Charles Brenner, PhD
@charlesmbrenner.bsky.social
NAD metabolism
truth in science
truth in science
Pinned
happy to announce that i have post-doc openings for mid-2016 to advance this science
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
happy to announce that i have post-doc openings for mid-2016 to advance this science
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
December 25, 2025 at 4:40 PM
happy to announce that i have post-doc openings for mid-2016 to advance this science
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
Reposted by Charles Brenner, PhD
RESEARCH |
@charlesmbrenner.bsky.social et al
@cityofhope.bsky.social
In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪
@charlesmbrenner.bsky.social et al
@cityofhope.bsky.social
In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency - Nature Metabolism
In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycerol-3-phosphate as a ChREBP-activating ligand, which could resolve paradoxes of FGF21 expression and clarify the logic of lipogenic transcription.
bit.ly
December 18, 2025 at 4:30 PM
RESEARCH |
@charlesmbrenner.bsky.social et al
@cityofhope.bsky.social
In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪
@charlesmbrenner.bsky.social et al
@cityofhope.bsky.social
In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪
Reposted by Charles Brenner, PhD
thank you, Christian
thanks to @russgoodman.bsky.social @markhermanmd.bsky.social @cnspracklen.bsky.social
Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others
thanks to @russgoodman.bsky.social @markhermanmd.bsky.social @cnspracklen.bsky.social
Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others
www.nature.com/articles/s42...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency - Nature Metabolism
In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycer...
www.nature.com
November 16, 2025 at 8:23 PM
thank you, Christian
thanks to @russgoodman.bsky.social @markhermanmd.bsky.social @cnspracklen.bsky.social
Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others
thanks to @russgoodman.bsky.social @markhermanmd.bsky.social @cnspracklen.bsky.social
Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others
heading to helsinki to join @keisakamoto.bsky.social @awartiovaara.bsky.social and others at tuesday's SWAN meeting:
healthy aging, mitochondrial disease, MASLD, rare disease and more!
healthy aging, mitochondrial disease, MASLD, rare disease and more!
August 18, 2025 at 10:29 AM
heading to helsinki to join @keisakamoto.bsky.social @awartiovaara.bsky.social and others at tuesday's SWAN meeting:
healthy aging, mitochondrial disease, MASLD, rare disease and more!
healthy aging, mitochondrial disease, MASLD, rare disease and more!
Reposted by Charles Brenner, PhD
Congrats on this exciting new work! Uncovering how glycerol-3-phosphate activates ChREBP, FGF21, and lipogenesis in Citrin Deficiency adds valuable insight to metabolic regulation. Looking forward to seeing how this advances the field! 🚀🧬👏
July 10, 2025 at 5:45 PM
Congrats on this exciting new work! Uncovering how glycerol-3-phosphate activates ChREBP, FGF21, and lipogenesis in Citrin Deficiency adds valuable insight to metabolic regulation. Looking forward to seeing how this advances the field! 🚀🧬👏
Reposted by Charles Brenner, PhD
@charlesmbrenner.bsky.social nice podcast with Drs Nadolsky
February 13, 2025 at 8:29 PM
@charlesmbrenner.bsky.social nice podcast with Drs Nadolsky
happy to say i got a completely routine email today requesting that i ad hoc on an april 2 study section
In case I need to say it, today is a good day to drop an email to your fav PO or SRO and let them know you appreciate them.
This is turning all regular old SROs and POs at the NIH into political appointments.
January 30, 2025 at 1:20 AM
happy to say i got a completely routine email today requesting that i ad hoc on an april 2 study section
thank you, Paul
IMO the mystery is why more folks don't call BS when it is so plain to see and why editors continue to review papers from groups that are obfuscatory
IMO the mystery is why more folks don't call BS when it is so plain to see and why editors continue to review papers from groups that are obfuscatory
Perspectives as Charles Brenner challenges David Sinclair on longevity claims ipscell.com/2025/01/pers... It's rare to see professors going at it like this in public #stemcell #stemcells I tend to agree with @charlesmbrenner.bsky.social and the hype on longevity & in vivo reprogramming bother me
Perspectives as Charles Brenner challenges David Sinclair on longevity claims - The Niche
Professor discusses how Charles Brenner has become arguably the most outspoken critic of longevity hype and David Sinclair.
ipscell.com
January 30, 2025 at 1:18 AM
thank you, Paul
IMO the mystery is why more folks don't call BS when it is so plain to see and why editors continue to review papers from groups that are obfuscatory
IMO the mystery is why more folks don't call BS when it is so plain to see and why editors continue to review papers from groups that are obfuscatory
Reposted by Charles Brenner, PhD
The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
www.biorxiv.org
January 3, 2025 at 11:04 PM
The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...
Reposted by Charles Brenner, PhD
The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
www.biorxiv.org
January 3, 2025 at 11:04 PM
The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...
jackson state really brings it
January 1, 2025 at 4:41 PM
jackson state really brings it
Reposted by Charles Brenner, PhD
I’m celebrating tonight with my father in law, Jack Strominger, who is about to enjoy his 100th New Years!
He wants to know whether any other scientist has published in their 100th year. He’s proud to have a paper in the works. I told him you all would know! Please RT
He wants to know whether any other scientist has published in their 100th year. He’s proud to have a paper in the works. I told him you all would know! Please RT
December 31, 2024 at 11:56 PM
I’m celebrating tonight with my father in law, Jack Strominger, who is about to enjoy his 100th New Years!
He wants to know whether any other scientist has published in their 100th year. He’s proud to have a paper in the works. I told him you all would know! Please RT
He wants to know whether any other scientist has published in their 100th year. He’s proud to have a paper in the works. I told him you all would know! Please RT
Reposted by Charles Brenner, PhD
happy newyearsnukkah 🕎
January 1, 2025 at 3:05 AM
happy newyearsnukkah 🕎
may it be so again!
for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....
January 1, 2025 at 3:57 AM
may it be so again!
Reposted by Charles Brenner, PhD
for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....
January 1, 2025 at 2:48 AM
for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....
Reposted by Charles Brenner, PhD
Reposted by Charles Brenner, PhD
I convert tax dollars to pdfs
December 30, 2024 at 7:37 PM
I convert tax dollars to pdfs
Reposted by Charles Brenner, PhD
www.biorxiv.org/content/10.1...
Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
www.biorxiv.org
December 28, 2024 at 9:02 PM
www.biorxiv.org/content/10.1...
Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!
Reposted by Charles Brenner, PhD
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1
December 28, 2024 at 12:17 AM
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1
Reposted by Charles Brenner, PhD
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency www.biorxiv.org/content/10.1...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
www.biorxiv.org
December 28, 2024 at 12:38 PM
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency www.biorxiv.org/content/10.1...
all..... i will fix the post with working links soon as i can
December 29, 2024 at 3:27 PM
all..... i will fix the post with working links soon as i can
Reposted by Charles Brenner, PhD
Congrats on the new work, Charles! 🎉 Excited to dive into your findings on ChREBP and FGF21. Your research always brings fresh insights to the table! Keep up the amazing work! #ResearchInnovation #Biochemistry
December 29, 2024 at 8:27 AM
Congrats on the new work, Charles! 🎉 Excited to dive into your findings on ChREBP and FGF21. Your research always brings fresh insights to the table! Keep up the amazing work! #ResearchInnovation #Biochemistry
excited to share new work "Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 29, 2024 at 5:13 AM
excited to share new work "Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Charles Brenner, PhD
Just when it seemed we had uncovered everything about Nampt, the rate-limiting enzyme in salvage NAD+ biosynthesis, first author Shu Feng in @charlesmbrenner.bsky.social lab and colleagues reveal an exciting discovery: Nampt is a protein phosphoribosylase! www.nature.com/articles/s42...
Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins - Nature Metabolism
The NAD+ synthesis enzyme NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase, which restricts the virion incorporation of viral proteins and underpins its antiviral effect
www.nature.com
November 22, 2024 at 12:09 AM
Just when it seemed we had uncovered everything about Nampt, the rate-limiting enzyme in salvage NAD+ biosynthesis, first author Shu Feng in @charlesmbrenner.bsky.social lab and colleagues reveal an exciting discovery: Nampt is a protein phosphoribosylase! www.nature.com/articles/s42...