Christian Endisch, MD
@christianendisch.bsky.social
Neurologist interested in neuroprognostication and disorders of consciousness
https://scholar.google.de/citations?user=AGbhaIwAAAAJ&hl=de
https://scholar.google.de/citations?user=AGbhaIwAAAAJ&hl=de
Pinned
Christian Endisch
Christian Endisch is a neurologist in the department of neurology at the Charité Universitätsmedizin Berlin in Germany. He obtained his medical degree from the Charité Universitätsmedizin Berlin, undertaking study visits in Denmark and Sweden, and successfully defended his doctoral thesis with summa cum laude. His main research focus is on neuroprognostication and neurophysiological techniques in patients with disorders of consciousness.
www.thelancet.com
Tremendous honor to have @thelancet.bsky.social Neuroloy featuring me and our research in the rubric Lifeline ⭐️⭐️⭐️
🙏 Thanks to all my mentors in the field of @ercresus.bsky.social @neurocritical.bsky.social @jama.com @neurocritcarej.bsky.social @dgn-ev.bsky.social
www.thelancet.com/journals/lan...
🙏 Thanks to all my mentors in the field of @ercresus.bsky.social @neurocritical.bsky.social @jama.com @neurocritcarej.bsky.social @dgn-ev.bsky.social
www.thelancet.com/journals/lan...
Reposted by Christian Endisch, MD
Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes academic.oup.com/brain/advanc...
Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes
Liu et al. show that cutaneous α-synuclein signatures differ between brain-first and body-first subtypes of Parkinson’s disease, providing direct pathologi
academic.oup.com
October 30, 2025 at 1:46 PM
Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes academic.oup.com/brain/advanc...
Reposted by Christian Endisch, MD
Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients.
📝 This Review discusses PFO-associated stroke management.
ja.ma/430lxyZ
📝 This Review discusses PFO-associated stroke management.
ja.ma/430lxyZ
October 28, 2025 at 4:01 PM
Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients.
📝 This Review discusses PFO-associated stroke management.
ja.ma/430lxyZ
📝 This Review discusses PFO-associated stroke management.
ja.ma/430lxyZ
Reposted by Christian Endisch, MD
#eNeuro | SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice
https://doi.org/10.1523/ENEURO.0276-25.2025
https://doi.org/10.1523/ENEURO.0276-25.2025
September 29, 2025 at 7:34 AM
#eNeuro | SpinalTRAQ: A Novel Pipeline for Volumetric Cervical Spinal Cord Analysis Identifies the Corticospinal Tract Synaptic Projectome in Healthy and Post-stroke Mice
https://doi.org/10.1523/ENEURO.0276-25.2025
https://doi.org/10.1523/ENEURO.0276-25.2025
Reposted by Christian Endisch, MD
Chen et al. report in “Efficacy and Safety of Twelve Anti-Dyskinetic Drugs in Parkinson's Disease” that amantadine ER is more effective than IR for dyskinesia, and both reduce OFF time better than other drugs.
📚 Read now: onlinelibrary.wiley.com/doi/10.1111/...
#Neurology
@ean.org #WileyNeuro
📚 Read now: onlinelibrary.wiley.com/doi/10.1111/...
#Neurology
@ean.org #WileyNeuro
September 23, 2025 at 4:14 PM
Chen et al. report in “Efficacy and Safety of Twelve Anti-Dyskinetic Drugs in Parkinson's Disease” that amantadine ER is more effective than IR for dyskinesia, and both reduce OFF time better than other drugs.
📚 Read now: onlinelibrary.wiley.com/doi/10.1111/...
#Neurology
@ean.org #WileyNeuro
📚 Read now: onlinelibrary.wiley.com/doi/10.1111/...
#Neurology
@ean.org #WileyNeuro
Reposted by Christian Endisch, MD
RCT: For patients with spinal cord injury, augmenting mean arterial pressure >85 vs 65 mmHg did not improve 6‐month neurological outcomes, and the MAP >85 group had more respiratory complications, longer mechanical ventilation, and worse organ dysfunction.
#NCS2025
ja.ma/4naOW1t
#NCS2025
ja.ma/4naOW1t
September 19, 2025 at 4:30 AM
RCT: For patients with spinal cord injury, augmenting mean arterial pressure >85 vs 65 mmHg did not improve 6‐month neurological outcomes, and the MAP >85 group had more respiratory complications, longer mechanical ventilation, and worse organ dysfunction.
#NCS2025
ja.ma/4naOW1t
#NCS2025
ja.ma/4naOW1t
Reposted by Christian Endisch, MD
To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. @parkinsondotorg.bsky.social
September 16, 2025 at 6:53 PM
To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. @parkinsondotorg.bsky.social
Reposted by Christian Endisch, MD
What is the 2025 update on antibody therapies for Alzheimer’s? Spoiler alert: think EAC or effectiveness, access and cost. A critically important topic in a recent piece in JAMA. Early adopters enthusiastic, safety signals remain consistent w/ trials, questions remain. @alzassociation.bsky.social
September 1, 2025 at 1:37 PM
What is the 2025 update on antibody therapies for Alzheimer’s? Spoiler alert: think EAC or effectiveness, access and cost. A critically important topic in a recent piece in JAMA. Early adopters enthusiastic, safety signals remain consistent w/ trials, questions remain. @alzassociation.bsky.social
Reposted by Christian Endisch, MD
A new study by Puja Agarwal, Sonal Agrawal, Julie Schneider, et al. @rushalzheimers.bsky.social provides more evidence that #MIND & other diets like it can protect against #Dementia – as well as giving us some clues as to why. Learn More @jamanetworkopen.com 👉
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
August 17, 2025 at 1:09 PM
A new study by Puja Agarwal, Sonal Agrawal, Julie Schneider, et al. @rushalzheimers.bsky.social provides more evidence that #MIND & other diets like it can protect against #Dementia – as well as giving us some clues as to why. Learn More @jamanetworkopen.com 👉
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Christian Endisch, MD
Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients.
This review discusses PFO-associated stroke management.
ja.ma/4orDOyr
This review discusses PFO-associated stroke management.
ja.ma/4orDOyr
July 28, 2025 at 4:12 PM
Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients.
This review discusses PFO-associated stroke management.
ja.ma/4orDOyr
This review discusses PFO-associated stroke management.
ja.ma/4orDOyr
Reposted by Christian Endisch, MD
🚨 New 2-in-1 paper: a review on #EEG brain oscillations (www.sciencedirect.com/science/arti...) and a website with recorded talks from a symposium that featured 8 speakers discussing the present and future of the field (brain-waves-workshop.github.io/2024/).
🧠 #neuroimaging #neuroskyence
🧠 #neuroimaging #neuroskyence
EEG brain waves and alpha rhythms: Past, current and future direction
Nearly a century after the first EEG recordings, we assess the progress made in EEG research, focusing on the challenges, novel theories and methods, …
www.sciencedirect.com
July 14, 2025 at 7:00 PM
🚨 New 2-in-1 paper: a review on #EEG brain oscillations (www.sciencedirect.com/science/arti...) and a website with recorded talks from a symposium that featured 8 speakers discussing the present and future of the field (brain-waves-workshop.github.io/2024/).
🧠 #neuroimaging #neuroskyence
🧠 #neuroimaging #neuroskyence
Reposted by Christian Endisch, MD
Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients
www.resuscitationjournal.com/article/S03...
#Resuscitation
www.resuscitationjournal.com/article/S03...
#Resuscitation
July 25, 2025 at 6:30 AM
Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients
www.resuscitationjournal.com/article/S03...
#Resuscitation
www.resuscitationjournal.com/article/S03...
#Resuscitation
Reposted by Christian Endisch, MD
SpikeNet2, a deep-learning model shown to achieve expert-level performance in detecting epileptiform discharges from EEG recordings while significantly reducing false positives, demonstrates strong generalizability across diverse datasets. Learn more: nejm.ai/4lq1Qr4
#AI #MedSky #NeuroSky
#AI #MedSky #NeuroSky
July 21, 2025 at 4:32 PM
SpikeNet2, a deep-learning model shown to achieve expert-level performance in detecting epileptiform discharges from EEG recordings while significantly reducing false positives, demonstrates strong generalizability across diverse datasets. Learn more: nejm.ai/4lq1Qr4
#AI #MedSky #NeuroSky
#AI #MedSky #NeuroSky
Reposted by Christian Endisch, MD
#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaul
Cardiac arrest from neurological causes: for whom the brain tolls
Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown.
The main reason for this is that the medical literature is mainly concerned with cardiac
arrest due to cardiac cau...
www.resuscitationjournal.com
July 20, 2025 at 8:12 AM
#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaul
Reposted by Christian Endisch, MD
Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – a retrospective cohort study
www.resuscitationjournal.com/article/S03...
#Resuscitation
www.resuscitationjournal.com/article/S03...
#Resuscitation
July 19, 2025 at 3:00 PM
Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – a retrospective cohort study
www.resuscitationjournal.com/article/S03...
#Resuscitation
www.resuscitationjournal.com/article/S03...
#Resuscitation
Reposted by Christian Endisch, MD
Neurologic etiologies of cardiac arrest are associated with early withdrawal of life-sustaining therapy
www.resuscitationjournal.com/article/S03...
#Resuscitation
www.resuscitationjournal.com/article/S03...
#Resuscitation
July 20, 2025 at 6:30 AM
Neurologic etiologies of cardiac arrest are associated with early withdrawal of life-sustaining therapy
www.resuscitationjournal.com/article/S03...
#Resuscitation
www.resuscitationjournal.com/article/S03...
#Resuscitation
Reposted by Christian Endisch, MD
A pooled analysis of of the four INTERACT trials suggests intensive blood pressure-lowering initiated within several hours of intracerebral haemorrhage onset was safe and improved functional recovery, without a clear effect on haematoma growth. Check it out in our latest issue: tinyurl.com/mrnmv5f6
July 7, 2025 at 3:13 PM
A pooled analysis of of the four INTERACT trials suggests intensive blood pressure-lowering initiated within several hours of intracerebral haemorrhage onset was safe and improved functional recovery, without a clear effect on haematoma growth. Check it out in our latest issue: tinyurl.com/mrnmv5f6
Reposted by Christian Endisch, MD
Al-Salahat et al: Outcomes of Spinal Cord Infarction with Thrombolysis: A Nationwide Analysis
Link: link.springer.com/ar...
@neurocritical #neurocritcare
Link: link.springer.com/ar...
@neurocritical #neurocritcare
June 20, 2025 at 12:00 PM
Al-Salahat et al: Outcomes of Spinal Cord Infarction with Thrombolysis: A Nationwide Analysis
Link: link.springer.com/ar...
@neurocritical #neurocritcare
Link: link.springer.com/ar...
@neurocritical #neurocritcare
Brain injury after cardiac arrest is not as homogeneous and global as previously thought ❗️
We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬
@resuscitation.bsky.social
@neurocritical.bsky.social
www.sciencedirect.com/science/arti...
We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬
@resuscitation.bsky.social
@neurocritical.bsky.social
www.sciencedirect.com/science/arti...
Histopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patients
Understanding the pathophysiology of hypoxic-ischemic encephalopathy (HIE) provides important knowledge for the interpretation of neuroprognostic inve…
www.sciencedirect.com
May 20, 2025 at 7:44 PM
Brain injury after cardiac arrest is not as homogeneous and global as previously thought ❗️
We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬
@resuscitation.bsky.social
@neurocritical.bsky.social
www.sciencedirect.com/science/arti...
We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬
@resuscitation.bsky.social
@neurocritical.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Christian Endisch, MD
Do we need to rethink near-death experiences? What’s really happening in the brain? NDEs might be a hardwired coping strategy: the dissociation, calmness, and detachment when facing death may actually be an evolutionarily protective response.
May 18, 2025 at 2:41 PM
Do we need to rethink near-death experiences? What’s really happening in the brain? NDEs might be a hardwired coping strategy: the dissociation, calmness, and detachment when facing death may actually be an evolutionarily protective response.
Reposted by Christian Endisch, MD
Is the "New Brunswick Neurological Syndrome of Unknown Cause" actually a new disease? The data out strongly suggest NO. We must carefully study and share data on clusters of 'unknown' cases, and especially those cases that draw intense attention from the media. Examine and use pathology.
May 9, 2025 at 3:39 PM
Is the "New Brunswick Neurological Syndrome of Unknown Cause" actually a new disease? The data out strongly suggest NO. We must carefully study and share data on clusters of 'unknown' cases, and especially those cases that draw intense attention from the media. Examine and use pathology.
‼️Largest cohort of postmortem 🧠 autopsies after cardiac arrest ‼️
@resusplus.bsky.social @ercresus.bsky.social
Correlation between
🧠 🔬 Microscopic brain injury
✳️ Duration of resuscitation
✳️ Regain of consciousness
📖Read more:
www.sciencedirect.com/science/arti...
@resusplus.bsky.social @ercresus.bsky.social
Correlation between
🧠 🔬 Microscopic brain injury
✳️ Duration of resuscitation
✳️ Regain of consciousness
📖Read more:
www.sciencedirect.com/science/arti...
Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest
To study the histopathologically quantified severity of hypoxic-ischemic encephalopathy (HIE) in deceased cardiac arrest unbiased by death causes and …
www.sciencedirect.com
April 12, 2025 at 6:45 AM
‼️Largest cohort of postmortem 🧠 autopsies after cardiac arrest ‼️
@resusplus.bsky.social @ercresus.bsky.social
Correlation between
🧠 🔬 Microscopic brain injury
✳️ Duration of resuscitation
✳️ Regain of consciousness
📖Read more:
www.sciencedirect.com/science/arti...
@resusplus.bsky.social @ercresus.bsky.social
Correlation between
🧠 🔬 Microscopic brain injury
✳️ Duration of resuscitation
✳️ Regain of consciousness
📖Read more:
www.sciencedirect.com/science/arti...
Reposted by Christian Endisch, MD
Zhang et al: Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy
Link:link.springer.com/ar...
@neurocritical #neurocritcare
Link:link.springer.com/ar...
@neurocritical #neurocritcare
April 10, 2025 at 12:00 PM
Zhang et al: Contralateral Neurovascular Coupling in Patients with Ischemic Stroke After Endovascular Thrombectomy
Link:link.springer.com/ar...
@neurocritical #neurocritcare
Link:link.springer.com/ar...
@neurocritical #neurocritcare
Reposted by Christian Endisch, MD
Neurological problems are a significant concern for patients receiving CAR T-cell therapy, yet there are no best practice guidelines.
In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt
In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt
April 2, 2025 at 11:12 AM
Neurological problems are a significant concern for patients receiving CAR T-cell therapy, yet there are no best practice guidelines.
In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt
In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt
Reposted by Christian Endisch, MD
3/ Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of cohort studies🔗 tinyurl.com/4z6w3vv5
Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies
Our findings suggest that WLST decisions are significantly more common in patients
with ABI versus patients without ABI and occur earlier in this group. The rationale
for early WLST following ABI warr...
tinyurl.com
March 28, 2025 at 11:11 AM
3/ Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of cohort studies🔗 tinyurl.com/4z6w3vv5
Reposted by Christian Endisch, MD
OP-ED: "Consciousness or pseudo-consciousness? A clash of two paradigms" by Meritorious Investigator Christof Koch and collaborators
🧠📈 www.nature.com/articles/s41...
🧠📈 www.nature.com/articles/s41...
Consciousness or pseudo-consciousness? A clash of two paradigms - Nature Neuroscience
Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...
www.nature.com
March 13, 2025 at 8:29 PM
OP-ED: "Consciousness or pseudo-consciousness? A clash of two paradigms" by Meritorious Investigator Christof Koch and collaborators
🧠📈 www.nature.com/articles/s41...
🧠📈 www.nature.com/articles/s41...