Wouter De Coster
@wdecoster.bsky.social
Dad. Scientist at VIB. Bioinformatics postdoc. Sequencing technologies enthusiastic. Geneticist. He/him.
Reposted by Wouter De Coster
As new human assemblies become available on beta.ensembl.org - which human reference genome will you choose? This article explores the question with insights from Ensembl’s own Fergal Martin - www.nature.com/articles/s41...
#HumanGenomics #Pangenomes #ReferenceGenomes
#HumanGenomics #Pangenomes #ReferenceGenomes
Choose your human genome reference wisely - Nature Methods
Scientists can choose between multiple human genome references, and a pangenome reference is coming. Deciding what to use when is not quite straightforward.
www.nature.com
November 4, 2025 at 12:28 PM
As new human assemblies become available on beta.ensembl.org - which human reference genome will you choose? This article explores the question with insights from Ensembl’s own Fergal Martin - www.nature.com/articles/s41...
#HumanGenomics #Pangenomes #ReferenceGenomes
#HumanGenomics #Pangenomes #ReferenceGenomes
Reposted by Wouter De Coster
Did not expect to see disk space become an issue but after a disk clean up and restart I ended up with 243 and 244 gbp for these two @nanoporetech.com flowcells 🎉🚀🧬 💚🟩💚🟩💚🟩
November 4, 2025 at 12:10 PM
Did not expect to see disk space become an issue but after a disk clean up and restart I ended up with 243 and 244 gbp for these two @nanoporetech.com flowcells 🎉🚀🧬 💚🟩💚🟩💚🟩
Reposted by Wouter De Coster
I am looking to get my hands on some #Illumina 5-base methylation data - does anyone have a bam file that I could use for some testing? Please RT for reach!
October 21, 2025 at 9:36 AM
I am looking to get my hands on some #Illumina 5-base methylation data - does anyone have a bam file that I could use for some testing? Please RT for reach!
My current favorite strategy for using LLMs to code (specifically, GitHub Copilot agent mode) is to write a paragraph or more of instructions, and finish with "Do not start writing any code yet. First, tell me all the questions you still have about this plan".
October 21, 2025 at 12:47 PM
My current favorite strategy for using LLMs to code (specifically, GitHub Copilot agent mode) is to write a paragraph or more of instructions, and finish with "Do not start writing any code yet. First, tell me all the questions you still have about this plan".
Reposted by Wouter De Coster
Why yes Windows, I did want to save this email attachment in C:\Users\pbayer\AppData\Local\Microsoft\Olk\Attachments\ooa-6b0f86af-a548-4060-9a83-7d943fcaa440\157ef8591494ef374d2433d75c318962f8bc4054af4a1be24c8e02b89b6d5ec9
that's just a logical place for it
that's just a logical place for it
October 17, 2025 at 2:34 AM
Why yes Windows, I did want to save this email attachment in C:\Users\pbayer\AppData\Local\Microsoft\Olk\Attachments\ooa-6b0f86af-a548-4060-9a83-7d943fcaa440\157ef8591494ef374d2433d75c318962f8bc4054af4a1be24c8e02b89b6d5ec9
that's just a logical place for it
that's just a logical place for it
Reposted by Wouter De Coster
(forgetting the word for antibiotics) do i need cancel culture
October 11, 2025 at 7:09 PM
(forgetting the word for antibiotics) do i need cancel culture
Reposted by Wouter De Coster
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
October 5, 2025 at 9:08 AM
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
We are hiring a postdoctoral researcher to identify genes involved in frontotemporal dementia using short- and long-read sequencing data. More information is available at jobs.vib.be/j/124543/pos....
Postdoctoral researcher - VIB
The Laboratory of Advanced and Translational Neurogenomics at the VIB-Center for Molecular Neurology, led by Dr. Rosa Rademakers, is seeking a highly motivated and talented postdoctoral researcher to ...
jobs.vib.be
September 26, 2025 at 8:58 AM
We are hiring a postdoctoral researcher to identify genes involved in frontotemporal dementia using short- and long-read sequencing data. More information is available at jobs.vib.be/j/124543/pos....
Reposted by Wouter De Coster
NEWS! Nation capable of spotting spurious link between paracetamol and autism still baffled by obvious link between guns and mass shootings
Nation capable of spotting spurious link between paracetamol and autism still baffled by obvious link between guns and mass shootings
The United States has once again demonstrated its unique talent for scientific deduction by confidently declaring there may be a link between pregnant women taking paracetamol and children developi…
buff.ly
September 23, 2025 at 7:18 AM
NEWS! Nation capable of spotting spurious link between paracetamol and autism still baffled by obvious link between guns and mass shootings
Reposted by Wouter De Coster
minimap2.com is potentially a phishing site. Please don't use anything from that website.
github.com/lh3/minimap2...
github.com/lh3/minimap2...
Phishing site : minimap2.com · Issue #1316 · lh3/minimap2
Not sure how to label this one, but I have come across a website minimap2.com which appears to be AI generated but is serving it's own copy of the Github repository. If you search the address or em...
github.com
September 9, 2025 at 3:40 PM
minimap2.com is potentially a phishing site. Please don't use anything from that website.
github.com/lh3/minimap2...
github.com/lh3/minimap2...
Reposted by Wouter De Coster
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 8:40 AM
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
Reposted by Wouter De Coster
Which tool should I use nowadays to identify pathogens in long-read DNA sequencing from human brain samples?
September 8, 2025 at 1:42 PM
Which tool should I use nowadays to identify pathogens in long-read DNA sequencing from human brain samples?
Reposted by Wouter De Coster
Ok this is mad
"...an ant that lays individuals from two distinct species. In this life cycle, females must clone males of another species because they require their sperm to produce the worker caste"
www.nature.com/articles/s41...
"...an ant that lays individuals from two distinct species. In this life cycle, females must clone males of another species because they require their sperm to produce the worker caste"
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 4, 2025 at 11:02 PM
Ok this is mad
"...an ant that lays individuals from two distinct species. In this life cycle, females must clone males of another species because they require their sperm to produce the worker caste"
www.nature.com/articles/s41...
"...an ant that lays individuals from two distinct species. In this life cycle, females must clone males of another species because they require their sperm to produce the worker caste"
www.nature.com/articles/s41...
Reposted by Wouter De Coster
Reposted by Wouter De Coster
For @nanoporetech.com geeks I’ve just been pointed at this very helpful site - nanoporetech.github.io/ont-output-s... - I hadn't seen this before and it's very useful!
Oxford Nanopore Output Specifications
nanoporetech.github.io
July 17, 2025 at 9:24 AM
For @nanoporetech.com geeks I’ve just been pointed at this very helpful site - nanoporetech.github.io/ont-output-s... - I hadn't seen this before and it's very useful!
Could you send me a Zoom link? Is Teams okay?
The new coke vs. pepsi question.
The new coke vs. pepsi question.
June 30, 2025 at 10:39 AM
Could you send me a Zoom link? Is Teams okay?
The new coke vs. pepsi question.
The new coke vs. pepsi question.
Reposted by Wouter De Coster
Reposted by Wouter De Coster
If you want to check if a human gene has copy-number changes or lands in a complex region, try pangene.bioinweb.org. Recently updated with more and better assemblies.
April 26, 2025 at 1:06 AM
If you want to check if a human gene has copy-number changes or lands in a complex region, try pangene.bioinweb.org. Recently updated with more and better assemblies.
Reposted by Wouter De Coster
This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...
June 4, 2025 at 9:00 PM
This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...
Reposted by Wouter De Coster
🚨 Training Alert: Dive into long-read single-cell RNAseq with #scywalker
🗓️ June 5, 2025
📍 Ghent – VIB/UGent FSVM II
🎟️ Registration deadline is Monday May 26th:
https://training.vib.be/all-trainings/scywalker-processing-long-read-single-cell-rnaseq-data
🗓️ June 5, 2025
📍 Ghent – VIB/UGent FSVM II
🎟️ Registration deadline is Monday May 26th:
https://training.vib.be/all-trainings/scywalker-processing-long-read-single-cell-rnaseq-data
May 23, 2025 at 6:27 AM
🚨 Training Alert: Dive into long-read single-cell RNAseq with #scywalker
🗓️ June 5, 2025
📍 Ghent – VIB/UGent FSVM II
🎟️ Registration deadline is Monday May 26th:
https://training.vib.be/all-trainings/scywalker-processing-long-read-single-cell-rnaseq-data
🗓️ June 5, 2025
📍 Ghent – VIB/UGent FSVM II
🎟️ Registration deadline is Monday May 26th:
https://training.vib.be/all-trainings/scywalker-processing-long-read-single-cell-rnaseq-data
Reposted by Wouter De Coster
Our spotlight winner, Ruben Cools, presented his full talk exploring how they are bridging genotype and phenotype through long Oxford Nanopore read, single-molecule multiomics. #NanoporeConf
May 22, 2025 at 4:02 PM
Our spotlight winner, Ruben Cools, presented his full talk exploring how they are bridging genotype and phenotype through long Oxford Nanopore read, single-molecule multiomics. #NanoporeConf
If only I could use such an incredibly wide screen to browse long reads on IGV #nanoporeconf
May 21, 2025 at 12:38 PM
If only I could use such an incredibly wide screen to browse long reads on IGV #nanoporeconf
Reposted by Wouter De Coster
Everyone in the past was neurotypical, which is how we got things like this single-author, eight-volume encyclopedia of ferns
May 6, 2025 at 1:20 PM
Everyone in the past was neurotypical, which is how we got things like this single-author, eight-volume encyclopedia of ferns
Reposted by Wouter De Coster
✨ We’re off for three days of next-generation sequencing at #RNGS25 in Antwerp! Experts from academia and industry will showcase innovations transforming healthcare, agriculture, and more.
🎤 Kicking off: Rosa Rademakers on GOLGA8A repeat expansion & its link to FTD. Stay tuned! 🔬 #Genomics
🎤 Kicking off: Rosa Rademakers on GOLGA8A repeat expansion & its link to FTD. Stay tuned! 🔬 #Genomics
March 19, 2025 at 2:08 PM