Will Oldham
@willoldham.bsky.social
Scientist, physician, husband, father of daughters.
I study how cell metabolism contributes to the lung diseases pulmonary hypertension and fibrosis.
oldhamlab.org
I study how cell metabolism contributes to the lung diseases pulmonary hypertension and fibrosis.
oldhamlab.org
Reposted by Will Oldham
When I ask a patient what medicines they take and they wave their hands and say “it’s in the chart” I need them to understand that “the patient’s chart” is a mythical concept, more akin to the scattered scribblings of the British constitution rather than a single, comprehensive document.
January 9, 2024 at 3:40 PM
When I ask a patient what medicines they take and they wave their hands and say “it’s in the chart” I need them to understand that “the patient’s chart” is a mythical concept, more akin to the scattered scribblings of the British constitution rather than a single, comprehensive document.
Reposted by Will Oldham
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 28, 2025 at 4:25 PM
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Reposted by Will Oldham
Handed out, yet again, the basic #ScrawledGrantAdvice Aims page structure
August 12, 2025 at 7:14 PM
Handed out, yet again, the basic #ScrawledGrantAdvice Aims page structure
Reposted by Will Oldham
some light teasing for an upcoming quarto revealjs plugin I have been working on
August 12, 2025 at 7:03 PM
some light teasing for an upcoming quarto revealjs plugin I have been working on
July 30, 2025 at 10:15 PM
Woohoo! Latest preprint from the lab describing how fibroblasts can use alanine to bypass glutamine requirements for differentiation and ECM production. It's a lovely example of metabolic flexibility with implications for how we study cell metabolism. Shout out to Fei Li, who led this work! #cureipf
TGF-β Coordinates Alanine Synthesis and Import for Myofibroblast Differentiation in Pulmonary Fibrosis https://www.biorxiv.org/content/10.1101/2025.07.23.666333v1
July 24, 2025 at 8:45 PM
Woohoo! Latest preprint from the lab describing how fibroblasts can use alanine to bypass glutamine requirements for differentiation and ECM production. It's a lovely example of metabolic flexibility with implications for how we study cell metabolism. Shout out to Fei Li, who led this work! #cureipf
Still regretting the 4 month period 13 years ago when I went all in on the Mac office suite...
June 25, 2025 at 5:13 PM
Still regretting the 4 month period 13 years ago when I went all in on the Mac office suite...
Reposted by Will Oldham
📢 Get ready to submit your abstract to PVRI 2026 Dublin — registrations & the abstract portal will open on 1 July! Stay tuned for full details on how to register and submit your abstract! pvrinstitute.org/pvri2026
#PVRI2026 #PulmonaryHypertension #GlobalScience #Congress
#PVRI2026 #PulmonaryHypertension #GlobalScience #Congress
June 11, 2025 at 11:31 AM
📢 Get ready to submit your abstract to PVRI 2026 Dublin — registrations & the abstract portal will open on 1 July! Stay tuned for full details on how to register and submit your abstract! pvrinstitute.org/pvri2026
#PVRI2026 #PulmonaryHypertension #GlobalScience #Congress
#PVRI2026 #PulmonaryHypertension #GlobalScience #Congress
Reposted by Will Oldham
This JUST came up again and @ruben.the100.ci pointed me to the @malte.the100.ci blog explaining how to do it:
medium.com/@malte.elson...
it was @malte.the100.ci blogging, but not at the 100% CI. we shouldnt speak of this dark period, but the advice is still useful.
it was @malte.the100.ci blogging, but not at the 100% CI. we shouldnt speak of this dark period, but the advice is still useful.
Retaining copyright for figures in academic publications to allow easy citation and reuse
tl;dr
1. Scientists routinely cannot reuse or quote figures in publications, even their own, due to copyright agreements.
2. Figures can be…
medium.com
June 10, 2025 at 9:26 PM
This JUST came up again and @ruben.the100.ci pointed me to the @malte.the100.ci blog explaining how to do it:
Reposted by Will Oldham
Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
June 4, 2025 at 6:34 PM
Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
Reposted by Will Oldham
our lightsaber
The history of micropipettes that you didn't know you wanted to know
Making the Micropipette
The innovation and litigation behind biology’s most ubiquitous tool.
www.asimov.press
June 5, 2025 at 12:17 AM
our lightsaber
Excited to announce that, In 26 days, I will be joining Brown University Health! Excited for new colleagues, new opportunities, and renewed energy to advance our work toward a cure for pulmonary fibrosis!
May 5, 2025 at 8:47 PM
Excited to announce that, In 26 days, I will be joining Brown University Health! Excited for new colleagues, new opportunities, and renewed energy to advance our work toward a cure for pulmonary fibrosis!
Such a great meeting! Looking forward to #PVRI2026 in Dublin!
NEW editorial just published: PVRI International Conference 2025: Embracing Heterogeneity by our hashtag#PVRI2025 scientific organising committee members Katarina Zeder & Navneet Singh. Not to be missed! Read the full article ➡️ onlinelibrary.wiley.com/doi/full/10....
May 2, 2025 at 2:21 PM
Such a great meeting! Looking forward to #PVRI2026 in Dublin!
Reposted by Will Oldham
#rstats folks: If you have a habit of updating your library after an R upgrade by copying the old one and run update.packages().
--> DON'T DO THAT <--
Especially not with 4.5.0. You will overwrite base packages with ones from a previous version and as these are not on CRAN, things go bad.
--> DON'T DO THAT <--
Especially not with 4.5.0. You will overwrite base packages with ones from a previous version and as these are not on CRAN, things go bad.
April 24, 2025 at 5:29 PM
#rstats folks: If you have a habit of updating your library after an R upgrade by copying the old one and run update.packages().
--> DON'T DO THAT <--
Especially not with 4.5.0. You will overwrite base packages with ones from a previous version and as these are not on CRAN, things go bad.
--> DON'T DO THAT <--
Especially not with 4.5.0. You will overwrite base packages with ones from a previous version and as these are not on CRAN, things go bad.
Reposted by Will Oldham
Thanks so much @navneetsinghmd.bsky.social @brownpvd.bsky.social for the opportunity to visit and hospitality! Wonderful to be able to see you all! @gauravchoudhury.bsky.social @willoldham.bsky.social
What a delight it was to have @sashaprisco.bsky.social visit us today to talk about her innovative work. Take home point: modulation of the gut micro- and myco-biome can have profound effects on the RV in experimental PAH! @atscommunity.bsky.social @ahascience.bsky.social @pvrinstitute.bsky.social
April 14, 2025 at 7:56 PM
Thanks so much @navneetsinghmd.bsky.social @brownpvd.bsky.social for the opportunity to visit and hospitality! Wonderful to be able to see you all! @gauravchoudhury.bsky.social @willoldham.bsky.social
Reposted by Will Oldham
This helped me a lot: www.tidyverse.org/blog/2020/08...
Taking Control of Plot Scaling
Learn how to control scaling of the content in your plot when you render plots to different sizes.
www.tidyverse.org
April 3, 2025 at 10:06 PM
This helped me a lot: www.tidyverse.org/blog/2020/08...
#rstats folks! Does anyone have workflow tips on using ggplot2 in both manuscripts and slide presentations? Currently using targets to generate panels/figures themed for manuscript. These are not easy to port to slides given size of points, fonts, etc. Any advice appreciated!
April 3, 2025 at 3:48 PM
#rstats folks! Does anyone have workflow tips on using ggplot2 in both manuscripts and slide presentations? Currently using targets to generate panels/figures themed for manuscript. These are not easy to port to slides given size of points, fonts, etc. Any advice appreciated!
Breaking in a new column today and, gosh, sometimes it’s nice to be able to SEE the science! #scienceincolor
March 26, 2025 at 7:40 PM
Breaking in a new column today and, gosh, sometimes it’s nice to be able to SEE the science! #scienceincolor
Reposted by Will Oldham
I do not pay the kind of attention to college basketball that I once did but it is still important to take time out of my day to root against Duke
March 23, 2025 at 7:56 PM
I do not pay the kind of attention to college basketball that I once did but it is still important to take time out of my day to root against Duke
Reposted by Will Oldham
🏋️♀️ Strength training is vital for women entering #menopause - boosting metabolic, mental, & bone health. But like any intervention, it needs proper assessment & guidance. I started at 43, lifting heavy: no injuries. The secret? Good coaching, mobility, movement literacy, slow progression, and rest.
March 20, 2025 at 6:02 PM
🏋️♀️ Strength training is vital for women entering #menopause - boosting metabolic, mental, & bone health. But like any intervention, it needs proper assessment & guidance. I started at 43, lifting heavy: no injuries. The secret? Good coaching, mobility, movement literacy, slow progression, and rest.
Reposted by Will Oldham
Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...
Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy - Nature Communications
Senescent cells accumulate in tissues with aging and disease but are difficult to detect due to distinct cell-type-specific senescence phenotypes. Here, the authors present the SenePy algorithm to ide...
www.nature.com
February 24, 2025 at 7:31 PM
Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...
Reposted by Will Oldham
Happy to share our work on cold storage of pcls. Hoping this will be of interest to many and will help to store, share and expand the use of PCLS in #lungresearch. Kudoz to Camila and Fee who Share first authorship. @atscommunity.bsky.social respiratory-research.biomedcentral.com/articles/10....
Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies - Respiratory Research
Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, gen...
respiratory-research.biomedcentral.com
February 18, 2025 at 11:06 PM
Happy to share our work on cold storage of pcls. Hoping this will be of interest to many and will help to store, share and expand the use of PCLS in #lungresearch. Kudoz to Camila and Fee who Share first authorship. @atscommunity.bsky.social respiratory-research.biomedcentral.com/articles/10....
Reposted by Will Oldham
Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis - Nature Genetics
Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.
www.nature.com
February 4, 2025 at 2:11 PM
Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!
Reposted by Will Oldham
Say what you will about the antiquity of beepers as a technology, but when that’s the only number anyone can reach you at, then the person holding the beeper is the only person who gets disturbed by the beeping.
January 20, 2025 at 3:46 AM
Say what you will about the antiquity of beepers as a technology, but when that’s the only number anyone can reach you at, then the person holding the beeper is the only person who gets disturbed by the beeping.
Reposted by Will Oldham
How to snipe techie people of a certain age...
January 15, 2025 at 5:01 PM
How to snipe techie people of a certain age...