Empty drops in scRNA-seq uncover the surprising prevalence of sequestered neuropeptide mRNA and pervasive sequencing artifacts #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
February 16, 2026 at 8:00 AM
Empty drops in scRNA-seq uncover the surprising prevalence of sequestered neuropeptide mRNA and pervasive sequencing artifacts #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
Empty drops in scRNA-seq uncover the surprising prevalence of sequestered neuropeptide mRNA and pervasive sequencing artifacts https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
February 15, 2026 at 5:46 PM
Empty drops in scRNA-seq uncover the surprising prevalence of sequestered neuropeptide mRNA and pervasive sequencing artifacts https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
Empty drops in scRNA-seq uncover the surprising prevalence of sequestered neuropeptide mRNA and pervasive sequencing artifacts https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
February 15, 2026 at 5:46 PM
Empty drops in scRNA-seq uncover the surprising prevalence of sequestered neuropeptide mRNA and pervasive sequencing artifacts https://www.biorxiv.org/content/10.64898/2026.02.13.705850v1
Migraine News: Positive results from a phase II clinical trial offer hope for people with severe migraine who've had past treatment failures. Bocunebart targets PACAP, a key neuropeptide involved in the disease, & reduces the number of migraine days monthly. news.cision.com/h--lundbeck-...
Lundbeck announces positive phase IIb top-line results with bocunebart (Lu AG09222; anti-PACAP mAb) in migraine prevention
· The intravenous (IV) part of the phase IIb dose-finding PROCEED trial of bocunebart (Lu AG09222)
news.cision.com
February 13, 2026 at 6:13 PM
Migraine News: Positive results from a phase II clinical trial offer hope for people with severe migraine who've had past treatment failures. Bocunebart targets PACAP, a key neuropeptide involved in the disease, & reduces the number of migraine days monthly. news.cision.com/h--lundbeck-...
#Lundbeck #phase3 #migraineprevention #migrainepreventiondrug #bocunebart #antiPACAPantibody #phase2b #PROCEEDtrial #intravenousbocunebart #LuAG09222 #monthlymigrainedays #MMD #PACAP #neuropeptide #pathophysiologyofmigraine #migrainetreatment #PACAPpathway #migrainepreventionmarket
zurl.co/M7FHE
zurl.co/M7FHE
Lundbeck preps phase 3 for migraine prevention drug
Lundbeck seems to have brought its migraine prevention drug bocunebart back on track with positive data for an intravenous formulation.
pharmaphorum.com
February 13, 2026 at 12:53 PM
The neuropeptide pigment-dispersing factor enhanced food intake and alleviated antifeedant effects by azadirachtin in Spodoptera frugiperda larvae
#Drosophila
#Drosophila
The neuropeptide pigment-dispersing factor enhanced food intake and alleviated antifeedant effects by azadirachtin in Spodoptera frugiperda larvae
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
February 12, 2026 at 6:23 PM
The neuropeptide pigment-dispersing factor enhanced food intake and alleviated antifeedant effects by azadirachtin in Spodoptera frugiperda larvae
#Drosophila
#Drosophila
8) Lots of ME/CFS patients also have sleep disturbances, so the authors were also interested in orexin, a neuropeptide that keeps us awake and is disrupted in nacrolepsy.
They plan to look at this more closely but preliminary results also suggest a decrease in ME/CFS.
They plan to look at this more closely but preliminary results also suggest a decrease in ME/CFS.
February 7, 2026 at 1:54 PM
8) Lots of ME/CFS patients also have sleep disturbances, so the authors were also interested in orexin, a neuropeptide that keeps us awake and is disrupted in nacrolepsy.
They plan to look at this more closely but preliminary results also suggest a decrease in ME/CFS.
They plan to look at this more closely but preliminary results also suggest a decrease in ME/CFS.
Soma Ca2+ is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons CurrentBiology
Soma Ca2+ is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons
Klose et al. demonstrate in sLNv clock terminals that activity-dependent endogenous neuropeptide release occurs at midmorning, many hours after the daily activity-independent Ca2+ peak in the soma. Thus, soma Ca2+ does not indicate synaptic activity and peptidergic transmission that regulates delayed clock-dependent behaviors.
dlvr.it
February 5, 2026 at 3:06 AM
Soma Ca2+ is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons CurrentBiology
Soma Ca2+ is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons CurrentBiology
Soma Ca2+ is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons
Klose et al. demonstrate in sLNv clock terminals that activity-dependent endogenous neuropeptide release occurs at midmorning, many hours after the daily activity-independent Ca2+ peak in the soma. Thus, soma Ca2+ does not indicate synaptic activity and peptidergic transmission that regulates delayed clock-dependent behaviors.
dlvr.it
February 3, 2026 at 2:05 PM
Soma Ca2+ is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons CurrentBiology
Fast-aging neurons are enriched for neuropeptide and protein biosynthesis pathways. These neuron types show earlier structural decline and loss of neuron-specific function. And indeed, pharmacological inhibition of translation prevents degeneration of fast-aging neurons. (5/n)
February 3, 2026 at 10:31 AM
Fast-aging neurons are enriched for neuropeptide and protein biosynthesis pathways. These neuron types show earlier structural decline and loss of neuron-specific function. And indeed, pharmacological inhibition of translation prevents degeneration of fast-aging neurons. (5/n)
"Hey, uh... Just one more thing. Is there any reason you left the bar, drink still in hand after the murder? Because I been hearin' about this stuff - a synthetic neuropeptide that can store data in a liquid form. Wouldn't you know it the victim's capsule got punctured? Funny, in't it?"
January 28, 2026 at 6:12 PM
"Hey, uh... Just one more thing. Is there any reason you left the bar, drink still in hand after the murder? Because I been hearin' about this stuff - a synthetic neuropeptide that can store data in a liquid form. Wouldn't you know it the victim's capsule got punctured? Funny, in't it?"
A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
#Drosophila
#Drosophila
A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 28, 2026 at 7:24 AM
A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
#Drosophila
#Drosophila
For anyone who's never heard of orexin:
"Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite."
"There are 50,000–80,000 orexin-producing neurons in the human brain, located predominantly in the perifornical area and lateral hypothalamus."
(Wikipedia)
"Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite."
"There are 50,000–80,000 orexin-producing neurons in the human brain, located predominantly in the perifornical area and lateral hypothalamus."
(Wikipedia)
January 24, 2026 at 10:51 AM
For anyone who's never heard of orexin:
"Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite."
"There are 50,000–80,000 orexin-producing neurons in the human brain, located predominantly in the perifornical area and lateral hypothalamus."
(Wikipedia)
"Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite."
"There are 50,000–80,000 orexin-producing neurons in the human brain, located predominantly in the perifornical area and lateral hypothalamus."
(Wikipedia)
Neuropeptide S as a potential risk locus for migraine in the Portuguese population https://www.medrxiv.org/content/10.64898/2026.01.20.26344443v1
January 22, 2026 at 5:40 PM
Neuropeptide S as a potential risk locus for migraine in the Portuguese population https://www.medrxiv.org/content/10.64898/2026.01.20.26344443v1
Qingjun Zhou, Qun Wang et al. from Shandong First Medical University investigate the role of sensory neuropeptide calcitonin gene-related peptide (CGRP) in postrefractive surgery dry eye caused by corneal nerve severing in mice.
doi.org/10.1167/iovs.67.1.45
doi.org/10.1167/iovs.67.1.45
January 21, 2026 at 3:34 PM
Qingjun Zhou, Qun Wang et al. from Shandong First Medical University investigate the role of sensory neuropeptide calcitonin gene-related peptide (CGRP) in postrefractive surgery dry eye caused by corneal nerve severing in mice.
doi.org/10.1167/iovs.67.1.45
doi.org/10.1167/iovs.67.1.45
Soma Ca(2+) is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons
#Drosophila
#Drosophila
Soma Ca(2+) is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 14, 2026 at 6:23 AM
Soma Ca(2+) is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons
#Drosophila
#Drosophila
Perricone MD Unveils Enhanced Neuropeptide Collection with Two Innovative Serums for Aging Skin#USA#Skincare#San_Francisco#Perricone_MD#Neuropeptide_Collection
Perricone MD Unveils Enhanced Neuropeptide Collection with Two Innovative Serums for Aging Skin
Perricone MD relaunches its Neuropeptide Collection, introducing two advanced serums designed for effective anti-aging results, targeting deep wrinkles and sagging.
third-news.com
January 13, 2026 at 4:03 PM
Perricone MD Unveils Enhanced Neuropeptide Collection with Two Innovative Serums for Aging Skin#USA#Skincare#San_Francisco#Perricone_MD#Neuropeptide_Collection
Product Description
VIP peptide, also known as vasoactive intestinal peptide, is a neuropeptide composed of 28 amino acids and is extensively studied in neurotransmission, smooth muscle relaxation mechanisms, immune modulation pathways, and receptor-mediated
arizona-mall.com/product/vip-...
VIP peptide, also known as vasoactive intestinal peptide, is a neuropeptide composed of 28 amino acids and is extensively studied in neurotransmission, smooth muscle relaxation mechanisms, immune modulation pathways, and receptor-mediated
arizona-mall.com/product/vip-...
VIP Peptide 5-10mg Raw material wholesale
VIP peptide is a high-purity synthetic vasoactive intestinal peptide supplied as lyophilized powder in sterile vials. With vial strengths of 5 mg and 10 mg, it is widely used in neuropeptide and receptor signaling research.
arizona-mall.com
January 13, 2026 at 4:43 AM
Product Description
VIP peptide, also known as vasoactive intestinal peptide, is a neuropeptide composed of 28 amino acids and is extensively studied in neurotransmission, smooth muscle relaxation mechanisms, immune modulation pathways, and receptor-mediated
arizona-mall.com/product/vip-...
VIP peptide, also known as vasoactive intestinal peptide, is a neuropeptide composed of 28 amino acids and is extensively studied in neurotransmission, smooth muscle relaxation mechanisms, immune modulation pathways, and receptor-mediated
arizona-mall.com/product/vip-...
Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergichub neuron https://www.biorxiv.org/content/10.64898/2026.01.09.698615v1
January 11, 2026 at 2:15 AM
Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergichub neuron https://www.biorxiv.org/content/10.64898/2026.01.09.698615v1
Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergichub neuron https://www.biorxiv.org/content/10.64898/2026.01.09.698615v1
January 11, 2026 at 2:15 AM
Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergichub neuron https://www.biorxiv.org/content/10.64898/2026.01.09.698615v1
RNA sequencing revealed upregulation of neuropeptide signaling clusters, suggesting transcriptional rejuvenation of brain regions linked to cognition and metabolic control.
📈 What About Humans?
📈 What About Humans?
January 9, 2026 at 1:00 AM
RNA sequencing revealed upregulation of neuropeptide signaling clusters, suggesting transcriptional rejuvenation of brain regions linked to cognition and metabolic control.
📈 What About Humans?
📈 What About Humans?
Lund et al. @ucph.bsky.social reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
January 7, 2026 at 3:31 PM
Lund et al. @ucph.bsky.social reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
In @jcb.org, Lund et al. reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
January 7, 2026 at 3:30 PM
In @jcb.org, Lund et al. reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
For the mineral metabolism-heads, check out this paper: Drosophila (bone-less, PTH-less, the horror!) control extracellular Ca2+ by releasing a neuropeptide in low Ca2+, which acts on receptors in Malpighian tubules to induce Ca mobilization from mineralized granules. www.nature.com/articles/s41...
Neuroendocrine control of calcium mobilization in the fruit fly - Nature
The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.
www.nature.com
January 5, 2026 at 7:41 PM
For the mineral metabolism-heads, check out this paper: Drosophila (bone-less, PTH-less, the horror!) control extracellular Ca2+ by releasing a neuropeptide in low Ca2+, which acts on receptors in Malpighian tubules to induce Ca mobilization from mineralized granules. www.nature.com/articles/s41...
#SnapshotsinNeuroscience | Featured on the #eNeuro blog from Orozco Ramirez et al, an adult male fruit fly brain with expression of membrane-tethered GFP in neurons that express the neuropeptide F receptor and detected with anti-GFP antibodies
Photo Credit: Donnoban Orozco Ramirez
vist.ly/4kgnu
Photo Credit: Donnoban Orozco Ramirez
vist.ly/4kgnu
January 4, 2026 at 12:09 PM
#SnapshotsinNeuroscience | Featured on the #eNeuro blog from Orozco Ramirez et al, an adult male fruit fly brain with expression of membrane-tethered GFP in neurons that express the neuropeptide F receptor and detected with anti-GFP antibodies
Photo Credit: Donnoban Orozco Ramirez
vist.ly/4kgnu
Photo Credit: Donnoban Orozco Ramirez
vist.ly/4kgnu