#myeloperoxidase
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kinetoplastpapers.bsky.social
Evaluation of phenyl hydrazide-based compounds as myeloperoxidase inhibitors pubmed.ncbi.nlm.nih.gov/41606227/
January 30, 2026 at 12:52 AM
filiplardon.bsky.social
Als veel myeloperoxidase vrijkomt en vermengd wordt met slijm zorgt dit voor geel tot groen snot. Hoewel groen slijm vaak wijst op een bacteriële infectie, kan het ook voorkomen wanneer je lichaam een immuunreactie op virale ziekteverwekkers opzet. 〰️4/5
January 24, 2026 at 7:17 AM
filiplardon.bsky.social
Concreet maakt het met behulp van waterstofperoxide, hypochloorzuur aan – een stof die ziekteverwekkers effectief vernietigt (vergelijkbaar met het effect van verdund bleekmiddel). Myeloperoxidase bevat een ijzerhoudend heem‑molecuul dat een groene kleur heeft. 〰️3/5
January 24, 2026 at 7:17 AM
filiplardon.bsky.social
tegen de bacteriën of virussen. Daarbij komt een enzyme vrij uit de afweercellen (vooral uit een bepaald type leukocyten, de neutrofielen), myeloperoxidase genaamd, dat een belangrijke rol speelt in je afweersysteem. Myeloperoxidase helpt de indringers te doden door agressieve stoffen te maken. 〰️2/5
January 24, 2026 at 7:17 AM
rokeefemd.bsky.social
Although positive ANCA serologies (p-ANCA pattern with antibodies directed against myeloperoxidase - anti-MPO) are highly specific, they are not sufficient for a diagnosis.
January 21, 2026 at 10:00 PM
sodatroubles.bsky.social
eGFR Slope Predicts Survival and Renal Outcomes in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis: Development and Validation of a Pathogen-Free Model
#nephsky #nephrology
karger.com/kdd/article/...
eGFR Slope Predicts Survival and Renal Outcomes in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis: Development and Validation of a Pathogen-Free Model
Abstract. Objectives: This study explores the potential of estimated glomerular filtration rate (eGFR) slope as a noninvasive marker for predicting renal survival and patient survival in myeloperoxida...
karger.com
January 20, 2026 at 3:44 PM
acr-journals.bsky.social
Transcriptomics study of proinflamm. neutrophils, particularly low-density granulocytes, in SLE showed enrichment of aberrant splicing in genes containing U12-type minor introns, which likely contribute to altered neutrophil phenotypes and promote SLE pathogenesis

A&R
doi.org/10.1002/art....
Reduced expression of Nox component CYBA (P22phox) in SLE neutrophils. A) Western blot (upper and middle and respective densitometry analysis (lower) showing the expression of CYBA (P22phox) and myeloperoxidase (MPO, as a house keeping protein) in neutrophils from healthy controls (n=6), SLE (n=11) or CGD (n=2) patients. The top Western gel compares LDGs with autologous NDGs whereas the bottom Western represents NDGs only. B) Nox activity measured after stimulation with either fMLF (upper graph) or PMA (lower graph) in neutrophils obtained from SLE patients (n=7) or healthy controls (n=12). C) Images of neutrophils stained with an antibody against P22phox and a secondary antibody (FITC conjugated, green). Nuclei are stained blue with Hoechst (magnification 40x). D) Expression of P22phox in neutrophils measured by flow cytometry. Results represent mean + SEM.
January 19, 2026 at 1:32 PM
vasculitides.bsky.social
Trimethoprim-sulfamethoxazole and the risk of early severe infection in elderly-onset myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis
Trimethoprim-sulfamethoxazole and the risk of early severe infection in elderly-onset myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis - PubMed
Trimethoprim-sulfamethoxazole and the risk of early severe infection in elderly-onset myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis
pubmed.ncbi.nlm.nih.gov
December 28, 2025 at 11:00 PM
drbenweitz.bsky.social
Melatonin and Pycnogenol both help to lower Myeloperoxidase (MPO), a marker of arterial inflammation that we measure to assess CVD risk www.ahajournals.org/doi/10.1161/...
Reduction of Myeloperoxidase Activity by Melatonin and Pycnogenol May Contribute to their Blood Pressure Lowering Effect | Hypertension
www.ahajournals.org
December 27, 2025 at 7:58 PM
bibliotecahuvh.bsky.social
Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan disease academic.oup.com/cardiovascre... #hvhebron #cardio
Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan disease
AbstractAims. Patients suffering from Marfan syndrome (MFS), the most prevalent inherited connective tissue disorder, face premature mortality due to disse
academic.oup.com
December 23, 2025 at 12:08 PM
vasculitides.bsky.social
Pericardial Effusion as an Early Manifestation of Myeloperoxidase (MPO)-Positive Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis With Eosinophilia
Pericardial Effusion as an Early Manifestation of Myeloperoxidase (MPO)-Positive Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis With Eosinophilia - PubMed
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare but life-threatening autoimmune disease that primarily targets the kidneys and lungs. Cardiac involvement is far less common, and when it does occur, it is often overlooked until late in the disease course. We describe …
pubmed.ncbi.nlm.nih.gov
December 10, 2025 at 12:49 AM
vasculitides.bsky.social
Lower Myeloperoxidase-ANCA Titres at Diagnosis Are Associated with End-Stage Kidney Disease Progression During Follow-Up in Rituximab-Treated Patients with Microscopic Polyangiitis
Lower Myeloperoxidase-ANCA Titres at Diagnosis Are Associated with End-Stage Kidney Disease Progression During Follow-Up in Rituximab-Treated Patients with Microscopic Polyangiitis - PubMed
<span><i>Background and Objectives</i>: To investigate whether myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) titres at diagnosis are associated with the risk of end-stage kidney disease (ESKD) progression in patients with microscopic polyangiitis (MPA) treated with rituximab. <i>Materia</i></span> …
pubmed.ncbi.nlm.nih.gov
December 10, 2025 at 12:47 AM
z3r0gravitas.bsky.social
1/2
Always cool seeing big general science YouTube channels cover our chronic illnesses.

Perhaps sad that them just calling the scale of the problem right is a thrill...

But Anton Petrov actually informed me on NETs -> microclots, from a #TeamClots study, earlier this year.
Description by Gemini Fast: A screenshot from a video titled "Bizarre Structures Inside Blood May Be Responsible for Long COVID." A man with short dark hair, wearing a blue t-shirt, is speaking, positioned in front of a massive, 3D visualization of a blue and orange spiky molecular structure (likely the SARS-CoV-2 virus). Description by Gemini Fast: A false-color, fluorescence micrograph of a microscopic structure, likely a Long COVID microclot. The structure glows red, green, and cyan against a black background and is labeled with arrows pointing to its components: ThT (Thioflavin T, indicating amyloid structures), MPO (Myeloperoxidase), and DNA, suggesting a complex of Neutrophil Extracellular Traps (NETs). Description by Gemini Fast: A screenshot showing the title page of a research article from the Journal of Medical Virology. The title reads: "Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients." The names of the researchers and their international affiliations are listed below.
December 8, 2025 at 4:21 AM
vasculitides.bsky.social
Regulatory T cell therapy for myeloperoxidase-specific anti-neutrophil cytoplasmic antibody associated vasculitis
Regulatory T cell therapy for myeloperoxidase-specific anti-neutrophil cytoplasmic antibody associated vasculitis - PubMed
Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease characterized by the inflammation of small vessels. It is most commonly caused by ANCA targeting proteinase 3 (PR3) and myeloperoxidase (MPO) which are found in neutrophil lysosomes. The most commo …
pubmed.ncbi.nlm.nih.gov
November 28, 2025 at 10:53 PM
pride-ebi.bsky.social
PXD061940 🚨

Human umbilical vein endothelial cells exposed to Myeloperoxidase-oxidized LDLs (Mox-LDLs) induce mitochondrial activation and stress responses.

🚨 New dataset alert! 🚨
November 24, 2025 at 11:00 PM
hannahgarner.bsky.social
Excited to share this highlight of a beautiful study into how myeloperoxidase acts as a chromatin transformer
November 20, 2025 at 2:45 PM
biorxiv-cellbio.bsky.social
Myeloperoxidase impairs mucociliary transport on human airway epithelium https://www.biorxiv.org/content/10.1101/2025.11.17.688903v1
November 18, 2025 at 3:30 PM
biorxivpreprint.bsky.social
Myeloperoxidase impairs mucociliary transport on human airway epithelium https://www.biorxiv.org/content/10.1101/2025.11.17.688903v1
November 18, 2025 at 3:30 PM
longcovidadvoc.com
They also had higher NET activity: myeloperoxidase, neutrophil elastase, and cell-free DNA - all signs of neutrophils being abnormally activated. 4/
November 17, 2025 at 12:25 PM
cp-trendsimmuno.bsky.social
Myeloperoxidase transforms chromatin into an immune weapon #immunology
Myeloperoxidase transforms chromatin into an immune weapon
Burn et al. reveal a previously unrecognised, non-catalytic function of myeloperoxidase (MPO) in neutrophil extracellular trap (NET) formation; integrating super-resolution microscopy and biochemical approaches, they demonstrated that MPO’s oligomeric state governs chromatin decondensation, redefining MPO as a structural chromatin modifier with implications for diseases driven by dysregulated NETosis.
dlvr.it
November 17, 2025 at 6:15 AM
vasculitides.bsky.social
Kidney Transplantation After Rituximab Treatment for End-Stage Renal Failure With Myeloperoxidase Anti-neutrophil Cytoplasmic and Anti-glomerular Basement Membrane Antibody Positivity: A Case Report
Kidney Transplantation After Rituximab Treatment for End-Stage Renal Failure With Myeloperoxidase Anti-neutrophil Cytoplasmic and Anti-glomerular Basement Membrane Antibody Positivity: A Case Report - PubMed
Double positivity for myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) and anti-glomerular basement membrane (anti-GBM) antibody is associated with distinct clinical features, including older age at onset, prolonged symptom duration, and a combination of severe renal involvement and p …
pubmed.ncbi.nlm.nih.gov
November 12, 2025 at 11:46 PM
vasculitides.bsky.social
Myeloperoxidase-anti-neutrophil cytoplasmic antibody positivity and disease characteristics, treatment, and prognosis in eosinophilic granulomatosis with polyangiitis
Myeloperoxidase-anti-neutrophil cytoplasmic antibody positivity and disease characteristics, treatment, and prognosis in eosinophilic granulomatosis with polyangiitis - PubMed
Patients with MPO-ANCA-positive EGPA demonstrated different baseline clinical characteristics from MPO-ANCA-negative patients. However, subsequent relapses and serious infectious diseases were comparable.
pubmed.ncbi.nlm.nih.gov
November 12, 2025 at 10:52 PM
stephanhacker2.bsky.social
Great talk by @kimmb1.bsky.social of our @led3hub.bsky.social at the #Reedijk Symposium. She talked about the power of activity-based probes to study protein function on the example of live cell imaging of myeloperoxidase activity to study NETosis. www.nature.com/articles/s42...
#ChemBio #ChemSky
November 7, 2025 at 9:07 AM
helixbrief.bsky.social
The researchers quantified double-stranded DNA, myeloperoxidase, and neutrophil elastase in the infarct-related artery, contralateral coronary artery, and peripheral blood. They also analyzed coronary thrombi and the DNASE1 Q222R genotype.
October 24, 2025 at 6:27 AM
drclairesmith.bsky.social
🚨 New preprint from the group - #Neutrophil myeloperoxidase as a functional biomarker for RSV severity: implications for in vitro therapeutic screening. www.biorxiv.org/content/10.1...
Neutrophil myeloperoxidase as a functional biomarker for RSV severity: implications for in vitro therapeutic screening.
Neutrophils play a dual role in respiratory syncytial virus (RSV) infection, contributing to both viral clearance and lung damage. Analysis of peripheral blood-derived neutrophils from infants with RS...
www.biorxiv.org
October 15, 2025 at 8:39 AM