Vittorio Rispoli
@vittoriorispoli.bsky.social
Reposted by Vittorio Rispoli
New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !
We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.
www.nature.com/articles/s41...
We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.
www.nature.com/articles/s41...
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering
A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.
www.nature.com
September 24, 2025 at 12:01 PM
New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !
We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.
www.nature.com/articles/s41...
We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.
www.nature.com/articles/s41...
Reposted by Vittorio Rispoli
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
August 22, 2025 at 2:21 PM
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
We're excited to share our latest work:
“A Twisting Diagnosis: A New Case of VPS16-Related Hyperkinetic Spectrum and Literature Review” — now published in @Movement Disorders Clinical Practice #MDCP_Journal
Find out more here:
onlinelibrary.wiley.com/share/author...
“A Twisting Diagnosis: A New Case of VPS16-Related Hyperkinetic Spectrum and Literature Review” — now published in @Movement Disorders Clinical Practice #MDCP_Journal
Find out more here:
onlinelibrary.wiley.com/share/author...
onlinelibrary.wiley.com
August 19, 2025 at 7:35 PM
We're excited to share our latest work:
“A Twisting Diagnosis: A New Case of VPS16-Related Hyperkinetic Spectrum and Literature Review” — now published in @Movement Disorders Clinical Practice #MDCP_Journal
Find out more here:
onlinelibrary.wiley.com/share/author...
“A Twisting Diagnosis: A New Case of VPS16-Related Hyperkinetic Spectrum and Literature Review” — now published in @Movement Disorders Clinical Practice #MDCP_Journal
Find out more here:
onlinelibrary.wiley.com/share/author...
Reposted by Vittorio Rispoli
Can we reboot walking after Parkinson's disease DBS?
Can AI teach deep brain stimulation devices to help people 'walk the walk?' A new study by Wang says MAYBE. Using personalized data-driven models, they optimized DBS for walking.
@parkinsondotorg.bsky.social #parkinson @ucsfhealth.bsky.social
Can AI teach deep brain stimulation devices to help people 'walk the walk?' A new study by Wang says MAYBE. Using personalized data-driven models, they optimized DBS for walking.
@parkinsondotorg.bsky.social #parkinson @ucsfhealth.bsky.social
June 28, 2025 at 1:13 PM
Can we reboot walking after Parkinson's disease DBS?
Can AI teach deep brain stimulation devices to help people 'walk the walk?' A new study by Wang says MAYBE. Using personalized data-driven models, they optimized DBS for walking.
@parkinsondotorg.bsky.social #parkinson @ucsfhealth.bsky.social
Can AI teach deep brain stimulation devices to help people 'walk the walk?' A new study by Wang says MAYBE. Using personalized data-driven models, they optimized DBS for walking.
@parkinsondotorg.bsky.social #parkinson @ucsfhealth.bsky.social
Reposted by Vittorio Rispoli
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:24 PM
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
Reposted by Vittorio Rispoli
Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh
shorturl.at/5Atjh
Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo
Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe
shorturl.at
June 10, 2025 at 6:47 PM
Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh
shorturl.at/5Atjh
Reposted by Vittorio Rispoli
academic.oup.com/brain/advanc.... This is interesting
Classifying neurogenic dysphagia as a movement disorder
Swallowing is a complex sensorimotor task with widespread control throughout the nervous system. Jones et al. explore swallowing disorders in neurological
academic.oup.com
May 26, 2025 at 4:55 PM
academic.oup.com/brain/advanc.... This is interesting
Reposted by Vittorio Rispoli
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
May 22, 2025 at 8:41 PM
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
Reposted by Vittorio Rispoli
The apomorphine era has arrived…but do you know how we got here? After nearly two centuries of false starts, misuses, and rediscoveries, apomorphine is finally center stage in Parkinson’s disease therapy with the FDA approval of a subcutaneous infusion pump in 2025. Do you know the history?
May 23, 2025 at 1:56 PM
The apomorphine era has arrived…but do you know how we got here? After nearly two centuries of false starts, misuses, and rediscoveries, apomorphine is finally center stage in Parkinson’s disease therapy with the FDA approval of a subcutaneous infusion pump in 2025. Do you know the history?
Reposted by Vittorio Rispoli
Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation?
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
May 19, 2025 at 7:13 PM
Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation?
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
@lukasgoede.bsky.social says yes – new study here:
onlinelibrary.wiley.com/doi/10.1002/...
A 🧵
@netstim.org @braincircuits.bsky.social @lead-dbs.org
Reposted by Vittorio Rispoli
Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?
Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...
doi.org
May 19, 2025 at 7:14 PM
Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Reposted by Vittorio Rispoli
#Glycosphingolipidomics alterations iincluding #peripheral #immunity dependant profiles in #Parkinsons disease New Manuscript allert in #NatComm go.nature.com/43AalJZ
#Neurology
#Medicine
#Neurology
#Medicine
Extended coverage of human serum glycosphingolipidome by 4D-RP-LC TIMS-PASEF unravels association with Parkinson’s disease - Nature Communications
4D-TIMS-glycosphingolipidomics expedite clinical serum profiling of 376 GSLs covering ganglio- and neolacto-series, neutrals and sulfatides. Clinical phenotyping of Parkinson’s disease cohort (sub)gro...
go.nature.com
May 17, 2025 at 12:24 PM
#Glycosphingolipidomics alterations iincluding #peripheral #immunity dependant profiles in #Parkinsons disease New Manuscript allert in #NatComm go.nature.com/43AalJZ
#Neurology
#Medicine
#Neurology
#Medicine
Reposted by Vittorio Rispoli
MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
May 14, 2025 at 7:24 PM
MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
Reposted by Vittorio Rispoli
New paper in Imaging Neuroscience by Jack A. Reeves, Ferdinand Schweser, et al:
IRONMAP: Iron network mapping and analysis protocol for detecting over-time brain iron abnormalities in neurological disease
doi.org/10.1162/imag...
IRONMAP: Iron network mapping and analysis protocol for detecting over-time brain iron abnormalities in neurological disease
doi.org/10.1162/imag...
April 20, 2025 at 4:43 AM
New paper in Imaging Neuroscience by Jack A. Reeves, Ferdinand Schweser, et al:
IRONMAP: Iron network mapping and analysis protocol for detecting over-time brain iron abnormalities in neurological disease
doi.org/10.1162/imag...
IRONMAP: Iron network mapping and analysis protocol for detecting over-time brain iron abnormalities in neurological disease
doi.org/10.1162/imag...
Reposted by Vittorio Rispoli
Are we getting closer to noninvasive temporal interference stimulation instead of DBS? Maybe? DBS has been amazing; as we seek citius, altius, fortius; the swifter, higher and stronger approaches, we realize that the mountain is quite steep. TIS modulated beta oscillations deep in the human brain.
April 11, 2025 at 3:29 PM
Are we getting closer to noninvasive temporal interference stimulation instead of DBS? Maybe? DBS has been amazing; as we seek citius, altius, fortius; the swifter, higher and stronger approaches, we realize that the mountain is quite steep. TIS modulated beta oscillations deep in the human brain.
Reposted by Vittorio Rispoli
🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
April 9, 2025 at 6:19 PM
🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
Reposted by Vittorio Rispoli
Wouldn't it be cool to be able to stimulate deep w/in the brain w/o the need for brain surgery, and without actually making a physical lesion in the brain (i.e. FUS or pallidotomy)? This paper provides 'proof of concept' that a transcranial ultrasound stimulation (TUS) approach may be achievable.
March 30, 2025 at 3:25 PM
Wouldn't it be cool to be able to stimulate deep w/in the brain w/o the need for brain surgery, and without actually making a physical lesion in the brain (i.e. FUS or pallidotomy)? This paper provides 'proof of concept' that a transcranial ultrasound stimulation (TUS) approach may be achievable.
Reposted by Vittorio Rispoli
Excited to have my PhD project paper exploring the network mechanisms of neuromodulation accepted for publication!
We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.
We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.
February 18, 2025 at 2:52 PM
Excited to have my PhD project paper exploring the network mechanisms of neuromodulation accepted for publication!
We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.
We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.
Reposted by Vittorio Rispoli
Very excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.
Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001...
@laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
@laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
February 28, 2025 at 3:46 PM
Very excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.
Reposted by Vittorio Rispoli
ICYMI: New online! Parkinson disease pathology can originate in the kidney https://bit.ly/41sGYrY
February 24, 2025 at 9:22 PM
ICYMI: New online! Parkinson disease pathology can originate in the kidney https://bit.ly/41sGYrY
Reposted by Vittorio Rispoli
Out now in Brain Stimulation
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
February 22, 2025 at 12:31 AM
Out now in Brain Stimulation
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
Reposted by Vittorio Rispoli
@europepmc.org does have all* of PubMed indexed (and indeed partners with PMC for full text) - in addition to other sources (incl. for preprints).
OpenAlex (openalex.org) and Lens (lens.org) similarly include all* PubMed records, as does @openaire.bsky.social (but less easy to filter in webUI)
1/
OpenAlex (openalex.org) and Lens (lens.org) similarly include all* PubMed records, as does @openaire.bsky.social (but less easy to filter in webUI)
1/
OpenAlex
openalex.org
January 29, 2025 at 9:42 AM
@europepmc.org does have all* of PubMed indexed (and indeed partners with PMC for full text) - in addition to other sources (incl. for preprints).
OpenAlex (openalex.org) and Lens (lens.org) similarly include all* PubMed records, as does @openaire.bsky.social (but less easy to filter in webUI)
1/
OpenAlex (openalex.org) and Lens (lens.org) similarly include all* PubMed records, as does @openaire.bsky.social (but less easy to filter in webUI)
1/
Reposted by Vittorio Rispoli
A "key transcriptomic hallmark" in Parkinson's: Lower SNCA expression in genetic (SNCA, GBA, LRRK2) and non-genetic cohorts. This finding, "previously obscured by immune cell signatures," further supports the loss of function hypothesis. @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 28, 2025 at 2:33 AM
A "key transcriptomic hallmark" in Parkinson's: Lower SNCA expression in genetic (SNCA, GBA, LRRK2) and non-genetic cohorts. This finding, "previously obscured by immune cell signatures," further supports the loss of function hypothesis. @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Vittorio Rispoli
All that jerks is not myoclonus, not all who needle find benefit.
Our editorial on the new IAPRD myoclonus classification is online.
@albertoespay.bsky.social
www.prd-journal.com/article/S135...
Our editorial on the new IAPRD myoclonus classification is online.
@albertoespay.bsky.social
www.prd-journal.com/article/S135...
January 21, 2025 at 10:00 PM
All that jerks is not myoclonus, not all who needle find benefit.
Our editorial on the new IAPRD myoclonus classification is online.
@albertoespay.bsky.social
www.prd-journal.com/article/S135...
Our editorial on the new IAPRD myoclonus classification is online.
@albertoespay.bsky.social
www.prd-journal.com/article/S135...
Reposted by Vittorio Rispoli
"One email at a time, one informational interview after another, I became comfortable, confident, and strategic in building my network of mentors."
One mentor isn’t enough, wrote Erika Moore in this 2021 #ScienceWorkingLife essay. https://scim.ag/3DWR4YV #NationalMentoringMonth
One mentor isn’t enough, wrote Erika Moore in this 2021 #ScienceWorkingLife essay. https://scim.ag/3DWR4YV #NationalMentoringMonth
January 19, 2025 at 3:07 PM
"One email at a time, one informational interview after another, I became comfortable, confident, and strategic in building my network of mentors."
One mentor isn’t enough, wrote Erika Moore in this 2021 #ScienceWorkingLife essay. https://scim.ag/3DWR4YV #NationalMentoringMonth
One mentor isn’t enough, wrote Erika Moore in this 2021 #ScienceWorkingLife essay. https://scim.ag/3DWR4YV #NationalMentoringMonth