It’s just somehow funny because it’s so bad.

Until we do RCTs - which are hard to imagine happening for this particular scenario - we shouldn't be saying coffee improves liver health, only that it is associated with it. I'll also add that the biologic plausibility of a causal link is lacking, or at least very hand wavy.

Agree that there's an epidemiologic link, but epidemiology is poorly suited to assess causality. We as physicians have learned that countless times, look at the virtually the entire vitamin D field. Coffee drinkers are different than non coffee drinkers.

Seems you are confusing correlation with causation.

This reconciles many prior observations about this transcription factor, including recent work from our lab that that reductive stress (increased cytosolic NADH/NAD+) activates ChREBP - presumably via cytosolic G3P dehydrogenase whose enzymatic activity is coupled to the cytosolic NADH/NAD+ ratio.