Vivek Mutalik
@vivekmutalik.bsky.social
Dad, Teacher, Artist, Gardener and Scientist.
Change is permanent. This moment will pass. It has to.
Ps.
All I post is my personal opinion, in my personal times, using my personal tools, not my employers.
Change is permanent. This moment will pass. It has to.
Ps.
All I post is my personal opinion, in my personal times, using my personal tools, not my employers.
Pinned
Vivek Mutalik
@vivekmutalik.bsky.social
· Nov 21
Tapping the treasure trove of atypical phages
With advancements in genomics technologies, a vast diversity of ‘atypical’ phages, that is, with single-stranded DNA or RNA genomes, are being uncover…
www.sciencedirect.com
#phagesky
Some partnerships are always fun!! Excited to share one such 🎉 product w Simon Roux, perspectives on our favorite “atypical” phages, for special issue to celebrate my former mentor Carol Gross @ UCSF
Tapping the treasure trove of atypical phages
www.sciencedirect.com/science/arti...
Some partnerships are always fun!! Excited to share one such 🎉 product w Simon Roux, perspectives on our favorite “atypical” phages, for special issue to celebrate my former mentor Carol Gross @ UCSF
Tapping the treasure trove of atypical phages
www.sciencedirect.com/science/arti...
Reposted by Vivek Mutalik
Amazing piece of work from @rtoshiro.bsky.social
& Kim Seed at UC Berkeley. 🙌
Played a tiny role in this work.
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses
www.biorxiv.org/content/10.1...
& Kim Seed at UC Berkeley. 🙌
Played a tiny role in this work.
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses
www.biorxiv.org/content/10.1...
bsky.app
November 15, 2025 at 3:37 PM
Amazing piece of work from @rtoshiro.bsky.social
& Kim Seed at UC Berkeley. 🙌
Played a tiny role in this work.
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses
www.biorxiv.org/content/10.1...
& Kim Seed at UC Berkeley. 🙌
Played a tiny role in this work.
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses
www.biorxiv.org/content/10.1...
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 15, 2025 at 3:26 PM
Reposted by Vivek Mutalik
#microsky #microbiomesky
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases | Science www.science.org/doi/abs/10.1...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases | Science www.science.org/doi/abs/10.1...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 14, 2025 at 7:49 AM
#microsky #microbiomesky
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases | Science www.science.org/doi/abs/10.1...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases | Science www.science.org/doi/abs/10.1...
Reposted by Vivek Mutalik
Reposted by Vivek Mutalik
Reposted by Vivek Mutalik
www.biorxiv.org
November 12, 2025 at 5:28 PM
Reposted by Vivek Mutalik
Microbial Primer: Artificial intelligence for microbiologists
#microsky
www.microbiologyresearch.org/content/jour...
#microsky
www.microbiologyresearch.org/content/jour...
Microbial Primer: Artificial intelligence for microbiologists
Artificial intelligence (AI) and machine learning (ML) are reshaping microbiology, enabling rapid antibiotic discovery, resistance prediction and clinical diagnostics. For microbiologists, the goal is...
www.microbiologyresearch.org
November 14, 2025 at 5:11 AM
Microbial Primer: Artificial intelligence for microbiologists
#microsky
www.microbiologyresearch.org/content/jour...
#microsky
www.microbiologyresearch.org/content/jour...
😳
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 2:00 AM
😳
Reposted by Vivek Mutalik
every company in 2025
November 12, 2025 at 5:59 PM
every company in 2025
Reposted by Vivek Mutalik
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
November 12, 2025 at 4:49 AM
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
Reposted by Vivek Mutalik
ooof this feels like most every university rn
November 12, 2025 at 3:28 AM
ooof this feels like most every university rn
🥲
November 11, 2025 at 1:08 PM
🥲
40 days for nothing 🤦🏽♂️
November 10, 2025 at 2:54 AM
40 days for nothing 🤦🏽♂️
Intrinsic resistance pathways & #ResistanceBreaking. Study shows that inhibiting efflux pumps & cell envelope biogenesis sensitizes #bacteria to #antibiotics, but rapid evolutionary recovery may limit long-term effectiveness of resistance-breaking strategies #AMR @plosbiology.org 🧪 plos.io/4huAtvo
November 9, 2025 at 4:53 PM
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications
Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...
www.nature.com
November 9, 2025 at 4:51 PM
Reposted by Vivek Mutalik
Strain displacement in microbiomes via ecological competition
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
Strain displacement in microbiomes via ecological competition - Nature Microbiology
Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
www.nature.com
November 7, 2025 at 2:19 PM
Strain displacement in microbiomes via ecological competition
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster
www.nature.com/articles/s41...
#microsky
Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli: Trends in Biotechnology www.cell.com/trends/biote...
Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli: Trends in Biotechnology www.cell.com/trends/biote...
Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli
We developed an integrated platform that combines in situ transposon mutagenesis,
biosensor-guided selection, and multiplex automated genome engineering. This approach
significantly accelerates the id...
www.cell.com
November 8, 2025 at 9:06 PM
#microsky
Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli: Trends in Biotechnology www.cell.com/trends/biote...
Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli: Trends in Biotechnology www.cell.com/trends/biote...
😳😬
November 7, 2025 at 10:03 PM
😳😬
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses - Nature Communications
In this study, the authors show that Salmonella enterica serovar Typhimurium co-opts the host mitochondrial citrate carrier (CIC) to regulate the redox state of its vacuole, facilitating intracellular...
www.nature.com
November 7, 2025 at 4:41 PM
🚨New preprint out!
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
November 7, 2025 at 7:03 AM