Raffaele Sarnataro
@rafsarnataro.bsky.social
Fulford Junior Research Fellow @SomervilleCollege.bsky.social | Sleep(ing) Neuroscientist @ox.ac.uk 🧠 | Alumnus @SNS.it @WellcomeTrust.bsky.social | 🇮🇹🇪🇺
Pinned
1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇
Reposted by Raffaele Sarnataro
Presynaptic Release Probability Determines the Need for Sleep https://www.biorxiv.org/content/10.1101/2025.10.16.682770v1
October 16, 2025 at 8:15 PM
Presynaptic Release Probability Determines the Need for Sleep https://www.biorxiv.org/content/10.1101/2025.10.16.682770v1
Reposted by Raffaele Sarnataro
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 4:17 PM
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
Reposted by Raffaele Sarnataro
Sleep might be an “inescapable consequence” of aerobic metabolism, new findings in fruit flies suggest.
By @vcallier.bsky.social
#neuroskyence
www.thetransmitter.org/sleep/mitoch...
By @vcallier.bsky.social
#neuroskyence
www.thetransmitter.org/sleep/mitoch...
Mitochondria set ‘ancient’ metabolic thermostat for sleep in flies, separate from circadian rhythms
During waking hours, a specialized set of sleep neurons in the fly brain accumulates reactive oxygen species, which eventually trigger sleep to clean up and repair the damage they do.
www.thetransmitter.org
September 9, 2025 at 1:49 PM
Sleep might be an “inescapable consequence” of aerobic metabolism, new findings in fruit flies suggest.
By @vcallier.bsky.social
#neuroskyence
www.thetransmitter.org/sleep/mitoch...
By @vcallier.bsky.social
#neuroskyence
www.thetransmitter.org/sleep/mitoch...
Reposted by Raffaele Sarnataro
✨ Now out in Biomedical Optics Express: Cleared tissue dual-view oblique plane microscopy 🔬: doi.org/10.1364/BOE.... (🧵1/6)
Optica Publishing Group
doi.org
September 2, 2025 at 10:57 PM
✨ Now out in Biomedical Optics Express: Cleared tissue dual-view oblique plane microscopy 🔬: doi.org/10.1364/BOE.... (🧵1/6)
Happy to have given a tiny contribution (as tiny as a fly brain!) to this new light-sheet microscopy technology.
Congratulations to @ld-light.bsky.social and the whole team
Congratulations to @ld-light.bsky.social and the whole team
We demonstrate our method on biological samples with a range of RIs, including a whole fly brain 🧠 (imaged in < 3 min⚡) and > 1 cm long mouse bone 🐭🦴 (🧵 5/6).
September 3, 2025 at 9:59 PM
Happy to have given a tiny contribution (as tiny as a fly brain!) to this new light-sheet microscopy technology.
Congratulations to @ld-light.bsky.social and the whole team
Congratulations to @ld-light.bsky.social and the whole team
🚨 What's the interplay between sleep and mitochondrial dynamics in neurons?
I am happy to share this invited review I wrote for The Journal of Physiology
@jphysiol.bsky.social
👉 physoc.onlinelibrary.wiley.com/doi/full/10....
🧵 Thread 👇
#Neuroscience #SleepResearch
I am happy to share this invited review I wrote for The Journal of Physiology
@jphysiol.bsky.social
👉 physoc.onlinelibrary.wiley.com/doi/full/10....
🧵 Thread 👇
#Neuroscience #SleepResearch
Neurobiology of mitochondrial dynamics in sleep
Abstract figure legend In neurons, variations in sleep history are accompanied by alterations in mitochondrial dynamics, including changes in size, fission and fusion events, the emergence of extra-l...
physoc.onlinelibrary.wiley.com
September 2, 2025 at 8:18 AM
🚨 What's the interplay between sleep and mitochondrial dynamics in neurons?
I am happy to share this invited review I wrote for The Journal of Physiology
@jphysiol.bsky.social
👉 physoc.onlinelibrary.wiley.com/doi/full/10....
🧵 Thread 👇
#Neuroscience #SleepResearch
I am happy to share this invited review I wrote for The Journal of Physiology
@jphysiol.bsky.social
👉 physoc.onlinelibrary.wiley.com/doi/full/10....
🧵 Thread 👇
#Neuroscience #SleepResearch
Reposted by Raffaele Sarnataro
Un nuovo studio condotto in D. melanogaster rivela che il bisogno di sonno potrebbe nascere direttamente dal metabolismo dei neuroni. Il sonno, insomma, sarebbe una conseguenza inevitabile della respirazione cellulare
www.scienzainrete.it/articolo/cos...
www.scienzainrete.it/articolo/cos...
A cosa serve il sonno? La risposta può essere nel metabolismo neuronale
Perché dormiamo? La risposta a questa domanda rimane uno dei grandi misteri della biologia. Come scrisse il neurofisiologo Alan Rechtschaffen: «Se il sonno non avesse una funzione assolutamente vitale...
www.scienzainrete.it
August 29, 2025 at 3:43 PM
Un nuovo studio condotto in D. melanogaster rivela che il bisogno di sonno potrebbe nascere direttamente dal metabolismo dei neuroni. Il sonno, insomma, sarebbe una conseguenza inevitabile della respirazione cellulare
www.scienzainrete.it/articolo/cos...
www.scienzainrete.it/articolo/cos...
Reposted by Raffaele Sarnataro
Tired? Well that sleepy feeling may be driven by 'leaky' mitochondria, according to a new study.
I spoke to Gero Miesenboeck from @ox.ac.uk for @nature.com all about the new study.
It's here on the Nature Podcast at 12:11:
I spoke to Gero Miesenboeck from @ox.ac.uk for @nature.com all about the new study.
It's here on the Nature Podcast at 12:11:
‘Stealth flippers’ helped this extinct mega-predator stalk its prey
Hear the biggest stories from the world of science | 16 July 2025
www.nature.com
July 18, 2025 at 2:23 PM
Tired? Well that sleepy feeling may be driven by 'leaky' mitochondria, according to a new study.
I spoke to Gero Miesenboeck from @ox.ac.uk for @nature.com all about the new study.
It's here on the Nature Podcast at 12:11:
I spoke to Gero Miesenboeck from @ox.ac.uk for @nature.com all about the new study.
It's here on the Nature Podcast at 12:11:
Reposted by Raffaele Sarnataro
Congratulations to the SWC Emerging Neuroscientists Seminar Series winners!
- Dimokratis Karamanlis, University of Geneva
- @rafsarnataro.bsky.social & Peter S. Hasenhuetl, @ox.ac.uk
- Saurabh Vyas, @columbiauniversity.bsky.social
- @sblumenstock.bsky.social, University of California San Diego
- Dimokratis Karamanlis, University of Geneva
- @rafsarnataro.bsky.social & Peter S. Hasenhuetl, @ox.ac.uk
- Saurabh Vyas, @columbiauniversity.bsky.social
- @sblumenstock.bsky.social, University of California San Diego
August 8, 2025 at 8:41 AM
Congratulations to the SWC Emerging Neuroscientists Seminar Series winners!
- Dimokratis Karamanlis, University of Geneva
- @rafsarnataro.bsky.social & Peter S. Hasenhuetl, @ox.ac.uk
- Saurabh Vyas, @columbiauniversity.bsky.social
- @sblumenstock.bsky.social, University of California San Diego
- Dimokratis Karamanlis, University of Geneva
- @rafsarnataro.bsky.social & Peter S. Hasenhuetl, @ox.ac.uk
- Saurabh Vyas, @columbiauniversity.bsky.social
- @sblumenstock.bsky.social, University of California San Diego
Reposted by Raffaele Sarnataro
Mitochondria may have been labelled the "energy powerhouses" of cells, but they also seem to have an underappreciated role in sleep.
Our brain's mitochondria may play a crucial role in the onset of sleep
Textbooks say that mitochondria exist to supply cells with energy, but experiments in fruit flies suggest they are also involved in sleep
www.newscientist.com
July 24, 2025 at 3:37 PM
Mitochondria may have been labelled the "energy powerhouses" of cells, but they also seem to have an underappreciated role in sleep.
Thanks @dereklowe.bsky.social for featuring our work in @science.org blog "The Pipeline"
“Why do we sleep” has been a surprisingly hard question. But it looks like the answer may be “ Because we breathe”. Our mitochondria need a break!
It All Comes Down to the Mitochondria
www.science.org
July 31, 2025 at 4:37 AM
Thanks @dereklowe.bsky.social for featuring our work in @science.org blog "The Pipeline"
1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇
July 22, 2025 at 3:19 PM
1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇
Reposted by Raffaele Sarnataro
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
March 6, 2025 at 7:16 PM
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Honoured to be the guest on the 100th episode of the
@neuroversepod.bsky.social podcast!🎙️
With Clara Lenherr and @carolina-soares.bsky.social, I discussed the neurobiology of sleep—a topic that continues to fascinate and challenge us. Thank you to the Neuroverse team for inviting me.
🧵👇
@neuroversepod.bsky.social podcast!🎙️
With Clara Lenherr and @carolina-soares.bsky.social, I discussed the neurobiology of sleep—a topic that continues to fascinate and challenge us. Thank you to the Neuroverse team for inviting me.
🧵👇
June 10, 2025 at 11:43 AM
Honoured to be the guest on the 100th episode of the
@neuroversepod.bsky.social podcast!🎙️
With Clara Lenherr and @carolina-soares.bsky.social, I discussed the neurobiology of sleep—a topic that continues to fascinate and challenge us. Thank you to the Neuroverse team for inviting me.
🧵👇
@neuroversepod.bsky.social podcast!🎙️
With Clara Lenherr and @carolina-soares.bsky.social, I discussed the neurobiology of sleep—a topic that continues to fascinate and challenge us. Thank you to the Neuroverse team for inviting me.
🧵👇
Reposted by Raffaele Sarnataro
Cleared tissue dual-view oblique plane microscopy https://www.biorxiv.org/content/10.1101/2025.05.12.653537v1
May 16, 2025 at 2:49 AM
Cleared tissue dual-view oblique plane microscopy https://www.biorxiv.org/content/10.1101/2025.05.12.653537v1
Reposted by Raffaele Sarnataro
Cleared tissue dual-view oblique plane microscopy https://www.biorxiv.org/content/10.1101/2025.05.12.653537v1
May 16, 2025 at 2:49 AM
Cleared tissue dual-view oblique plane microscopy https://www.biorxiv.org/content/10.1101/2025.05.12.653537v1
Reposted by Raffaele Sarnataro
Nature research paper: Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
https://go.nature.com/4bG20He
https://go.nature.com/4bG20He
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature
Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state of a stably bound NADPH cofactor.
go.nature.com
March 21, 2025 at 3:00 PM
Nature research paper: Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
https://go.nature.com/4bG20He
https://go.nature.com/4bG20He
Reposted by Raffaele Sarnataro
Why do we need to sleep? In a preprint, researchers posit that it may be an "inescapable consequence" of how we power our cells. That and more of the best in Science and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
November 4, 2024 at 5:40 PM
Why do we need to sleep? In a preprint, researchers posit that it may be an "inescapable consequence" of how we power our cells. That and more of the best in Science and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪