Archana Dhasarathy
@adhasarathy.bsky.social
Chromatin, TFs, epigenetic memory, and Epithelial- mesenchymal cell state transitions. Also will post about dogs/ cats/ animals/ nature.
Reposted by Archana Dhasarathy
Reposted by Archana Dhasarathy
Afting, C., Walther, T., Drozdowski, O. M., Schlagheck, C., Schwarz, U. S., Wittbrodt, J., & Göpfrich, K. (2024). DNA microbeads for spatio-temporally controlled morphogen release within organoids. Nature Nanotechnology www.nature.com/articles/s41... #EpithelialMechanics
February 10, 2026 at 8:00 AM
Afting, C., Walther, T., Drozdowski, O. M., Schlagheck, C., Schwarz, U. S., Wittbrodt, J., & Göpfrich, K. (2024). DNA microbeads for spatio-temporally controlled morphogen release within organoids. Nature Nanotechnology www.nature.com/articles/s41... #EpithelialMechanics
Reposted by Archana Dhasarathy
Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
February 9, 2026 at 8:32 AM
Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Reposted by Archana Dhasarathy
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 10:37 AM
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Reposted by Archana Dhasarathy
If you are a student whose NSF GRFP application was returned without review for vague 'eligibility' reasons:
1) Let your department chair & Graduate School know. Encourage them to contact NSF & congress
2) Write to your congressional reps.
3) Write to grfp@nsf.gov to request re-consideration;
1) Let your department chair & Graduate School know. Encourage them to contact NSF & congress
2) Write to your congressional reps.
3) Write to grfp@nsf.gov to request re-consideration;
January 30, 2026 at 5:15 PM
If you are a student whose NSF GRFP application was returned without review for vague 'eligibility' reasons:
1) Let your department chair & Graduate School know. Encourage them to contact NSF & congress
2) Write to your congressional reps.
3) Write to grfp@nsf.gov to request re-consideration;
1) Let your department chair & Graduate School know. Encourage them to contact NSF & congress
2) Write to your congressional reps.
3) Write to grfp@nsf.gov to request re-consideration;
Reposted by Archana Dhasarathy
Cool thread with examples of the role of cell junctions in collective cell migration! 🧪
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
January 31, 2026 at 2:08 PM
Cool thread with examples of the role of cell junctions in collective cell migration! 🧪
Reposted by Archana Dhasarathy
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
January 28, 2026 at 5:02 PM
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Reposted by Archana Dhasarathy
One of the best things I’ve read in a while:
January 25, 2026 at 10:39 PM
One of the best things I’ve read in a while:
Reposted by Archana Dhasarathy
Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.
White. Hot. Rage.
White. Hot. Rage.
January 24, 2026 at 7:31 PM
Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.
White. Hot. Rage.
White. Hot. Rage.
Reposted by Archana Dhasarathy
FACETS Journal is looking for a Co-Editor-in-Chief to curate content, support diverse voices in research, and collaborate with our editorial team. Expertise in ecology, conservation biology, biodiversity, or environmental sciences is ideal.
Learn more ▶️ https://ow.ly/Gbzv50Xo3Ks
Learn more ▶️ https://ow.ly/Gbzv50Xo3Ks
January 23, 2026 at 1:45 PM
FACETS Journal is looking for a Co-Editor-in-Chief to curate content, support diverse voices in research, and collaborate with our editorial team. Expertise in ecology, conservation biology, biodiversity, or environmental sciences is ideal.
Learn more ▶️ https://ow.ly/Gbzv50Xo3Ks
Learn more ▶️ https://ow.ly/Gbzv50Xo3Ks
Thank you so much for the great talk and wonderful science conversations! @takakulab.bsky.social and our students and other faculty really appreciated your sharing your science with us!
Today we had very nice interactions in the University of North Dakota (remotely)! Thank you very much @adhasarathy.bsky.social, Motoki Takaku & Co for the invitation to give this talk and hosting the visit!
January 22, 2026 at 4:25 PM
Thank you so much for the great talk and wonderful science conversations! @takakulab.bsky.social and our students and other faculty really appreciated your sharing your science with us!
Reposted by Archana Dhasarathy
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
January 21, 2026 at 10:48 AM
🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
Reposted by Archana Dhasarathy
Reposted by Archana Dhasarathy
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
January 20, 2026 at 10:53 PM
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
Reposted by Archana Dhasarathy
⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out!
➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
Antisense transcription can induce expression memory via stable promoter repression - Genome Biology
Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...
link.springer.com
January 20, 2026 at 11:02 AM
⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out!
➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
Reposted by Archana Dhasarathy
Loved this from @simonmaechling.bsky.social - chemistry FTW…
@dereklowe.bsky.social @carolynbertozzi.bskyverified.social
@dereklowe.bsky.social @carolynbertozzi.bskyverified.social
January 19, 2026 at 2:08 PM
Loved this from @simonmaechling.bsky.social - chemistry FTW…
@dereklowe.bsky.social @carolynbertozzi.bskyverified.social
@dereklowe.bsky.social @carolynbertozzi.bskyverified.social
Reposted by Archana Dhasarathy
I wrote about this for Nature last July - good advice here from some award-winning academic mentors around the world: www.nature.com/articles/d41...
Rubbish years: how to boost lab group morale when world events crash in
Award-winning mentors share best practice to keep your team going amid political upheavals, economic downturns and other events.
www.nature.com
January 18, 2026 at 2:05 AM
I wrote about this for Nature last July - good advice here from some award-winning academic mentors around the world: www.nature.com/articles/d41...
Some joy in this crazy world.
January 15, 2026 at 4:55 PM
Some joy in this crazy world.
Reposted by Archana Dhasarathy
Janssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....
January 2, 2026 at 8:00 AM
Janssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....
Reposted by Archana Dhasarathy
Read the full story in our preprint! 👇
biorxiv.org/content/10.6...
Excited to share this work with my co-first author Kevin Sabath - a fantastic collaboration between the
@alex-stark.bsky.social and @plaschkalab.bsky.social labs! 🤝🧪
biorxiv.org/content/10.6...
Excited to share this work with my co-first author Kevin Sabath - a fantastic collaboration between the
@alex-stark.bsky.social and @plaschkalab.bsky.social labs! 🤝🧪
Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID
Transcription from CpG island (CGI) promoters controls the expression of two-thirds of mammalian genes, yet despite their prevalence, it remains unknown whether CGI-specific co-activators with intrins...
biorxiv.org
December 29, 2025 at 7:30 PM
Read the full story in our preprint! 👇
biorxiv.org/content/10.6...
Excited to share this work with my co-first author Kevin Sabath - a fantastic collaboration between the
@alex-stark.bsky.social and @plaschkalab.bsky.social labs! 🤝🧪
biorxiv.org/content/10.6...
Excited to share this work with my co-first author Kevin Sabath - a fantastic collaboration between the
@alex-stark.bsky.social and @plaschkalab.bsky.social labs! 🤝🧪
Reposted by Archana Dhasarathy
Robert F. Kennedy Jr. has stated that the 1918 flu pandemic was caused by a lab virus from vaccine research, a defective influenza vaccine. Let’s analyze what a lie this is. First, in 1918, 107 years ago, virology was in its infancy
December 27, 2025 at 11:42 PM
Robert F. Kennedy Jr. has stated that the 1918 flu pandemic was caused by a lab virus from vaccine research, a defective influenza vaccine. Let’s analyze what a lie this is. First, in 1918, 107 years ago, virology was in its infancy
Reposted by Archana Dhasarathy
Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken https://theonion.com/heroic-dog-saves-family-of-5-from-herb-roasted-chicken/
December 26, 2025 at 9:15 PM
Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken https://theonion.com/heroic-dog-saves-family-of-5-from-herb-roasted-chicken/
Reposted by Archana Dhasarathy
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
December 25, 2025 at 6:33 AM
This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy
Reposted by Archana Dhasarathy
Walking around the #NIH hospital and seeing all kinds of patients getting care here: kids in wheelchairs, adults in masks and chemo caps.
And all of this is being cut down, undermined, and destroyed by Trump. It should make us all incredibly angry.
And all of this is being cut down, undermined, and destroyed by Trump. It should make us all incredibly angry.
December 17, 2025 at 8:03 PM
Walking around the #NIH hospital and seeing all kinds of patients getting care here: kids in wheelchairs, adults in masks and chemo caps.
And all of this is being cut down, undermined, and destroyed by Trump. It should make us all incredibly angry.
And all of this is being cut down, undermined, and destroyed by Trump. It should make us all incredibly angry.