Keith Robison
@omicsomics.bsky.social
Computational biologist & blogger
The Joy of Rediscovery
Finding a fundamental constant lurking in routine data
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omicsomics.blogspot.com/2025/12/the-...
Finding a fundamental constant lurking in routine data
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omicsomics.blogspot.com/2025/12/the-...
The Joy of Rediscovery
A key goal of science is to discover new information, and it is one of the great joys of science to believe you have done so. Sometimes it ...
omicsomics.blogspot.com
December 30, 2025 at 2:48 AM
The Joy of Rediscovery
Finding a fundamental constant lurking in routine data
🧬🖥️
omicsomics.blogspot.com/2025/12/the-...
Finding a fundamental constant lurking in routine data
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omicsomics.blogspot.com/2025/12/the-...
omicsomics.blogspot.com/2025/12/rnac...
UltraMarathonRT: When Your Reverse Transcription Must Go Long
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UltraMarathonRT: When Your Reverse Transcription Must Go Long
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RNAConnect: When Your Reverse Transcription Must Go Long
The 1960s, 1970s and 1980s were both the early years and golden years for nucleic acid enzymology. Scientists unraveling the secrets of DNA ...
omicsomics.blogspot.com
December 16, 2025 at 4:53 PM
omicsomics.blogspot.com/2025/12/rnac...
UltraMarathonRT: When Your Reverse Transcription Must Go Long
🧬🖥️
UltraMarathonRT: When Your Reverse Transcription Must Go Long
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Reposted by Keith Robison
Oh this poll is fascinating
December 4, 2025 at 8:32 PM
Oh this poll is fascinating
Reposted by Keith Robison
losing my mind at the 25% of GOP voters who think most Italian Americans are "more loyal to a foreign country than to the United States."
December 4, 2025 at 9:00 PM
losing my mind at the 25% of GOP voters who think most Italian Americans are "more loyal to a foreign country than to the United States."
Reposted by Keith Robison
So, let's play make-believe and pretend that Prasad has rock solid proof the vaccine killed 10 kids.
He is now sitting on it, refusing to give doctors on the ground the information they need to inform their patients.
The opposite of radical transparency.
endpoints.news/fda-says-it-...
He is now sitting on it, refusing to give doctors on the ground the information they need to inform their patients.
The opposite of radical transparency.
endpoints.news/fda-says-it-...
FDA says it won't release details of claimed Covid vaccine deaths in 'near term'
Details from an investigation by CBER Director Vinay Prasad into 10 alleged child deaths related to Covid-19 vaccines won't be coming soon, an FDA spokesperson told Endpoints News on Wednesday.
endpoints.news
December 3, 2025 at 6:16 PM
So, let's play make-believe and pretend that Prasad has rock solid proof the vaccine killed 10 kids.
He is now sitting on it, refusing to give doctors on the ground the information they need to inform their patients.
The opposite of radical transparency.
endpoints.news/fda-says-it-...
He is now sitting on it, refusing to give doctors on the ground the information they need to inform their patients.
The opposite of radical transparency.
endpoints.news/fda-says-it-...
Reposted by Keith Robison
According to the microbial ecologist Puri López-García, pictured here at a salt flat in the Chilean Andes, some 25% to 50% of all bacterial cells may be parasites of other cells.
A Cell So Minimal That It Challenges Definitions of Life | Quanta Magazine
The newly described microbe represents a world of parasitic, intercellular biodiversity only beginning to be revealed by genome sequencing.
www.quantamagazine.org
November 25, 2025 at 9:04 PM
According to the microbial ecologist Puri López-García, pictured here at a salt flat in the Chilean Andes, some 25% to 50% of all bacterial cells may be parasites of other cells.
Reposted by Keith Robison
Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
World first: Radboudumc pioneers new genetic test in clinical practice - New test is faster, more efficient, and provides more diagnoses for rare diseases
17 November 2025
www.radboudumc.nl
November 17, 2025 at 8:29 AM
Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social.
www.radboudumc.nl/en/news-item...
(1/n)
A cadre of former colleagues is developing software tools for tracking designed genome edits, propagating annotations to the edited genomes & aligning in a graph-aware manner to assess the success of editing
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
Some news: Last April, I left Ginkgo Bioworks after 8+ years as a software engineer there. Since then, I’ve been working on starting a new company called GenHub with a couple other ex-Ginkgo people, Bob Van Hove and Chris Mitchell. (1/5)
November 13, 2025 at 3:57 AM
A cadre of former colleagues is developing software tools for tracking designed genome edits, propagating annotations to the edited genomes & aligning in a graph-aware manner to assess the success of editing
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
If you are a synthetic biologist, you should check it out
bsky.app/profile/hofe...
Another podcast host foolhardy enough to have me on! 🤣
Seriously, I thoroughly enjoyed the session
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Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Seriously, I thoroughly enjoyed the session
🧬🖥️
Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Ep 2: Evolution of Biotech with Keith Robison
YouTube video by Legible Bio
youtu.be
November 10, 2025 at 10:19 PM
Another podcast host foolhardy enough to have me on! 🤣
Seriously, I thoroughly enjoyed the session
🧬🖥️
Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Seriously, I thoroughly enjoyed the session
🧬🖥️
Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...
Nineteen - musings on shrinking the number of amino acids in a proteome
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omicsomics.blogspot.com/2025/11/nine...
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omicsomics.blogspot.com/2025/11/nine...
Nineteen
If I had been more atop things, I would have written this just under a week ago, on the nineteenth anniversary of my starting to write in th...
omicsomics.blogspot.com
November 5, 2025 at 4:18 AM
Nineteen - musings on shrinking the number of amino acids in a proteome
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omicsomics.blogspot.com/2025/11/nine...
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omicsomics.blogspot.com/2025/11/nine...
GitHub - meadm/GenomeCheck: Streamlit app within a docker container for carrying out genome QC and comparisons
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
GitHub - meadm/GenomeCheck: Streamlit app within a docker container for carrying out genome QC and comparisons
Streamlit app within a docker container for carrying out genome QC and comparisons - meadm/GenomeCheck
github.com
October 30, 2025 at 4:23 PM
GitHub - meadm/GenomeCheck: Streamlit app within a docker container for carrying out genome QC and comparisons
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
Written by a great colleague who is hunting for a new gig
github.com/meadm/Genome...
Reposted by Keith Robison
Bacterial telomeres are common, just not so much in RefSeq 'complete' genomes. But they can be added by the new tool David Faurdal wrote. I am thrilled to see this out as a preprint here: www.biorxiv.org/content/10.1... @tilmweber.bsky.social @thombooth.bsky.social
October 15, 2025 at 10:04 AM
Bacterial telomeres are common, just not so much in RefSeq 'complete' genomes. But they can be added by the new tool David Faurdal wrote. I am thrilled to see this out as a preprint here: www.biorxiv.org/content/10.1... @tilmweber.bsky.social @thombooth.bsky.social
Reposted by Keith Robison
Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
The multifaceted roles of NAD+ in bacterial immunity
In this review, Vaysset and Bernheim examine how nicotinamide adenine dinucleotide
(NAD+) is a key player in diverse and widespread bacterial antiphage defense systems
and phage counterdefense. The au...
www.cell.com
October 17, 2025 at 5:55 PM
Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
@hugovaysset.bsky.social reviewed them all!
Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
Reposted by Keith Robison
Long-form complaint about the #ASHG25 event info system from @omicsomics.bsky.social omicsomics.blogspot.com/2025/10/ashg...
ASHG Posters: The Agony and The Ecstasy
ASHG is a huge meeting, probably the second largest I've ever attended after ASCO. ASBMB is similar in size perhaps, though I think a hair ...
omicsomics.blogspot.com
October 15, 2025 at 8:14 PM
Long-form complaint about the #ASHG25 event info system from @omicsomics.bsky.social omicsomics.blogspot.com/2025/10/ashg...
Reposted by Keith Robison
The link to download all abstracts is here. It's always a little well hidden. In previous years it was somewhere like a "Resources" page where no one would ever think to look. #ASHG25 www.ashg.org/wp-content/u...
October 15, 2025 at 8:13 PM
The link to download all abstracts is here. It's always a little well hidden. In previous years it was somewhere like a "Resources" page where no one would ever think to look. #ASHG25 www.ashg.org/wp-content/u...
October 15, 2025 at 7:07 PM
Reposted by Keith Robison
Ultra-sensitive DNA sequencing maps mutations that precede cancer. #DNAseq #Sequencing #GeneticVariants #CancerMutations #Genomics @nature.com 🧬 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
October 14, 2025 at 5:05 PM
Ultra-sensitive DNA sequencing maps mutations that precede cancer. #DNAseq #Sequencing #GeneticVariants #CancerMutations #Genomics @nature.com 🧬 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
