Erich M. Schwarz
@erichmschwarz.bsky.social
Molecular biologist using functional genomics. Started with C. elegans, then diversified.
Reposted by Erich M. Schwarz
!
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades | PNAS
Rates of phenotypic evolution vary across traits, and these evolutionary patterns
themselves evolve. Understanding how development contributes to s...
www.pnas.org
August 23, 2025 at 1:47 PM
!
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes.
genome.cshlp.org/content/35/8...
genome.cshlp.org/content/35/8...
August 1, 2025 at 9:55 PM
After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes.
genome.cshlp.org/content/35/8...
genome.cshlp.org/content/35/8...
Like many others, I'm unable to reach nih.gov on the Web. Moreover, the FTP site for NCBI (ftp.ncbi.nlm.nih.gov) also seems to be unreachable. First time I've seen this in decades.
National Institutes of Health (NIH)
Official website of the National Institutes of Health (NIH). NIH is one of the world's foremost medical research centers. An agency of the U.S. Department of Health and Human Services, the NIH is the ...
nih.gov
March 1, 2025 at 11:14 PM
Like many others, I'm unable to reach nih.gov on the Web. Moreover, the FTP site for NCBI (ftp.ncbi.nlm.nih.gov) also seems to be unreachable. First time I've seen this in decades.
Finally got this preprinted:
"...immunoregulation was observed primarily in mature adult hookworm intestine directly exposed to host blood; it may include hookworm genes activated in response to the host immune system in order to neutralize the host immune system."
www.biorxiv.org/content/10.1...
"...immunoregulation was observed primarily in mature adult hookworm intestine directly exposed to host blood; it may include hookworm genes activated in response to the host immune system in order to neutralize the host immune system."
www.biorxiv.org/content/10.1...
Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host’s immune system
Hookworms are intestinal parasitic nematodes that chronically infect ∼500 million people, with reinfection common even after clearance by drugs. How infecting hookworms successfully overcome host prot...
www.biorxiv.org
February 5, 2025 at 4:48 PM
Finally got this preprinted:
"...immunoregulation was observed primarily in mature adult hookworm intestine directly exposed to host blood; it may include hookworm genes activated in response to the host immune system in order to neutralize the host immune system."
www.biorxiv.org/content/10.1...
"...immunoregulation was observed primarily in mature adult hookworm intestine directly exposed to host blood; it may include hookworm genes activated in response to the host immune system in order to neutralize the host immune system."
www.biorxiv.org/content/10.1...
Reposted by Erich M. Schwarz
I just realized there was a new canu release, and its the last one:
"""
Goodbye.
Do not expect another release. This is it, folks. The sequencing technology has moved on and Canu is all but obsolete now. Thanks for all the feedback, citations and bug reports.
"""
🧬🖥️🦠
"""
Goodbye.
Do not expect another release. This is it, folks. The sequencing technology has moved on and Canu is all but obsolete now. Thanks for all the feedback, citations and bug reports.
"""
🧬🖥️🦠
Release Canu v2.3 · marbl/canu
These are release notes for Canu version 2.3, which was released on December 17th, 2024. Canu is specialized for assembly of single-molecule sequences. Full documentation can be found at http://can...
github.com
December 19, 2024 at 6:21 PM
I just realized there was a new canu release, and its the last one:
"""
Goodbye.
Do not expect another release. This is it, folks. The sequencing technology has moved on and Canu is all but obsolete now. Thanks for all the feedback, citations and bug reports.
"""
🧬🖥️🦠
"""
Goodbye.
Do not expect another release. This is it, folks. The sequencing technology has moved on and Canu is all but obsolete now. Thanks for all the feedback, citations and bug reports.
"""
🧬🖥️🦠
"...self-fertility not only required mutations that activated the spermatogenesis program in XX germ lines, but prior to these there must have been mutations that decanalized the sex-determination process, allowing for subsequent changes to germ cell fates."
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
December 20, 2024 at 5:28 AM
"...self-fertility not only required mutations that activated the spermatogenesis program in XX germ lines, but prior to these there must have been mutations that decanalized the sex-determination process, allowing for subsequent changes to germ cell fates."
academic.oup.com/genetics/adv...
academic.oup.com/genetics/adv...
"...active development of WormBase ParaSite is temporarily on hold, due to a break in funding, and are currently unable to load new datasets." Not good news for anybody analyzing any worm genome, outside of a small set of C. elegans-adjacent nematode species.
wbparasite.wordpress.com/2024/12/12/t...
wbparasite.wordpress.com/2024/12/12/t...
Temporary break in service
We are sorry to announce that active development of WormBase ParaSite is temporarily on hold, due to a break in funding, and are currently unable to load new datasets. We remain committed to our go…
wbparasite.wordpress.com
December 17, 2024 at 7:08 PM
"...active development of WormBase ParaSite is temporarily on hold, due to a break in funding, and are currently unable to load new datasets." Not good news for anybody analyzing any worm genome, outside of a small set of C. elegans-adjacent nematode species.
wbparasite.wordpress.com/2024/12/12/t...
wbparasite.wordpress.com/2024/12/12/t...
After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off.
But here's the genome now!
www.biorxiv.org/content/10.1...
But here's the genome now!
www.biorxiv.org/content/10.1...
CGC1, a new reference genome for Caenorhabditis elegans
The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...
www.biorxiv.org
December 6, 2024 at 3:13 PM
After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off.
But here's the genome now!
www.biorxiv.org/content/10.1...
But here's the genome now!
www.biorxiv.org/content/10.1...