Chris. Bart.
@chriba.bsky.social
Interested in data
Currently pharmacometrics and causal inference
Legacy: drug design, risk management, protein structures, protein folding, ...
https://scholar.google.com/citations?user=R3QYvdUAAAAJ
Currently pharmacometrics and causal inference
Legacy: drug design, risk management, protein structures, protein folding, ...
https://scholar.google.com/citations?user=R3QYvdUAAAAJ
Pinned
Chris. Bart.
@chriba.bsky.social
· Nov 15
To fully realize the potential of our clinical trials, go beyond randomization, and use #causalinference and #pharmacometrics modelling and simulation. Advancing both we show that non-linear mixed effects modelling implements standardization using latent exchangeability.
doi.org/10.1002/psp4...
doi.org/10.1002/psp4...
Nonlinear mixed‐effects modeling as a method for causal inference to predict exposures under desired within‐subject dose titration schemes
The ICH E9 (R1) guidance and the related estimand framework propose to clearly define and separate the clinical question of interest formulated as estimand from the estimation method. With that it be....
doi.org
For years, we were looking for ways to use non-linear mixed effects modeling for causal inference. NOTHING! Now we started to advance things ourselves. Huge potential. Much remains to be done.
#causal #causalinference #nlme #stats
#causal #causalinference #nlme #stats
Reposted by Chris. Bart.
More than 97 percent effective. www.npr.org/sections/goa...
New malaria drug could be a life-saver as the standard drug shows signs of weakness
The best drug to fight malaria is facing increased resistance from the parasites it fights. Now there's an alternative in the pipeline and it looks promising.
www.npr.org
November 13, 2025 at 5:44 PM
More than 97 percent effective. www.npr.org/sections/goa...
Reposted by Chris. Bart.
In longitudinal studies, dropout leads to a monotone missing data pattern. We show in a new article that monotonicity sometimes enables and sometimes prevents the identification of the full law, i.e., the joint distribution of actual variables and response indicators. openreview.net/pdf?id=kVthd...
November 13, 2025 at 11:39 AM
In longitudinal studies, dropout leads to a monotone missing data pattern. We show in a new article that monotonicity sometimes enables and sometimes prevents the identification of the full law, i.e., the joint distribution of actual variables and response indicators. openreview.net/pdf?id=kVthd...
Reposted by Chris. Bart.
EU GDP is up 1.4% since last year, but growth is spread unevenly
Fastest: Ireland (17.1%, artifact of US pharma activity), Cyprus (3.6%), Bulgaria (3.5%), Croatia (3.4%), & Poland (3.2%)
Slowest: Luxembourg (-.4%), Finland (-.3%), Germany (-.2%), Austria (-.1%), & Hungary (.1%)
Fastest: Ireland (17.1%, artifact of US pharma activity), Cyprus (3.6%), Bulgaria (3.5%), Croatia (3.4%), & Poland (3.2%)
Slowest: Luxembourg (-.4%), Finland (-.3%), Germany (-.2%), Austria (-.1%), & Hungary (.1%)
September 9, 2025 at 12:46 PM
EU GDP is up 1.4% since last year, but growth is spread unevenly
Fastest: Ireland (17.1%, artifact of US pharma activity), Cyprus (3.6%), Bulgaria (3.5%), Croatia (3.4%), & Poland (3.2%)
Slowest: Luxembourg (-.4%), Finland (-.3%), Germany (-.2%), Austria (-.1%), & Hungary (.1%)
Fastest: Ireland (17.1%, artifact of US pharma activity), Cyprus (3.6%), Bulgaria (3.5%), Croatia (3.4%), & Poland (3.2%)
Slowest: Luxembourg (-.4%), Finland (-.3%), Germany (-.2%), Austria (-.1%), & Hungary (.1%)
Reposted by Chris. Bart.
💡A new paper by Elias Bareinboim and Drago Plecko underscores the intractability of ignorability assumptions commonly invoked in the potential outcomes framework, explains why structural causal models—explicitly grounded in well-defined causal mechanisms—are far easier to interpret. 1/2
August 24, 2025 at 1:19 PM
💡A new paper by Elias Bareinboim and Drago Plecko underscores the intractability of ignorability assumptions commonly invoked in the potential outcomes framework, explains why structural causal models—explicitly grounded in well-defined causal mechanisms—are far easier to interpret. 1/2
Reposted by Chris. Bart.
Stretching DuckDB w/ Common Crawl, ~1.7B rows, ~300 parquet files. ~2-3s for single-column aggregations, ~2-3 mins to SUMMARIZE the data, peaking at ~12-14GB memory usage. Not exactly real-time, but the fact you can do this on a laptop with no server setups or Spark pipelines is still amazing.
August 15, 2025 at 3:10 AM
Stretching DuckDB w/ Common Crawl, ~1.7B rows, ~300 parquet files. ~2-3s for single-column aggregations, ~2-3 mins to SUMMARIZE the data, peaking at ~12-14GB memory usage. Not exactly real-time, but the fact you can do this on a laptop with no server setups or Spark pipelines is still amazing.
Reposted by Chris. Bart.
Xi Jinping masters the dark arts of the trade war
How scared should you be of “the China squeeze”?
Xi Jinping masters the dark arts of the trade war
econ.st
August 12, 2025 at 7:31 PM
Xi Jinping masters the dark arts of the trade war
Reposted by Chris. Bart.
Donald Trump’s trade policy will be hard to dislodge. Its beneficiaries will be well-organised; its victims may not even realise why they are poorer than they could have been
Donald Trump thinks he’s winning on trade, but America will lose
The harm from tariffs will be lasting and deep
econ.st
August 8, 2025 at 6:10 PM
Donald Trump’s trade policy will be hard to dislodge. Its beneficiaries will be well-organised; its victims may not even realise why they are poorer than they could have been
@lshtm.bsky.social and colleagues:
Any reports of Ascaris exhibiting self-replicating behavior within host— adult worms residing in sites like throat, nasal cavity, or tear ducts, and depositing eggs in these warm, humid microenvironments?
#Ascariasis #Parasitology #Helminths #TropicalMedicine
Any reports of Ascaris exhibiting self-replicating behavior within host— adult worms residing in sites like throat, nasal cavity, or tear ducts, and depositing eggs in these warm, humid microenvironments?
#Ascariasis #Parasitology #Helminths #TropicalMedicine
August 7, 2025 at 1:07 PM
@lshtm.bsky.social and colleagues:
Any reports of Ascaris exhibiting self-replicating behavior within host— adult worms residing in sites like throat, nasal cavity, or tear ducts, and depositing eggs in these warm, humid microenvironments?
#Ascariasis #Parasitology #Helminths #TropicalMedicine
Any reports of Ascaris exhibiting self-replicating behavior within host— adult worms residing in sites like throat, nasal cavity, or tear ducts, and depositing eggs in these warm, humid microenvironments?
#Ascariasis #Parasitology #Helminths #TropicalMedicine
Reposted by Chris. Bart.
To the dismay of dozens of countries, the American president has returned to the madness of Liberation Day. These charts show the damage they will have to endure econ.st/4lez3Fv
August 4, 2025 at 10:00 PM
To the dismay of dozens of countries, the American president has returned to the madness of Liberation Day. These charts show the damage they will have to endure econ.st/4lez3Fv
Reposted by Chris. Bart.
The soaring rate is based on exports of Trump’s favourite metal
America’s tariff avalanche catches Switzerland unawares
The soaring rate is based on exports of Trump’s favourite metal
econ.st
August 4, 2025 at 6:30 PM
The soaring rate is based on exports of Trump’s favourite metal
Reposted by Chris. Bart.
Donald Trump’s agenda has been consumed by his chaotic tariffs, a war on the civil service and attacks on the Fed. The dangers of his approach are starting to percolate into the economic data, as these charts illustrate
Ten indicators of what’s going on with America’s economy
Trumponomics has begun to hit America’s growth
econ.st
August 2, 2025 at 6:20 PM
Donald Trump’s agenda has been consumed by his chaotic tariffs, a war on the civil service and attacks on the Fed. The dangers of his approach are starting to percolate into the economic data, as these charts illustrate
Reposted by Chris. Bart.
What did Switzerland do to be given 39% tariffs? www.cnbc.com/2025/08/01/s...
Switzerland's tariff shock: The 39% U.S. hit no one saw coming
The duty would be a "devastating" blow to the export-reliant Swiss economy and businesses, analysts say.
www.cnbc.com
August 1, 2025 at 3:19 PM
What did Switzerland do to be given 39% tariffs? www.cnbc.com/2025/08/01/s...
Reposted by Chris. Bart.
Switzerland in ‘shock’ at 39% US tariff blow https://on.ft.com/4ofunll
Switzerland in ‘shock’ at 39% US tariff blow
New duty level on Swiss goods one of highest in the world and exceeds 31% rate outlined by Donald Trump in April
on.ft.com
August 1, 2025 at 9:39 AM
Switzerland in ‘shock’ at 39% US tariff blow https://on.ft.com/4ofunll
Reposted by Chris. Bart.
Sorry guys, I know you don't like it, but every time you talk to a statistician, you realize how useless traditional stats is at conveying any idea about causal inference.
July 31, 2025 at 8:23 AM
Sorry guys, I know you don't like it, but every time you talk to a statistician, you realize how useless traditional stats is at conveying any idea about causal inference.
Reposted by Chris. Bart.
Ok so this Pinheiro and Bates book - physical copy on my shelf having survived multiple international moves and downsizings - has been my bible on mixed effects models. But it's 25 years old, is there a modern (#rstats) equivalent i should upgrade to?
July 26, 2025 at 10:17 PM
Ok so this Pinheiro and Bates book - physical copy on my shelf having survived multiple international moves and downsizings - has been my bible on mixed effects models. But it's 25 years old, is there a modern (#rstats) equivalent i should upgrade to?
Reposted by Chris. Bart.
📊 Data update: We've just updated to the 2025 release of the OECD Government at a Glance dataset.
It has general government spending data up to 2024 and spending by function data up to 2023.
This update was led on our team by @parriagadap.bsky.social.
It has general government spending data up to 2024 and spending by function data up to 2023.
This update was led on our team by @parriagadap.bsky.social.
July 22, 2025 at 4:48 PM
📊 Data update: We've just updated to the 2025 release of the OECD Government at a Glance dataset.
It has general government spending data up to 2024 and spending by function data up to 2023.
This update was led on our team by @parriagadap.bsky.social.
It has general government spending data up to 2024 and spending by function data up to 2023.
This update was led on our team by @parriagadap.bsky.social.
Reposted by Chris. Bart.
Heatwaves can overheat cables and stress power generation☀️
In fact, the recent heatwave in Europe may have impacted up to 15% of France’s nuclear capacity, as 17 out of 18 French nuclear facilities experienced capacity reductions 🇫🇷
https://loom.ly/0KDPRPY
In fact, the recent heatwave in Europe may have impacted up to 15% of France’s nuclear capacity, as 17 out of 18 French nuclear facilities experienced capacity reductions 🇫🇷
https://loom.ly/0KDPRPY
July 6, 2025 at 2:02 PM
Heatwaves can overheat cables and stress power generation☀️
In fact, the recent heatwave in Europe may have impacted up to 15% of France’s nuclear capacity, as 17 out of 18 French nuclear facilities experienced capacity reductions 🇫🇷
https://loom.ly/0KDPRPY
In fact, the recent heatwave in Europe may have impacted up to 15% of France’s nuclear capacity, as 17 out of 18 French nuclear facilities experienced capacity reductions 🇫🇷
https://loom.ly/0KDPRPY
Reposted by Chris. Bart.
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
erictopol.substack.com/p/new-anti-a...
July 5, 2025 at 5:09 PM
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
erictopol.substack.com/p/new-anti-a...
Reposted by Chris. Bart.
T cell therapies are reshaping cancer treatment. Success may depend on boosting self-renewing, stem-like T cells. This insight also offers new strategies for treating autoimmune diseases by targeting harmful T cell regeneration…Simple summary
July 3, 2025 at 2:32 PM
T cell therapies are reshaping cancer treatment. Success may depend on boosting self-renewing, stem-like T cells. This insight also offers new strategies for treating autoimmune diseases by targeting harmful T cell regeneration…Simple summary
Reposted by Chris. Bart.
{tinytable} is a dead simple, ultra-flexible, and dependency-free #Rstats 📦 to turn data frames into beautiful tables: html, word, pdf, latex, typst, markdown, etc.
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
July 3, 2025 at 12:59 PM
{tinytable} is a dead simple, ultra-flexible, and dependency-free #Rstats 📦 to turn data frames into beautiful tables: html, word, pdf, latex, typst, markdown, etc.
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
Reposted by Chris. Bart.
We’re looking for someone who can analyse the performance of our journalism and translate complex data into clear, jargon-free insights that support editorial decision-making. Apply by July 13th
The Economist is hiring a Senior Editorial Analyst
Our Audience team is recruiting a specialist to assess the engagement around our journalism and drive data-modelling and statistical projects
econ.trib.al
June 29, 2025 at 5:21 PM
We’re looking for someone who can analyse the performance of our journalism and translate complex data into clear, jargon-free insights that support editorial decision-making. Apply by July 13th
Reposted by Chris. Bart.
has anyone written a nice review or summary of Bayesian approaches to causal inference? most of what I'm aware of is focused on frequentist approaches, or implicitly frequentist (caring about bias, ignoring variance); and methods which may not translate easily to the Bayes world (e.g. weighting)
June 28, 2025 at 7:12 AM
has anyone written a nice review or summary of Bayesian approaches to causal inference? most of what I'm aware of is focused on frequentist approaches, or implicitly frequentist (caring about bias, ignoring variance); and methods which may not translate easily to the Bayes world (e.g. weighting)
Reposted by Chris. Bart.
It's a musical #MEstimatorMonday (25/52) since we will focus on *instrumental* variables (IV)
IV analysis is nice because we can get around unmeasured confounding (at the cost of a more easily interpretable parameter)
IV analysis is nice because we can get around unmeasured confounding (at the cost of a more easily interpretable parameter)
June 24, 2025 at 12:39 AM
It's a musical #MEstimatorMonday (25/52) since we will focus on *instrumental* variables (IV)
IV analysis is nice because we can get around unmeasured confounding (at the cost of a more easily interpretable parameter)
IV analysis is nice because we can get around unmeasured confounding (at the cost of a more easily interpretable parameter)
Reposted by Chris. Bart.
we're living through one of the greatest technological revolutions in the history of mankind and it's not AI
Solar + storage is now $104 per MWh in Las Vegas or similar regions for nearly 100% clean firm power. There is no way new nuclear can compete with this. Even new gas plants will struggle and that is assuming access to cheap gas over the life-cycle of the plant, which is kind of a crazy gamble TBH.
Batteries are so cheap now, solar power doesn’t sleep
Batteries are now cheap enough to make 24/7 solar power affordable, unlocking round-the-clock clean energy in the world’s sunniest cities.
electrek.co
June 23, 2025 at 4:17 AM
we're living through one of the greatest technological revolutions in the history of mankind and it's not AI
Reposted by Chris. Bart.
I was so happy to see my friend, Daniel Sharfstein, quoted in this way. His work is brilliant.
June 12, 2025 at 8:47 PM
I was so happy to see my friend, Daniel Sharfstein, quoted in this way. His work is brilliant.