#CancerRes
LightNews LightNews
efigbo.bsky.social
‼️ The final version of our study on the role of KDM6A/B in Ewing sarcoma is now out!! 🎉

Check it out here: aacrjournals.org/cancerres/ar...
November 15, 2025 at 4:55 PM
pmresearch-uhn.bsky.social
New research shows that a common mutation in blood stem cells (TET2) may boost the effectiveness of immunotherapy, enhancing response to immune checkpoint inhibitors, led by Drs. Robert Vanner and John Dick at @uhn.ca @uhnresearch.ca @pmresearch-uhn.bsky.social.

aacrjournals.org/cancerres/ar...
November 12, 2025 at 2:51 PM
cosimocommisso.bsky.social
Thrilled to share our new paper published in Cancer Research (@theaacr.bsky.social), led by outstanding work from Priyanka Gupta in our lab. Our study uncovers how stromal aging fundamentally reshapes pancreatic ductal adenocarcinoma (PDAC) biology. aacrjournals.org/cancerres/ar...
The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer
Abstract. Aging is a critical yet understudied determinant in pancreatic ductal adenocarcinoma (PDAC) risk and outcomes. Despite a strong epidemiological association with age, conventional PDAC precli...
aacrjournals.org
November 10, 2025 at 3:14 PM
andreamorandi.bsky.social
🚨 Our new paper is now out in 𝘊𝘢𝘯𝘤𝘦𝘳 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩!

ESR1 mutations in ER⁺ breast cancer rewire lipid metabolism, creating a ferroptosis vulnerability 🔬
ACSL4 is a key biomarker & combo with SERDs offers a new strategy.
👏 Congrats to the whole #TBTlab & collaborators!

aacrjournals.org/cancerres/ar...
ESR1 Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer
Abstract. Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancer. Point mutations in the ligand-binding domain of the gene encoding the estrogen receptor (ES...
aacrjournals.org
November 7, 2025 at 8:20 PM
brettgarabedian.bsky.social
“In this study, we identified integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for #Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC” #SialicAcid #Glycotime

aacrjournals.org/cancerres/ar...
Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
AbstractTumor-associated macrophages (TAM) in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) exhibit immunosuppressive phenotypes and impaired phagocytic activity, facilitati...
aacrjournals.org
November 6, 2025 at 3:52 AM
luohc2025.bsky.social
Our team harnesses large-scale T-cell receptor profiling to uncover tumor-specific signals, potentially revolutionizing indeterminate pulmonary nodule diagnosis! #CancerResearch #Immunotherapy #PrecisionMedicineteam.
aacrjournals.org/cancerres/ar....
November 4, 2025 at 1:42 AM
marcus-ruscetti.bsky.social
What are the genetic determinants of immune suppression and immunotherapy resistance in cancer? In a recent study from our lab, Kat Murphy developed innovative genetically engineered mouse models of late-stage prostate cancer to address this question.
aacrjournals.org/cancerres/ar...
MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T-cell and Immunotherapy Responses in Prostate Cancer
AbstractPatients with castration-resistant prostate cancer (CRPC) are generally unresponsive to tumor-targeted treatments and immunotherapies. Genetic alterations acquired during the evolution of CRPC...
aacrjournals.org
November 3, 2025 at 6:28 PM
marcus-ruscetti.bsky.social
Could not be more proud of Kat and all she has accomplished in graduate school and beyond!

Be sure to also check out her recent paper in Cancer Research elucidating genetic mechanisms of immune suppression and immunotherapy resistance in prostate cancer.

aacrjournals.org/cancerres/ar...
November 3, 2025 at 6:15 PM
scinews.bsky.social
New antibody therapy reawakens immune system to fight pancreatic cancer

"Study reveals how pancreatic tumors evade immunity using a sugar disguise, and how a new antibody restores immunity in mice"

aacrjournals.org/cancerres/ar...
November 3, 2025 at 3:11 PM
ycluster.bsky.social
We found diverse pathways to resistance led to a shared vulnerability to CDK12/13 inhibitors, which exacerbated mitotic arrest through loss of CDK12-dependent TP73 expression. Combining CDK12/13 and KRAS inhibitors up front prevented the onset of drug resistance!

aacrjournals.org/cancerres/ar...
Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors
Abstract. The onset of acquired resistance limits the efficacy of KRASG12C inhibitors in lung cancer patients. Experiments in preclinical model systems and retrospective analyses of patients treated w...
aacrjournals.org
October 31, 2025 at 3:24 AM
ycluster.bsky.social
I'm excited to share two Haura lab papers out in Cancer Research: we derived a panel of cell lines with resistance to KRAS inhibitors and dissected their mechanisms of resistance by mutliomics linked to drug and CRISPR screens and lots of good ol' validation assays.

aacrjournals.org/cancerres/ar...
RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wildtype RAS Activation in Non-Small Cell Lung Cancer
Abstract. Small molecule KRASG12C(OFF) inhibitors that bind to the inactive GDP-bound state of KRAS have demonstrated efficacy in patients with KRASG12C mutant tumors, yet responses tend to be transie...
aacrjournals.org
October 31, 2025 at 3:21 AM
grnfluoresceblg.bsky.social
miR-10b not mormally expressed but over expressed in glioma & glioblastoma.

aacrjournals.org/cancerres/ar...
Human Glioma Growth Is Controlled by MicroRNA-10b
Findings characterize the oncogenic functions of microRNA-10b in glioma biology by in silico, in vitro and in vivo approaches.
aacrjournals.org
October 30, 2025 at 8:06 AM
lucidscientific.bsky.social
Resipher in Action! Check out this example of how it deepens research within cancer metabolism and therapeutic discovery.

Resipher was critical for capturing the sharp reduction in mitochondrial respiration that accompanied the metabolic stress. Publication >>> aacrjournals.org/cancerres/ar...
October 29, 2025 at 1:32 PM
melanoma-mrv.bsky.social
Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells url: aacrjournals.org/cancerres/ar...
Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells
The transglutaminase TGM2 is negatively associated with the neural crest lineage-specific transcription factor SOX10 and is an immunomodulatory protein in cutaneous melanoma.
aacrjournals.org
October 28, 2025 at 5:27 AM
benoitmiotto.bsky.social
📌New paper📌
Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer url: aacrjournals-org.insb.bib.cnrs.fr/cancerres/ar...
Login Page
aacrjournals-org.insb.bib.cnrs.fr
October 23, 2025 at 2:07 PM
davidmoralesalamo.bsky.social
Exercise creates a systemic metabolic "shield" that reprograms distant organs, limiting tumor growth & metastasis—exercise-induced metabolic changes suppress cancer progression in mouse models.

Yet, people still do not exercise during treatment...

aacrjournals.org/cancerres/ar...
An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Exercise protects against cancer progression and metastasis by inducing a high nutrient demand in internal organs, indicating that reducing nutrient availability to tumor cells represents a potential ...
aacrjournals.org
October 21, 2025 at 10:48 AM
melanoma-mrv.bsky.social
Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells url: aacrjournals.org/cancerres/ar...
Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells
The transglutaminase TGM2 is negatively associated with the neural crest lineage-specific transcription factor SOX10 and is an immunomodulatory protein in cutaneous melanoma.
aacrjournals.org
October 19, 2025 at 10:10 PM
lgoodbu.bsky.social
aacrjournals.org/cancerres/ar...
Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation
Abstract. Pancreatic cancer is associated with a high rate of metastasis and poor prognosis. The formation of a premetastatic niche (PMN) facilitates cancer cell spread and contributes to cancer morta...
aacrjournals.org
October 19, 2025 at 6:57 AM
emilylasse.bsky.social
I’m happy to announce that my thesis work has officially been accepted and is currently online! This has been a labor of love. Thank you to everyone who helped me get here especially @mpm-lab.bsky.social who has consistently empowered me and my research interests.
aacrjournals.org/cancerres/ar...
Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation
Abstract. Pancreatic cancer is associated with a high rate of metastasis and poor prognosis. The formation of a premetastatic niche (PMN) facilitates cancer cell spread and contributes to cancer morta...
aacrjournals.org
October 17, 2025 at 6:52 PM
trevorgraham.bsky.social
The second is about potential fitness costs of cancer drug resistance, and how we might exploit them using approaches like adaptive therapy. (building on our work with @mlockley.bsky.social in ovarian cancer: aacrjournals.org/cancerres/ar...). Description here: www.icr.ac.uk/study-and-ca...
Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
Carboplatin adaptive therapy improves treatment efficacy without increasing daily dose due to reduced fitness of drug-resistant populations, which can be tracked using cfDNA and could direct adaptive ...
aacrjournals.org
October 14, 2025 at 8:26 PM
efigbo.bsky.social
📢 Thrilled to share our latest paper, KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma, from my PhD, is now published in Cancer Research!

Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...

#Epigenetics #Cancer #EwingSarcoma

Huge thanks to the team!
KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
Abstract. Ewing Sarcoma (EwS) is a highly aggressive tumor arising in bones and soft tissues driven by the fusion oncoprotein EWSR1::FLI1. This aberrant transcription factor binds to GGAA microsatelli...
aacrjournals.org
October 14, 2025 at 7:38 PM
christophertape.bsky.social
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
October 14, 2025 at 5:07 PM
jeffreytownsend.bsky.social
We analyzed 9,230 lung adenocarcinoma (LUAD) tumors to assess the mutational context and oncogenic potential of KRAS G12A and G12V and G12C and G12D variants. Their cancer effect sizes were similar—large compared to variants at other sites of KRAS.

aacrjournals.org/cancerres/ar...
October 14, 2025 at 1:07 PM
benoitmiotto.bsky.social
Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer url: aacrjournals.org/cancerres/ar...
Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer
Abstract. Commonly used in cancer therapy, topoisomerase II (TOP2) poisons are designed to stabilize the normally transient DNA TOP2 cleavage complexes in chromatin, leading to deleterious DNA double-...
aacrjournals.org
October 3, 2025 at 7:21 PM
lucidscientific.bsky.social
The study investigates the mechanism by which the ceramide analog LCL768 induces mitophagy and metabolic stress in HNSCC. Resipher was used to measure real-time OCR over 24 hours to assess the impact of mitophagy on mitochondrial respiration.

View it here >>> aacrjournals.org/cancerres/ar...
October 3, 2025 at 12:34 PM