April Hayes
@aprilhayes.bsky.social
(she/her) postdoc @ Uni of Exeter in Cornwall 🌊mainly stress out bacteria and track AMR. big fan of the sea, reading, & sunsets 🌞
Reposted by April Hayes
Our contribution to this special issue: a review on data analysis of human gut microbiome data from global populations
www.cell.com/trends/micro...
www.cell.com/trends/micro...
Analyzing human gut microbiome data from global populations: challenges and resources
Research on the human gut microbiome is expanding rapidly; yet, most published studies
focus on populations from high-income regions such as North America and Europe. Underrepresentation
of population...
www.cell.com
November 12, 2025 at 2:13 AM
Our contribution to this special issue: a review on data analysis of human gut microbiome data from global populations
www.cell.com/trends/micro...
www.cell.com/trends/micro...
Reposted by April Hayes
Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 11, 2025 at 5:15 PM
Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by April Hayes
A glitch in the matrix? No! I have another PhD available on temperature and AMR, this time with @swbiodtp.bsky.social. Join a friendly group (padpadpadpad.netlify.app/about) in Cornwall to do evolutionary ecology, experimental evolution, and combine phenotyping and sequencing. 🧪🦠 #microsky
November 11, 2025 at 10:15 AM
A glitch in the matrix? No! I have another PhD available on temperature and AMR, this time with @swbiodtp.bsky.social. Join a friendly group (padpadpadpad.netlify.app/about) in Cornwall to do evolutionary ecology, experimental evolution, and combine phenotyping and sequencing. 🧪🦠 #microsky
Reposted by April Hayes
Strain displacement in microbiomes via ecological competition www.nature.com/articles/s41... #jcampubs
Strain displacement in microbiomes via ecological competition - Nature Microbiology
Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
www.nature.com
November 10, 2025 at 4:49 PM
Strain displacement in microbiomes via ecological competition www.nature.com/articles/s41... #jcampubs
Reposted by April Hayes
Functional redundancy matters: the more overlapping microbial functions you have, the more resilient your #microbiome. We showed a strong negative correlation between redundancy loss and increase in #antimicrobial resistance protein upon #drug treatment of microbiomes.
@quadraminstitute.bsky.social
@quadraminstitute.bsky.social
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
Nature Communications - Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong...
rdcu.be
October 29, 2025 at 10:22 AM
Functional redundancy matters: the more overlapping microbial functions you have, the more resilient your #microbiome. We showed a strong negative correlation between redundancy loss and increase in #antimicrobial resistance protein upon #drug treatment of microbiomes.
@quadraminstitute.bsky.social
@quadraminstitute.bsky.social
Reposted by April Hayes
Are you, or someone you know, looking for a PhD, starting in Oct 2026?
Do you like bacteria, genomics & puzzles?🦠🧬🧩
Do you wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 2 Dec 🗓️
#PhDposition #academicsky
Find out more ⬇️
Do you like bacteria, genomics & puzzles?🦠🧬🧩
Do you wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 2 Dec 🗓️
#PhDposition #academicsky
Find out more ⬇️
PhD Out of order: investigating genetic and environmental drivers of genome rearrangement (LANGRIDGE_Q26DTP) 2026/27 | UEA
PhD Out of order: investigating genetic and environmental drivers of genome rearrangement (LANGRIDGE_Q26DTP) 2026/27 | UEA
www.uea.ac.uk
October 17, 2025 at 7:04 AM
Are you, or someone you know, looking for a PhD, starting in Oct 2026?
Do you like bacteria, genomics & puzzles?🦠🧬🧩
Do you wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 2 Dec 🗓️
#PhDposition #academicsky
Find out more ⬇️
Do you like bacteria, genomics & puzzles?🦠🧬🧩
Do you wanna work in a cutting edge of science, with some awesome people @quadraminstitute.bsky.social?
Please apply or share by 2 Dec 🗓️
#PhDposition #academicsky
Find out more ⬇️
Reposted by April Hayes
Countless drugs & chemicals now coexist in the environment, mixtures "that may be quietly shaping the evolution of antibiotic resistance."
The fantastic Dr April Hayes explains how:
theconversation.com/growing-cocktail-of-medicines-in-worlds-waterways-could-be-fuelling-antibiotic-resistance-266945
The fantastic Dr April Hayes explains how:
theconversation.com/growing-cocktail-of-medicines-in-worlds-waterways-could-be-fuelling-antibiotic-resistance-266945
Growing cocktail of medicines in world’s waterways could be fuelling antibiotic resistance
Every flush sends traces of our medicines into rivers. When antibiotics mix with common drugs like painkillers or hormones, bacteria can evolve to resist treatment.
theconversation.com
October 14, 2025 at 2:34 PM
Countless drugs & chemicals now coexist in the environment, mixtures "that may be quietly shaping the evolution of antibiotic resistance."
The fantastic Dr April Hayes explains how:
theconversation.com/growing-cocktail-of-medicines-in-worlds-waterways-could-be-fuelling-antibiotic-resistance-266945
The fantastic Dr April Hayes explains how:
theconversation.com/growing-cocktail-of-medicines-in-worlds-waterways-could-be-fuelling-antibiotic-resistance-266945
I wrote a piece for The Conversation that came out today focused on our new study but also in general about mixtures of drugs in the environment and what that could mean for AMR -
theconversation.com/growing-cock...
theconversation.com/growing-cock...
Growing cocktail of medicines in world’s waterways could be fuelling antibiotic resistance
Every flush sends traces of our medicines into rivers. When antibiotics mix with common drugs like painkillers or hormones, bacteria can evolve to resist treatment.
theconversation.com
October 14, 2025 at 2:02 PM
I wrote a piece for The Conversation that came out today focused on our new study but also in general about mixtures of drugs in the environment and what that could mean for AMR -
theconversation.com/growing-cock...
theconversation.com/growing-cock...
how do non-antibiotic drugs act in mixture with ciprofloxacin? we found in our recent study doi.org/10.1093/isme... that these NADs enhance selection for AMR within complex bacterial communities. we tested this mixture at environmental concs, and identified effects on growth, intI1, and other genes
October 14, 2025 at 2:00 PM
how do non-antibiotic drugs act in mixture with ciprofloxacin? we found in our recent study doi.org/10.1093/isme... that these NADs enhance selection for AMR within complex bacterial communities. we tested this mixture at environmental concs, and identified effects on growth, intI1, and other genes
Reposted by April Hayes
Research assistant + postdoc position on a NERC funded project working w @darrenobbard.bsky.social and collaborating with @savebutterflies.bsky.social on the ecological and evolutionary drivers of the virome of UK moths @uniexecec.bsky.social. Descriptions below and links here benlongdon.com/join/
October 7, 2025 at 2:47 PM
Research assistant + postdoc position on a NERC funded project working w @darrenobbard.bsky.social and collaborating with @savebutterflies.bsky.social on the ecological and evolutionary drivers of the virome of UK moths @uniexecec.bsky.social. Descriptions below and links here benlongdon.com/join/
Reposted by April Hayes
what postdocs actually want:
- to not have their grants canceled
- reasonable chances at getting an academic position
- job security
- a thriving private sector so the entire research system can flourish <3
higher ed institutions in 2025:
- best i can do is an origami night
- to not have their grants canceled
- reasonable chances at getting an academic position
- job security
- a thriving private sector so the entire research system can flourish <3
higher ed institutions in 2025:
- best i can do is an origami night
September 15, 2025 at 3:14 PM
what postdocs actually want:
- to not have their grants canceled
- reasonable chances at getting an academic position
- job security
- a thriving private sector so the entire research system can flourish <3
higher ed institutions in 2025:
- best i can do is an origami night
- to not have their grants canceled
- reasonable chances at getting an academic position
- job security
- a thriving private sector so the entire research system can flourish <3
higher ed institutions in 2025:
- best i can do is an origami night
cool phd position with a really great PI and associated supervisory team alert
I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky
Please share the ad below with anyone who may be interested.
Please share the ad below with anyone who may be interested.
October 6, 2025 at 3:45 PM
cool phd position with a really great PI and associated supervisory team alert
Reposted by April Hayes
📢🚨 Check out @drgdavidson.bsky.social's 3-year senior PDRA role below @uniofeastanglia.bsky.social!
Super exciting project exploring wildlife ecology 🐾 and gut microbiome bioinformatics 🧬!
👉 Apply: vacancies.uea.ac.uk/vacancies/18...
💬 Informal enquiries to Gabrielle welcome!
Super exciting project exploring wildlife ecology 🐾 and gut microbiome bioinformatics 🧬!
👉 Apply: vacancies.uea.ac.uk/vacancies/18...
💬 Informal enquiries to Gabrielle welcome!
September 30, 2025 at 12:35 PM
📢🚨 Check out @drgdavidson.bsky.social's 3-year senior PDRA role below @uniofeastanglia.bsky.social!
Super exciting project exploring wildlife ecology 🐾 and gut microbiome bioinformatics 🧬!
👉 Apply: vacancies.uea.ac.uk/vacancies/18...
💬 Informal enquiries to Gabrielle welcome!
Super exciting project exploring wildlife ecology 🐾 and gut microbiome bioinformatics 🧬!
👉 Apply: vacancies.uea.ac.uk/vacancies/18...
💬 Informal enquiries to Gabrielle welcome!
Reposted by April Hayes
If you generate or reuse #microbiome data, check out these guidelines for equitable sequence data reuse. Grateful to @alexjprobst.bsky.social and his team for leading this important work and for bringing together 160+ microbiome scientists (myself included) to contribute!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
September 26, 2025 at 9:44 PM
If you generate or reuse #microbiome data, check out these guidelines for equitable sequence data reuse. Grateful to @alexjprobst.bsky.social and his team for leading this important work and for bringing together 160+ microbiome scientists (myself included) to contribute!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by April Hayes
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
September 25, 2025 at 9:29 PM
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
Reposted by April Hayes
Join myself and others in Exeter, alongside artist Steve McCracken, for a curated trail of art and science. Get real time insights into pollution while spotting new artworks of birds. @ecehh.org
www.eventbrite.co.uk/e/walking-to...
www.eventbrite.co.uk/e/walking-to...
Walking Tour: Sensing Exeter’s Air Quality : A Bird’s View
A curated trail of art and science. Get real time insights into pollution while spotting new artworks of birds.
www.eventbrite.co.uk
September 17, 2025 at 9:33 AM
Join myself and others in Exeter, alongside artist Steve McCracken, for a curated trail of art and science. Get real time insights into pollution while spotting new artworks of birds. @ecehh.org
www.eventbrite.co.uk/e/walking-to...
www.eventbrite.co.uk/e/walking-to...
Reposted by April Hayes
Open postdoc position in in my lab in Berlin @mpiib-berlin.mpg.de.
Join us to push the frontier in ancient microbial genomics. Please apply until Oct 17th. Reach out in case you have any questions.
www.mpiib-berlin.mpg.de/2193291/job_...
Join us to push the frontier in ancient microbial genomics. Please apply until Oct 17th. Reach out in case you have any questions.
www.mpiib-berlin.mpg.de/2193291/job_...
September 15, 2025 at 8:03 AM
Open postdoc position in in my lab in Berlin @mpiib-berlin.mpg.de.
Join us to push the frontier in ancient microbial genomics. Please apply until Oct 17th. Reach out in case you have any questions.
www.mpiib-berlin.mpg.de/2193291/job_...
Join us to push the frontier in ancient microbial genomics. Please apply until Oct 17th. Reach out in case you have any questions.
www.mpiib-berlin.mpg.de/2193291/job_...
Reposted by April Hayes
more exciting work showing the effects that non-antibiotic pharmaceuticals can have on microbial communities 🦠🧫💊
First @biorxivpreprint.bsky.social from Eda Deniz Erdem's PhD:
"Selective spread of mobile antibiotic resistance genes in wastewater microbiomes driven by the non-antibiotic pharmaceutical carbamazepine"
www.biorxiv.org/content/10.1...
#AMR #microsky
"Selective spread of mobile antibiotic resistance genes in wastewater microbiomes driven by the non-antibiotic pharmaceutical carbamazepine"
www.biorxiv.org/content/10.1...
#AMR #microsky
Selective spread of mobile antibiotic resistance genes in wastewater microbiomes driven by the non-antibiotic pharmaceutical carbamazepine
Carbamazepine (CBZ), a widely used anticonvulsant, is a persistent aquatic micropollutant that withstands biodegradation and accumulates in wastewater-impacted environments. While non-antibiotic pharm...
www.biorxiv.org
September 11, 2025 at 10:41 AM
more exciting work showing the effects that non-antibiotic pharmaceuticals can have on microbial communities 🦠🧫💊
Reposted by April Hayes
Finding microbes in cancer sequencing data has been controversial. Are we seeing real biology… or just contamination + batch effects?
September 3, 2025 at 7:00 PM
Finding microbes in cancer sequencing data has been controversial. Are we seeing real biology… or just contamination + batch effects?
Reposted by April Hayes
🤩🎢 #MVIF Season 5 is just about to start!
Ten #microbiome events, free to attend, great to present your latest results. #ECR, #preprints, unpublished work are welcome!
👉 www.microbiome-vif.org
All talks get a DOI, and those associated with preprints are added to their #bioRxiv #medRxiv pages too.
Ten #microbiome events, free to attend, great to present your latest results. #ECR, #preprints, unpublished work are welcome!
👉 www.microbiome-vif.org
All talks get a DOI, and those associated with preprints are added to their #bioRxiv #medRxiv pages too.
September 2, 2025 at 1:20 AM
🤩🎢 #MVIF Season 5 is just about to start!
Ten #microbiome events, free to attend, great to present your latest results. #ECR, #preprints, unpublished work are welcome!
👉 www.microbiome-vif.org
All talks get a DOI, and those associated with preprints are added to their #bioRxiv #medRxiv pages too.
Ten #microbiome events, free to attend, great to present your latest results. #ECR, #preprints, unpublished work are welcome!
👉 www.microbiome-vif.org
All talks get a DOI, and those associated with preprints are added to their #bioRxiv #medRxiv pages too.
Reposted by April Hayes
PhD opportunity, please share:
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a ...
gw4biomed.ac.uk
September 2, 2025 at 9:48 AM
PhD opportunity, please share:
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
We are looking for a prospective PhD student to start in October 2026 who is excited about bacteria (Klebsiella pneumoniae), how they interact, and how they exchange DNA.
All details can be found on the funder website 👉 gw4biomed.ac.uk/developing-c...
Reposted by April Hayes
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes
Background Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...
www.biorxiv.org
August 29, 2025 at 2:05 PM
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
Reposted by April Hayes
💊 Non-antibiotic drugs & resistance
A new study shows common medicines like ibuprofen and acetaminophen can boost E. coli resistance to antibiotics, raising concerns for aged care settings.
🔗 www.nature.com/articles/s44...
#SciComm 🧪 #AMR
A new study shows common medicines like ibuprofen and acetaminophen can boost E. coli resistance to antibiotics, raising concerns for aged care settings.
🔗 www.nature.com/articles/s44...
#SciComm 🧪 #AMR
The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli
www.nature.com
August 27, 2025 at 9:08 AM
💊 Non-antibiotic drugs & resistance
A new study shows common medicines like ibuprofen and acetaminophen can boost E. coli resistance to antibiotics, raising concerns for aged care settings.
🔗 www.nature.com/articles/s44...
#SciComm 🧪 #AMR
A new study shows common medicines like ibuprofen and acetaminophen can boost E. coli resistance to antibiotics, raising concerns for aged care settings.
🔗 www.nature.com/articles/s44...
#SciComm 🧪 #AMR
Reposted by April Hayes
I'm super bummed to be missing #ESEB2025 @eseb2025.bsky.social due to a cancelled flight! Here's a quick overview of my talk "Gene- and genome-focused perspectives on microbial pangenomes" slated to be part of The Evolution of Microbial Pangenomes -- which I recommend you attend tomorrow (Fri) !
1/n
1/n
August 21, 2025 at 4:57 PM
I'm super bummed to be missing #ESEB2025 @eseb2025.bsky.social due to a cancelled flight! Here's a quick overview of my talk "Gene- and genome-focused perspectives on microbial pangenomes" slated to be part of The Evolution of Microbial Pangenomes -- which I recommend you attend tomorrow (Fri) !
1/n
1/n