Healthspan
@healthspanmed.bsky.social
Healthspan is the first online medical clinic dedicated to fighting age-related diseases and increasing human performance by fighting cellular senescence.
🧬 Is aging just wear-and-tear, or is it a built-in flaw in our biological “software”?
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
November 22, 2025 at 1:00 AM
🧬 Is aging just wear-and-tear, or is it a built-in flaw in our biological “software”?
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
New Research Review: The Surprising Role of Rapamcyin in Treating Long COVID and Post-Viral Symptoms: hspan.io/j5Cyvz
November 21, 2025 at 1:00 AM
New Research Review: The Surprising Role of Rapamcyin in Treating Long COVID and Post-Viral Symptoms: hspan.io/j5Cyvz
New Research Review: The Surprising Role of Rapamcyin in Treating Long COVID and Post-Viral Symptoms: hspan.io/j5Cyvz
November 21, 2025 at 1:00 AM
New Research Review: The Surprising Role of Rapamcyin in Treating Long COVID and Post-Viral Symptoms: hspan.io/j5Cyvz
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
November 19, 2025 at 1:00 AM
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
🧬 Why are geroscientists interested in SGLT2 inhibitors for longevity?
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
November 18, 2025 at 8:00 PM
🧬 Why are geroscientists interested in SGLT2 inhibitors for longevity?
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
November 15, 2025 at 8:00 PM
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
New Research Review: SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging
gethealthspan.com/science/art...
gethealthspan.com/science/art...
November 15, 2025 at 10:00 AM
New Research Review: SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging
gethealthspan.com/science/art...
gethealthspan.com/science/art...
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
November 14, 2025 at 9:00 AM
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
November 13, 2025 at 11:48 PM
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
October 14, 2025 at 7:00 PM
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
🧬 Why are geroscientists interested in SGLT2 inhibitors for longevity?
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
September 11, 2025 at 7:00 PM
🧬 Why are geroscientists interested in SGLT2 inhibitors for longevity?
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
September 11, 2025 at 1:00 PM
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
September 11, 2025 at 12:00 AM
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
🧬 Is aging just wear-and-tear, or is it a built-in flaw in our biological “software”?
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
September 10, 2025 at 7:00 PM
🧬 Is aging just wear-and-tear, or is it a built-in flaw in our biological “software”?
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
Hair loss is often dismissed as a mere cosmetic issue—but mounting evidence suggests it’s a powerful biomarker of systemic aging.
Recent research highlights two cellular processes at the heart of follicle health: senescence and autophagy (a cellular “cleanup” program).
Let's review 🧵👇
Recent research highlights two cellular processes at the heart of follicle health: senescence and autophagy (a cellular “cleanup” program).
Let's review 🧵👇
September 1, 2025 at 8:00 AM
Hair loss is often dismissed as a mere cosmetic issue—but mounting evidence suggests it’s a powerful biomarker of systemic aging.
Recent research highlights two cellular processes at the heart of follicle health: senescence and autophagy (a cellular “cleanup” program).
Let's review 🧵👇
Recent research highlights two cellular processes at the heart of follicle health: senescence and autophagy (a cellular “cleanup” program).
Let's review 🧵👇
🧠 Is Alzheimer’s really a disease of misfolded proteins—or a crisis of cellular energy?
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
September 1, 2025 at 12:00 AM
🧠 Is Alzheimer’s really a disease of misfolded proteins—or a crisis of cellular energy?
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
🚨 How Endogenous Fructose Fuels Inflammation and Accelerates Aging—Watch Now
www.youtube.com/watch?v=vBo...
www.youtube.com/watch?v=vBo...
August 30, 2025 at 7:00 PM
🚨 How Endogenous Fructose Fuels Inflammation and Accelerates Aging—Watch Now
www.youtube.com/watch?v=vBo...
www.youtube.com/watch?v=vBo...
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
August 30, 2025 at 9:00 AM
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
August 30, 2025 at 12:00 AM
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
August 29, 2025 at 12:00 AM
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
1. A central question in gerontology is why “young blood” appears to enhance tissue repair in older organisms. Research by Drs. Irina and Michael Conboy at UC Berkeley has provided compelling evidence through parabiosis experiments, wherein an older mouse is surgically joined to a younger one.
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August 28, 2025 at 12:00 AM
1. A central question in gerontology is why “young blood” appears to enhance tissue repair in older organisms. Research by Drs. Irina and Michael Conboy at UC Berkeley has provided compelling evidence through parabiosis experiments, wherein an older mouse is surgically joined to a younger one.
🧵👇
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🚨🚨 New Research Review: Harnessing Chronobiology for Metabolic Health: The Role of Brown Fat and Circadian Rhythms
hspan.io/DI4bdJ
hspan.io/DI4bdJ
August 26, 2025 at 12:00 AM
🚨🚨 New Research Review: Harnessing Chronobiology for Metabolic Health: The Role of Brown Fat and Circadian Rhythms
hspan.io/DI4bdJ
hspan.io/DI4bdJ
🧠 Is Alzheimer’s really a disease of misfolded proteins—or a crisis of cellular energy?
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
August 25, 2025 at 8:00 AM
🧠 Is Alzheimer’s really a disease of misfolded proteins—or a crisis of cellular energy?
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
August 25, 2025 at 12:00 AM
🧬 Why are longevity researchers increasingly excited about SGLT2 inhibitors?
🧬 Is aging just wear-and-tear, or is it a built-in flaw in our biological “software”?
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
August 24, 2025 at 7:00 PM
🧬 Is aging just wear-and-tear, or is it a built-in flaw in our biological “software”?
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇
Dr. João Pedro de Magalhães proposes an interesting perspective: our DNA is the hardware, while the epigenome acts as software.
Over time, this “software” may become maladaptive, driving the aging
Read more 🧵👇