Alessio Vagnoni
@alessiovagnoni.bsky.social
Cell biologist. Interested in neurons, intracellular trafficking, ageing, and other things. Posting mainly about science.
www.vagnonilab.com
www.vagnonilab.com
Reposted by Alessio Vagnoni
Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...
Global 3Rs Winners
LEARN MORE / APPLY 2025 Award Winners ASIA-PACIFIC Bing Zhou, Ph.D., M.D. “Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11” Cell Metabolism Sha
www.aaalac.org
November 14, 2025 at 12:40 PM
Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...
We have a postdoctoral position available in the lab europeandrosophilasociety.org/job/postdoct.... Get in touch if interested!
Postdoctoral position at MIA, Coimbra, Portugal | European Drosophila Society
europeandrosophilasociety.org
September 13, 2025 at 9:35 PM
We have a postdoctoral position available in the lab europeandrosophilasociety.org/job/postdoct.... Get in touch if interested!
Reposted by Alessio Vagnoni
1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇
July 22, 2025 at 3:19 PM
1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇
Reposted by Alessio Vagnoni
Our BBSRC CircadiAgeing sLola project launches today with
@hughp.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @mbra3.bsky.social @alessiovagnoni.bsky.social studying clock excitability, circadian rhythms and healthy ageing
circadiageing.blogs.bristol.ac.uk
@hughp.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @mbra3.bsky.social @alessiovagnoni.bsky.social studying clock excitability, circadian rhythms and healthy ageing
circadiageing.blogs.bristol.ac.uk
July 1, 2025 at 5:01 PM
Our BBSRC CircadiAgeing sLola project launches today with
@hughp.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @mbra3.bsky.social @alessiovagnoni.bsky.social studying clock excitability, circadian rhythms and healthy ageing
circadiageing.blogs.bristol.ac.uk
@hughp.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @mbra3.bsky.social @alessiovagnoni.bsky.social studying clock excitability, circadian rhythms and healthy ageing
circadiageing.blogs.bristol.ac.uk
Reposted by Alessio Vagnoni
The CircadiAgeing project explores how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues.
circadiageing.blogs.bristol.ac.uk
circadiageing.blogs.bristol.ac.uk
Circadiageing | Clock excitability, circadian rhythms and healthy ageing
circadiageing.blogs.bristol.ac.uk
June 30, 2025 at 1:28 PM
The CircadiAgeing project explores how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues.
circadiageing.blogs.bristol.ac.uk
circadiageing.blogs.bristol.ac.uk
Reposted by Alessio Vagnoni
VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.
FlyBase Homepage
FlyBase: a database for drosophila genetics and molecular biology
flybase.org
June 12, 2025 at 1:45 PM
VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.
Reposted by Alessio Vagnoni
Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.sciencedirect.com/science/arti...
@dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging
www.sciencedirect.com/science/arti...
@dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging
May 30, 2025 at 12:34 PM
Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.sciencedirect.com/science/arti...
@dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging
www.sciencedirect.com/science/arti...
@dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging
Reposted by Alessio Vagnoni
The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
www.nature.com
March 27, 2025 at 9:08 AM
The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
Reposted by Alessio Vagnoni
Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence https://www.biorxiv.org/content/10.1101/2025.03.31.646469v1
April 1, 2025 at 4:31 PM
Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence https://www.biorxiv.org/content/10.1101/2025.03.31.646469v1
www.nature.com/articles/s41...
Fun collab with T.Calì&M.Brini, led by postdoc Lucia Barazzuol and supported by Tatiana Tykhonenko and PhD student Tia Griffiths @kingsioppn.bsky.social @wohlmicroscopy.bsky.social @nc3rs.bsky.social
Fun collab with T.Calì&M.Brini, led by postdoc Lucia Barazzuol and supported by Tatiana Tykhonenko and PhD student Tia Griffiths @kingsioppn.bsky.social @wohlmicroscopy.bsky.social @nc3rs.bsky.social
Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters - Cell Death & Disease
Cell Death & Disease - Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters
www.nature.com
March 28, 2025 at 12:24 AM
www.nature.com/articles/s41...
Fun collab with T.Calì&M.Brini, led by postdoc Lucia Barazzuol and supported by Tatiana Tykhonenko and PhD student Tia Griffiths @kingsioppn.bsky.social @wohlmicroscopy.bsky.social @nc3rs.bsky.social
Fun collab with T.Calì&M.Brini, led by postdoc Lucia Barazzuol and supported by Tatiana Tykhonenko and PhD student Tia Griffiths @kingsioppn.bsky.social @wohlmicroscopy.bsky.social @nc3rs.bsky.social
Reposted by Alessio Vagnoni
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology
Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...
www.nature.com
March 26, 2025 at 1:56 PM
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alessio Vagnoni
Drosophila larval motor neurons labelled with GFP (green) showing activated ATF4 expression (magenta) due to knockdown of the mitochondrial complex I subunit NDUFS1 #FluorescenceFriday
Imaged by @batemanlab.bsky.social
Imaged by @batemanlab.bsky.social
March 7, 2025 at 2:58 PM
Drosophila larval motor neurons labelled with GFP (green) showing activated ATF4 expression (magenta) due to knockdown of the mitochondrial complex I subunit NDUFS1 #FluorescenceFriday
Imaged by @batemanlab.bsky.social
Imaged by @batemanlab.bsky.social
Reposted by Alessio Vagnoni
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites - Nature Communications
Protein-mediated transport is implicated in trafficking fatty acids at contact sites of lipid droplets and mitochondria. Here, the authors use proteomics to catalogue the proteins at this contact site...
www.nature.com
March 3, 2025 at 3:51 PM
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alessio Vagnoni
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
March 3, 2025 at 3:55 PM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
imAGEin: one-in-a-kind 2Y Erasmus Mundus Joint Master @euerasmusplus.bsky.social on the Biology of #ageing. shorturl.at/n4jsd Partners: @ucoimbra.bsky.social @sorbonne-universite.fr @univcotedazur.bsky.social @unisevilla.bsky.social @unicologne.bsky.social. 15 scholarships available to cover costs.
imAGEin Programme - Life
life.univ-cotedazur.eu
February 4, 2025 at 6:58 AM
imAGEin: one-in-a-kind 2Y Erasmus Mundus Joint Master @euerasmusplus.bsky.social on the Biology of #ageing. shorturl.at/n4jsd Partners: @ucoimbra.bsky.social @sorbonne-universite.fr @univcotedazur.bsky.social @unisevilla.bsky.social @unicologne.bsky.social. 15 scholarships available to cover costs.
Reposted by Alessio Vagnoni
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
February 2, 2025 at 8:47 AM
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
www.biorxiv.org/content/10.1...
Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.
@uclqsion.bsky.social #aging
Reposted by Alessio Vagnoni
Do you want to hear the latest and greatest about the neuronal cytoskeleton? Join us in Chile next April for #NeuroCyto2025, organized by @monicamsousa.bsky.social, Kassandra Ori-McKenney and Tomás Falzone! Registration is open until March 5: neurocytoskeleton.com/2025/
January 12, 2025 at 2:57 PM
Do you want to hear the latest and greatest about the neuronal cytoskeleton? Join us in Chile next April for #NeuroCyto2025, organized by @monicamsousa.bsky.social, Kassandra Ori-McKenney and Tomás Falzone! Registration is open until March 5: neurocytoskeleton.com/2025/
Reposted by Alessio Vagnoni
I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF
December 23, 2024 at 4:11 PM
I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF
Reposted by Alessio Vagnoni
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alessio Vagnoni
Announcing award of our 5 year BBSRC sLola CircadiAgeing: clock excitability, circadian rhythms & healthy ageing grant with @hughp.bsky.social @MeganGJackson @mbra3.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @alessiovagnoni.bsky.social Edgar Buhl
bristol.ac.uk/news/2024/de...
bristol.ac.uk/news/2024/de...
December 13, 2024 at 12:08 PM
Announcing award of our 5 year BBSRC sLola CircadiAgeing: clock excitability, circadian rhythms & healthy ageing grant with @hughp.bsky.social @MeganGJackson @mbra3.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @alessiovagnoni.bsky.social Edgar Buhl
bristol.ac.uk/news/2024/de...
bristol.ac.uk/news/2024/de...