Keith Robison
@omicsomics.bsky.social
Computational biologist & blogger
Reposted by Keith Robison
PRIZM: Combining Low-N Data and Zero-shot Models to Design Enhanced Protein Variants https://www.biorxiv.org/content/10.64898/2026.02.08.704628v1
February 10, 2026 at 9:47 PM
PRIZM: Combining Low-N Data and Zero-shot Models to Design Enhanced Protein Variants https://www.biorxiv.org/content/10.64898/2026.02.08.704628v1
Reposted by Keith Robison
Its still so baffling that in the age of Ai and wide access to information, more people are not interested in amateur biology. I'm not even talking bioengineering.
Tissue culture, breeding, microbial prospecting, biochemistry, etc.
The world lays before you undescribed, and yet
Tissue culture, breeding, microbial prospecting, biochemistry, etc.
The world lays before you undescribed, and yet
February 10, 2026 at 9:59 PM
Its still so baffling that in the age of Ai and wide access to information, more people are not interested in amateur biology. I'm not even talking bioengineering.
Tissue culture, breeding, microbial prospecting, biochemistry, etc.
The world lays before you undescribed, and yet
Tissue culture, breeding, microbial prospecting, biochemistry, etc.
The world lays before you undescribed, and yet
Pancreatic Adenocarcinoma Mutation Trajectories at Single Cell Resolution
🧬🖥️
omicsomics.blogspot.com/2026/02/panc...
🧬🖥️
omicsomics.blogspot.com/2026/02/panc...
Pancreatic Adenocarcinoma Mutation Trajectories at Single Cell Resolution
Single cell RNA sequencing is nearly ubiquitous; single cell DNA sequencing has been much rarer. I'm going to dive in a bit - but not a ful...
omicsomics.blogspot.com
February 9, 2026 at 3:07 AM
Pancreatic Adenocarcinoma Mutation Trajectories at Single Cell Resolution
🧬🖥️
omicsomics.blogspot.com/2026/02/panc...
🧬🖥️
omicsomics.blogspot.com/2026/02/panc...
Reposted by Keith Robison
Anne Frank died from a typhus epidemic that spread through the concentration camp where she was imprisoned.
Two active cases of tuberculosis and 18 cases of COVID-19 have been identified at a massive immigration detention center in El Paso, according to the local Democratic member of Congress.
www.texastribune.org/2026/02/07/i...
www.texastribune.org/2026/02/07/i...
Two tuberculosis cases detected at Camp East Montana ICE facility
Eighteen cases of COVID-19 were also identified. U.S. Rep. Veronica Escobar on Friday visited the 5,000-bed tent facility on the Fort Bliss Army base and said she saw many "chronic issues."
www.texastribune.org
February 7, 2026 at 11:35 PM
Anne Frank died from a typhus epidemic that spread through the concentration camp where she was imprisoned.
Reposted by Keith Robison
Reposted by Keith Robison
Not something you see in textbooks very often: tripolar mitosis.
February 7, 2026 at 8:00 AM
Not something you see in textbooks very often: tripolar mitosis.
Reposted by Keith Robison
I have always liked watching ski jumping and I particularly enjoy watching this opening round of women’s ski jumping because of how long the men at the ski jumping association insisted women couldn’t do it and blocked them for years.
February 8, 2026 at 1:22 AM
I have always liked watching ski jumping and I particularly enjoy watching this opening round of women’s ski jumping because of how long the men at the ski jumping association insisted women couldn’t do it and blocked them for years.
Reposted by Keith Robison
I wonder how many plant species have gone extinct, but their genomic legacy lives on as intact subgenomes of extant allopolyploids.
February 8, 2026 at 1:12 AM
I wonder how many plant species have gone extinct, but their genomic legacy lives on as intact subgenomes of extant allopolyploids.
Reposted by Keith Robison
If this works, we can essentially produce two species out of a single allopolypoid (de-hybridization). If the original donor of a subgenome has already gone extinct, we would be able to de-extinct it for real.
Wow. Sounds so cool in my head.
Wow. Sounds so cool in my head.
February 8, 2026 at 2:14 AM
If this works, we can essentially produce two species out of a single allopolypoid (de-hybridization). If the original donor of a subgenome has already gone extinct, we would be able to de-extinct it for real.
Wow. Sounds so cool in my head.
Wow. Sounds so cool in my head.
Reposted by Keith Robison
I wonder if we can manipulate meiosis in allopolyploids, such that instead of homologs separating, homeologs separate.
Take allopolyploid AABB, normal meiosis generates meiotic products w/ karyotype AB. What if we can manipulate it to make meiotic products w/ karyotypes AA & BB?
#PlantScience
Take allopolyploid AABB, normal meiosis generates meiotic products w/ karyotype AB. What if we can manipulate it to make meiotic products w/ karyotypes AA & BB?
#PlantScience
I wonder how many plant species have gone extinct, but their genomic legacy lives on as intact subgenomes of extant allopolyploids.
February 8, 2026 at 2:14 AM
I wonder if we can manipulate meiosis in allopolyploids, such that instead of homologs separating, homeologs separate.
Take allopolyploid AABB, normal meiosis generates meiotic products w/ karyotype AB. What if we can manipulate it to make meiotic products w/ karyotypes AA & BB?
#PlantScience
Take allopolyploid AABB, normal meiosis generates meiotic products w/ karyotype AB. What if we can manipulate it to make meiotic products w/ karyotypes AA & BB?
#PlantScience
How cold is it in Boston for #SLAS2026 ?
So cold you can freeze soap bubbles!
But it is plenty warm on our autonomous lab tours - still many spots open! And if those don’t work, DM me to discuss alternate times
calendly.com/kcarpenter-g...
So cold you can freeze soap bubbles!
But it is plenty warm on our autonomous lab tours - still many spots open! And if those don’t work, DM me to discuss alternate times
calendly.com/kcarpenter-g...
Autonomous Lab Tour at Ginkgo HQ - Ginkgo Bioworks
Head to Ginkgo HQ just down the street from SLAS for a tour of our 50-robot autonomous lab! The short ride is on us :) Click here for a free Uber voucher from the convention center and back: https://r...
calendly.com
February 8, 2026 at 2:50 AM
How cold is it in Boston for #SLAS2026 ?
So cold you can freeze soap bubbles!
But it is plenty warm on our autonomous lab tours - still many spots open! And if those don’t work, DM me to discuss alternate times
calendly.com/kcarpenter-g...
So cold you can freeze soap bubbles!
But it is plenty warm on our autonomous lab tours - still many spots open! And if those don’t work, DM me to discuss alternate times
calendly.com/kcarpenter-g...
Reposted by Keith Robison
GPT-5 lowers the cost of cell-free protein synthesis openai.com/index/gpt-5-...
Paper (OpenAI + Ginkgo Bioworks): Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis (pdf) cdn.openai.com/pdf/5a12a3bc...
Paper (OpenAI + Ginkgo Bioworks): Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis (pdf) cdn.openai.com/pdf/5a12a3bc...
February 6, 2026 at 7:01 PM
GPT-5 lowers the cost of cell-free protein synthesis openai.com/index/gpt-5-...
Paper (OpenAI + Ginkgo Bioworks): Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis (pdf) cdn.openai.com/pdf/5a12a3bc...
Paper (OpenAI + Ginkgo Bioworks): Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis (pdf) cdn.openai.com/pdf/5a12a3bc...
Reposted by Keith Robison
📰 GPT-5 Powers Autonomous Lab for Protein Synthesis
OpenAI and Ginkgo Bioworks have joined forces to create a groundbreaking autonomous laboratory, where the advanced GPT-5 AI system is directing the optimization of cell-free protein synthesis. This collaboration marks a...
#AINews #AI #Teknoloji
OpenAI and Ginkgo Bioworks have joined forces to create a groundbreaking autonomous laboratory, where the advanced GPT-5 AI system is directing the optimization of cell-free protein synthesis. This collaboration marks a...
#AINews #AI #Teknoloji
GPT-5 Powers Autonomous Lab for Protein Synthesis
OpenAI and Ginkgo Bioworks have joined forces to create a groundbreaking autonomous laboratory, where the advanced GPT-5 AI system is directing the optimization of cell-free protein synthesis. This collaboration marks a significant step towards accelerating biological research and development, thoug
aihaberleri.org
February 7, 2026 at 2:47 AM
📰 GPT-5 Powers Autonomous Lab for Protein Synthesis
OpenAI and Ginkgo Bioworks have joined forces to create a groundbreaking autonomous laboratory, where the advanced GPT-5 AI system is directing the optimization of cell-free protein synthesis. This collaboration marks a...
#AINews #AI #Teknoloji
OpenAI and Ginkgo Bioworks have joined forces to create a groundbreaking autonomous laboratory, where the advanced GPT-5 AI system is directing the optimization of cell-free protein synthesis. This collaboration marks a...
#AINews #AI #Teknoloji
Reposted by Keith Robison
New: Washington Post Executive Editor Matt Murray and HR Chief Wayne Connell tell employees to stay home for a zoom webinar ahead of “significant actions across the company.” Widely expected layoffs are scheduled to begin today.
February 4, 2026 at 11:13 AM
New: Washington Post Executive Editor Matt Murray and HR Chief Wayne Connell tell employees to stay home for a zoom webinar ahead of “significant actions across the company.” Widely expected layoffs are scheduled to begin today.
If you are coming to Boston for SLAS, we are offering tours of our autonomous laboratory
You can book a tour here
calendly.com/kcarpenter-g...
You can book a tour here
calendly.com/kcarpenter-g...
Autonomous Lab Tour at Ginkgo HQ - Ginkgo Bioworks
Head to Ginkgo HQ just down the street from SLAS for a tour of our 50-robot autonomous lab! The short ride is on us :) Click here for a free Uber voucher from the convention center and back: https://r...
calendly.com
February 4, 2026 at 12:42 PM
If you are coming to Boston for SLAS, we are offering tours of our autonomous laboratory
You can book a tour here
calendly.com/kcarpenter-g...
You can book a tour here
calendly.com/kcarpenter-g...
Reposted by Keith Robison
Workflow graphical editor and translator to Nextflow f1000research.com/articles/15-...
F1000Research Article: Workflow graphical editor and translator to Nextflow.
Read the latest article version by Ilya Kiselev, Anna Ryabova, Fedor Kolpakov, at F1000Research.
f1000research.com
February 2, 2026 at 5:02 PM
Workflow graphical editor and translator to Nextflow f1000research.com/articles/15-...
Reposted by Keith Robison
For anyone interested in the history of molecular biology, I cannot recommend Judson's The Eighth Day of Creation highly enough. One of the great book on the history of science.
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
January 31, 2026 at 2:20 PM
For anyone interested in the history of molecular biology, I cannot recommend Judson's The Eighth Day of Creation highly enough. One of the great book on the history of science.
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
Reposted by Keith Robison
To summarize:
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
January 30, 2026 at 7:58 PM
To summarize:
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
Most important
Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.
He was part of an organized team working on this problem. He got lots of help.
11/14
Reposted by Keith Robison
He said that "All of the professors told him that this was too hard, don't do this... He just ignored them.
He putzed around Cambridge and figured it out. And then he figured out the structure of hemoglobin which absolutely transformed hematology."
Great story. But completely inaccurate.
3/14
He putzed around Cambridge and figured it out. And then he figured out the structure of hemoglobin which absolutely transformed hematology."
Great story. But completely inaccurate.
3/14
January 30, 2026 at 7:58 PM
He said that "All of the professors told him that this was too hard, don't do this... He just ignored them.
He putzed around Cambridge and figured it out. And then he figured out the structure of hemoglobin which absolutely transformed hematology."
Great story. But completely inaccurate.
3/14
He putzed around Cambridge and figured it out. And then he figured out the structure of hemoglobin which absolutely transformed hematology."
Great story. But completely inaccurate.
3/14
Has anyone read this much hyped paper (I haven’t yet talked myself into posting for access)?
What is the nature of the tumor model?
I hate to be a wet blanket, but my hunch is this won’t translate anywhere near as impressively to human patients
www.pnas.org/doi/10.1073/...
What is the nature of the tumor model?
I hate to be a wet blanket, but my hunch is this won’t translate anywhere near as impressively to human patients
www.pnas.org/doi/10.1073/...
A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS
Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates.
Recent studies using RAS inhibitors have opened the door to mo...
www.pnas.org
January 31, 2026 at 12:32 AM
Has anyone read this much hyped paper (I haven’t yet talked myself into posting for access)?
What is the nature of the tumor model?
I hate to be a wet blanket, but my hunch is this won’t translate anywhere near as impressively to human patients
www.pnas.org/doi/10.1073/...
What is the nature of the tumor model?
I hate to be a wet blanket, but my hunch is this won’t translate anywhere near as impressively to human patients
www.pnas.org/doi/10.1073/...
Reposted by Keith Robison
Mmm. So the disagreement we all have with ONT here is *really* about the bigger picture future direction of the company [and the field], not about support for us users.
Companies aren't used to getting big picture feedback from users, so they defaulted to answering with a 'fix' for existing users..
Companies aren't used to getting big picture feedback from users, so they defaulted to answering with a 'fix' for existing users..
January 29, 2026 at 5:54 PM
Mmm. So the disagreement we all have with ONT here is *really* about the bigger picture future direction of the company [and the field], not about support for us users.
Companies aren't used to getting big picture feedback from users, so they defaulted to answering with a 'fix' for existing users..
Companies aren't used to getting big picture feedback from users, so they defaulted to answering with a 'fix' for existing users..
Reposted by Keith Robison
ONT claimed that they were primarily making this decision for accessibility reasons. I rejected this claim, because making something a lot more expensive doesn't make it more accessible.
If ONT wanted to improve accessibility, it'd be better to offer more support, rather than shut it down.
If ONT wanted to improve accessibility, it'd be better to offer more support, rather than shut it down.
January 29, 2026 at 6:36 PM
ONT claimed that they were primarily making this decision for accessibility reasons. I rejected this claim, because making something a lot more expensive doesn't make it more accessible.
If ONT wanted to improve accessibility, it'd be better to offer more support, rather than shut it down.
If ONT wanted to improve accessibility, it'd be better to offer more support, rather than shut it down.