Ahmet O. Ceceli
@aoceceli.bsky.social
Instructor @ Mt. Sinai. Studying the neuroscience of addiction, reward, habits, and some related things with NIDA K99.
Check out our new preprint documenting how Mindfulness-Oriented Recovery Enhancement rebalances neural responses to drug and natural reward cues in opioid use disorder! W/ Yuefeng Huang, @narcatms.bsky.social, @drericgarland.bsky.social et al
@sinaibrain.bsky.social
www.medrxiv.org/content/10.6...
@sinaibrain.bsky.social
www.medrxiv.org/content/10.6...
Mindfulness-Oriented Recovery Enhancement rebalances prefrontal responses to drug and natural reward cues in opioid use disorder
Despite decades of clinical implementation of medications for opioid use disorder (OUD), overdose mortality rates remain high, underscoring a critical gap in treatments that target brain mechanisms dr...
www.medrxiv.org
February 18, 2026 at 2:22 PM
Check out our new preprint documenting how Mindfulness-Oriented Recovery Enhancement rebalances neural responses to drug and natural reward cues in opioid use disorder! W/ Yuefeng Huang, @narcatms.bsky.social, @drericgarland.bsky.social et al
@sinaibrain.bsky.social
www.medrxiv.org/content/10.6...
@sinaibrain.bsky.social
www.medrxiv.org/content/10.6...
Reposted by Ahmet O. Ceceli
Students need to remember that Inigo Montoya method for emails and greetings:
"Hello, my name is Inigo Montoya. You killed my father. Prepare to die.”
Polite Greeting
Name
Relevant Personal Link
Manage Expectations
Keep it BRIEF.
"Hello, my name is Inigo Montoya. You killed my father. Prepare to die.”
Polite Greeting
Name
Relevant Personal Link
Manage Expectations
Keep it BRIEF.
am i the only 1 who wishes ppl would remind me that we've interacted before if it's plausible i've forgotten? I've had like 3-4 emails that seems like 'cold emails' ab research opportunities but then it turns out we've exchanged emails in the past & it's awkward to not have realized this? just me?
February 10, 2026 at 4:44 PM
Students need to remember that Inigo Montoya method for emails and greetings:
"Hello, my name is Inigo Montoya. You killed my father. Prepare to die.”
Polite Greeting
Name
Relevant Personal Link
Manage Expectations
Keep it BRIEF.
"Hello, my name is Inigo Montoya. You killed my father. Prepare to die.”
Polite Greeting
Name
Relevant Personal Link
Manage Expectations
Keep it BRIEF.
Reposted by Ahmet O. Ceceli
New work from the lab! With @jameswyngaarden.bsky.social
α-tACS Modulates Reward-Dependent Pupil Responses and Corticostriatal Connectivity https://www.biorxiv.org/content/10.64898/2026.01.30.702963v1
February 5, 2026 at 10:46 AM
New work from the lab! With @jameswyngaarden.bsky.social
Reposted by Ahmet O. Ceceli
🚨 Prospects of GLP-1 Therapies for Addiction and Mental Health Comorbidities—Quo Vadis?
jamanetwork.com/journals/jam...
@jamapsychiatry.com
jamanetwork.com/journals/jam...
@jamapsychiatry.com
GLP-1 Therapies for Addiction and Mental Health Comorbidities
This narrative review discusses the current landscape of glucagon-like peptide-1 therapies in the context of alcohol and other substance use disorders, mental health considerations, and gaps and oppor...
jamanetwork.com
January 22, 2026 at 3:08 AM
🚨 Prospects of GLP-1 Therapies for Addiction and Mental Health Comorbidities—Quo Vadis?
jamanetwork.com/journals/jam...
@jamapsychiatry.com
jamanetwork.com/journals/jam...
@jamapsychiatry.com
Reposted by Ahmet O. Ceceli
Wrapping up my 4th #ACNP while savoring this view. Grateful to the presenters as I learned a ton from the panels and posters at #acnp2026. Looking fwd to returning in 2027! @acnporg.bsky.social @sinaibrain.bsky.social
January 16, 2026 at 2:52 PM
Wrapping up my 4th #ACNP while savoring this view. Grateful to the presenters as I learned a ton from the panels and posters at #acnp2026. Looking fwd to returning in 2027! @acnporg.bsky.social @sinaibrain.bsky.social
Come talk addiction cogneuro (or anything else really...) with me at poster TH54 @5p! @acnporg.bsky.social @sinaibrain.bsky.social #acnp2026
In attendance with the @narcatms.bsky.social lab! Excited to see old friends and meet new ones. And for everyone to check out poster TH54 on Thursday 5-7p where I'll talk about goals and habits in addiction! #acnp2026
Day 1 of #ACNP2026 is officially underway!
We are starting the morning strong with the President’s Plenary, followed by a dynamic Data Blitz session.
We are starting the morning strong with the President’s Plenary, followed by a dynamic Data Blitz session.
January 15, 2026 at 9:05 PM
Come talk addiction cogneuro (or anything else really...) with me at poster TH54 @5p! @acnporg.bsky.social @sinaibrain.bsky.social #acnp2026
In attendance with the @narcatms.bsky.social lab! Excited to see old friends and meet new ones. And for everyone to check out poster TH54 on Thursday 5-7p where I'll talk about goals and habits in addiction! #acnp2026
Day 1 of #ACNP2026 is officially underway!
We are starting the morning strong with the President’s Plenary, followed by a dynamic Data Blitz session.
We are starting the morning strong with the President’s Plenary, followed by a dynamic Data Blitz session.
January 12, 2026 at 7:20 PM
In attendance with the @narcatms.bsky.social lab! Excited to see old friends and meet new ones. And for everyone to check out poster TH54 on Thursday 5-7p where I'll talk about goals and habits in addiction! #acnp2026
Reposted by Ahmet O. Ceceli
Interactions between striatal–prefrontal & hippocampal–prefrontal systems shape value-based learning & goal-directed behavior during adolescence; asynchronous maturation of these circuits may contribute to vulnerability to mental health disorders
Striatal and hippocampal contributions to value-based learning in adolescence
Neuropsychopharmacology - Striatal and hippocampal contributions to value-based learning in adolescence
www.nature.com
January 6, 2026 at 4:31 PM
Interactions between striatal–prefrontal & hippocampal–prefrontal systems shape value-based learning & goal-directed behavior during adolescence; asynchronous maturation of these circuits may contribute to vulnerability to mental health disorders
Reposted by Ahmet O. Ceceli
This paper had a pretty shocking headline result (40% of voxels!), so I dug into it, and I think it is wrong. Essentially: they compare two noisy measures and find that about 40% of voxels have different sign between the two. I think this is just noise!
Would love to hear expert views on this paper. It appears to show that the operationalization of brain activity the field has relied on for 3 decades—the BOLD response—is not actually a sensible measure of brain activity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
BOLD signal changes can oppose oxygen metabolism across the human cortex - Nature Neuroscience
Using quantitative brain imaging, the authors show opposite fMRI BOLD signal to metabolic activity due to variable oxygen extraction across the human cortex. This questions the canonical interpretatio...
www.nature.com
January 5, 2026 at 5:22 PM
This paper had a pretty shocking headline result (40% of voxels!), so I dug into it, and I think it is wrong. Essentially: they compare two noisy measures and find that about 40% of voxels have different sign between the two. I think this is just noise!
Reposted by Ahmet O. Ceceli
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...
December 24, 2025 at 4:46 PM
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...
Greater automaticity -> greater devaluation sensitivity?? my mind -> blown
Two facets of automaticity: motor automaticity opposes habit formation: https://doi.org/10.31234/osf.io/xatzp_v1
December 25, 2025 at 1:45 AM
Greater automaticity -> greater devaluation sensitivity?? my mind -> blown
Reposted by Ahmet O. Ceceli
"Socioeconomic status (SES) — not IQ or psychopathology — showed the strongest associations with both resting-state functional connectivity and cortical thickness in the ABCD Study." www.biorxiv.org/content/10.6...
December 24, 2025 at 9:02 PM
"Socioeconomic status (SES) — not IQ or psychopathology — showed the strongest associations with both resting-state functional connectivity and cortical thickness in the ABCD Study." www.biorxiv.org/content/10.6...
Reposted by Ahmet O. Ceceli
Hiring a Postdoc at UC San Diego to assist with clinical trials and neuroscience of Psychedelic-Assisted Therapy for addiction. Clinical psychology or psychiatry training preferred. Postdoc will provide psychedelic-assisted therapy sessions, analyze data, and write papers. Competitive salary! DM me.
December 19, 2025 at 6:29 AM
Hiring a Postdoc at UC San Diego to assist with clinical trials and neuroscience of Psychedelic-Assisted Therapy for addiction. Clinical psychology or psychiatry training preferred. Postdoc will provide psychedelic-assisted therapy sessions, analyze data, and write papers. Competitive salary! DM me.
Reposted by Ahmet O. Ceceli
Hate: Overextending claims about psychology/cognitive neuroscience based on resting-state fMRI
December 17, 2025 at 11:56 PM
Hate: Overextending claims about psychology/cognitive neuroscience based on resting-state fMRI
Reposted by Ahmet O. Ceceli
AI-assisted coding: 10 simple rules to maintain scientific rigor www.thetransmitter.org/artificial-i... - my latest in @thetransmitter.bsky.social
AI-assisted coding: 10 simple rules to maintain scientific rigor
These guidelines can help researchers ensure the integrity of their work while accelerating progress on important scientific questions.
www.thetransmitter.org
December 16, 2025 at 1:48 PM
AI-assisted coding: 10 simple rules to maintain scientific rigor www.thetransmitter.org/artificial-i... - my latest in @thetransmitter.bsky.social
Reposted by Ahmet O. Ceceli
Objective estimates of drug-biased behavior outperform subjective drug use measures in predicting addiction treatment outcomes?! Read more about it in our new paper in @biologicalpsych.bsky.social GOS w/ @nataliemcclain.bsky.social @narcatms.bsky.social et al!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Moving beyond self-report in characterizing drug addiction: Using drug-biased behavior to predict treatment completion and dropout in heroin-primary, medication-maintained opioid use disorder.
Drug addiction is accompanied by enhanced salience attributed to drug over nondrug cues. This bias can be objectively measured and is reliable yet und…
www.sciencedirect.com
December 11, 2025 at 10:49 PM
Objective estimates of drug-biased behavior outperform subjective drug use measures in predicting addiction treatment outcomes?! Read more about it in our new paper in @biologicalpsych.bsky.social GOS w/ @nataliemcclain.bsky.social @narcatms.bsky.social et al!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Ahmet O. Ceceli
Excited to share our new GLP-1 receptor agonist study! Chronic semaglutide potentiates motivation for small food rewards and associated cues, but reduces intake when food is freely available—surprising twist! #GLP-1, #behavior #neuroscience #pharmacology 1/
🔗 www.biorxiv.org/cgi/content/...
🔗 www.biorxiv.org/cgi/content/...
Chronic semaglutide treatment enhances the incentive motivational value of a small food reward and associated cue in male and female rats
Rationale: Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, are increasingly utilized in clinical practice due to their efficacy in promoting sustained weight loss following chr...
www.biorxiv.org
December 10, 2025 at 5:22 PM
Excited to share our new GLP-1 receptor agonist study! Chronic semaglutide potentiates motivation for small food rewards and associated cues, but reduces intake when food is freely available—surprising twist! #GLP-1, #behavior #neuroscience #pharmacology 1/
🔗 www.biorxiv.org/cgi/content/...
🔗 www.biorxiv.org/cgi/content/...
Reposted by Ahmet O. Ceceli
ManuscriptCentral Wrapped!
In 2025, you submitted 5 papers
AND all got rejected 🎉
You spent 💯 minutes in total trying to submit your papers!
You reviewed for 10 journals that would never publish your papers ❤️
In 2025, you submitted 5 papers
AND all got rejected 🎉
You spent 💯 minutes in total trying to submit your papers!
You reviewed for 10 journals that would never publish your papers ❤️
They should do MyChart Wrapped
December 3, 2025 at 11:40 PM
ManuscriptCentral Wrapped!
In 2025, you submitted 5 papers
AND all got rejected 🎉
You spent 💯 minutes in total trying to submit your papers!
You reviewed for 10 journals that would never publish your papers ❤️
In 2025, you submitted 5 papers
AND all got rejected 🎉
You spent 💯 minutes in total trying to submit your papers!
You reviewed for 10 journals that would never publish your papers ❤️
Reposted by Ahmet O. Ceceli
Cocaine Addiction Trinity
Three subtypes of cocaine use disorder and their neurobehavioral profiles
A ‘Relief Type’ with high negative emotionality
A ‘Cognitive Type’ with lower executive function
An ‘Undefined Type’ with no apparent impairments
www.nature.com/articles/s41...
Three subtypes of cocaine use disorder and their neurobehavioral profiles
A ‘Relief Type’ with high negative emotionality
A ‘Cognitive Type’ with lower executive function
An ‘Undefined Type’ with no apparent impairments
www.nature.com/articles/s41...
Subtypes of cocaine use disorder and their neurobehavioral profiles - Translational Psychiatry
Translational Psychiatry - Subtypes of cocaine use disorder and their neurobehavioral profiles
www.nature.com
December 4, 2025 at 4:31 PM
Cocaine Addiction Trinity
Three subtypes of cocaine use disorder and their neurobehavioral profiles
A ‘Relief Type’ with high negative emotionality
A ‘Cognitive Type’ with lower executive function
An ‘Undefined Type’ with no apparent impairments
www.nature.com/articles/s41...
Three subtypes of cocaine use disorder and their neurobehavioral profiles
A ‘Relief Type’ with high negative emotionality
A ‘Cognitive Type’ with lower executive function
An ‘Undefined Type’ with no apparent impairments
www.nature.com/articles/s41...
Reposted by Ahmet O. Ceceli
Distributed activity in the human posterior putamen distinguishes goal-directed from habitual control in humans https://www.biorxiv.org/content/10.1101/2025.11.26.690863v1
November 28, 2025 at 1:15 PM
Distributed activity in the human posterior putamen distinguishes goal-directed from habitual control in humans https://www.biorxiv.org/content/10.1101/2025.11.26.690863v1
Reposted by Ahmet O. Ceceli
New lab paper: "Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis." Across 17 different studies, fear conditioning consistently distorted temporal source memory for information encoded before and after. www.sciencedirect.com/science/arti...
Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis
Episodic memory allows us to remember when an event occurred by situating it within a coherent temporal context. Pavlovian fear conditioning, a widely…
www.sciencedirect.com
December 1, 2025 at 4:05 PM
New lab paper: "Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis." Across 17 different studies, fear conditioning consistently distorted temporal source memory for information encoded before and after. www.sciencedirect.com/science/arti...
Reposted by Ahmet O. Ceceli
1/2
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
Optimizing the frequency of ecological momentary assessments using signal processing | Psychological Medicine | Cambridge Core
Optimizing the frequency of ecological momentary assessments using signal processing - Volume 55
www.cambridge.org
November 27, 2025 at 12:04 AM
1/2
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
Very interesting paper framing decision biases as habit-like choice repetitions. I wonder if any element of non reinforced preference change (www.sciencedirect.com/science/arti...) is at work here.
Very happy that this is out www.nature.com/articles/s44.... Together with @stefankiebel.bsky.social we show that decision biases in context-dependent decision making, previously attributed to different forms of value normalization, are very well explained by habit-like action repetition.
Action repetition biases choice in context-dependent decision-making - Communications Psychology
This study shows that decision biases previously attributed to value normalization (e.g. relative value learning or range normalization) are better explained by action repetition. Repeating an action ...
www.nature.com
November 30, 2025 at 4:27 PM
Very interesting paper framing decision biases as habit-like choice repetitions. I wonder if any element of non reinforced preference change (www.sciencedirect.com/science/arti...) is at work here.