JAMA Network Open
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JAMA Network Open is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
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Among infants <1 year, 59% receiving antiseizure medication before video EEG had EEG-confirmed epileptiform activity, suggesting clinical decision-making aligns with seizure pathology. ja.ma/4sdy2SA
December 25, 2025 at 4:00 PM
Among infants <1 year, 59% receiving antiseizure medication before video EEG had EEG-confirmed epileptiform activity, suggesting clinical decision-making aligns with seizure pathology. ja.ma/4sdy2SA
Lesbian, gay, and bisexual individuals had higher odds of needing but being unable to afford medical care, prescription medications, and mental health care compared to heterosexual individuals, finds this survey study. ja.ma/4avGExD
December 25, 2025 at 3:00 PM
Lesbian, gay, and bisexual individuals had higher odds of needing but being unable to afford medical care, prescription medications, and mental health care compared to heterosexual individuals, finds this survey study. ja.ma/4avGExD
In this cross-sectional study, eviction was associated with increased firearm violence exposure, and eviction augmented associations between low collective efficacy and firearm violence. ja.ma/4b2zZLt
December 25, 2025 at 2:00 PM
In this cross-sectional study, eviction was associated with increased firearm violence exposure, and eviction augmented associations between low collective efficacy and firearm violence. ja.ma/4b2zZLt
Alcohol-related hospitalizations remained stable, between 2016 and 2022, while inpatient mortality, length of stay, patient complexity, and costs have increased, contributing $33 billion in health care spending in 2022 alone. ja.ma/4qoDikz
December 25, 2025 at 1:00 PM
Alcohol-related hospitalizations remained stable, between 2016 and 2022, while inpatient mortality, length of stay, patient complexity, and costs have increased, contributing $33 billion in health care spending in 2022 alone. ja.ma/4qoDikz
The numbers are in.
This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree?
🔗 ja.ma/3L6t7lU
This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree?
🔗 ja.ma/3L6t7lU
December 25, 2025 at 12:00 PM
The numbers are in.
This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree?
🔗 ja.ma/3L6t7lU
This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree?
🔗 ja.ma/3L6t7lU
In this cohort study of former or current heavy smokers, former heavy smokers could be screened between 3 and 17 years later than current heavy smokers in order to more closely reflect their risk levels. ja.ma/3MOWrhj
December 25, 2025 at 12:00 PM
In this cohort study of former or current heavy smokers, former heavy smokers could be screened between 3 and 17 years later than current heavy smokers in order to more closely reflect their risk levels. ja.ma/3MOWrhj
In this qualitative study of medical students who were first-generation college students, participants reported facing premedical challenges, including financial instability and limited medical school–related social connections. ja.ma/4jin5LO
December 24, 2025 at 3:00 PM
In this qualitative study of medical students who were first-generation college students, participants reported facing premedical challenges, including financial instability and limited medical school–related social connections. ja.ma/4jin5LO
This machine learning model was trained on a large multicenter dataset of unruptured intracranial aneurysms to predict future rupture risk across international cohorts, supporting more precise and personalized treatment decisions. ja.ma/3YaC9kS
December 24, 2025 at 2:00 PM
This machine learning model was trained on a large multicenter dataset of unruptured intracranial aneurysms to predict future rupture risk across international cohorts, supporting more precise and personalized treatment decisions. ja.ma/3YaC9kS
For older adults hip fractures, higher neighborhood socioeconomic deprivation was associated with an average of 23 fewer days spent at home over the following year. ja.ma/3LgzJOA
December 24, 2025 at 1:00 PM
For older adults hip fractures, higher neighborhood socioeconomic deprivation was associated with an average of 23 fewer days spent at home over the following year. ja.ma/3LgzJOA
Adjuvant chemotherapy use almost doubled in premenopausal patients with node-positive tumors and with a low to intermediate genomic risk from 2019 to 2022 but decreased for patients with node-negative disease. ja.ma/44JZXQd
December 24, 2025 at 12:00 PM
Adjuvant chemotherapy use almost doubled in premenopausal patients with node-positive tumors and with a low to intermediate genomic risk from 2019 to 2022 but decreased for patients with node-negative disease. ja.ma/44JZXQd
The numbers are in.
The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree?
🔗 ja.ma/4jam7B9
The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree?
🔗 ja.ma/4jam7B9
December 23, 2025 at 4:30 PM
The numbers are in.
The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree?
🔗 ja.ma/4jam7B9
The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree?
🔗 ja.ma/4jam7B9
In adults with obesity, type 2 diabetes, and OSA, initiation of incretin receptor agonists/GLP1RAs, particularly tirzepatide, was associated with decreased risk of CPAP use, hospitalization, and mortality compared with SGLT2Is. ja.ma/4jecC3O
December 23, 2025 at 2:30 PM
In adults with obesity, type 2 diabetes, and OSA, initiation of incretin receptor agonists/GLP1RAs, particularly tirzepatide, was associated with decreased risk of CPAP use, hospitalization, and mortality compared with SGLT2Is. ja.ma/4jecC3O
In this cross-sectional study of travelers’ diarrhea antimicrobial resistance patterns, there was marked variability of nonsusceptibility to 2 major classes of antibiotics commonly used for treating travelers’ diarrhea among global regions. ja.ma/44CZGi2
December 23, 2025 at 2:00 PM
In this cross-sectional study of travelers’ diarrhea antimicrobial resistance patterns, there was marked variability of nonsusceptibility to 2 major classes of antibiotics commonly used for treating travelers’ diarrhea among global regions. ja.ma/44CZGi2
Survival for patients with colorectal liver metastases in Denmark improved for patients with synchronous and early metachronous CRLM, but not for those with late metachronous CRLM, highlighting the need for timing-based care strategies. ja.ma/4scghD8
December 23, 2025 at 1:30 PM
Survival for patients with colorectal liver metastases in Denmark improved for patients with synchronous and early metachronous CRLM, but not for those with late metachronous CRLM, highlighting the need for timing-based care strategies. ja.ma/4scghD8
Long-term exposure to specific PM2.5 components in air pollution was associated with higher depression risk, especially in those with comorbidities, in this study of 23.7 million US Medicare beneficiaries. ja.ma/44GRM7e
December 23, 2025 at 1:00 PM
Long-term exposure to specific PM2.5 components in air pollution was associated with higher depression risk, especially in those with comorbidities, in this study of 23.7 million US Medicare beneficiaries. ja.ma/44GRM7e
Clinically integrated prior authorization software was associated with reduced denials, shortened approval times/reduced care delays, and improved staff satisfaction, in this quality improvement study of radiation oncology practices. ja.ma/4j7Aaam
December 23, 2025 at 12:30 PM
Clinically integrated prior authorization software was associated with reduced denials, shortened approval times/reduced care delays, and improved staff satisfaction, in this quality improvement study of radiation oncology practices. ja.ma/4j7Aaam
After bariatric surgery, patients on incretin-based therapies had a 55% lower risk of new-onset alcohol use disorder (AUD) and 41% lower risk of AUD medication initiation, suggesting potential neurobehavioral benefits beyond weight loss. ja.ma/4pSbzcs
December 23, 2025 at 12:00 PM
After bariatric surgery, patients on incretin-based therapies had a 55% lower risk of new-onset alcohol use disorder (AUD) and 41% lower risk of AUD medication initiation, suggesting potential neurobehavioral benefits beyond weight loss. ja.ma/4pSbzcs
Discrepancies between allergist assessments and #EHR documentation of #PenicillinAllergy persist, with nearly half of cases in a recent study showing disagreement, especially in risk classification. ja.ma/48YLuRC
December 20, 2025 at 5:30 PM
Discrepancies between allergist assessments and #EHR documentation of #PenicillinAllergy persist, with nearly half of cases in a recent study showing disagreement, especially in risk classification. ja.ma/48YLuRC
Documentation of high-risk penicillin allergy in electronic health records is only modestly consistent with allergist assessments, and high-risk penicillin allergy flags rarely align with specialist-determined risk or testing results. ja.ma/49874mN
December 20, 2025 at 5:00 PM
Documentation of high-risk penicillin allergy in electronic health records is only modestly consistent with allergist assessments, and high-risk penicillin allergy flags rarely align with specialist-determined risk or testing results. ja.ma/49874mN
Commercial LLMs integrated into health care applications remain highly vulnerable to prompt injection attacks, with a 94% success rate for generating unsafe or contraindicated medical recommendations in simulated dialogues. ja.ma/4amWHhj
December 20, 2025 at 4:30 PM
Commercial LLMs integrated into health care applications remain highly vulnerable to prompt injection attacks, with a 94% success rate for generating unsafe or contraindicated medical recommendations in simulated dialogues. ja.ma/4amWHhj
In a multicenter cohort of over 22000 children, the PECARN rule more accurately risk stratifies for cervical spine injury and guides imaging decisions after blunt trauma than NEXUS or Canadian C-Spine rules. ja.ma/3L9VjEs
December 20, 2025 at 4:00 PM
In a multicenter cohort of over 22000 children, the PECARN rule more accurately risk stratifies for cervical spine injury and guides imaging decisions after blunt trauma than NEXUS or Canadian C-Spine rules. ja.ma/3L9VjEs
Consistent use and integration of #PatientReportedOutcomes such as the QLQ-AYA30 into routine oncology practice may improve clinical decision-making and support equitable care for young cancer survivors. ja.ma/45l9ygr
December 20, 2025 at 3:30 PM
Consistent use and integration of #PatientReportedOutcomes such as the QLQ-AYA30 into routine oncology practice may improve clinical decision-making and support equitable care for young cancer survivors. ja.ma/45l9ygr
The new tool for #AYAOncology captures quality of life issues relevant to adolescents and young adults with #cancer in diverse cultural and clinical contexts, supporting its use in clinical trials and routine care. ja.ma/4p3VlM4
December 20, 2025 at 3:00 PM
The new tool for #AYAOncology captures quality of life issues relevant to adolescents and young adults with #cancer in diverse cultural and clinical contexts, supporting its use in clinical trials and routine care. ja.ma/4p3VlM4
Persistent bedbound status in late life may serve as a prognostic indicator for approaching death in individuals with #Dementia or frailty, prompting consideration of hospice and care planning. ja.ma/48NdPeP
December 20, 2025 at 2:30 PM
Persistent bedbound status in late life may serve as a prognostic indicator for approaching death in individuals with #Dementia or frailty, prompting consideration of hospice and care planning. ja.ma/48NdPeP
Nearly 1 in 6 community-dwelling older adults is bedbound during the last year of life, with those with dementia facing a 5x higher likelihood. Bedbound individuals require substantially more caregiving hours and paid support. ja.ma/3MK9bFT
December 20, 2025 at 2:00 PM
Nearly 1 in 6 community-dwelling older adults is bedbound during the last year of life, with those with dementia facing a 5x higher likelihood. Bedbound individuals require substantially more caregiving hours and paid support. ja.ma/3MK9bFT