Marc A. Marti-Renom
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mamartirenom.bsky.social
Marc A. Marti-Renom
@mamartirenom.bsky.social

Looking at genomes with 3D glasses as part of http://marciuslab.org.
President of @SCB.iec.cat
Proud member of @icreacommunity.bsky.social.
Happy at @CNAG-eu.bsky.social and @CRG.eu in Barcelona.

#4DNucleome #3Dgenomics #microbiome #biogeography .. more

Biology 80%
Medicine 9%
Pinned
Fantastic #Blutorial by our friends and colleagues at the @batllelab.bsky.social . We are so happy to collaborate with them.

@meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼

aacrjournals.org/cancerdiscov...
I wrote some reflections this afternoon about how the discovery of the double helix changed the course of science. Gift link: nyti.ms/4qPS3y6

Congrats Wendy!! Good for you four and good for the field. Sure cool science ahead! 👏🏻🍾
Our lab is actively looking for posdocs and there is NOW an Open Call for Postdoc contracts (3 years) here: www.aei.gob.es/en/announcem...
www.aei.gob.es
Our lab is actively looking for PhD students and there is NOW an Open Call for PhD fellowship at the IRB Barcelona!!!!! phd.irbbarcelona.org
Application Guidelines - IRB PhD Call 2026 NOW OPEN! | Irb
phd.irbbarcelona.org
🔬 #ColorectalCancer evades #immunotherapy using a dual barrier:

A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.

📰 @natgenet.nature.com

➡️ bit.ly/49BJaC0

#IRBScience @batllelab.bsky.social

🧪
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇

Great lab to do your PhD!👇🏼
OFERTA DE EMPLEO (por favor difundir):

Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
OFERTA DE EMPLEO (por favor difundir):

Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇

Congrats Cees! Happy for all of you, what a team! 👏🏼 This is very good for our field! 🎉

A must read... at character resolution! 🤯
Our latest paper has just been published in Cell!

doi.org/10.1016/j.ce...

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Our latest paper has just been published in Cell!

doi.org/10.1016/j.ce...

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
🧬 The #BGE continent-wide network behind the sequencing and assembly of these genomes includes @genoscopeumr.bsky.social opeumr.bsky.social, @cnag-eu.bsky.social u.bsky.social, @sangerinstitute.bsky.social, @scilifelab.se b.se, Università degli Studi di Firenze, and Università degli Studi di Bari.
#PCBCommunity |🧬El @batllelab.bsky.social de @irbbarcelona.org, amb @mamartirenom.bsky.social del @cnag-eu.bsky.social, descobreix que en el #càncer colorectal amb la mutació de l’oncogèn #KRAS, la pressió del tractament pot redirigir els estats cel·lulars en lloc d'eliminar-les. 🔬

👉 tuit.cat/IAkSn
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....

I detected the discrepancy. Thanks for clarifying!! Salut Luca!

*Congrats Luca and Team!* 👏🏻BTW. In post #3 it should say seconds instead of minutes, no? 🤔

Super place for your PhD (I know 😉)... apply! 👇🏼
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.

More info: www.crg.eu/en/content/t...
🚨New advances in colorectal cancer!
Why do some colorectal cancers resist KRAS-targeted therapies?

🔝Our new study in Cancer Discovery discovery reveals the answer, and opens the door to more effective treatments. By @mamartirenom.bsky.social (CNAG) & @irbbarcelona.org

🔗 www.cnag.eu/news/study-r...
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.

More info: www.crg.eu/en/content/t...

👏🏻 Félicitations mon ami!
Science-peripheral post (ignore unless you read in Greek or French): I was surprised and truly honored to receive the Aix-Marseille Metropolitain for the French translation of my novel ‘The last bear of the woods’ (Kichli 2023)—a great thanks to my translators M. Volkich and H. Zervas.
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
We are happy to share our latest work in @nature.com . We study the genomic and cellular basis of facultative symbiosis in Oculina patagonica - a Mediterranean coral remarkable for its ability to survive long periods without algal symbionts. Led by Shani Levy and @xgrau.bsky.social
rdcu.be/eLbaZ
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...
I adored writing this piece. It brings together several of the things preoccupying me right now, like chromatin organization and gene regulation. There's so much more to be said on that. Also, these marine critters look gorgeous.
www.quantamagazine.org/loops-of-dna...
Loops of DNA Equipped Ancient Life To Become Complex | Quanta Magazine
New work shows that physical folding of the genome to control genes located far away may have been an early evolutionary development.
www.quantamagazine.org
Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...
John Innes Centre
jobs.jic.ac.uk
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🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions.
These markers can spare patients from ineffective treatments and ease pressure on healthcare systems.
www.biorxiv.org/content/10.1...
www.biorxiv.org
RIP John Gurdon
So sad to hear the news - John truly was an inspiration to so many, and one of a kind.

www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk