Russell Goodman
@russgoodman.bsky.social
Hepatologist and scientist at MGH studying hepatic metabolism in liver disease. Per reviewer #2, "No particular expertise in liver disease or metabolism".
www.biorxiv.org/content/10.1...
Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
www.biorxiv.org
December 28, 2024 at 9:02 PM
www.biorxiv.org/content/10.1...
Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!