Javeria Hashmi
@netphys.bsky.social
Neuroscientist: pain perception, human neuroimaging, networks and graphs, cautious Neuro AI, clinical translation
Pinned
Javeria Hashmi
@netphys.bsky.social
· Nov 4
Sunavsky et al. find that chronic low back pain is associated with hyperconnectivity between the nucleus accumbens and prefrontal cortex regions, a pattern that predicts pain intensity and was partly reproduced between different study cohorts #PAIN bit.ly/4neD5zr
Can machine learning really beat classic stats at classifying chronic pain?
Excited to share the first in our series of papers using hypothesis-driven analyses to identify reproducible, verifiable biomarkers of chronic pain. We validated findings across three cohorts (N=197).
#PainResearch
#ML
#AI
Excited to share the first in our series of papers using hypothesis-driven analyses to identify reproducible, verifiable biomarkers of chronic pain. We validated findings across three cohorts (N=197).
#PainResearch
#ML
#AI
Reposted by Javeria Hashmi
This piece really nails how I have been feeling in the last couple of weeks. fortune.com/2026/02/11/s...
Something big is happening in AI — and most people will be blindsided | Fortune
It’s not like a light switch... more like the moment you realize the water has been rising around you and is now at your chest.
fortune.com
February 12, 2026 at 3:51 AM
This piece really nails how I have been feeling in the last couple of weeks. fortune.com/2026/02/11/s...
Reposted by Javeria Hashmi
"..hippocampal-prefrontal systems represent emotion concepts in a map-like way at multiple levels of abstraction.."
Map-like representations of emotion knowledge in hippocampal-prefrontal systems
by
@yumengma.bsky.social and @pkragel.bsky.social
www.nature.com/articles/s41...
Map-like representations of emotion knowledge in hippocampal-prefrontal systems
by
@yumengma.bsky.social and @pkragel.bsky.social
www.nature.com/articles/s41...
February 9, 2026 at 9:35 AM
"..hippocampal-prefrontal systems represent emotion concepts in a map-like way at multiple levels of abstraction.."
Map-like representations of emotion knowledge in hippocampal-prefrontal systems
by
@yumengma.bsky.social and @pkragel.bsky.social
www.nature.com/articles/s41...
Map-like representations of emotion knowledge in hippocampal-prefrontal systems
by
@yumengma.bsky.social and @pkragel.bsky.social
www.nature.com/articles/s41...
Reposted by Javeria Hashmi
Well-predicting machine learning in no way means that you can understand how the world works.
open.substack.com/pub/kording/...
open.substack.com/pub/kording/...
Forward vs Inverse problems: why high performance machine learning usually means little about how the world works
Understanding causality from machine learning is unfortunately usually impossible; life sciences take note
open.substack.com
February 7, 2026 at 6:31 PM
Well-predicting machine learning in no way means that you can understand how the world works.
open.substack.com/pub/kording/...
open.substack.com/pub/kording/...
Reposted by Javeria Hashmi
February 8, 2026 at 8:28 AM
Reposted by Javeria Hashmi
Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again.
#Pinks #ProudBlue
#Pinks #ProudBlue
February 5, 2026 at 11:50 AM
Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again.
#Pinks #ProudBlue
#Pinks #ProudBlue
Reposted by Javeria Hashmi
The cortex layer 6b theory of attention www.cell.com/neuron/fullt...
January 30, 2026 at 3:59 PM
The cortex layer 6b theory of attention www.cell.com/neuron/fullt...
Reposted by Javeria Hashmi
For aficionados of timing, prediction, psychophysics-and anyone who wants to look at something other than the news to be distracted-a new study by Matthias Grabenhorst and Georgios Michalareas:
The anticipation of imminent events is time-scale invariant
www.pnas.org/doi/epdf/10....
#neuroskyence
The anticipation of imminent events is time-scale invariant
www.pnas.org/doi/epdf/10....
#neuroskyence
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 8, 2026 at 2:55 PM
For aficionados of timing, prediction, psychophysics-and anyone who wants to look at something other than the news to be distracted-a new study by Matthias Grabenhorst and Georgios Michalareas:
The anticipation of imminent events is time-scale invariant
www.pnas.org/doi/epdf/10....
#neuroskyence
The anticipation of imminent events is time-scale invariant
www.pnas.org/doi/epdf/10....
#neuroskyence
Initiating grant spiral 🌀 If you need me, leave offerings of coffee and low expectations.
#AcademicLife
#FundedOrFeral
#AcademicLife
#FundedOrFeral
a man in a suit and tie is making a sad face in front of a window .
ALT: a man in a suit and tie is making a sad face in front of a window .
media.tenor.com
January 7, 2026 at 4:33 PM
Initiating grant spiral 🌀 If you need me, leave offerings of coffee and low expectations.
#AcademicLife
#FundedOrFeral
#AcademicLife
#FundedOrFeral
Reposted by Javeria Hashmi
New paper led by wonder postdocs Francesca Greenstreet and @jessegeerts.bsky.social and @clopathlab.bsky.social trying to understand why –in the "what for" sense– there are multiple motor learning systems –supervised and RL-based– in the brain.
Check out Jesse's 🧵
www.biorxiv.org/content/10.6...
Check out Jesse's 🧵
www.biorxiv.org/content/10.6...
🧠 New year, new preprint!
Why does motor learning involve multiple brain regions? We propose that the cortico-cerebellar system learns a "map" of actions where similar movements are nearby, while basal ganglia do RL in this simplified space.
www.biorxiv.org/content/10.6...
Why does motor learning involve multiple brain regions? We propose that the cortico-cerebellar system learns a "map" of actions where similar movements are nearby, while basal ganglia do RL in this simplified space.
www.biorxiv.org/content/10.6...
January 6, 2026 at 1:43 PM
New paper led by wonder postdocs Francesca Greenstreet and @jessegeerts.bsky.social and @clopathlab.bsky.social trying to understand why –in the "what for" sense– there are multiple motor learning systems –supervised and RL-based– in the brain.
Check out Jesse's 🧵
www.biorxiv.org/content/10.6...
Check out Jesse's 🧵
www.biorxiv.org/content/10.6...
Reposted by Javeria Hashmi
𝗖𝗮𝗻 𝘄𝗲 𝘀𝘁𝘂𝗱𝘆 𝗯𝗿𝗮𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗳𝗠𝗥𝗜?
We employed Switching Linear Dynamical Systems to investigate the dynamics of resting-state networks
They are dynamic, not static!
Work with Xiaoyu Zhao with lots of new methods.
Thread.
#neuroskyence
www.biorxiv.org/content/10.6...
We employed Switching Linear Dynamical Systems to investigate the dynamics of resting-state networks
They are dynamic, not static!
Work with Xiaoyu Zhao with lots of new methods.
Thread.
#neuroskyence
www.biorxiv.org/content/10.6...
December 17, 2025 at 5:01 PM
𝗖𝗮𝗻 𝘄𝗲 𝘀𝘁𝘂𝗱𝘆 𝗯𝗿𝗮𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗳𝗠𝗥𝗜?
We employed Switching Linear Dynamical Systems to investigate the dynamics of resting-state networks
They are dynamic, not static!
Work with Xiaoyu Zhao with lots of new methods.
Thread.
#neuroskyence
www.biorxiv.org/content/10.6...
We employed Switching Linear Dynamical Systems to investigate the dynamics of resting-state networks
They are dynamic, not static!
Work with Xiaoyu Zhao with lots of new methods.
Thread.
#neuroskyence
www.biorxiv.org/content/10.6...
Reposted by Javeria Hashmi
human, macaque, marmoset!
Cross-species consensus atlas of the primate basal ganglia https://www.biorxiv.org/content/10.64898/2025.12.15.694496v1
December 16, 2025 at 2:28 PM
human, macaque, marmoset!
“The fact that we can make disastrous decisions even as we foresee their consequences is the great, unsolved mystery of human behavior.”
—Slavoj Zizek
Photo: Andy Miah | #SlavojZizek #literature #quotes #fblifestyle #philosophy
—Slavoj Zizek
Photo: Andy Miah | #SlavojZizek #literature #quotes #fblifestyle #philosophy
December 16, 2025 at 2:46 PM
“The fact that we can make disastrous decisions even as we foresee their consequences is the great, unsolved mystery of human behavior.”
—Slavoj Zizek
Photo: Andy Miah | #SlavojZizek #literature #quotes #fblifestyle #philosophy
—Slavoj Zizek
Photo: Andy Miah | #SlavojZizek #literature #quotes #fblifestyle #philosophy
Reposted by Javeria Hashmi
**How distributed is the brain-wide network that is recruited
for cognition?**
That goes to the top of the list!
#neuroskyence
doi.org/10.1038/s415...
for cognition?**
That goes to the top of the list!
#neuroskyence
doi.org/10.1038/s415...
December 5, 2025 at 6:51 PM
**How distributed is the brain-wide network that is recruited
for cognition?**
That goes to the top of the list!
#neuroskyence
doi.org/10.1038/s415...
for cognition?**
That goes to the top of the list!
#neuroskyence
doi.org/10.1038/s415...
Good stuff. thanks @pessoabrain.bsky.social
𝗕𝗲𝘆𝗼𝗻𝗱 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀: 𝗧𝗼𝘄𝗮𝗿𝗱 𝗮𝗱𝗮𝗽𝘁𝗶𝘃𝗲 𝗺𝗼𝗱𝗲𝗹𝘀 𝗼𝗳 𝗯𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗰𝗼𝗺𝗽𝗹𝗲𝘅𝗶𝘁𝘆
Discusses how more standard network models miss key points of brain complexity. And some more radical points at the end.
Wrote paper having in mind younger researchers more open to new ideas :-)
#neuroskyence
doi.org/10.1016/j.pl...
Discusses how more standard network models miss key points of brain complexity. And some more radical points at the end.
Wrote paper having in mind younger researchers more open to new ideas :-)
#neuroskyence
doi.org/10.1016/j.pl...
December 9, 2025 at 7:38 PM
Good stuff. thanks @pessoabrain.bsky.social
Reposted by Javeria Hashmi
New paper in Imaging Neuroscience by Hecheng Jin, Ting Xu, et al:
Is Pearson’s correlation coefficient enough for functional connectivity in fMRI?
doi.org/10.1162/IMAG...
Is Pearson’s correlation coefficient enough for functional connectivity in fMRI?
doi.org/10.1162/IMAG...
December 8, 2025 at 11:20 PM
New paper in Imaging Neuroscience by Hecheng Jin, Ting Xu, et al:
Is Pearson’s correlation coefficient enough for functional connectivity in fMRI?
doi.org/10.1162/IMAG...
Is Pearson’s correlation coefficient enough for functional connectivity in fMRI?
doi.org/10.1162/IMAG...
“Vanity of vanities… all is vanity. You kill yourself to get to the grave. Especially you kill yourself to get to the grave before you die; and the name of the grave is ‘success’, the name of that grave is hullabullo boom boom horseshit.”
—Jack Kerouac
—Jack Kerouac
December 7, 2025 at 4:09 PM
“Vanity of vanities… all is vanity. You kill yourself to get to the grave. Especially you kill yourself to get to the grave before you die; and the name of the grave is ‘success’, the name of that grave is hullabullo boom boom horseshit.”
—Jack Kerouac
—Jack Kerouac
Reposted by Javeria Hashmi
Zohran flip your hair again we need healthcare get him to give us healthcare.
November 21, 2025 at 9:26 PM
Zohran flip your hair again we need healthcare get him to give us healthcare.
“There’s a popular view that connectivity, in the Facebook sense, is a good thing. In my world, it’s really bad. Dense connectivity is the killer. It is death.” — Karl Friston. hbarjournal.substack.com/p/karl-frist...
Karl Friston — Functioning Brains and Psychotic Societies
On the Free Energy Principle, societal boundaries, cancer, and the beauty of sparsity.
hbarjournal.substack.com
November 21, 2025 at 6:13 PM
“There’s a popular view that connectivity, in the Facebook sense, is a good thing. In my world, it’s really bad. Dense connectivity is the killer. It is death.” — Karl Friston. hbarjournal.substack.com/p/karl-frist...
Reposted by Javeria Hashmi
Very cool new work from the Iglesias group at MGH: A probabilistic histological atlas of the human brain for MRI segmentation (also available at OpenNeuro - openneuro.org/datasets/ds0...) : www.nature.com/articles/s41...
A probabilistic histological atlas of the human brain for MRI segmentation - Nature
NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the multimodal serial h...
www.nature.com
November 21, 2025 at 3:32 PM
Very cool new work from the Iglesias group at MGH: A probabilistic histological atlas of the human brain for MRI segmentation (also available at OpenNeuro - openneuro.org/datasets/ds0...) : www.nature.com/articles/s41...
Reposted by Javeria Hashmi
fun old experiment (1968): O. Lippold believed that the alpha rhythm was related to the physiological tremor in eye muscles (also ~10 Hz). so in this experiment, the eyeball was cooled & warmed to shift the muscle tremor frequency. when they measured EEG, the alpha frequency seems to change.
November 21, 2025 at 1:38 PM
fun old experiment (1968): O. Lippold believed that the alpha rhythm was related to the physiological tremor in eye muscles (also ~10 Hz). so in this experiment, the eyeball was cooled & warmed to shift the muscle tremor frequency. when they measured EEG, the alpha frequency seems to change.
Reposted by Javeria Hashmi
Towards a computational phenomenology of meditative deconstruction: modelling ‘letting go’ and the deconstruction of experience with active inference osf.io/preprints/ps...
OSF
osf.io
November 21, 2025 at 11:22 AM
Towards a computational phenomenology of meditative deconstruction: modelling ‘letting go’ and the deconstruction of experience with active inference osf.io/preprints/ps...
Reposted by Javeria Hashmi
