Ben-Sahra Lab
@bensahralab.bsky.social
Nucleotide Metabolism, Molecular Metabolism, and Signaling Pathways
https://www.bensahralab.org/
https://www.bensahralab.org/
Reposted by Ben-Sahra Lab
Good Sunday, mitolovers. Here is the weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology, with truly remarkable papers: lnkd.in/e7HDuVuU @biomednews.bsky.social #keepreading
"Attention is the rarest and purest form of generosity."-Simone Weil
"Attention is the rarest and purest form of generosity."-Simone Weil
February 1, 2026 at 7:21 AM
Good Sunday, mitolovers. Here is the weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology, with truly remarkable papers: lnkd.in/e7HDuVuU @biomednews.bsky.social #keepreading
"Attention is the rarest and purest form of generosity."-Simone Weil
"Attention is the rarest and purest form of generosity."-Simone Weil
Reposted by Ben-Sahra Lab
Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity
Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...
www.science.org
January 16, 2026 at 6:14 PM
Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
Reposted by Ben-Sahra Lab
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
January 16, 2026 at 4:27 PM
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
Reposted by Ben-Sahra Lab
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis - Nature Immunology
Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.
www.nature.com
January 15, 2026 at 1:55 PM
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ben-Sahra Lab
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
January 13, 2026 at 4:12 PM
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
Reposted by Ben-Sahra Lab
Here’s a new compilation of papers about cancer metabolism published last month
MetaboList - December 2025
Special section about diet and cancer
metabolist.wordpress.com/2026/01/09/m...
MetaboList - December 2025
Special section about diet and cancer
metabolist.wordpress.com/2026/01/09/m...
MetaboList – December 2025
Diet and cancer Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation Tong et al, Zhen Lei Hubing Shi ∙ Xuelei Ma. Dietary restriction…
metabolist.wordpress.com
January 9, 2026 at 2:57 PM
Here’s a new compilation of papers about cancer metabolism published last month
MetaboList - December 2025
Special section about diet and cancer
metabolist.wordpress.com/2026/01/09/m...
MetaboList - December 2025
Special section about diet and cancer
metabolist.wordpress.com/2026/01/09/m...
Reposted by Ben-Sahra Lab
Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,
January 9, 2026 at 6:19 PM
Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,
Reposted by Ben-Sahra Lab
Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵
January 6, 2026 at 8:11 PM
Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵
Reposted by Ben-Sahra Lab
happy to announce that i have post-doc openings for mid-2016 to advance this science
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
December 25, 2025 at 4:40 PM
happy to announce that i have post-doc openings for mid-2016 to advance this science
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
please read our work, think about the most exciting questions & approaches, & be in touch for an interview
note that there are now human data in support of our model
www.medrxiv.org/content/10.6...
Reposted by Ben-Sahra Lab
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In vivo models bring FSP1 inhibitors to life - Nature Cell Biology
FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...
www.nature.com
December 12, 2025 at 4:15 PM
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ben-Sahra Lab
Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!
December 11, 2025 at 8:52 PM
Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!
Reposted by Ben-Sahra Lab
Good Sunday, all. Don't miss this week's selection of papers in #cancermetabolism and #mitochondrialbiology as there are some true gems: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave
"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave
December 7, 2025 at 6:47 AM
Good Sunday, all. Don't miss this week's selection of papers in #cancermetabolism and #mitochondrialbiology as there are some true gems: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave
"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave
Reposted by Ben-Sahra Lab
Reposted by Ben-Sahra Lab
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell www.cell.com/cell/fulltex...
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis
A fin-like structural loop in GPX4 is critical for anchoring the enzyme to cellular
membranes, thereby preventing ferroptosis. A patient-associated R152H mutation destabilizes
this loop, leading to fe...
www.cell.com
December 4, 2025 at 3:43 PM
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell www.cell.com/cell/fulltex...
Reposted by Ben-Sahra Lab
🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at frances.yap@northwestern.edu for details. sites.northwestern.edu/yaplab/. Pls repost #Microsky
Homepage | Yap Laboratory
sites.northwestern.edu
December 1, 2025 at 4:45 PM
🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at frances.yap@northwestern.edu for details. sites.northwestern.edu/yaplab/. Pls repost #Microsky
Reposted by Ben-Sahra Lab
Leveraging biochemical covariance to better understand biology
Leveraging biochemical covariance to better understand biology
In a recent Nature article, Xiao et al. report development of a metabolite-protein covariation architecture (MPCA) database from a diversity outbred mouse cohort that facilitates the deciphering of metabolite-protein relationships in liver and brown adipose tissue (BAT). Using these correlations, the authors describe a role for LRRC58 in controlling cysteine-taurine metabolism.
dlvr.it
November 25, 2025 at 11:57 PM
Leveraging biochemical covariance to better understand biology
Reposted by Ben-Sahra Lab
happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD!
tinyurl.com/3yutyd8c
tinyurl.com/3yutyd8c
Human plasma‐like medium enhances structural and metabolic maturation of human pluripotent stem cell‐derived cardiomyocytes
Human plasma-like medium (HPLM), a synthetic physiologic medium containing over 60 metabolites and small ions at concentrations reflective of adult human plasma, enhances the structural and metabolic....
tinyurl.com
November 21, 2025 at 9:26 PM
happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD!
tinyurl.com/3yutyd8c
tinyurl.com/3yutyd8c
Reposted by Ben-Sahra Lab
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 4:09 PM
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Reposted by Ben-Sahra Lab
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
Reposted by Ben-Sahra Lab
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 13, 2025 at 10:19 AM
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Reposted by Ben-Sahra Lab
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"There are years that ask questions and years that answer."-Zora Neale Hurston
Reposted by Ben-Sahra Lab
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 7:35 AM
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
Great work from @rjdlab.bsky.social !!
Great work from @rjdlab.bsky.social !!
Reposted by Ben-Sahra Lab
2. A new paper in @cp-molcell.bsky.social from @bensahralab.bsky.social (ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee) @luriecancer.bsky.social revealing a molecular link between succinate dehydrogenase and purine synthesis.
Read the paper here: lnkd.in/eibyMezn
Read the paper here: lnkd.in/eibyMezn
November 7, 2025 at 11:47 PM
2. A new paper in @cp-molcell.bsky.social from @bensahralab.bsky.social (ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee) @luriecancer.bsky.social revealing a molecular link between succinate dehydrogenase and purine synthesis.
Read the paper here: lnkd.in/eibyMezn
Read the paper here: lnkd.in/eibyMezn
Reposted by Ben-Sahra Lab
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 11:37 PM
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
Reposted by Ben-Sahra Lab
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 6, 2025 at 7:30 PM
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...