Álvaro López Codina
@alcodina.bsky.social
Predoctoral Research Assistant at the Llorca lab @cniostopcancer.bsky.social working on mTORC1 signaling and cryo-EM ❄️🔬. Intrigued by the structural mechanisms of protein assemblies involved in endomembrane signaling and trafficking 🧪.
Reposted by Álvaro López Codina
PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis www.biorxiv.org/content/10.6...
www.biorxiv.org
February 13, 2026 at 4:47 PM
PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis www.biorxiv.org/content/10.6...
Check out this cool #cryo-EM study spearheaded by our neighbor @tafurlab.bsky.social and his colleagues! A must-read for anyone interested in the molecular mechanisms governing (m)TORC1 regulation. Congrats to all involved! 🎉
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
New online: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
February 13, 2026 at 4:56 PM
Check out this cool #cryo-EM study spearheaded by our neighbor @tafurlab.bsky.social and his colleagues! A must-read for anyone interested in the molecular mechanisms governing (m)TORC1 regulation. Congrats to all involved! 🎉
Reposted by Álvaro López Codina
Our paper on [Bentopy](doi.org/10.1002/pro....) is out in Protein Science! We developed Bentopy to make assembling large-scale MD models more accessible, building on what we learned from trying to simulate whole-cell models. Here's our updated Martini JCVI-syn3A cell model👇
February 13, 2026 at 3:37 PM
Our paper on [Bentopy](doi.org/10.1002/pro....) is out in Protein Science! We developed Bentopy to make assembling large-scale MD models more accessible, building on what we learned from trying to simulate whole-cell models. Here's our updated Martini JCVI-syn3A cell model👇
Reposted by Álvaro López Codina
The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4-SOX2 pubmed.ncbi.nlm.nih.gov/41679301/ #cryoem
February 13, 2026 at 4:27 PM
The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4-SOX2 pubmed.ncbi.nlm.nih.gov/41679301/ #cryoem
Reposted by Álvaro López Codina
Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex www.biorxiv.org/content/10.64898/2026.02.12.705587v1 #cryoem
February 13, 2026 at 8:10 AM
Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex www.biorxiv.org/content/10.64898/2026.02.12.705587v1 #cryoem
Reposted by Álvaro López Codina
New online: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Nature Structural & Molecular Biology, Published online: 12 February 2026; doi:10.1038/s41594-026-01746-2Tafur et al. determined the cryo-electron microscopy structure of the SEA complex (GATOR) bound to its substrate, the EGO complex (Ragulator–Rag), and showed that its GAP activity is essential for both rapid inactivation and reactivation of TORC1.
dlvr.it
February 13, 2026 at 8:53 AM
New online: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Reposted by Álvaro López Codina
Martin V. Appleby et al.: Modelling of radiation damage and beam-induced heating of room-temperature samples at extremely high flux MX beamlines ##RadiationDamage##MacromolecularCrystallography... ##IUCrhttps://journals.iucr.org/paper?S2052252525011224
Modelling of radiation damage and beam-induced heating of room-temperature samples at extremely high flux MX beamlines
Modelling of radiation damage and beam-induced heating at extremely high flux macromolecular crystallography beamlines is presented.
journals.iucr.org
February 13, 2026 at 1:00 AM
Martin V. Appleby et al.: Modelling of radiation damage and beam-induced heating of room-temperature samples at extremely high flux MX beamlines ##RadiationDamage##MacromolecularCrystallography... ##IUCrhttps://journals.iucr.org/paper?S2052252525011224
Reposted by Álvaro López Codina
Actn4 Links Inactive Integrin α5 With Actin in Zebrafish Somites
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Actn4 Links Inactive Integrin α5 With Actin in Zebrafish Somites
Integrins are key plasma membrane proteins that mediate cell-ECM adhesion and communication, and they rely on a conformational change for their activa…
www.sciencedirect.com
February 13, 2026 at 10:17 AM
Actn4 Links Inactive Integrin α5 With Actin in Zebrafish Somites
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Álvaro López Codina
PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis https://www.biorxiv.org/content/10.64898/2026.02.12.705597v1
February 13, 2026 at 10:30 AM
PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis https://www.biorxiv.org/content/10.64898/2026.02.12.705597v1
Reposted by Álvaro López Codina
Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex pubmed.ncbi.nlm.nih.gov/41680390/ #cryoem
February 13, 2026 at 10:56 AM
Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex pubmed.ncbi.nlm.nih.gov/41680390/ #cryoem
Reposted by Álvaro López Codina
Today in #journalclub we learned that it takes two to TANGO: particle lists and spatial analysis! 💃🕺 Check out this new open-source Python package that lets you get more information from your cryo-ET data.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TANGO: Analysis and curation of particles in cryo-electron tomography - Nature Communications
Cryo-electron tomography visualizes molecules inside cells, but it lacks flexible tools to study their spatial organization. The authors present TANGO, a framework that utilizes neighborhoods of parti...
www.nature.com
February 13, 2026 at 11:12 AM
Today in #journalclub we learned that it takes two to TANGO: particle lists and spatial analysis! 💃🕺 Check out this new open-source Python package that lets you get more information from your cryo-ET data.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Álvaro López Codina
Have a look at the Insight on Research story on our Science paper www.science.org/doi/10.1126/... on the @mrclmb.bsky.social website: mrclmb.ac.uk/news-events/... including a great little animation from LMB VisLab.
Bridging the gap from chemistry to life: discovery of a tiny RNA that can copy itself | MRC Laboratory of Molecular Biology
Led by Edoardo Gianni, Philipp Holliger’s group in the LMB’s PNAC Division have identified a small self-replicating catalytic RNA (ribozyme), providing new ...
mrclmb.ac.uk
February 13, 2026 at 11:33 AM
Have a look at the Insight on Research story on our Science paper www.science.org/doi/10.1126/... on the @mrclmb.bsky.social website: mrclmb.ac.uk/news-events/... including a great little animation from LMB VisLab.
Reposted by Álvaro López Codina
A gallium arsenide hybrid-pixel counting detector for 100 keV cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/41680324/ #cryoem
February 13, 2026 at 11:51 AM
A gallium arsenide hybrid-pixel counting detector for 100 keV cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/41680324/ #cryoem
Reposted by Álvaro López Codina
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Excited to share our latest work in @science.org on a new small polymerase.
1/n
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
www.science.org
February 13, 2026 at 11:42 AM
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Reposted by Álvaro López Codina
New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/...
Outstanding work by @edogia.bsky.social
Outstanding work by @edogia.bsky.social
February 13, 2026 at 10:57 AM
New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/...
Outstanding work by @edogia.bsky.social
Outstanding work by @edogia.bsky.social
Reposted by Álvaro López Codina
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
February 13, 2026 at 2:05 PM
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
Reposted by Álvaro López Codina
How did life arise from simple chemical building blocks?
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
February 13, 2026 at 10:20 AM
How did life arise from simple chemical building blocks?
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
Reposted by Álvaro López Codina
So pleased this is finally out! Wonderful work by the incredibly talented @ma3ke.bsky.social and @janstevens.bsky.social to generate densely packed systems, even with complex topologies
Go to the paper for cool science, stay for the mesmerizing figures 🤩
Read more about it in this thread 👇
Go to the paper for cool science, stay for the mesmerizing figures 🤩
Read more about it in this thread 👇
Our paper about Bentopy is now published in Protein Science!
Bentopy makes assembling large-scale MD models accessible and fast.
doi.org/10.1002/pro....
@janstevens.bsky.social, @cg-martini.bsky.social
Bentopy makes assembling large-scale MD models accessible and fast.
doi.org/10.1002/pro....
@janstevens.bsky.social, @cg-martini.bsky.social
February 13, 2026 at 3:22 PM
So pleased this is finally out! Wonderful work by the incredibly talented @ma3ke.bsky.social and @janstevens.bsky.social to generate densely packed systems, even with complex topologies
Go to the paper for cool science, stay for the mesmerizing figures 🤩
Read more about it in this thread 👇
Go to the paper for cool science, stay for the mesmerizing figures 🤩
Read more about it in this thread 👇
Reposted by Álvaro López Codina
Our paper about Bentopy is now published in Protein Science!
Bentopy makes assembling large-scale MD models accessible and fast.
doi.org/10.1002/pro....
@janstevens.bsky.social, @cg-martini.bsky.social
Bentopy makes assembling large-scale MD models accessible and fast.
doi.org/10.1002/pro....
@janstevens.bsky.social, @cg-martini.bsky.social
February 13, 2026 at 3:07 PM
Our paper about Bentopy is now published in Protein Science!
Bentopy makes assembling large-scale MD models accessible and fast.
doi.org/10.1002/pro....
@janstevens.bsky.social, @cg-martini.bsky.social
Bentopy makes assembling large-scale MD models accessible and fast.
doi.org/10.1002/pro....
@janstevens.bsky.social, @cg-martini.bsky.social
Reposted by Álvaro López Codina
Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration. New study from Lin Luan, Jeremy Baskin @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social: rupress.org/jcb/article/...
#CellSignaling #Biochemistry
#CellSignaling #Biochemistry
February 13, 2026 at 3:30 PM
Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration. New study from Lin Luan, Jeremy Baskin @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social: rupress.org/jcb/article/...
#CellSignaling #Biochemistry
#CellSignaling #Biochemistry
Reposted by Álvaro López Codina
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
New online: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Nature Structural & Molecular Biology, Published online: 12 February 2026; doi:10.1038/s41594-026-01746-2Tafur et al. determined the cryo-electron microscopy structure of the SEA complex (GATOR) bound to its substrate, the EGO complex (Ragulator–Rag), and showed that its GAP activity is essential for both rapid inactivation and reactivation of TORC1.
dlvr.it
February 13, 2026 at 12:56 PM
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
Reposted by Álvaro López Codina
A team of researchers has discovered how an RNA promotes the growth of triple-negative breast cancer (#TNBC) by activating two distinct molecular pathways and identified a new combination treatment that suppresses TNBC in culture. #SciSignal https://scim.ag/4rotdW4
Stabilization of IQGAP1 by the mTORC2 component PRR5 mediates mitogenic LINC01133-to-ERK signaling in triple-negative breast cancer
A lincRNA promotes TNBC growth by activating the kinases AKT and ERK through an mTORC2 component.
scim.ag
February 13, 2026 at 4:00 PM
A team of researchers has discovered how an RNA promotes the growth of triple-negative breast cancer (#TNBC) by activating two distinct molecular pathways and identified a new combination treatment that suppresses TNBC in culture. #SciSignal https://scim.ag/4rotdW4
Reposted by Álvaro López Codina
🔵mTurquoise2-based glucose biosensors TINGL and THINGL from @joachimgoedhart.bsky.social and the Teusink Lab!
Find the plasmids here: www.addgene.org/browse/artic...
Find the plasmids here: www.addgene.org/browse/artic...
February 12, 2026 at 9:03 PM
🔵mTurquoise2-based glucose biosensors TINGL and THINGL from @joachimgoedhart.bsky.social and the Teusink Lab!
Find the plasmids here: www.addgene.org/browse/artic...
Find the plasmids here: www.addgene.org/browse/artic...
Reposted by Álvaro López Codina
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation | Science www.science.org/doi/10.1126/...
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
www.science.org
February 12, 2026 at 10:08 PM
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation | Science www.science.org/doi/10.1126/...
Reposted by Álvaro López Codina
Myosin-X Acts Upstream of L-Plastin to Drive Stress-Induced Tunneling Nanotubes
www.mdpi.com/2073-4409/15...
www.mdpi.com/2073-4409/15...
www.mdpi.com
February 13, 2026 at 2:13 AM
Myosin-X Acts Upstream of L-Plastin to Drive Stress-Induced Tunneling Nanotubes
www.mdpi.com/2073-4409/15...
www.mdpi.com/2073-4409/15...