
@biovitenskap.bsky.social
November 28, 2024 at 9:28 PM
A superbe afternoon sun over the Oslo fjord during the retreat of the BMB section. Thanks to all speakers and poster presenters for their contribution 👏👍
@biovitenskap.bsky.social
@biovitenskap.bsky.social
Reposted by Chymkowitch lab
@arnaudkr.bsky.social and I have been talking about organizing a single-molecule genomics meeting for years! We're excited to do so at EMBL while bridging the fields of single-molecule genomics and microscopy with our co-organizers. Hope to see you there! July 15-18 www.embl.org/about/info/c...
November 15, 2024 at 4:50 PM
@arnaudkr.bsky.social and I have been talking about organizing a single-molecule genomics meeting for years! We're excited to do so at EMBL while bridging the fields of single-molecule genomics and microscopy with our co-organizers. Hope to see you there! July 15-18 www.embl.org/about/info/c...