Emilie Wigdor
@emiliewigdor.bsky.social
Postdoc in neurogenetics | Sanders Lab at University of Oxford and IDRM
Pinned
Emilie Wigdor
@emiliewigdor.bsky.social
· Nov 20
a couple of cartoon characters standing next to each other with one wearing a purple earring
Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring
media.tenor.com
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Reposted by Emilie Wigdor
New paper on everyone’s favourite topic, QC!
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
Genotype-level quality control substantially reduces error rates in population-scale whole-genome sequencing
Population-scale whole-genome sequencing data will contain many individual-level genotype errors, even after allele-level quality control (QC). We establish the need for genotype-level QC using UK Bio...
www.biorxiv.org
November 8, 2025 at 9:31 AM
New paper on everyone’s favourite topic, QC!
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
Reposted by Emilie Wigdor
🚀 Very excited to share the first major work from my PhD!!
We combined MPRA and CRISPRa in excitatory neurons to test and validate cis-regulation therapies for hundreds of haploinsufficient neurodevelopmental disorder genes. 🧬🔬
www.biorxiv.org/content/10.1...
We combined MPRA and CRISPRa in excitatory neurons to test and validate cis-regulation therapies for hundreds of haploinsufficient neurodevelopmental disorder genes. 🧬🔬
www.biorxiv.org/content/10.1...
November 6, 2025 at 11:57 PM
🚀 Very excited to share the first major work from my PhD!!
We combined MPRA and CRISPRa in excitatory neurons to test and validate cis-regulation therapies for hundreds of haploinsufficient neurodevelopmental disorder genes. 🧬🔬
www.biorxiv.org/content/10.1...
We combined MPRA and CRISPRa in excitatory neurons to test and validate cis-regulation therapies for hundreds of haploinsufficient neurodevelopmental disorder genes. 🧬🔬
www.biorxiv.org/content/10.1...
Reposted by Emilie Wigdor
Read about our recent paper here: www.bdi.ox.ac.uk/news/first-d...
First direct evidence links gene to fat storage, hinting at new obesity therapies
A new study, involving researchers at the Big Data Institute, has shown for the first time that a little-known gene, SLTM, plays a direct role in how fat is stored inside human cells. While large popu...
www.bdi.ox.ac.uk
September 4, 2025 at 5:15 PM
Read about our recent paper here: www.bdi.ox.ac.uk/news/first-d...
Reposted by Emilie Wigdor
✨ NEW PUBLICATION ✨
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution
Overall and tissue-specific fat accumulation are associated with altered risk of cardiometabolic
disease and mortality. By combining exome-wide association analysis of traits related
to obesity and fa...
www.cell.com
September 4, 2025 at 3:21 PM
✨ NEW PUBLICATION ✨
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
New app deadline August 1st 📣
If you're interested in human genetics, stats, big data, and/or ML, this is in an incredible opportunity 🧬💻
✨Fully funded ✨ PhD at Oxford with @astheeggeggs.bsky.social, available to international students 🌎🌍🌏, embedded in the new and exciting SMARTBiomed Centre 🤩
If you're interested in human genetics, stats, big data, and/or ML, this is in an incredible opportunity 🧬💻
✨Fully funded ✨ PhD at Oxford with @astheeggeggs.bsky.social, available to international students 🌎🌍🌏, embedded in the new and exciting SMARTBiomed Centre 🤩
Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford.
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!
Research Studentships | statistics
bit.ly
July 21, 2025 at 10:31 AM
New app deadline August 1st 📣
If you're interested in human genetics, stats, big data, and/or ML, this is in an incredible opportunity 🧬💻
✨Fully funded ✨ PhD at Oxford with @astheeggeggs.bsky.social, available to international students 🌎🌍🌏, embedded in the new and exciting SMARTBiomed Centre 🤩
If you're interested in human genetics, stats, big data, and/or ML, this is in an incredible opportunity 🧬💻
✨Fully funded ✨ PhD at Oxford with @astheeggeggs.bsky.social, available to international students 🌎🌍🌏, embedded in the new and exciting SMARTBiomed Centre 🤩
Incredible opportunity for international and domestic students to do a PhD in stat gen at Oxford in a dynamic, engaging, fun and supportive environment! 🤩🧬🎓
Apply by June 30th for an October 2025 start!
Apply by June 30th for an October 2025 start!
Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford.
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!
Research Studentships | statistics
bit.ly
June 11, 2025 at 7:47 PM
Incredible opportunity for international and domestic students to do a PhD in stat gen at Oxford in a dynamic, engaging, fun and supportive environment! 🤩🧬🎓
Apply by June 30th for an October 2025 start!
Apply by June 30th for an October 2025 start!
Reposted by Emilie Wigdor
Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
www.nature.com
May 7, 2025 at 4:30 PM
Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n
Reposted by Emilie Wigdor
Very excited about this important piece of work with @angelicaronald.bsky.social characterising gene associations with age of walking onset. We also show using dHCP data that these are related to volume in key brain motor regions (like the deep grey nuclei and cerebellum) even as a newborn infant
Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
www.nature.com
May 8, 2025 at 6:07 AM
Very excited about this important piece of work with @angelicaronald.bsky.social characterising gene associations with age of walking onset. We also show using dHCP data that these are related to volume in key brain motor regions (like the deep grey nuclei and cerebellum) even as a newborn infant
Reposted by Emilie Wigdor
We have two vacancies for Junior Research Fellows to join the CPM team next academic year. Please repost and send to anyone who might be interested. shorturl.at/DOV5s
April 30, 2025 at 10:00 AM
We have two vacancies for Junior Research Fellows to join the CPM team next academic year. Please repost and send to anyone who might be interested. shorturl.at/DOV5s
Reposted by Emilie Wigdor
Delighted to share that the revised version of this work on the genetic basis of infertility is now out in @naturegenet.bsky.social ! Give it a read and let us know what you think - rdcu.be/ehEgG 🧬💻
April 14, 2025 at 12:41 PM
Delighted to share that the revised version of this work on the genetic basis of infertility is now out in @naturegenet.bsky.social ! Give it a read and let us know what you think - rdcu.be/ehEgG 🧬💻
Reposted by Emilie Wigdor
This is going to be a great lecture, do come along to the Sheldonian this afternoon to hear @philipcball.bsky.social
There's just 1 week to go until our Annual Lecture from @philipcball.bsky.social at the Sheldonian Theatre, 'How life works: Dealing with biology’s changing narrative'.
All welcome! You can register here: cpm.ox.ac.uk/event/cpm-an...
All welcome! You can register here: cpm.ox.ac.uk/event/cpm-an...
February 13, 2025 at 1:57 PM
This is going to be a great lecture, do come along to the Sheldonian this afternoon to hear @philipcball.bsky.social
Reposted by Emilie Wigdor
I’m racing a Half Ironman triathlon this June. 2km swim, 90km cycle, 20km run and raising money for the Meningitis Research Foundation.
Meningitis has ~2.5 million cases and 250,000 deaths annually predominantly among children. Any donation would be great!
gofund.me/a958252f
Meningitis has ~2.5 million cases and 250,000 deaths annually predominantly among children. Any donation would be great!
gofund.me/a958252f
Donate to Half Iron(wo)man for Meningitis Research, organized by Sophie Belman
I will be racing my first Half Ironman triathlon in Zurich this June. It includ… Sophie Belman needs your support for Half Iron(wo)man for Meningitis Research
gofund.me
February 9, 2025 at 7:29 PM
I’m racing a Half Ironman triathlon this June. 2km swim, 90km cycle, 20km run and raising money for the Meningitis Research Foundation.
Meningitis has ~2.5 million cases and 250,000 deaths annually predominantly among children. Any donation would be great!
gofund.me/a958252f
Meningitis has ~2.5 million cases and 250,000 deaths annually predominantly among children. Any donation would be great!
gofund.me/a958252f
Reposted by Emilie Wigdor
V. pleased to see this work out — huge effort from 10s of analysts, 100s of scientists, 1000000s of participants. 🤞 a key resource in future MDD research.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
January 14, 2025 at 5:59 PM
V. pleased to see this work out — huge effort from 10s of analysts, 100s of scientists, 1000000s of participants. 🤞 a key resource in future MDD research.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
Reposted by Emilie Wigdor
Ever get lost searching through genetic literature? We've built a new interface for bioRxiv+medRxiv to directly browse preprint findings on the genome! (1/N)
Try genorxiv: sitlabs.org/genorxiv
Try genorxiv: sitlabs.org/genorxiv
December 18, 2024 at 4:56 PM
Ever get lost searching through genetic literature? We've built a new interface for bioRxiv+medRxiv to directly browse preprint findings on the genome! (1/N)
Try genorxiv: sitlabs.org/genorxiv
Try genorxiv: sitlabs.org/genorxiv
Reposted by Emilie Wigdor
Meet Michael Griffiths, our most recent featured member.
Currently a Data Manager in the Sanders Group, Michael's varied career includes writing code on research vessels around the world to help understand the effects of oceans on the climate.
Find out more here: lnkd.in/erJXmd6k
Currently a Data Manager in the Sanders Group, Michael's varied career includes writing code on research vessels around the world to help understand the effects of oceans on the climate.
Find out more here: lnkd.in/erJXmd6k
November 25, 2024 at 12:31 PM
Meet Michael Griffiths, our most recent featured member.
Currently a Data Manager in the Sanders Group, Michael's varied career includes writing code on research vessels around the world to help understand the effects of oceans on the climate.
Find out more here: lnkd.in/erJXmd6k
Currently a Data Manager in the Sanders Group, Michael's varied career includes writing code on research vessels around the world to help understand the effects of oceans on the climate.
Find out more here: lnkd.in/erJXmd6k
Reposted by Emilie Wigdor
📢 Huge News! 📢
The MRC has launched two centres of research excellence to transform gene therapies: IDRM’s Paul Riley will co-direct the MRC/BHF CoRE in Advanced Cardiac Therapies & Stephan Sanders will direct the MRC CoRE in Therapeutic Genomics.
Read more: lnkd.in/g-3CmAsP
#GeneTherapies
The MRC has launched two centres of research excellence to transform gene therapies: IDRM’s Paul Riley will co-direct the MRC/BHF CoRE in Advanced Cardiac Therapies & Stephan Sanders will direct the MRC CoRE in Therapeutic Genomics.
Read more: lnkd.in/g-3CmAsP
#GeneTherapies
December 11, 2024 at 10:40 AM
📢 Huge News! 📢
The MRC has launched two centres of research excellence to transform gene therapies: IDRM’s Paul Riley will co-direct the MRC/BHF CoRE in Advanced Cardiac Therapies & Stephan Sanders will direct the MRC CoRE in Therapeutic Genomics.
Read more: lnkd.in/g-3CmAsP
#GeneTherapies
The MRC has launched two centres of research excellence to transform gene therapies: IDRM’s Paul Riley will co-direct the MRC/BHF CoRE in Advanced Cardiac Therapies & Stephan Sanders will direct the MRC CoRE in Therapeutic Genomics.
Read more: lnkd.in/g-3CmAsP
#GeneTherapies
Reposted by Emilie Wigdor
November 26, 2024 at 3:18 PM
Reposted by Emilie Wigdor
Congratulations to @nickywhiffin.bsky.social on being awarded the Balfour Lecturer! Her innovative contributions on the role of genetic variants in rare diseases are shaping the future of research and discovery. We look forward to her inspiring lecture!
genetics.org.uk/medals-and-p...
genetics.org.uk/medals-and-p...
November 22, 2024 at 11:10 AM
Congratulations to @nickywhiffin.bsky.social on being awarded the Balfour Lecturer! Her innovative contributions on the role of genetic variants in rare diseases are shaping the future of research and discovery. We look forward to her inspiring lecture!
genetics.org.uk/medals-and-p...
genetics.org.uk/medals-and-p...
Reposted by Emilie Wigdor
Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
Congratulations to @nickywhiffin.bsky.social on being awarded the Balfour Lecturer! Her innovative contributions on the role of genetic variants in rare diseases are shaping the future of research and discovery. We look forward to her inspiring lecture!
genetics.org.uk/medals-and-p...
genetics.org.uk/medals-and-p...
November 22, 2024 at 11:46 AM
Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
Reposted by Emilie Wigdor
Common variants don’t contribute to rare diseases, right? Wrong! Wonderful work published in Nature by @hilarycmartin.bsky.social, Qinqin Huang, @emiliewigdor.bsky.social and others in the Human Genetics Programme at Sanger showing that common vars contribute to rare neurodevelopmental diseases.
My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.
November 22, 2024 at 10:19 AM
Common variants don’t contribute to rare diseases, right? Wrong! Wonderful work published in Nature by @hilarycmartin.bsky.social, Qinqin Huang, @emiliewigdor.bsky.social and others in the Human Genetics Programme at Sanger showing that common vars contribute to rare neurodevelopmental diseases.
Reposted by Emilie Wigdor
Great to see this paper out in Nature today!
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
a couple of cartoon characters standing next to each other with one wearing a purple earring
Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring
media.tenor.com
November 21, 2024 at 3:46 PM
Great to see this paper out in Nature today!
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.
Reposted by Emilie Wigdor
Common genetic variants contribute more to rare diseases than previously thought www.nature.com/articles/d41... (note that the converse is also true!!!)
Common genetic variants contribute more to rare diseases than previously thought
Assessing the influence of common mutations on rare disease risk.
www.nature.com
November 21, 2024 at 9:40 AM
Common genetic variants contribute more to rare diseases than previously thought www.nature.com/articles/d41... (note that the converse is also true!!!)
Reposted by Emilie Wigdor
This was an important new step in making scientific research findings more accessible to the people whose data was powering the discoveries 🏆 It takes time, but it's so valuable for all involved. Bravo!
This paper covers concepts that aren’t usually discussed in the context of rare (single-gene) conditions. We included EasyRead and lay summaries, as well as an FAQ—written with input from patients and families. Find them in Supplementary Note 1!
November 20, 2024 at 5:29 PM
This was an important new step in making scientific research findings more accessible to the people whose data was powering the discoveries 🏆 It takes time, but it's so valuable for all involved. Bravo!
Reposted by Emilie Wigdor
I'm here now! Excited to share our latest research published in @Nature 🎉 Huge thanks to my amazing supervisor @hilsomartin and co-first @EmilieWigdor for their incredible support!
My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.
November 21, 2024 at 5:45 AM
I'm here now! Excited to share our latest research published in @Nature 🎉 Huge thanks to my amazing supervisor @hilsomartin and co-first @EmilieWigdor for their incredible support!