Gregor Weiss
@weiss-lab.bsky.social
Assistant Prof at University of Zürich
-- host-pathogen interactions across scales --
-- host-pathogen interactions across scales --
Reposted by Gregor Weiss
#Tuberculosis (TB) is preventable and curable.
Yet, it remains one of the world’s deadliest infectious killers, claiming 1.23 million lives in 2024.
The WHO Global Tuberculosis Report 2025 talks about the gains made so far and the challenges ahead due to severe funding cuts: bit.ly/4qT5ihk
Yet, it remains one of the world’s deadliest infectious killers, claiming 1.23 million lives in 2024.
The WHO Global Tuberculosis Report 2025 talks about the gains made so far and the challenges ahead due to severe funding cuts: bit.ly/4qT5ihk
November 12, 2025 at 2:51 PM
#Tuberculosis (TB) is preventable and curable.
Yet, it remains one of the world’s deadliest infectious killers, claiming 1.23 million lives in 2024.
The WHO Global Tuberculosis Report 2025 talks about the gains made so far and the challenges ahead due to severe funding cuts: bit.ly/4qT5ihk
Yet, it remains one of the world’s deadliest infectious killers, claiming 1.23 million lives in 2024.
The WHO Global Tuberculosis Report 2025 talks about the gains made so far and the challenges ahead due to severe funding cuts: bit.ly/4qT5ihk
The Center for Microscopy and Image Analysis at the University of Zurich is seeking a new Head:
jobs.uzh.ch/job-vacancie...
It is super fun to work with them, tons of expertise and cutting edge instrumentation in ❄️🔬
Application deadline: December 15, 2025.
jobs.uzh.ch/job-vacancie...
It is super fun to work with them, tons of expertise and cutting edge instrumentation in ❄️🔬
Application deadline: December 15, 2025.
UZH: Head of the Center for Microscopy and Image Analysis (Core Facility)
The Center for Microscopy and Image Analysis (ZMB) is a nationally and internationally recognized Core Facility at the University of Zurich (UZH), providing access to state-of-the-art light and electr...
jobs.uzh.ch
November 12, 2025 at 6:42 PM
The Center for Microscopy and Image Analysis at the University of Zurich is seeking a new Head:
jobs.uzh.ch/job-vacancie...
It is super fun to work with them, tons of expertise and cutting edge instrumentation in ❄️🔬
Application deadline: December 15, 2025.
jobs.uzh.ch/job-vacancie...
It is super fun to work with them, tons of expertise and cutting edge instrumentation in ❄️🔬
Application deadline: December 15, 2025.
Reposted by Gregor Weiss
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Gregor Weiss
just in time for the opening of the @hohmannulrich.bsky.social group at @imbmainz.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 7, 2025 at 6:03 PM
just in time for the opening of the @hohmannulrich.bsky.social group at @imbmainz.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
Reposted by Gregor Weiss
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
November 1, 2025 at 12:41 PM
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
Reposted by Gregor Weiss
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Gregor Weiss
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 8, 2025 at 9:18 PM
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gregor Weiss
Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
www.science.org
October 8, 2025 at 7:07 PM
Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Gregor Weiss
#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...
Link: www.biorxiv.org/content/10.1...
October 5, 2025 at 6:37 PM
#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪
Reposted by Gregor Weiss
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
September 30, 2025 at 9:52 AM
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓
Reposted by Gregor Weiss
Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own.
www.quantamagazine.org/tiny-tubes-r...
www.quantamagazine.org/tiny-tubes-r...
September 9, 2025 at 3:46 PM
Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own.
www.quantamagazine.org/tiny-tubes-r...
www.quantamagazine.org/tiny-tubes-r...
Reposted by Gregor Weiss
DNA and Cas9 on a CIS? Wow 🤯 Injecting excitement into the field! Very cool! @zhangf.bsky.social
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - @zhangf.bsky.social go.nature.com/46OFcoj
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - Nature Biotechnology
Ribonucleoproteins, nucleic acids and proteins are delivered into target cell types with nanosyringes.
go.nature.com
August 18, 2025 at 4:07 PM
DNA and Cas9 on a CIS? Wow 🤯 Injecting excitement into the field! Very cool! @zhangf.bsky.social
Reposted by Gregor Weiss
Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota
August 12, 2025 at 7:22 AM
Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota
It's been ~13 years ago in the lab of Grant Jensen, when Martin @pilhoferlab.bsky.social showed me how to prepare media, do first protein preps and negative stain EM. I had no idea how much more I’d learn from him over the next years - THANK YOU MARTIN for this incredible ride 🙏🙏🙏
Exciting Aug 1️⃣ for two incredible people- Gregor Weiss and Jingwei Xu! Both are starting their independent labs 🔬🧪 TODAY 🥳
I am incredibly thankful 🙏 for their contributions to the lab and that I could be part of their journey
-Martin
@xujwet.bsky.social
@weiss-lab.bsky.social
It was a wild ride👇
I am incredibly thankful 🙏 for their contributions to the lab and that I could be part of their journey
-Martin
@xujwet.bsky.social
@weiss-lab.bsky.social
It was a wild ride👇
August 1, 2025 at 1:48 PM
It's been ~13 years ago in the lab of Grant Jensen, when Martin @pilhoferlab.bsky.social showed me how to prepare media, do first protein preps and negative stain EM. I had no idea how much more I’d learn from him over the next years - THANK YOU MARTIN for this incredible ride 🙏🙏🙏
Reposted by Gregor Weiss
This surprisingly relaxing footage is from SIX MILES under the ocean – and it’s the deepest ecosystem yet discovered
July 31, 2025 at 3:38 PM
This surprisingly relaxing footage is from SIX MILES under the ocean – and it’s the deepest ecosystem yet discovered
Reposted by Gregor Weiss
#MicroSky Summer read!
Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛
How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social
www.sciencedirect.com/science/arti...
Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛
How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social
www.sciencedirect.com/science/arti...
Strategies and mechanisms of contact-dependent predation in bacteria
Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…
www.sciencedirect.com
July 25, 2025 at 4:59 PM
#MicroSky Summer read!
Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛
How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social
www.sciencedirect.com/science/arti...
Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛
How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social
www.sciencedirect.com/science/arti...
Come and join Martin‘s Lab at the University of Zurich and become our colleague 🧫🔬
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
July 25, 2025 at 1:33 PM
Come and join Martin‘s Lab at the University of Zurich and become our colleague 🧫🔬
Reposted by Gregor Weiss
Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
An Asgard archaeon from a modern analog of ancient microbial mats
It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...
www.biorxiv.org
July 23, 2025 at 8:48 AM
Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Reposted by Gregor Weiss
Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries
Cryo-electron tomography (cryo-ET) enables 3D visualization of complex biological environments without the need for purification, thereby preserving t…
www.sciencedirect.com
July 8, 2025 at 9:44 PM
Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Gregor Weiss
Happy to see our collaborative work on the contractile injection system (CIS) in Streptomyces published. We show that the membrane protein CisA gives Streptomyces CIS a licence to kill.
@pilhoferlab.bsky.social & Bastien Casu, @joesallmen.bsky.social #MicroSky
elifesciences.org/articles/104...
@pilhoferlab.bsky.social & Bastien Casu, @joesallmen.bsky.social #MicroSky
elifesciences.org/articles/104...
Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA
CryoEM, genetic, and cell biological analyses reveal that the conserved membrane protein CisA mediates membrane recruitment of contractile injection systems Streptomyces coelicolor, enabling their act...
elifesciences.org
July 9, 2025 at 6:46 AM
Happy to see our collaborative work on the contractile injection system (CIS) in Streptomyces published. We show that the membrane protein CisA gives Streptomyces CIS a licence to kill.
@pilhoferlab.bsky.social & Bastien Casu, @joesallmen.bsky.social #MicroSky
elifesciences.org/articles/104...
@pilhoferlab.bsky.social & Bastien Casu, @joesallmen.bsky.social #MicroSky
elifesciences.org/articles/104...
Reposted by Gregor Weiss
Excited and honored to be joining the EMBO Member community 🥳 Congratulations also to all the other newly elected members! -Martin
Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO
Sixty-nine new members join the community of leading life scientists in Europe and beyond
www.embo.org
July 2, 2025 at 7:04 AM
Excited and honored to be joining the EMBO Member community 🥳 Congratulations also to all the other newly elected members! -Martin
#cryoET folks, this is your chance to combine a beautiful location 🏔️ with cutting-edge imaging of weirdo microbes 🦠 Florian is an amazing colleague & scientist and I am sure he will also show you how to 🎿🚵🏼🏃♂️🍺
After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
June 27, 2025 at 12:53 PM
#cryoET folks, this is your chance to combine a beautiful location 🏔️ with cutting-edge imaging of weirdo microbes 🦠 Florian is an amazing colleague & scientist and I am sure he will also show you how to 🎿🚵🏼🏃♂️🍺
Reposted by Gregor Weiss
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM
wwwfbm.unil.ch
June 10, 2025 at 1:53 PM
New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...
A great day for #teamtomo
First, @cellarchlab.com shows the beauty of the mitochondrial respiratory chain (www.science.org/doi/10.1126/....
... and now my colleagues @florianwollweber.bsky.social & @xujwet.bsky.social visualized tubulins in Asgard archaea 😍🤯 www.cell.com/cell/fulltex...
First, @cellarchlab.com shows the beauty of the mitochondrial respiratory chain (www.science.org/doi/10.1126/....
... and now my colleagues @florianwollweber.bsky.social & @xujwet.bsky.social visualized tubulins in Asgard archaea 😍🤯 www.cell.com/cell/fulltex...
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
March 21, 2025 at 3:20 PM
A great day for #teamtomo
First, @cellarchlab.com shows the beauty of the mitochondrial respiratory chain (www.science.org/doi/10.1126/....
... and now my colleagues @florianwollweber.bsky.social & @xujwet.bsky.social visualized tubulins in Asgard archaea 😍🤯 www.cell.com/cell/fulltex...
First, @cellarchlab.com shows the beauty of the mitochondrial respiratory chain (www.science.org/doi/10.1126/....
... and now my colleagues @florianwollweber.bsky.social & @xujwet.bsky.social visualized tubulins in Asgard archaea 😍🤯 www.cell.com/cell/fulltex...
Reposted by Gregor Weiss
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 10:37 PM
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾