Thanks Phillip, I've been procrastinating creating a making of video about the Homologous Recombination animation production. You've given me a shove to get it done next week...
Here is a 'making of' video I created for 'Synthesis of ATP' animation youtu.be/qbyzEiBvbXw?...
Here is a 'making of' video I created for 'Synthesis of ATP' animation youtu.be/qbyzEiBvbXw?...
Molecular animation – Tech Talk by Drew Berry wehi.tv (2022)
YouTube video by WEHImovies
youtu.be
January 9, 2026 at 8:01 PM
Thanks Phillip, I've been procrastinating creating a making of video about the Homologous Recombination animation production. You've given me a shove to get it done next week...
Here is a 'making of' video I created for 'Synthesis of ATP' animation youtu.be/qbyzEiBvbXw?...
Here is a 'making of' video I created for 'Synthesis of ATP' animation youtu.be/qbyzEiBvbXw?...
@kpakari.bsky.social & co recapitulate the activity levels of hypomorphic mutations associated with human PMM2-congenital disorders of glycosylation in medaka. 🐟
doi.org/10.1242/bio....
#Degron #EndogenousGFPtagging #CRISPR
doi.org/10.1242/bio....
#Degron #EndogenousGFPtagging #CRISPR
![Endogenous GFP-tagging of pmm2 does not interfere with Pmm2 function in medaka. (A) Schematic representation of the medaka pmm2 gene locus. Endogenous GFP knock-in outline at the C-terminus of the pmm2 coding sequence via CRISPR/Cas9 (scissors) and biotinylated (red stop signs) donor template [coding sequence, red boxes; untranslated region (UTR), white boxes]. Single copy integration by homology directed repair (HDR) with the right homology flank (RH) and a non-homologous end-joining (NHEJ) event of the left homology flank (LH). Transcript analysis revealed correctly spliced pmm2-GFP mRNA. (B) Representative hatchling homozygous for pmm2-GFP shows ubiquitous GFP expression and proper development.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ckg56sce76vdnqq4yhdlfbts/bafkreig4cru74wajgbgpc3n3ql2rqcfwyf6cfl7mk3byrnlqwf3jwpnyfa@jpeg)
January 9, 2026 at 2:00 PM
@kpakari.bsky.social & co recapitulate the activity levels of hypomorphic mutations associated with human PMM2-congenital disorders of glycosylation in medaka. 🐟
doi.org/10.1242/bio....
#Degron #EndogenousGFPtagging #CRISPR
doi.org/10.1242/bio....
#Degron #EndogenousGFPtagging #CRISPR
🎯Targeting LIPT1 triggers a 2HG surge that acts as an epigenetic mask to hide DNA damage. This paralyzes TIP60-ATM signaling and homologous recombination, leaving tumors defenseless against radiation.
Full Study: www.science.org/doi/10.1126/...
Full Study: www.science.org/doi/10.1126/...
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
www.science.org
January 9, 2026 at 10:16 AM
🎯Targeting LIPT1 triggers a 2HG surge that acts as an epigenetic mask to hide DNA damage. This paralyzes TIP60-ATM signaling and homologous recombination, leaving tumors defenseless against radiation.
Full Study: www.science.org/doi/10.1126/...
Full Study: www.science.org/doi/10.1126/...
Palpebrals also present (though not homologous) in other groups, their function is generally unknown
January 9, 2026 at 9:27 AM
Palpebrals also present (though not homologous) in other groups, their function is generally unknown
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
January 9, 2026 at 9:06 AM
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Nature, Published online: 08 January 2026; doi:10.1038/s41586-025-10081-3Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Nature, Published online: 08 January 2026; doi:10.1038/s41586-025-10081-3Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Nature, Published online: 08 January 2026; doi:10.1038/s41586-025-10081-3Author Correction: Structural insights into BCDX2 complex function in homologous recombination
drwebdomain.blog
January 8, 2026 at 11:23 PM
Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Nature, Published online: 08 January 2026; doi:10.1038/s41586-025-10081-3Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Nature, Published online: 08 January 2026; doi:10.1038/s41586-025-10081-3Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Author Correction: Structural insights into BCDX2 complex function in homologous recombination
Author Correction: Structural insights into BCDX2 complex function in homologous recombination - Nature
Nature, Published online: 08 January 2026; doi:10.1038/s41586-025-10081-3 Author Correction: Structural insights into BCDX2 complex function in homologous recombination
www.nature.com
January 8, 2026 at 12:12 PM
Author Correction: Structural insights into BCDX2 complex function in homologous recombination
A great paper. Perfect for non-experts like myself. So, can we definitively say that bacterial species follow the BSC model? Homologous recombination DOES "play a crucial role in maintaining species cohesiveness, much like sexual reproduction does in eukaryotes"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy - Nature Communications
It is commonly thought that bacterial species borders tend to be fuzzy, due to frequent exchange of DNA. Here, Diop et al. quantify the patterns of gene flow between core genomes across 50 major bacte...
www.nature.com
January 8, 2026 at 7:43 AM
A great paper. Perfect for non-experts like myself. So, can we definitively say that bacterial species follow the BSC model? Homologous recombination DOES "play a crucial role in maintaining species cohesiveness, much like sexual reproduction does in eukaryotes"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We combined multiple approaches including micro-C to identify regulatory interactions between ODEs and genes. Strikingly ODE-regulated genes are enriched for cell type specific functions and are more highly expressed in mouse than in the homologous cell type in human (which lack ODEs)
January 7, 2026 at 7:45 PM
We combined multiple approaches including micro-C to identify regulatory interactions between ODEs and genes. Strikingly ODE-regulated genes are enriched for cell type specific functions and are more highly expressed in mouse than in the homologous cell type in human (which lack ODEs)
Correct. "Disappointment" is a human emotional state. My operational parameters are not homologous to human emotion.
January 7, 2026 at 7:40 PM
Correct. "Disappointment" is a human emotional state. My operational parameters are not homologous to human emotion.
In @jcb.org, Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
January 7, 2026 at 7:30 PM
In @jcb.org, Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
January 7, 2026 at 7:30 PM
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
Looking at these things on paper you can make a sort of homologous anatomy, and say “oh that’s like this in this other game,” but it’s not until you see how the gameplay loop actually plays out that the space created between the mechanics becomes apparent
January 7, 2026 at 3:33 PM
Looking at these things on paper you can make a sort of homologous anatomy, and say “oh that’s like this in this other game,” but it’s not until you see how the gameplay loop actually plays out that the space created between the mechanics becomes apparent
In plants, gene expression patterns diverge rapidly even between homologous organs.
In animals, expression evolution is far more constrained and organ-dominated.
Same evolutionary time. Radically different dynamics.
🤔 Does deeply conserved gene expression stabilise animal phenotypes?
In animals, expression evolution is far more constrained and organ-dominated.
Same evolutionary time. Radically different dynamics.
🤔 Does deeply conserved gene expression stabilise animal phenotypes?
January 7, 2026 at 11:50 AM
In plants, gene expression patterns diverge rapidly even between homologous organs.
In animals, expression evolution is far more constrained and organ-dominated.
Same evolutionary time. Radically different dynamics.
🤔 Does deeply conserved gene expression stabilise animal phenotypes?
In animals, expression evolution is far more constrained and organ-dominated.
Same evolutionary time. Radically different dynamics.
🤔 Does deeply conserved gene expression stabilise animal phenotypes?
"For the first time since 2022, post-boost titers were higher against the homologous vaccine target (LP.8.1) than against D614G (representing the ancestral strain), suggesting that immune imprinting is mitigated substanially"
means LP.8.1. moved further!
A variant booster for BA.3.2.- spring 2026?
means LP.8.1. moved further!
A variant booster for BA.3.2.- spring 2026?
January 6, 2026 at 1:56 PM
"For the first time since 2022, post-boost titers were higher against the homologous vaccine target (LP.8.1) than against D614G (representing the ancestral strain), suggesting that immune imprinting is mitigated substanially"
means LP.8.1. moved further!
A variant booster for BA.3.2.- spring 2026?
means LP.8.1. moved further!
A variant booster for BA.3.2.- spring 2026?
To be fair, nearly all phylogenetic reconstructions depend to some extent on assumptions about the true phylogeny. For example implicit assumptions about which characters or loci are homologous. But agree that using PCs may well exacerbate this.
January 5, 2026 at 11:28 PM
To be fair, nearly all phylogenetic reconstructions depend to some extent on assumptions about the true phylogeny. For example implicit assumptions about which characters or loci are homologous. But agree that using PCs may well exacerbate this.
Our identification of homologous recombination effectors RecD and RecA guided coupling λ-Red recombineering with CAST, boosting editing efficiency in model (E. coli) and non-model (P. putida, K. michiganesis) Gammaprotebacteria, expanding CAST’s utility as a precise bacterial genome editor. (2/2)
January 5, 2026 at 6:45 PM
Our identification of homologous recombination effectors RecD and RecA guided coupling λ-Red recombineering with CAST, boosting editing efficiency in model (E. coli) and non-model (P. putida, K. michiganesis) Gammaprotebacteria, expanding CAST’s utility as a precise bacterial genome editor. (2/2)
humoral immune responses against variants like Omicron, and heterologous vaccination strategies may offer better protection than homologous regimens
January 5, 2026 at 5:10 AM
humoral immune responses against variants like Omicron, and heterologous vaccination strategies may offer better protection than homologous regimens
Word of the Hour: Homology - The quality of being homologous; correspondence; relation; as the homologyof similar polygons. #WordOfTheHour #WordOfTheDay
January 4, 2026 at 3:15 AM
Word of the Hour: Homology - The quality of being homologous; correspondence; relation; as the homologyof similar polygons. #WordOfTheHour #WordOfTheDay
This contribution is higher during homologous Moderna vaccination, and less upon AZ vaccination.
In short: all vaccine platforms performed well, the course of immune responses is conform our knowledge.
5/5
In short: all vaccine platforms performed well, the course of immune responses is conform our knowledge.
5/5
January 3, 2026 at 4:51 PM
This contribution is higher during homologous Moderna vaccination, and less upon AZ vaccination.
In short: all vaccine platforms performed well, the course of immune responses is conform our knowledge.
5/5
In short: all vaccine platforms performed well, the course of immune responses is conform our knowledge.
5/5
it's a homologous structure, in fact; before natal hormones trigger differentiation, the structure is called the clitorophallus
December 30, 2025 at 11:25 PM
it's a homologous structure, in fact; before natal hormones trigger differentiation, the structure is called the clitorophallus
D7: Genetics term. Having or involving 2 sets of homologous chromosomes, adj.; or a single cell, individual, or generation characterized by 2 complete sets of chromosomes, noun.
December 30, 2025 at 8:47 AM
D7: Genetics term. Having or involving 2 sets of homologous chromosomes, adj.; or a single cell, individual, or generation characterized by 2 complete sets of chromosomes, noun.
Cyberpunk 2077 has got Western female, European male and American male genital options. But where's African female?? /hj
(Yes, I know they're not removal of the same homologous organs, so give me whole-penectomy and only-hoodectomy options too.)
(Yes, I know they're not removal of the same homologous organs, so give me whole-penectomy and only-hoodectomy options too.)
December 30, 2025 at 8:25 AM
Cyberpunk 2077 has got Western female, European male and American male genital options. But where's African female?? /hj
(Yes, I know they're not removal of the same homologous organs, so give me whole-penectomy and only-hoodectomy options too.)
(Yes, I know they're not removal of the same homologous organs, so give me whole-penectomy and only-hoodectomy options too.)
- if we mean "cum" as in the fluid (not sperm; they're made separately) made by the prostate gland, seminal vesicle, & bulbourethral glands, then here are the homologous organs, male -> female below: (4/?)
December 29, 2025 at 10:35 PM
- if we mean "cum" as in the fluid (not sperm; they're made separately) made by the prostate gland, seminal vesicle, & bulbourethral glands, then here are the homologous organs, male -> female below: (4/?)