Background Young women (YW) in Angola face multiple, intersecting challenges related to sexual and reproductive health (SRH), including high rates of early and unintended pregnancy, limited access to ...

Subscription and open access journals from Sage, the world's leading independent academic publisher.

Background We recently published the first real-world multicenter and multi-institutional study of cisplatin, gemcitabine, and durvalumab in patients with advanced biliary tract cancer (BTC). Here w...

AbstractAims. Endogenous endophthalmitis (EE) is a rarely reported complication of infective endocarditis (IE). In an international series, we sought to de

Abstract. Purpose: The microbiota is recognized as an important contributor to the efficacy of immunotherapies. The aim of this study is to analyse the role of gut microbiota, and related metabolites,...

Subscription and open access journals from Sage, the world's leading independent academic publisher.

Abstract. Purpose: Routine testing for dMMR/MSI in colorectal cancers (CRCs) is recommended for Lynch Syndrome screening, prognosis, and treatment guidance. In the metastatic setting, RASBRAF mutation...

The Endothelial Activation and Stress Index (EASIX) has been proposed as a predictor of endothelial complications such as cytokine release syndrome (C…

Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable c...

Pathogens adapting to the human host and to vaccination-induced immunity may follow parallel evolutionary paths. Bordetella parapertussis (Bpp) contributes significantly to the burden of whooping coug...

Thieme E-Books & E-Journals

Ascending aorta (AscAo) dilatation assessment and definition in pediatric bicuspid aortic valve (BAV) is challenging. We compared the Pediatric Heart Network (PHN) nomogram against the Halifax (HZ) on...

Background In this Debate, based on our clinical data from the “pre-nirsevimab” and “first year of nirsevimab implementation” bronchiolitis seasons, we challenge the validity of policy decisions that led to partial immunization coverage of eligible newborns and infants during the 2024–25 season in Italy. Main body Starting with a pre-nirsevimab prospective cohort of 780 newborns, we documented that 84 (9.2%) were diagnosed with acute bronchiolitis (45 of them (5.8% of the cohort) were RSV positive. 44 patients (5.6%) were hospitalized due to bronchiolitis, of which 7 (0.9%) patients were admitted to the Pediatric Intensive Care Unit. Among hospitalized, 31 infants (70%) had RSV infection. Secondly, we evaluated the impact on bronchiolitis admissions during the first year of nirsevimab use in our region, showing a negligible effect on the most severe cases, probably due to the fact that a low coverage will risk to miss the relatively small number of infants (about 10%) that will develop RSV bronchiolitis in the first year of life. These findings inspired our clinical insights and reflections arguing that without a long-term, cost-conscious approach to implementation, even major scientific breakthroughs like nirsevimab risk becoming public health failures. Conclusions Our clinical insights and reflections aim to inspire deeper engagement among policymakers, health agencies, and clinicians to better adapt and integrate RSV preventive strategies—maximizing benefit not only for susceptible infants, but for society at large. In a world of finite healthcare resources, optimizing both the reach and the value of such essential interventions is imperative, given the multitude and diversity of health needs our society is facing.

X-linked agammaglobulinemia (XLA) is caused by loss-of-function variants in Bruton’s tyrosine kinase, leading to absence of circulating B lymphocytes and inability to produce antibodies. Despite the f...

GD2 is a ganglioside expressed on the cell surface of a wide range of paediatric cancers. Expression is most consistently seen at a high level in neuroblastoma, though sarcomas and central nervous sys...

Headache disorders, in particular migraine, continue to be a major global health challenge, emphasising the need for effective management and prevention strategies. Much headache-attributed burden cou...

While apical ballooning represents the most common pattern presentation of Takotsubo syndrome (TTS), focal forms have been sporadically reported and lack detailed characterization. Aim of the study is...