Eric Thompson | Lightnews

Eric Thompson, Ph.D.

@azbiomarkers.bsky.social

270 followers 160 following 230 posts

Precision medicine translational pharmacologist and cancer biologist, utilizing evidence based medicine to move biomarkers into the clinic. Views are my own.

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Economics 26%

Political science 24%

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Reposted by Eric Thompson

Eric Topol @erictopol.bsky.social · 13d

It worked. Stem cells (mesenchymal) given to patients with a large heart attack reduced major adverse events in a randomized trial vs standard care www.bmj.com/content/391/...

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · 21d

The finance bros were way ahead of the curve - think Kronos that John Sperling had running in the mid 90's. They just need to hire Nicolas Flamel!

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · 22d

Any plans for the companies to drive strengthening of GINA so the risk of the data falling into underwriting hands is less acute? Genetic discrimination is legal outside of employment and health insurance.

Reposted by Simon Roux, Eric Thompson, Larry W. Hunter , and 1 more Simon Roux, Eric Thompson, Larry W. Hunter, Marc A. Martı́-Renom

The Francis Crick Institute @crick.ac.uk · Oct 9

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Oct 7

Apologies - the decision support interpretation isn’t quite there outside of these Rx ( e.g. DPYD for fluoropyrimidines).

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Oct 7

There are a couple of instances in cancer Rx when it is crucial, but the decision support interpretation isn’t quite there. I have these conversations all the time - en route to some now. Polite is all we can ask. We have to bring the science.

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Oct 7

Think I saw a recent announcement of a company re-entering this space. Have not checked their science.

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Oct 7

There is not enough data spanning the entire ADME enzymatic system to integrate findings into clinical decisions. There is not a monetary incentive to create these data. Until this is solved you are correct. The data existing often are not used (e.g. warfarin, irinoteca).

Reposted by Eric Thompson

The ASCO Post @ascopost.bsky.social · Oct 6

Phase II LUNAR Trial: PSMA-targeted radiopharmaceutical plus SBRT improved PFS in pts with oligometastatic prostate cancer (18 vs 7 mo), which helped to delay ADT by 24 months

Presented by Amar U. Kishan, MD, at the ASTRO Annual Meeting @astro-org.bsky.social

ascopost.com/news/septemb...

Prostate Cancer: Radiopharmaceutical Plus SBRT Delays Progression in Patients With Limited Metastatic Disease

In prostate cancer, radiopharmaceuticals typically target PSMA, delivering precise doses of radiation directly to tumors; these medicines are currently approved for later-stage prostate cancer. The LU...

ascopost.com

Reposted by Eric Thompson

Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · Oct 6

Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells www.nobelprize.org/prizes/medic...

For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review www.nature.com/articles/s41...
rdcu.be/eJHU8

Reposted by Eric Thompson

Nature @nature.com · Oct 6

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

go.nature.com

Reposted by Eric Thompson, Melissa Sweet

Science News @scinews.bsky.social · Oct 6

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Oct 3

Could be revolutionary if reproducible. EP2 GPCR. www.nature.com/articles/s41...

Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

www.nature.com

Reposted by Eric Thompson

c0nc0rdance @c0nc0rdance.bsky.social · Sep 29

You're watching 12 hrs of live cell imaging compressed into a GIF.

A multi-nucleated mouse pre-adipocyte tries to undergo mitosis, triggers a checkpoint because it has too much DNA, & undergoes apoptosis.

The last stage is called "blebbing", which is wonderfully descriptive.

(🔬: NanoLive Imaging)

Reposted by Eric Thompson

Eric Topol @erictopol.bsky.social · Sep 26

New: The link between air pollution and aortic dissection/aneurysm, adds to genetic susceptibility
www.nature.com/articles/s44...

Association of air pollution exposure and genetic susceptibility with increased risk of thoracic aortic aneurysm and dissection - Nature Cardiovascular Research

Ma et al. demonstrate that air pollution is associated with an increased risk of thoracic aortic aneurysm and dissection (TAAD), and that genetic susceptibility to TAAD amplifies this risk through multiplicative and additive interactions.

www.nature.com

Reposted by Eric Thompson

Eric Topol @erictopol.bsky.social · Sep 22

Where are the Covid nasal vaccines for the US to block infections and transmission?
Here's yet another with a very good profile in people for mucosal immunity and high neutralizing antibodies in all participants (from China)
www.nature.com/articles/s41...

Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant - Nature Biomedical Engineering

A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.

www.nature.com

Reposted by Eric Thompson

Nature Biotechnology @natbiotech.nature.com · Sep 19

In Brief: @novonordisk.bsky.social's #Wegovy gains accelerated FDA approval for treating metabolic dysfunction-associated steatohepatitis (MASH), also known as fatty liver disease www.nature.com/articles/s41...
rdcu.be/eHgPo

Wegovy approved for MASH - Nature Biotechnology

Nature Biotechnology - Wegovy approved for MASH

www.nature.com

Reposted by Eric Thompson

JCO Journals @jco-asco.bsky.social · Sep 19

We're thrilled to be here on BlueSky to bring you the latest practice-changing oncology research from all six JCO Journals! Follow-us for great content from #JCO, #JCOOP, #JCOGO, #JCOPO, #JCOCCI, & #JCOOA.

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Sep 11

Unless GINA is strengthened to include many more insurance utility cases this data will be sought by underwriters. It is their business model to accurately model risk, and these data can be a help for them. The harm to the subject is actually a win in this business setting. We need to expand GINA.

Reposted by Eric Thompson

Waggoner Lab @labwaggoner.bsky.social · Sep 10

Molecular subtypes of human skeletal muscle in cancer cachexia @nature.com
nature.com/articles/s41...

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Sep 4

The juxtaposition was remarkable. Perseverance is the key attribute in science.

Reposted by Eric Thompson

Compound Interest | Chemistry infographics @compoundchem.com · Aug 31

As summer fades, dahlias are blooming. This graphic looks at the chemical cause of their colours and why you won't spot a blue one! www.compoundchem.com/2021/09/12/d...
#ChemSky 🧪

Infographic on the chemistry of dahlia flower colours. The colours of dahlias are a result of anthocyanin-, chalcone- and aurone-derived pigments. Colourless sflavones also interact with and stabilise anthocyanin pigments. Chalcones and aurones lead to yellow and orange dahlias, while anthocyanins play a part in orange, pink, red and black dahlias. Blue dahlias aren't seen because dahlias lack an enzyme for making delphinidin, the anthocyanin which leads to blue flowers.

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Aug 28

www.nature.com/articles/s41...

The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature

An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as ...

www.nature.com

Reposted by Eric Thompson

Anna Obenauf @obenaufa.bsky.social · Aug 28

Anyone working in metastasis research – the BEUG Foundation has once again opened the call for their Metastasis Research Prize.
This prize is a wonderful recognition of innovative contributions and supports excellence in metastasis research across Europe.
www.beugstiftung-metastase.de/apply-now/

Apply now – Beugstiftung

www.beugstiftung-metastase.de

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Aug 26

Interesting data on the long term impact of air pollution on cancer risk - telomere shortening and gene mutations associated with exposures to industrial air pollution.

www.nature.com/articles/s41...

The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature

An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

www.nature.com

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Aug 26

I wonder how many tons of Coccidioidomycosis (Valley Fever)spores got distributed in that. Is there any indication of a spike in cases after a haboob?

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Aug 17

I’d second that - tenacity is the key. Many don’t have the stamina to follow through on a problem for years. The tenacity to make it through the negative results is key.

Reposted by Eric Thompson, Urška Demšar

Richard Sever @richardsever.bsky.social · Aug 15

"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?

One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...

Why would anyone want to be a scientist?

It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...

journals.biologists.com

Reposted by Eric Thompson

Nature Reviews Cancer @natrevcancer.nature.com · Aug 13

#ResearchHighlight 🚨
In a recent study, the Nussenzweig lab investigated the mechanisms underlying #cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of #gemcitabine.
📖⬇️

Same same but different - Nature Reviews Cancer

In a recent study published in Nature, Liu, Wang, et al. investigate the mechanisms underlying cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of other nucleoside analogues, such as gemcitabine.

www.nature.com

Eric Thompson, Ph.D. @azbiomarkers.bsky.social · Aug 13

You might find this interesting: journals.sagepub.com/doi/abs/10.1...

The Pen Is Mightier Than the Keyboard: Advantages of Longhand Over Laptop Note Taking

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