We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation.
Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...
More info here: bit.ly/biomedDPhil
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I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants.
This has implications for:
- Screening of rare disorders 🔎
- Target discovery 💊
- Improving trait prediction 📈
I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants.
This has implications for:
- Screening of rare disorders 🔎
- Target discovery 💊
- Improving trait prediction 📈