Alex Strudwick Young
@alextisyoung.bsky.social
Asst. Prof. @ UCLA Human Genetics. Statistical geneticist & part of the SSGAC. Mendelian inheritance is the most important natural experiment. alextisyoung.github.io
Pinned
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
Reposted by Alex Strudwick Young
Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @aysuo.bsky.social, @paturley.bsky.social, @alextisyoung.bsky.social, and @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025... Thread below for details.
September 18, 2025 at 3:07 PM
Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @aysuo.bsky.social, @paturley.bsky.social, @alextisyoung.bsky.social, and @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025... Thread below for details.
Reposted by Alex Strudwick Young
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1
May 20, 2025 at 10:18 AM
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
Reposted by Alex Strudwick Young
New review on the genetics of schizophrenia, depression, and bipolar disorder.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genomics of schizophrenia, bipolar disorder and major depressive disorder
Nature Reviews Genetics - Genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, revealing genetic architectures and risk mechanisms...
www.nature.com
May 14, 2025 at 2:11 AM
New review on the genetics of schizophrenia, depression, and bipolar disorder.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alex Strudwick Young
UK Genome Science meeting - Newcastle. 9th - 11th July 2025. Great speakers. Great community.
Early bird registration-16th May
Abstract submission-23rd May
Registration close-26th June
If you want that sweet sweet early bird deal - get going quick!
www.genomescience.org.uk
Early bird registration-16th May
Abstract submission-23rd May
Registration close-26th June
If you want that sweet sweet early bird deal - get going quick!
www.genomescience.org.uk
Genome Science UK 2025
Newcastle University
www.genomescience.org.uk
May 9, 2025 at 3:58 PM
UK Genome Science meeting - Newcastle. 9th - 11th July 2025. Great speakers. Great community.
Early bird registration-16th May
Abstract submission-23rd May
Registration close-26th June
If you want that sweet sweet early bird deal - get going quick!
www.genomescience.org.uk
Early bird registration-16th May
Abstract submission-23rd May
Registration close-26th June
If you want that sweet sweet early bird deal - get going quick!
www.genomescience.org.uk
Reposted by Alex Strudwick Young
Some really interesting contrasts in our new "assumption-free heritability" preprint: papers.ssrn.com/sol3/papers....
Nature, nurture, and socioeconomic outcomes: New evidence from sib pairs and molecular genetic data
A consequence of Mendel's First Law is that siblings' genetic relatedness varies randomly (with a mean of 50% and a standard deviation of ~4%). We use molecular
papers.ssrn.com
April 25, 2025 at 8:35 AM
Some really interesting contrasts in our new "assumption-free heritability" preprint: papers.ssrn.com/sol3/papers....
Reposted by Alex Strudwick Young
Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%!
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
May 8, 2025 at 12:01 PM
Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%!
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
Great work on estimating heritability using sibling relatedness variation (estimated using my software package snipar). Surprisingly low h2 for education and high h2 for IQ (with large SE). Give it a read!
Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%!
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1
@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social
May 8, 2025 at 12:55 PM
Great work on estimating heritability using sibling relatedness variation (estimated using my software package snipar). Surprisingly low h2 for education and high h2 for IQ (with large SE). Give it a read!
Reposted by Alex Strudwick Young
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
April 28, 2025 at 4:18 PM
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
Reposted by Alex Strudwick Young
A great opportunity to work with @alextisyoung.bsky.social if you're interested in methods development!
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
April 29, 2025 at 8:51 AM
A great opportunity to work with @alextisyoung.bsky.social if you're interested in methods development!
Reposted by Alex Strudwick Young
🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data.
Check it out 👇. It is very cool!
geneticscores.org
It is linked with the @pgscatalog.bsky.social
This was supported by INTERVENE
Check it out 👇. It is very cool!
geneticscores.org
It is linked with the @pgscatalog.bsky.social
This was supported by INTERVENE
GeneticScores.org
GeneticScores.org provides tools and data to help AI developers and human health researchers make better polygenic scores
geneticscores.org
April 28, 2025 at 11:31 AM
🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data.
Check it out 👇. It is very cool!
geneticscores.org
It is linked with the @pgscatalog.bsky.social
This was supported by INTERVENE
Check it out 👇. It is very cool!
geneticscores.org
It is linked with the @pgscatalog.bsky.social
This was supported by INTERVENE
Reposted by Alex Strudwick Young
Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.
2025 Human Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.
www.grc.org
April 24, 2025 at 2:31 PM
Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
April 28, 2025 at 4:18 PM
I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!
Reposted by Alex Strudwick Young
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
December 20, 2024 at 11:18 AM
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
Reposted by Alex Strudwick Young
Our UU colleague Wes Sundquist won the 2024 Breakthrough of the year! His long-term research into the structure and function of HIV’s capsid protein has led to the development lenacapavir, a game-changing new treatment that is extremely effective at preventing HIV.
www.science.org/content/arti...
www.science.org/content/arti...
Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention
A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access
www.science.org
December 14, 2024 at 1:23 AM
Our UU colleague Wes Sundquist won the 2024 Breakthrough of the year! His long-term research into the structure and function of HIV’s capsid protein has led to the development lenacapavir, a game-changing new treatment that is extremely effective at preventing HIV.
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Alex Strudwick Young
Reposted by Alex Strudwick Young
After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off.
But here's the genome now!
www.biorxiv.org/content/10.1...
But here's the genome now!
www.biorxiv.org/content/10.1...
CGC1, a new reference genome for Caenorhabditis elegans
The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...
www.biorxiv.org
December 6, 2024 at 3:13 PM
After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off.
But here's the genome now!
www.biorxiv.org/content/10.1...
But here's the genome now!
www.biorxiv.org/content/10.1...
Reposted by Alex Strudwick Young
Tumour mutational burden: clinical utility, challenges and emerging improvements
Tumour mutational burden: clinical utility, challenges and emerging improvements - Nature Reviews Clinical Oncology
Tumour mutational burden (TMB), reflecting the number of mutations present in the DNA of a tumour, is a biologically appealing biomarker of a response to immune-checkpoint inhibitors (ICIs). Nonethele...
www.nature.com
November 27, 2024 at 10:24 PM
Tumour mutational burden: clinical utility, challenges and emerging improvements
Great to see this paper out in Nature today!
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
a couple of cartoon characters standing next to each other with one wearing a purple earring
Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring
media.tenor.com
November 21, 2024 at 3:46 PM
Great to see this paper out in Nature today!
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
Reposted by Alex Strudwick Young
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
a couple of cartoon characters standing next to each other with one wearing a purple earring
Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring
media.tenor.com
November 20, 2024 at 4:03 PM
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Reposted by Alex Strudwick Young
Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals #icanhazpdf? www.nature.com/articles/s41...
Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals - Nature Human Behaviour
In 394,005 UK individuals with exome sequencing data, Wu et al. find 56 neuroticism-associated genes (18 novel) and quantify the heritability explained by rare coding variants, highlighting the associ...
www.nature.com
November 18, 2024 at 1:16 PM
Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals #icanhazpdf? www.nature.com/articles/s41...
Reposted by Alex Strudwick Young
Check out this University of Colorado newsletter that describes work being done by IBG faculty member @dangustavson.bsky.social using the VETSA twin dataset to examine genetic and environmental influences on cognitive decline. www.colorado.edu/asmagazine/2...
Detecting cognitive decline before its symptoms start
In his research on the brain, Daniel Gustavson looks for clues about when cognitive decline beginsAccording to Daniel Gustavson, assistant research professor in
www.colorado.edu
November 15, 2024 at 8:56 PM
Check out this University of Colorado newsletter that describes work being done by IBG faculty member @dangustavson.bsky.social using the VETSA twin dataset to examine genetic and environmental influences on cognitive decline. www.colorado.edu/asmagazine/2...
Reposted by Alex Strudwick Young
I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience.
Details here:
www.findaphd.com/phds/project...
Details here:
www.findaphd.com/phds/project...
New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath on FindAPhD.com
PhD Project - New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 11, 2024 at 2:23 PM
I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience.
Details here:
www.findaphd.com/phds/project...
Details here:
www.findaphd.com/phds/project...
Reposted by Alex Strudwick Young
Review: Inference and applications of ancestral recombination graphs https://www.nature.com/articles/s41576-024-00772-4 (read free: https://rdcu.be/dVyQH) 🧬🖥️
September 30, 2024 at 11:18 AM
Review: Inference and applications of ancestral recombination graphs https://www.nature.com/articles/s41576-024-00772-4 (read free: https://rdcu.be/dVyQH) 🧬🖥️
Reposted by Alex Strudwick Young
Perhaps this has not been said yet here:
Include figures and legends in the manuscript along with the text. Otherwise, I may not read your preprint. If I have to review it without them, I’ll be starting off on the wrong foot. I love science, but don’t make me angry.
Include figures and legends in the manuscript along with the text. Otherwise, I may not read your preprint. If I have to review it without them, I’ll be starting off on the wrong foot. I love science, but don’t make me angry.
September 30, 2024 at 2:52 PM
Perhaps this has not been said yet here:
Include figures and legends in the manuscript along with the text. Otherwise, I may not read your preprint. If I have to review it without them, I’ll be starting off on the wrong foot. I love science, but don’t make me angry.
Include figures and legends in the manuscript along with the text. Otherwise, I may not read your preprint. If I have to review it without them, I’ll be starting off on the wrong foot. I love science, but don’t make me angry.
Reposted by Alex Strudwick Young
🚨IBG is hiring for a Tenure Track Assistant Professor! Candidates should have a background in neurogenetics, high-content genomics, experience with iPSC-derived neurons and glia and neural organoids, and expertise in neurodegeneration. More details here:
jobs.colorado.edu/jobs/JobDeta...
jobs.colorado.edu/jobs/JobDeta...
Tenure Track Assistant Professorship focused on Neurodegeneration at the Institute for Behavioral Genetics
jobs.colorado.edu
September 30, 2024 at 5:43 PM
🚨IBG is hiring for a Tenure Track Assistant Professor! Candidates should have a background in neurogenetics, high-content genomics, experience with iPSC-derived neurons and glia and neural organoids, and expertise in neurodegeneration. More details here:
jobs.colorado.edu/jobs/JobDeta...
jobs.colorado.edu/jobs/JobDeta...