Fran Martínez-Jiménez
@franmj88.bsky.social
Group Leader of Computational Immunogenomics group at VHIO |
Data Mining lead at HartwigMedicalFoundation | Personal account | Advocate for social and environmental justice 🌍
https://www.franmartinezlab.com/
Data Mining lead at HartwigMedicalFoundation | Personal account | Advocate for social and environmental justice 🌍
https://www.franmartinezlab.com/
Reposted by Fran Martínez-Jiménez
New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...
Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics
This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.
www.nature.com
November 5, 2025 at 4:36 PM
New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...
Reposted by Fran Martínez-Jiménez
Fantastic #Blutorial by our friends and colleagues at the @batllelab.bsky.social . We are so happy to collaborate with them.
@meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼
aacrjournals.org/cancerdiscov...
@meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼
aacrjournals.org/cancerdiscov...
October 23, 2025 at 6:25 PM
Fantastic #Blutorial by our friends and colleagues at the @batllelab.bsky.social . We are so happy to collaborate with them.
@meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼
aacrjournals.org/cancerdiscov...
@meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼
aacrjournals.org/cancerdiscov...
Reposted by Fran Martínez-Jiménez
Postdoc | VHIO, Barcelona
Immunotherapies succeed in only ~20% of cases.
Help us break resistance by engineering the right environment.
Join the Aging & Cancer Lab 🌍
👉 Apply: vhiovidaprogramme.eu/recruitment/ | mauslab.org
Immunotherapies succeed in only ~20% of cases.
Help us break resistance by engineering the right environment.
Join the Aging & Cancer Lab 🌍
👉 Apply: vhiovidaprogramme.eu/recruitment/ | mauslab.org
October 21, 2025 at 9:35 AM
Postdoc | VHIO, Barcelona
Immunotherapies succeed in only ~20% of cases.
Help us break resistance by engineering the right environment.
Join the Aging & Cancer Lab 🌍
👉 Apply: vhiovidaprogramme.eu/recruitment/ | mauslab.org
Immunotherapies succeed in only ~20% of cases.
Help us break resistance by engineering the right environment.
Join the Aging & Cancer Lab 🌍
👉 Apply: vhiovidaprogramme.eu/recruitment/ | mauslab.org
Reposted by Fran Martínez-Jiménez
Finding somatic mutations in healthy tissue that can lead to cancer, at scale. Yet another path to primary prevention
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
October 8, 2025 at 3:38 PM
Finding somatic mutations in healthy tissue that can lead to cancer, at scale. Yet another path to primary prevention
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
1/
🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions.
These markers can spare patients from ineffective treatments and ease pressure on healthcare systems.
www.biorxiv.org/content/10.1...
🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions.
These markers can spare patients from ineffective treatments and ease pressure on healthcare systems.
www.biorxiv.org/content/10.1...
www.biorxiv.org
October 8, 2025 at 6:06 AM
1/
🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions.
These markers can spare patients from ineffective treatments and ease pressure on healthcare systems.
www.biorxiv.org/content/10.1...
🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions.
These markers can spare patients from ineffective treatments and ease pressure on healthcare systems.
www.biorxiv.org/content/10.1...
Reposted by Fran Martínez-Jiménez
Working alongside with Fran, a no brainer 👇🏼
🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu
Home - VIDA
vhiovidaprogramme.eu
October 7, 2025 at 1:52 PM
Working alongside with Fran, a no brainer 👇🏼
🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu
Home - VIDA
vhiovidaprogramme.eu
October 4, 2025 at 7:32 AM
🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu
Reposted by Fran Martínez-Jiménez
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
October 2, 2025 at 6:56 PM
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Fran Martínez-Jiménez
The obsession with economic output as a measure of human development puts sustainability on the back burner
Time to end the GDP mania
Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity
🧪 #SGDs #doughnuteconomics
www.nature.com/articles/d41...
Time to end the GDP mania
Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity
🧪 #SGDs #doughnuteconomics
www.nature.com/articles/d41...
End GDP mania: how the world should really measure prosperity
The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.
www.nature.com
October 1, 2025 at 8:57 PM
The obsession with economic output as a measure of human development puts sustainability on the back burner
Time to end the GDP mania
Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity
🧪 #SGDs #doughnuteconomics
www.nature.com/articles/d41...
Time to end the GDP mania
Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity
🧪 #SGDs #doughnuteconomics
www.nature.com/articles/d41...
Reposted by Fran Martínez-Jiménez
The richest 20% of nations, with 15% of the global population, contribute more than 40% of annual ecological overshoot; the poorest 40% of countries, with 42% of the global population, experience more than 60% of social shortfall 🧪
A new analysis by Fanning & Raworth
www.nature.com/articles/s41...
A new analysis by Fanning & Raworth
www.nature.com/articles/s41...
Doughnut of social and planetary boundaries monitors a world out of balance - Nature
A revised ‘Doughnut’ providing a visual assessment of trends in social deprivation and planetary degradation over the past two decades shows more than doubling of global GDP accompanied by accelerating ecological overshoot but only a modest reduction in human deprivation.
www.nature.com
October 1, 2025 at 9:01 PM
The richest 20% of nations, with 15% of the global population, contribute more than 40% of annual ecological overshoot; the poorest 40% of countries, with 42% of the global population, experience more than 60% of social shortfall 🧪
A new analysis by Fanning & Raworth
www.nature.com/articles/s41...
A new analysis by Fanning & Raworth
www.nature.com/articles/s41...
Reposted by Fran Martínez-Jiménez
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 2, 2025 at 11:44 AM
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Fran Martínez-Jiménez
Reposted by Fran Martínez-Jiménez
Experts are concerned, as a number of scientists 🧪have recorded huge die-offs of insects in nature reserves around the world. The reported collapse of insect populations in supposedly protected regions is part of a newer phenomenon. 🌏🐜
Read more in @theguardian.com:
Read more in @theguardian.com:
‘Half the tree of life’: ecologists’ horror as nature reserves are emptied of insects
A new point in history has been reached, entomologists say, as climate-led species’ collapse moves up the food chain even in supposedly protected regions free of pesticides
bit.ly
July 14, 2025 at 7:02 AM
Experts are concerned, as a number of scientists 🧪have recorded huge die-offs of insects in nature reserves around the world. The reported collapse of insect populations in supposedly protected regions is part of a newer phenomenon. 🌏🐜
Read more in @theguardian.com:
Read more in @theguardian.com:
Reposted by Fran Martínez-Jiménez
🚨 You have until 13 July to submit your abstract for #EMBLCanGen 👉 https://s.embl.org/can25-01-bl
🗓️ 11 – 14 November 2025
📍 EMBL Heidelberg & Virtual
Join top scientists and academic clinicians for an inspiring event to connect, collaborate, and accelerate breakthroughs in cancer genomics 🧬
🗓️ 11 – 14 November 2025
📍 EMBL Heidelberg & Virtual
Join top scientists and academic clinicians for an inspiring event to connect, collaborate, and accelerate breakthroughs in cancer genomics 🧬
July 3, 2025 at 1:00 PM
🚨 You have until 13 July to submit your abstract for #EMBLCanGen 👉 https://s.embl.org/can25-01-bl
🗓️ 11 – 14 November 2025
📍 EMBL Heidelberg & Virtual
Join top scientists and academic clinicians for an inspiring event to connect, collaborate, and accelerate breakthroughs in cancer genomics 🧬
🗓️ 11 – 14 November 2025
📍 EMBL Heidelberg & Virtual
Join top scientists and academic clinicians for an inspiring event to connect, collaborate, and accelerate breakthroughs in cancer genomics 🧬
Reposted by Fran Martínez-Jiménez
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
www.nature.com
June 23, 2025 at 9:03 AM
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Reposted by Fran Martínez-Jiménez
Reposted by Fran Martínez-Jiménez
Powerful stuff from @juliosaezrod.bsky.social who found himself on the other end of the process - as a patient not a computational biology researcher - giving him insight into both research and patient perspectives. Huge credit to Julio for talking about his experiences here
June 20, 2025 at 8:06 AM
Powerful stuff from @juliosaezrod.bsky.social who found himself on the other end of the process - as a patient not a computational biology researcher - giving him insight into both research and patient perspectives. Huge credit to Julio for talking about his experiences here
🌟 Are you passionate about computational immuno-oncology research with real clinical impact? 🌟
Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻
See offer here 👉 jobs.vhio.net/en/jobs/6016...
#Bioinformatics #SingleCellRNA #Immunogenomics
Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻
See offer here 👉 jobs.vhio.net/en/jobs/6016...
#Bioinformatics #SingleCellRNA #Immunogenomics
June 9, 2025 at 7:56 AM
🌟 Are you passionate about computational immuno-oncology research with real clinical impact? 🌟
Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻
See offer here 👉 jobs.vhio.net/en/jobs/6016...
#Bioinformatics #SingleCellRNA #Immunogenomics
Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻
See offer here 👉 jobs.vhio.net/en/jobs/6016...
#Bioinformatics #SingleCellRNA #Immunogenomics
Reposted by Fran Martínez-Jiménez
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 21, 2025 at 3:44 PM
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Reposted by Fran Martínez-Jiménez
Wrapping up the week after three great days at the @helloeacr.bsky.social 'Defence is the Best Attack' conference. Thanks for the opportunity to (poster) present our work on immunoediting from @franmj88.bsky.social 's lab, and to learn from colleagues in immuno-oncology.
May 16, 2025 at 11:25 AM
Wrapping up the week after three great days at the @helloeacr.bsky.social 'Defence is the Best Attack' conference. Thanks for the opportunity to (poster) present our work on immunoediting from @franmj88.bsky.social 's lab, and to learn from colleagues in immuno-oncology.
Reposted by Fran Martínez-Jiménez
Now online in Cancer Discovery: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes - by Carlota Arenillas, Rodrigo Toledo, and colleagues doi.org/10.1158/2159... @vhio.bsky.social
April 9, 2025 at 2:04 PM
Now online in Cancer Discovery: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes - by Carlota Arenillas, Rodrigo Toledo, and colleagues doi.org/10.1158/2159... @vhio.bsky.social
Reposted by Fran Martínez-Jiménez
If you are interested in vascular malformations you may want to check our new work published today in Cancer Discovery, where we discover a somatic genetic event causing vascular malformations in PTEN hamartoma tumor syndrome (PHTS) aacrjournals.org/cancerdiscov...
Somatic uniparental disomy of PTEN in endothelial cells causes vascular malformations in patients with PTEN Hamartoma Tumor Syndrome
Abstract. PTEN Hamartoma Tumor Syndrome (PHTS) is a rare tumor risk disorder caused by germline loss-of-function mutations in PTEN. Half of these patients develop vascular malformations, a hamartoma c...
aacrjournals.org
March 28, 2025 at 3:12 PM
If you are interested in vascular malformations you may want to check our new work published today in Cancer Discovery, where we discover a somatic genetic event causing vascular malformations in PTEN hamartoma tumor syndrome (PHTS) aacrjournals.org/cancerdiscov...
Reposted by Fran Martínez-Jiménez
I wrote a deep dive post on Roche SBX announcement this week. Edwin Cuppen (not on #Bluesky) who heads the Hartwig Institute highlights what this new tech means for entities like him.
February 28, 2025 at 10:55 AM
I wrote a deep dive post on Roche SBX announcement this week. Edwin Cuppen (not on #Bluesky) who heads the Hartwig Institute highlights what this new tech means for entities like him.
Reposted by Fran Martínez-Jiménez
We are excited to share our work on Context-dependent response of endothelial cells to PIK3CA mutation. A tour the force of many; thank you all for your invaluable contribution. @aangulou.bsky.social @ruibenedito.bsky.social @debocklab.bsky.social @sandradcastillo.bsky.social
bit.ly/4blKSqa
bit.ly/4blKSqa
Context-dependent response of endothelial cells to PIK3CA mutation
Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of...
bit.ly
February 26, 2025 at 12:19 PM
We are excited to share our work on Context-dependent response of endothelial cells to PIK3CA mutation. A tour the force of many; thank you all for your invaluable contribution. @aangulou.bsky.social @ruibenedito.bsky.social @debocklab.bsky.social @sandradcastillo.bsky.social
bit.ly/4blKSqa
bit.ly/4blKSqa
Reposted by Fran Martínez-Jiménez
🚨 Exciting news‼️ The first call of our VIDA Postdoctoral Programme is officially OPEN! 🚀
Funded by a Marie Skłodowska-Curie Actions COFUND grant, #VHIOVIDA is recruiting 12 postdoctoral researchers.
🗓️ Deadline for application, March 13 👉 https://linke.to/VHIOVIDA25
#VHIOAcademy
Funded by a Marie Skłodowska-Curie Actions COFUND grant, #VHIOVIDA is recruiting 12 postdoctoral researchers.
🗓️ Deadline for application, March 13 👉 https://linke.to/VHIOVIDA25
#VHIOAcademy
February 24, 2025 at 9:02 AM
🚨 Exciting news‼️ The first call of our VIDA Postdoctoral Programme is officially OPEN! 🚀
Funded by a Marie Skłodowska-Curie Actions COFUND grant, #VHIOVIDA is recruiting 12 postdoctoral researchers.
🗓️ Deadline for application, March 13 👉 https://linke.to/VHIOVIDA25
#VHIOAcademy
Funded by a Marie Skłodowska-Curie Actions COFUND grant, #VHIOVIDA is recruiting 12 postdoctoral researchers.
🗓️ Deadline for application, March 13 👉 https://linke.to/VHIOVIDA25
#VHIOAcademy