Nik Baya
@nbaya.bsky.social
Postdoc in Samocha Lab at MGH and Broad Institute. Oxford PhD in Genomic Medicine and Statistics. Passionate about using data science to improve global public health.
Why do some individuals defy their polygenic score?
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
January 6, 2026 at 6:31 PM
Why do some individuals defy their polygenic score?
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
Read about our recent paper here: www.bdi.ox.ac.uk/news/first-d...
First direct evidence links gene to fat storage, hinting at new obesity therapies
A new study, involving researchers at the Big Data Institute, has shown for the first time that a little-known gene, SLTM, plays a direct role in how fat is stored inside human cells. While large popu...
www.bdi.ox.ac.uk
September 4, 2025 at 5:15 PM
Read about our recent paper here: www.bdi.ox.ac.uk/news/first-d...
✨ NEW PUBLICATION ✨
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution
Overall and tissue-specific fat accumulation are associated with altered risk of cardiometabolic
disease and mortality. By combining exome-wide association analysis of traits related
to obesity and fa...
www.cell.com
September 4, 2025 at 3:21 PM
✨ NEW PUBLICATION ✨
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
Check out this PhD opportunity to work with a great supervisor at Oxford! 🌟
Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford.
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!
More info here: bit.ly/biomedDPhil
🗓️ App deadline: June 30th 2025.
Please share!
Research Studentships | statistics
bit.ly
June 9, 2025 at 2:00 PM
Check out this PhD opportunity to work with a great supervisor at Oxford! 🌟
So excited to give a talk at #ESHG2025! ✨
I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants.
This has implications for:
- Screening of rare disorders 🔎
- Target discovery 💊
- Improving trait prediction 📈
I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants.
This has implications for:
- Screening of rare disorders 🔎
- Target discovery 💊
- Improving trait prediction 📈
May 26, 2025 at 2:33 PM
So excited to give a talk at #ESHG2025! ✨
I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants.
This has implications for:
- Screening of rare disorders 🔎
- Target discovery 💊
- Improving trait prediction 📈
I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants.
This has implications for:
- Screening of rare disorders 🔎
- Target discovery 💊
- Improving trait prediction 📈