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JAMA Network Open
@jamanetworkopen.com
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JAMA Network Open is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

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jamanetworkopen.com
Calling all early-career researchers! Applications for the JAMA Network Open Editorial Fellowship will close this Sunday, February 15.

Fellows will experience the publishing process firsthand, team up with experienced editors, & coauthor commentary.

🔗Apply here: ja.ma/3Z6cRVa
JAMA Network Open. Text reads: "Call for Applications: Editorial Fellowship. Due February 15, 2026. Learn more >". Background shows a laptop and notebook with a pen. There's also a JN logo at the top right.
February 11, 2026 at 12:00 PM
jamanetworkopen.com
Blood total tau, phosphorylated tau, and brain-derived tau were elevated after multiple traumatic injuries, correlating with injury severity and outcome, with sustained BD-tau elevation in the acute phase. bit.ly/3ZtmZYC
The image shows six scatter plots. A, B, and C show serum tau levels for T-tau, BD-tau, and P-tau231, respectively, comparing 'No shock', 'Shock', and 'Healthy' groups on 'Day 0' and 'Day 1'. D, E, and F show correlations with shock parameters for base excess, lactate, and RBC transfusion.
February 10, 2026 at 7:30 PM
jamanetworkopen.com
Post-COVID-19, #iGAS incidence was over 70 times higher among persons experiencing homelessness in Toronto than among housed adults, with distinct risk profiles and strains. bit.ly/4tAGOLp
Bar graph comparing 'Isolates, %' of housed persons vs. persons experiencing homelessness across different 'emm Type' (49, 82, 92, 74, 80, 53, 81, 12, 1, 89, 28, 77, Other). 'emm Type' 49, 82, 92, and 80 shows higher percentages in persons experiencing homelessness.
February 10, 2026 at 6:30 PM
jamanetworkopen.com
Nonsurgical management and bilateral mastectomy for low-risk, hormone receptor–positive #DCIS both increased from 2004 to 2022; endocrine therapy peaked in 2020 then declined, with persistent sociodemographic variation. bit.ly/3O06NeZ
Line graph from 2004-2022 showing treatment modality percentage. Key: 'No surgery' (blue), 'Lumpectomy' (purple), 'Lumpectomy plus radiotherapy' (green), 'Unilateral mastectomy' (yellow), 'Bilateral mastectomy' (orange).
February 10, 2026 at 6:15 PM
jamanetworkopen.com
Combined #GLP-1 receptor agonist and progestin therapy for benign uterine disease or hyperplasia was associated with lower #EndometrialCancer risk and reduced hysterectomy rates compared to progestin alone. bit.ly/4ksq5Wr
JAMA Network Open article: "GLP-1 Receptor Agonists Plus Progestins and Endometrial Cancer Risk in Nonmalignant Uterine Diseases" by Ting-Tai Yen@1, Tina Yi Jin Hsieh@2, Gin-Yi Lee@3, published February 10, 2026.
February 10, 2026 at 6:00 PM
jamanetworkopen.com
A learning health systems intervention for justice-involved youth improved timeliness of #SubstanceUseDisorder risk screening, treatment initiation, and engagement across two service systems. bit.ly/4rzL23O
Bar graph showing "Step achievement, % of youths". It compares 'Preintervention control' and 'LHS intervention implementation' across cascade steps: Arrested, Screened, Identified, Referred, Initiated, and Engaged.
February 10, 2026 at 5:45 PM
jamanetworkopen.com
Participation in a multicenter #EmergencyMedicine #OUD clinical trial was associated with greater clinician training, expanded research, improved care, and increased professional opportunities at engaged sites.

bit.ly/4tqgsLL
Two bar graphs. A: Number of ED clinicians trained to administer/prescribe buprenorphine shows attendings and residents at over 1600, APPs at about 400. B: Number and type of community partner collaborations with opioid treatment programs the highest.
February 9, 2026 at 6:45 PM
jamanetworkopen.com
Among RNs who left hospital roles, adequate staffing, flexible scheduling, and higher wages or benefits were cited as key factors that would increase the likelihood of returning to hospital #Nursing roles.

bit.ly/4rEn07Q
Table: Organizational Factors That Would Increase Nonretired Nurses' Likelihood of Returning to Work as a Nurse Overall and by Age Category. Factors include: Adequate staffing, flexible scheduling, better wages, career advancement, other, want to work but cannot find employment, nothing.
February 9, 2026 at 6:30 PM
jamanetworkopen.com
Wastewater analysis in Australia indicated overall declines in #Tobacco use but documented increases in nicotine from #Vaping and expansion of the illicit tobacco market between 2017 and 2023.

bit.ly/3ZZcso4
The image displays graphs of nicotine consumption by region from 2017-2023. It includes major cities, inner regional, and outer regional to remote areas. The graphs show trends over time, with equations and P values noted for each region.
February 9, 2026 at 6:15 PM
jamanetworkopen.com
Higher stage at diagnosis was linked to lower 3-year survival for childhood solid tumors, with regional survival differences sometimes explained by stage and sometimes by other factors in the #BENCHISTA study.

bit.ly/4bFH3OE
Six bar graphs show survival rates for different childhood cancers across European regions. Cancers include Neuroblastoma, Wilms tumor, Medulloblastoma, Osteosarcoma, Ewing sarcoma, and Rhabdomyosarcoma, each broken down by stage. Key denotes European areas.
February 9, 2026 at 6:00 PM
jamanetworkopen.com
Systematic review and meta-analysis: Routine predischarge car seat tolerance screening was not associated with reduced 30-day mortality or readmission in preterm or at-risk full-term infants; approximately 1 in 9 failed initial screening.

bit.ly/4bPSO5j
JAMA Network Open article titled "Predischarge Car Seat Tolerance Screening in Preterm and At-Risk Full-Term Infants: A Systematic Review and Meta-Analysis" by Brian C. King text@1 text@2, Nisha Dalvie text@3, and Susanne Hay text@1 text@2, published February 9, 2026.
February 9, 2026 at 5:45 PM
jamanetworkopen.com
Receipt of early intervention (#EI) services before age 3 in children with moderate to severe developmental delays was linked with improved third-grade math and English language arts achievement.

bit.ly/4tpBkCX
The image contains 4 scatter plots. The top 2 plots display 'z Score difference' for 'ELA' and 'Math'. The bottom 2 plots display 'Incidence ratio' for 'ELA' and 'Math'. X axis has labels Overall, 1, 2, 3, 4 and 5. Y axis range varies in all plots.
February 9, 2026 at 5:15 PM
jamanetworkopen.com
Outpatient #Telemedicine visits were associated with lower 30-day episode charges and fewer subsequent visits than in-person care, with comparable charges for mental and behavioral health conditions.

bit.ly/4tG2Zjk
Two bar graphs compare 'In person' and 'Telemedicine' visits. Graph A, 'Total charges,' shows 'In person' at nearly $500 and 'Telemedicine' around $100. Graph B, 'Subsequent visits,' indicates 'In person' at 4.5 and 'Telemedicine' at 3.5.
February 9, 2026 at 5:15 PM
jamanetworkopen.com
RCT: Internet-based cognitive resilience training reduced the risk of #PTSD or major depressive disorder at 1-year follow-up among early career paramedics compared to psychoeducation or standard practice.

bit.ly/3MnahHH
JAMA Network Open: RCT: Cognitive Resilience Training to Prevent PTSD and MDD in Paramedic Recruits. Population: 198 Men, 372 Women, paramedics, mean age 24. Intervention: 570 participants, 195@number Internet-delivered, 178@number Standard practice. Findings: PTSD lower in iCT-R group.
February 9, 2026 at 5:00 PM
jamanetworkopen.com
Analysis of US commercial health plans found that higher net prices, but not rebates, were associated with more frequent coverage restrictions for specialty drugs; rebates did not decrease the likelihood of access restrictions.

bit.ly/3ZQKw5M
JAMA Network Open article titled "Drug Prices, Rebates, and Health Plan Coverage Restrictions" by Molly T. Beinfeld, MPH1, Fariel LaMountain, BA1, and Glenn A. Phillips, PhD2. Published online February 6, 2026.
February 7, 2026 at 3:30 PM
jamanetworkopen.com
Survey data indicate that 68% of US adults support “Baby Bonds”—public investment accounts for children born into low-income households—with bipartisan support and greater favorability among those with fewer assets.

jamanetwork.com/journals/jam...
The image contains multiple bar graphs showing the survey-weighted probability of support across various demographics. Categories include sex, age, race, parental and marital status, political affiliation, education, health, religious attendance, employment, income, savings, debt and home ownership.
February 7, 2026 at 3:00 PM
jamanetworkopen.com
Among older adults recovering from #TBI, most reported good outcomes on standard measures, but interviews revealed critical effects of caregiver support, emotional adaptation, and unmet needs for post-injury guidance.

bit.ly/45Q3NYx
Three bar graphs show A: QOLIBRI-OS scores ranging from 0-19 to 80-100, peaking at 60-79 and 80-100. B: PHQ-9 scores ranging from 0-4 to 20-27, peaking at 0-4. C: GOS-E categories, peaking at GR+.
February 7, 2026 at 2:30 PM
jamanetworkopen.com
About 20% of US women eligible for cervical #cancer screening preferred home-based self-sampling, while 61% preferred clinic-based testing; preference for self-sampling was higher among those who had experienced prejudice/discrimination in medical care.

bit.ly/3ZiajDP
Bar graph showing reasons for not getting tested for COVID-19. The most common reason is privacy, followed by avoiding embarassment, preferring not to take time off work, other reasons, saving transportation cost and living far from the practitioner.
February 7, 2026 at 2:00 PM
jamanetworkopen.com
Safety of advanced therapies for #CrohnDisease—tumor necrosis factor antagonists, anti-integrins, interleukin inhibitors, and Janus kinase inhibitors—was comparable, with no significant differences in serious infection, VT, or cardiovascular event risk.

bit.ly/4rzRyaQ
Hazard ratio chart showing lower/higher risk of VTE with different advanced therapies. TNF antagonists, Vedolizumab, IL-12/23 antagonists, IL-23 antagonists and JAK inhibitors are listed with hazard ratios and confidence intervals.
February 7, 2026 at 1:30 PM
jamanetworkopen.com
Combining 5-minute Apgar scores with umbilical artery pH improved risk estimation for mortality and severe intraventricular hemorrhage in very preterm infants, supporting joint use for more precise outcome assessment.

bit.ly/3MbdABS
Four forest plots displaying ARR(95% CI) on the x-axis from 0.5 to 10. Each plot contains three data points for: Apgar score <7 UA-pH <7.20, Apgar score <7 UA-pH ≥7.20, and Apgar score ≥7 UA-pH <7.20. Titles are A Death or severe morbidity, B In-hospital death, C IVH >Grade 2, D Moderate or severe BPD.
February 7, 2026 at 1:00 PM
jamanetworkopen.com
In this nonrandomized clinical trial, the MUTTON-HF intervention incorporating Indigenous recipes and locally sourced Native food was feasible and acceptable for patients with heart failure in rural Navajo Nation.

jamanetwork.com/journals/jam...
Map of parts of Arizona and New Mexico, showing central food hub locations (red), mini-hubs for food pickup (green), and patient communities of residence (blue). Includes scale (136.2 km x 91.4 km) and compass rose. Text: text@1.
February 7, 2026 at 12:30 PM
jamanetworkopen.com
RCT: Peer navigator intervention after nonfatal opioid overdose did not significantly reduce #opioid-related adverse events at 12 months vs standard care in emergency department patients in New York City.

bit.ly/4tlitch
JAMA Network Open visual abstract titled, "RCT: Peer Navigator Intervention and Opioid-Related Adverse Events" shows population(190 men, 55 women, 2 transgender), intervention(247 patients), findings, settings/locations, primary outcome and a bar graph.
February 7, 2026 at 12:00 PM
jamanetworkopen.com
A nationwide autopsy study in Japan found latent #Cancer prevalence to be several-fold higher than clinical diagnoses, with metastatic latent cancers rising over time, demonstrating the continuing importance of autopsy for cancer epidemiology.

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The image shows 5 graphs comparing detection rates and nationwide incidence rates for different cancers (prostate, thyroid, lung, kidney/urinary, colon/rectum) by age, with male/female data differentiated. Detection rates increase with age for most cancers.
February 6, 2026 at 3:00 PM
jamanetworkopen.com
Infants in vegan households had similar growth patterns to omnivorous peers but higher odds of underweight in early infancy, with differences diminishing by 24 months and no significant effects on stunting or overweight.

bit.ly/46jLriM
Growth charts comparing length, weight, and head circumference for girls and boys from 0-24 months, across omnivorous, vegetarian, and vegan diets. The graphs show similar growth patterns across all diets for each measurement.
February 6, 2026 at 2:30 PM
jamanetworkopen.com
In patients with #Cancer, greater financial toxicity was associated with lower satisfaction with life, a relationship partially explained by less hopefulness and reduced perceived social support.

jamanetwork.com/journals/jam...
JAMA Network Open article titled 'Financial Toxicity, Hope, and Satisfaction With Life in Patients Receiving Ambulatory Cancer Care' by Grace L. Smith et al. Published online February 5, 2026. doi:10.1001/jamanetworkopen.2025.57328
February 6, 2026 at 2:00 PM