Alex Strudwick Young
alextisyoung.bsky.social
Alex Strudwick Young
@alextisyoung.bsky.social
Asst. Prof. @ UCLA Human Genetics. Statistical geneticist & part of the SSGAC. Mendelian inheritance is the most important natural experiment. alextisyoung.github.io
Yeah isn't this exactly what one would expect and similar to things like bmi?
December 17, 2024 at 6:17 AM
I see. Well yes but it might be tricky because inherited variants would tend to have smaller effect sizes than de novos independently of assortment.
November 22, 2024 at 12:14 AM
I'm not sure why assortment would affect this?
November 21, 2024 at 8:28 PM
When there is assortment, common and rare variant contributions will become correlated and this needs to be taken into account when analyzing either.
November 21, 2024 at 3:46 PM
This paper provides the first direct evidence of this by showing a surprisingly large correlation between the common variant education polygenic score and a rare variant burden score.
November 21, 2024 at 3:46 PM
It's possible that this is because the parents' genetics affect the offspring through the env but it could be assortment: parents with lower education polygenic scores based on common variants are more likely to mate with individuals with rare variants that cause neurodevelopmental conditions.
November 21, 2024 at 3:46 PM