Wan-Chen Lin
@wchlin.bsky.social
Chemical neurobiologist at Academia Sinica, Taiwan.
http://www.ibms.sinica.edu.tw/wan-chen-lin/
http://www.ibms.sinica.edu.tw/wan-chen-lin/
Reposted by Wan-Chen Lin
Reposted by Wan-Chen Lin
When chemistry meets neurons! Game-changing paper on multifunctional fluorescent ligands. Luke and Pratik built the nerdy toys; we got to play! Jason Vevea nailed biotin-HTL for mito magic. My lab rocked the JQ1 HTL to shuffle chromatin in mins. 1st collab win for our Neuronal Cell Biology Division.
October 28, 2025 at 4:57 PM
When chemistry meets neurons! Game-changing paper on multifunctional fluorescent ligands. Luke and Pratik built the nerdy toys; we got to play! Jason Vevea nailed biotin-HTL for mito magic. My lab rocked the JQ1 HTL to shuffle chromatin in mins. 1st collab win for our Neuronal Cell Biology Division.
Reposted by Wan-Chen Lin
The plastic used to form these tangram puzzles is edible — but it might not taste great. Made from a specialized plant-based cellulose polymer, citric acid and squid ink, the plastic is colored not by dyes or pigments but a phenomenon called structural color. [1/3]
July 23, 2025 at 4:27 PM
The plastic used to form these tangram puzzles is edible — but it might not taste great. Made from a specialized plant-based cellulose polymer, citric acid and squid ink, the plastic is colored not by dyes or pigments but a phenomenon called structural color. [1/3]
Excited to post my lab's first publication on Bluesky, featuring photopharmacology of GABA(A) receptors. Great job by my PhD student (Simon) and founding lab member (Jay-Rong). Thank you and congratulations! 🎉👍🍺
bpspubs.onlinelibrary.wiley.com/doi/abs/10.1...
bpspubs.onlinelibrary.wiley.com/doi/abs/10.1...
BPS Publications
Background and Purpose Neuronal inhibition is largely mediated by type-A GABA receptors (GABAARs), a family of ligand-gated chloride-permeable channels, which can be sub-classified by their subunit ...
bpspubs.onlinelibrary.wiley.com
May 20, 2025 at 2:10 PM
Excited to post my lab's first publication on Bluesky, featuring photopharmacology of GABA(A) receptors. Great job by my PhD student (Simon) and founding lab member (Jay-Rong). Thank you and congratulations! 🎉👍🍺
bpspubs.onlinelibrary.wiley.com/doi/abs/10.1...
bpspubs.onlinelibrary.wiley.com/doi/abs/10.1...
Reposted by Wan-Chen Lin
I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao!
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
April 21, 2025 at 4:07 PM
I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao!
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
Reposted by Wan-Chen Lin
New Night Science Podcast episode! Martin Schwartz from
Yale talks with us about the importance of stupidity in scientific research, how the ego can obstruct creativity, and how resilience, self-discovery, and "passionate indifference" – are key in science.
podcasts.apple.com/us/podcast/n...
Yale talks with us about the importance of stupidity in scientific research, how the ego can obstruct creativity, and how resilience, self-discovery, and "passionate indifference" – are key in science.
podcasts.apple.com/us/podcast/n...
April 21, 2025 at 11:30 AM
New Night Science Podcast episode! Martin Schwartz from
Yale talks with us about the importance of stupidity in scientific research, how the ego can obstruct creativity, and how resilience, self-discovery, and "passionate indifference" – are key in science.
podcasts.apple.com/us/podcast/n...
Yale talks with us about the importance of stupidity in scientific research, how the ego can obstruct creativity, and how resilience, self-discovery, and "passionate indifference" – are key in science.
podcasts.apple.com/us/podcast/n...
Reposted by Wan-Chen Lin
New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...
High-performance genetically-encoded green and red fluorescent biosensors for pyruvate
Pyruvate is the end-product of glycolysis and a central metabolite involved in many biochemical pathways. However, a lack of high-performance (i.e., Δ F / F > 10) single fluorescent protein (FP)-base...
www.biorxiv.org
April 19, 2025 at 6:42 AM
New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...
Reposted by Wan-Chen Lin
I am very proud to announce that my PhD paper finally came out in Cell! In this *very* collaborative study, we develop and release a deep-learning approach to predict neuron type identity from their electrical signature. doi.org/10.1016/j.ce... 1/16 🧵
March 1, 2025 at 1:14 PM
I am very proud to announce that my PhD paper finally came out in Cell! In this *very* collaborative study, we develop and release a deep-learning approach to predict neuron type identity from their electrical signature. doi.org/10.1016/j.ce... 1/16 🧵
Reposted by Wan-Chen Lin
Nature research paper: De novo design of transmembrane fluorescence-activating proteins
https://go.nature.com/4k2OAZA
https://go.nature.com/4k2OAZA
De novo design of transmembrane fluorescence-activating proteins - Nature
A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands.
go.nature.com
February 20, 2025 at 8:46 AM
Nature research paper: De novo design of transmembrane fluorescence-activating proteins
https://go.nature.com/4k2OAZA
https://go.nature.com/4k2OAZA
Reposted by Wan-Chen Lin
The prominence of the pervasive PIEZO ion channels keeps showing up, now for regulating adipose tissue glucose uptake and energy storage
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism
Systemic metabolism ensures energy homeostasis through inter-organ crosstalk regulating thermogenic adipose tissue. Unlike the well-described inductiv…
www.sciencedirect.com
February 6, 2025 at 5:36 PM
The prominence of the pervasive PIEZO ion channels keeps showing up, now for regulating adipose tissue glucose uptake and energy storage
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...
Reposted by Wan-Chen Lin
Ten simple rules for developing good reading habits during graduate school and beyond
journals.plos.org/ploscompbiol...
journals.plos.org/ploscompbiol...
January 26, 2025 at 9:41 AM
Ten simple rules for developing good reading habits during graduate school and beyond
journals.plos.org/ploscompbiol...
journals.plos.org/ploscompbiol...
Reposted by Wan-Chen Lin
December 15, 2024 at 11:16 AM
Reposted by Wan-Chen Lin
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...
A temperature-inducible protein module for control of mammalian cell fate - Nature Methods
The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...
www.nature.com
January 23, 2025 at 6:34 PM
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...
Reposted by Wan-Chen Lin
Reposted by Wan-Chen Lin
Slow-motion videos reveal tree frogs making some of the most dramatic landings in nature.
Learn more: scim.ag/4gTAurn
Learn more: scim.ag/4gTAurn
January 15, 2025 at 7:49 PM
Slow-motion videos reveal tree frogs making some of the most dramatic landings in nature.
Learn more: scim.ag/4gTAurn
Learn more: scim.ag/4gTAurn
Reposted by Wan-Chen Lin
Here are *some* of my favorite studies on dendrites and spines from 2024 👀 - feeling very excited and inspired about the field! 🔥 Happy new year y'all!
January 10, 2025 at 3:58 PM
Here are *some* of my favorite studies on dendrites and spines from 2024 👀 - feeling very excited and inspired about the field! 🔥 Happy new year y'all!
Reposted by Wan-Chen Lin
December 27, 2024 at 1:28 AM
Reposted by Wan-Chen Lin
Many academics point to bioRxiv as “the one thing improving science publishing”.
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
December 21, 2024 at 2:01 PM
Many academics point to bioRxiv as “the one thing improving science publishing”.
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
Reposted by Wan-Chen Lin
Anyone up for some #ToxTuesday?
A lot of us love spicy foods, and the capsaicin in chili peppers that gives us that heat can be addictive. But is there anything hotter? I'm glad you asked. Yes, yes there is. And it's called RESINIFERATOXIN
A lot of us love spicy foods, and the capsaicin in chili peppers that gives us that heat can be addictive. But is there anything hotter? I'm glad you asked. Yes, yes there is. And it's called RESINIFERATOXIN
December 17, 2024 at 4:36 PM
Anyone up for some #ToxTuesday?
A lot of us love spicy foods, and the capsaicin in chili peppers that gives us that heat can be addictive. But is there anything hotter? I'm glad you asked. Yes, yes there is. And it's called RESINIFERATOXIN
A lot of us love spicy foods, and the capsaicin in chili peppers that gives us that heat can be addictive. But is there anything hotter? I'm glad you asked. Yes, yes there is. And it's called RESINIFERATOXIN
Reposted by Wan-Chen Lin
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Neuroscience methods - YouTube
Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...
www.youtube.com
December 13, 2024 at 11:33 AM
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Reposted by Wan-Chen Lin
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
Reposted by Wan-Chen Lin
"If we don't feel stupid it means we are not really trying"
Very encouraging quote from this inspiring article. The other two are also excellent!
I'll add this piece of advice, which a friendly ultramarathoner once gave me:
"Enjoy the highs, manage the lows!"
#econsky
Very encouraging quote from this inspiring article. The other two are also excellent!
I'll add this piece of advice, which a friendly ultramarathoner once gave me:
"Enjoy the highs, manage the lows!"
#econsky
Three must read papers for PhD students. #scisky #PhD #science #research #academicsky
1. The importance of stupidity in scientific research
Open Access
journals.biologists.com/jcs/article/...
1. The importance of stupidity in scientific research
Open Access
journals.biologists.com/jcs/article/...
November 26, 2024 at 2:04 AM
"If we don't feel stupid it means we are not really trying"
Very encouraging quote from this inspiring article. The other two are also excellent!
I'll add this piece of advice, which a friendly ultramarathoner once gave me:
"Enjoy the highs, manage the lows!"
#econsky
Very encouraging quote from this inspiring article. The other two are also excellent!
I'll add this piece of advice, which a friendly ultramarathoner once gave me:
"Enjoy the highs, manage the lows!"
#econsky
Reposted by Wan-Chen Lin
Not a new paper, but still helps (1/2)
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
November 30, 2024 at 2:21 PM
Not a new paper, but still helps (1/2)
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
Reposted by Wan-Chen Lin
ChemBio fans please repost the #ChemicalBiology Feed bsky.app/profile/thor...
@carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social
#chemsky
@carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social
#chemsky
November 25, 2024 at 1:02 AM
Reposted by Wan-Chen Lin
2/ To kick off the thread, here are 22 persuasive communication devices that you should watch out for when writing or reading a research article.
https://buff.ly/3Z9Mb5C
https://buff.ly/3Z9Mb5C
Point of View: Beware ‘persuasive communication devices’ when writing and reading scientific articles
Authors should be open about the limitations of their work and not overstate its importance.
buff.ly
November 26, 2024 at 3:42 PM
2/ To kick off the thread, here are 22 persuasive communication devices that you should watch out for when writing or reading a research article.
https://buff.ly/3Z9Mb5C
https://buff.ly/3Z9Mb5C