Ali Amini
@aliamini419.bsky.social
Infectious Diseases Clinical Lecturer, Oxford | Immunologist - viruses, vaccines and MAIT cells! | Manc. Dad. MUFC
Reposted by Ali Amini
We’re delighted to hear that our favourite cell type (Regulatory T cells!) have been recognised in the Nobel Prize this year! Huge congratulations to Mary, Fred, and Shimon for their pivotal work in the field & here’s to many exciting Treg advances to come!🥳👏🎉
October 7, 2025 at 10:37 AM
We’re delighted to hear that our favourite cell type (Regulatory T cells!) have been recognised in the Nobel Prize this year! Huge congratulations to Mary, Fred, and Shimon for their pivotal work in the field & here’s to many exciting Treg advances to come!🥳👏🎉
Reposted by Ali Amini
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Definitely more important than MHRA suicide risks. Five days ciprofloxacin up to year-long resistance in the gut microbiome (10 % got same gyrA mutation with no fitness cost). Probably had impact on tonic mucosal immune responses too.
Reporting in Nature, Eitan Yaffe and colleagues demonstrate that resistance to an antibiotic can rapidly emerge in commensal gut bacteria in vivo, and that such resistant lineages can persist for a long period following cessation of the antibiotic. 👇 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Brief antibiotic use drives human gut bacteria towards low-cost resistance - Nature
Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure a...
www.nature.com
April 25, 2025 at 7:07 PM
Definitely more important than MHRA suicide risks. Five days ciprofloxacin up to year-long resistance in the gut microbiome (10 % got same gyrA mutation with no fitness cost). Probably had impact on tonic mucosal immune responses too.
Reposted by Ali Amini
Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 25, 2025 at 6:08 PM
Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ali Amini
Ex vivo models capture the cellular and functional richness of respiratory tract tissues and enable study of viral pathogenesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 25, 2025 at 6:13 PM
Ex vivo models capture the cellular and functional richness of respiratory tract tissues and enable study of viral pathogenesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ali Amini
From 2022 to 2023 the city of new york reported a 28% increase in cases of tuberculosis. This article examines the reasons. The biggest one is the continued loss of public health funding.
www.healthbeat.org/newyork/2025...
www.healthbeat.org/newyork/2025...
Tuberculosis in NYC: Why have cases been on the rise?
In the 1990s, NYC faced a surge of tuberculosis. The city bolstered its TB control program and brought those cases down. But in recent years, they’ve started to tick up again. Here’s what to know abou...
www.healthbeat.org
April 25, 2025 at 5:30 PM
From 2022 to 2023 the city of new york reported a 28% increase in cases of tuberculosis. This article examines the reasons. The biggest one is the continued loss of public health funding.
www.healthbeat.org/newyork/2025...
www.healthbeat.org/newyork/2025...
Reposted by Ali Amini
Come get our #immune data, free #FAIRsharing is at @immportdb.bsky.social
- from @columbiauniversity.bsky.social
@icahn.bsky.social
@yalemedicine.bsky.social
@stanfordimmunology.bsky.social
@benaroyaresearch.bsky.social
@lji.org
MIT, Seattle Children's
#AAI2025
#ImmuneSky #IDsky
- from @columbiauniversity.bsky.social
@icahn.bsky.social
@yalemedicine.bsky.social
@stanfordimmunology.bsky.social
@benaroyaresearch.bsky.social
@lji.org
MIT, Seattle Children's
#AAI2025
#ImmuneSky #IDsky
April 23, 2025 at 5:01 PM
Come get our #immune data, free #FAIRsharing is at @immportdb.bsky.social
- from @columbiauniversity.bsky.social
@icahn.bsky.social
@yalemedicine.bsky.social
@stanfordimmunology.bsky.social
@benaroyaresearch.bsky.social
@lji.org
MIT, Seattle Children's
#AAI2025
#ImmuneSky #IDsky
- from @columbiauniversity.bsky.social
@icahn.bsky.social
@yalemedicine.bsky.social
@stanfordimmunology.bsky.social
@benaroyaresearch.bsky.social
@lji.org
MIT, Seattle Children's
#AAI2025
#ImmuneSky #IDsky
Reposted by Ali Amini
Deciphering the role of histone modifications in memory and exhausted CD8 T cells @ejohnwherry.bsky.social @amylizbaxter.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 23, 2025 at 7:54 PM
Deciphering the role of histone modifications in memory and exhausted CD8 T cells @ejohnwherry.bsky.social @amylizbaxter.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ali Amini
www.nature.com/articles/s41...
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature Medicine
Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...
www.nature.com
April 23, 2025 at 11:11 AM
www.nature.com/articles/s41...
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.
Reposted by Ali Amini
#Medsky🧪 #idsky #immunodky #pharmasky #publichealth Review discusses how #vaccine #adjuvants function & highlight knowledge gaps that need to be addressed to develop improved vaccines against emerging pathogens. @sciimmunology.bsky.social
scim.ag/430weCB
scim.ag/430weCB
February 17, 2025 at 8:44 PM
#Medsky🧪 #idsky #immunodky #pharmasky #publichealth Review discusses how #vaccine #adjuvants function & highlight knowledge gaps that need to be addressed to develop improved vaccines against emerging pathogens. @sciimmunology.bsky.social
scim.ag/430weCB
scim.ag/430weCB
Reposted by Ali Amini
#Medsky🧪#Idsky #immunosky #publichealth A study in @naturemedicine.bsky.social shows how global aircraft-based #wastewater surveillance networks would perform in identifying sources of pandemic outbreaks and what the optimal location of monitoring sites would be. go.nature.com/4gIknMm
Pandemic monitoring with global aircraft-based wastewater surveillance networks - Nature Medicine
By simulating the implementation of airport-based wastewater surveillance sites at the global level, a modeling study shows how this early warning system would perform in identifying sources of pandem...
go.nature.com
February 17, 2025 at 9:03 PM
#Medsky🧪#Idsky #immunosky #publichealth A study in @naturemedicine.bsky.social shows how global aircraft-based #wastewater surveillance networks would perform in identifying sources of pandemic outbreaks and what the optimal location of monitoring sites would be. go.nature.com/4gIknMm
Reposted by Ali Amini
An amazing team effort! Thanks to all the eosinophiles involved and @biainfection.bsky.social
First paper to share here
Delightful to have been part of the all new UK guidelines on the diagnosis of and management of eosinophilia!
www.journalofinfection.com/article/S016...
Delightful to have been part of the all new UK guidelines on the diagnosis of and management of eosinophilia!
www.journalofinfection.com/article/S016...
UK guidelines for the investigation and management of eosinophilia in returning travellers and migrants
Eosinophilia is a common finding in returning travellers, migrants and other travelling
groups. In this setting it often indicates an underlying helminth infection. Infections
associated with eosinoph...
www.journalofinfection.com
November 23, 2024 at 4:15 PM
An amazing team effort! Thanks to all the eosinophiles involved and @biainfection.bsky.social
Reposted by Ali Amini
I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature
Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.
www.nature.com
November 20, 2024 at 7:04 PM
I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ali Amini
Gut IgA1 and IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, and show unique changes of both frequency and reactivity in IBD @gmagrilab.bsky.social
doi.org/10.1084/jem....
doi.org/10.1084/jem....
November 19, 2024 at 5:38 PM
Gut IgA1 and IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, and show unique changes of both frequency and reactivity in IBD @gmagrilab.bsky.social
doi.org/10.1084/jem....
doi.org/10.1084/jem....
Reposted by Ali Amini
Really great review for the ID trainee (and refresher for the ID provider) #IDSky @cidjournal.bsky.social
academic.oup.com/cid/advance-...
academic.oup.com/cid/advance-...
Current and future strategies for the prevention and treatment of cytomegalovirus infections in transplantation
Abstract. Successful prevention and treatment of cytomegalovirus (CMV) infection remains a central focus of clinical care in solid organ and allogeneic hem
academic.oup.com
November 19, 2024 at 3:58 PM
Really great review for the ID trainee (and refresher for the ID provider) #IDSky @cidjournal.bsky.social
academic.oup.com/cid/advance-...
academic.oup.com/cid/advance-...
Reposted by Ali Amini
Posting this because these images are making the rounds again. Plus, someone told me it was the best thing I ever did, and I was flattered.
p.s. only possible since I've been directly involved with several papers that meet these exact criteria, so mea culpa
blogs.jwatch.org/hiv-id-obser...
p.s. only possible since I've been directly involved with several papers that meet these exact criteria, so mea culpa
blogs.jwatch.org/hiv-id-obser...
November 19, 2024 at 3:47 AM
Posting this because these images are making the rounds again. Plus, someone told me it was the best thing I ever did, and I was flattered.
p.s. only possible since I've been directly involved with several papers that meet these exact criteria, so mea culpa
blogs.jwatch.org/hiv-id-obser...
p.s. only possible since I've been directly involved with several papers that meet these exact criteria, so mea culpa
blogs.jwatch.org/hiv-id-obser...
Reposted by Ali Amini
Most accurate Oded post ever...
"It appears that your recommended reviewers are not really your friends, Mr. Bond"
November 16, 2024 at 1:42 AM
Most accurate Oded post ever...
Radiology reports, 2040: brain volumes commensurate with age and genotype. In depth phenotyping of UK biobank cohort never ceases to amaze!
November 19, 2024 at 10:17 AM
Radiology reports, 2040: brain volumes commensurate with age and genotype. In depth phenotyping of UK biobank cohort never ceases to amaze!
Reposted by Ali Amini
This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models!
bit.ly/SI_adp3720
bit.ly/SI_adp3720
November 18, 2024 at 10:22 PM
This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models!
bit.ly/SI_adp3720
bit.ly/SI_adp3720
Reposted by Ali Amini
"Why doesn't the NHS use its GP data?". Because of privacy... Because it's hard... But we solved it. We developed new privacy protections... We built docs.OpenSAFELY.org! 181 projects! 31 organisations! Now, they come together, for the first time, in 3D!
www.bennett.ox.ac.uk/blog/2024/10...
www.bennett.ox.ac.uk/blog/2024/10...
OpenSAFELY Symposium 2024: there's still time to sign up | Bennett Institute for Applied Data Science
It’s not too late to register for our 2nd Annual OpenSAFELY Symposium, which is happening in London on 25/26 November.
www.bennett.ox.ac.uk
November 19, 2024 at 9:40 AM
"Why doesn't the NHS use its GP data?". Because of privacy... Because it's hard... But we solved it. We developed new privacy protections... We built docs.OpenSAFELY.org! 181 projects! 31 organisations! Now, they come together, for the first time, in 3D!
www.bennett.ox.ac.uk/blog/2024/10...
www.bennett.ox.ac.uk/blog/2024/10...
Reposted by Ali Amini
Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k
November 18, 2024 at 8:06 AM
Physician/scientists, let me know if you want to be added to this list: go.bsky.app/9PwKh1k
Reposted by Ali Amini
Results 10 yrs metagenomic sequencing for CNS infections www.nature.com/articles/s41...
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
November 13, 2024 at 5:15 PM
Results 10 yrs metagenomic sequencing for CNS infections www.nature.com/articles/s41...
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
Reposted by Ali Amini
My first post - hi everyone! My lab was intrigued by the interaction between starvation and infrction so med student Jessy Jindal wrote a review, led by senior immunologist Barbara Kronsteiner. Very interesting evolved responses www.sciencedirect.com/science/arti...
Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection
Sickness-associated anorexia, the reduction in appetite seen during infection, is a widely conserved and well-recognized symptom of acute infection, y…
www.sciencedirect.com
November 16, 2024 at 10:48 AM
My first post - hi everyone! My lab was intrigued by the interaction between starvation and infrction so med student Jessy Jindal wrote a review, led by senior immunologist Barbara Kronsteiner. Very interesting evolved responses www.sciencedirect.com/science/arti...
Reposted by Ali Amini
November 12, 2024 at 11:30 PM
Reposted by Ali Amini
Treating lupus by depleting B cells with CAR T cells has been shown successful
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease | Science | AAAS www.science.org/content/arti...
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease | Science | AAAS www.science.org/content/arti...
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease
CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand
www.science.org
November 15, 2024 at 11:28 AM
Treating lupus by depleting B cells with CAR T cells has been shown successful
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease | Science | AAAS www.science.org/content/arti...
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease | Science | AAAS www.science.org/content/arti...